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The map label for this gene is uhpC [H]

Identifier: 194734088

GI number: 194734088

Start: 2315652

End: 2316974

Strand: Direct

Name: uhpC [H]

Synonym: SeSA_A2437

Alternate gene names: 194734088

Gene position: 2315652-2316974 (Clockwise)

Preceding gene: 194734716

Following gene: 194736830

Centisome position: 49.17

GC content: 50.87

Gene sequence:

>1323_bases
ATGAGTATAAAAACATTTATTTTCAGCCAGCCCGATAAGCCGATTGTAAAAGAGAAAAAAGAGATAGACCAGACCTATAA
AAAATTTCGTTTTGAGATTATCGCCTCGGTCTTTATCTCTTATGCCGTCTTTTATCTTACCCGTAAAAACTTCTCCGCCG
CGATGCCGGCCATGCTGACGCAAACGTCGCTGACCGCAGAAGACTTCGCCATTATGTCTTCTATTTTTTACATTCTTTAT
GGCGCGATGAAGTTTGTCGGCGGGATGCTGGTCGATAAAATTAACCCGAAAGCCATGACCGGCCCGGTGCTGATTGGCGT
GGGGATTGTAAATATTCTGTTCGGCTTTTCCGATAGCGTGGCGGCATTCTACGTACTGTACAGCCTCAACGCGATATTAC
AGGGCACCAGCTTTCCGCCGATGGCGAAAATTATGGCCTCGTGGTTTTCGAAAAACGAACGGGGACGCTGGTGGGCTATC
GTTGAAGCGGCGCACAATATCGGCGGCAGCCTCGCGCCGCTGCTGACCAGTTTTGCTATCGCCTTTAGCGGTAGCTGGAA
AATGGGGTTTTATGTTCCCGGCGCCATTTCGCTGCTGATGGGGATAGTGGCGCTATTTACCATTAAAGATCGTCCCGGTA
CGTTAGGTTTGCCCAACGTGGGGCAGTGGCGTAACGACCCGACGGAACTGGCCCAGGTCAAGGCCAGCCCGGTCAACCTG
AGCTTCTGGCAGATTTTTGTGAAATATATCCTGACCAATCCACTGGTATGGATCATTATTATCGGTGATATGTCGGTTTA
TATTGCGCGCACCATCCTTAACGACTGGCCGCAGATTTACTATTCGCAGGTTCACGGCTGGAGCCTGATAAAAGCGAACT
CGATTATTTCCTGGTTTGAGGCGGGCGGACTGGCAGGTGGGTTGCTGGCAGGCTACTTGTCTGACTTTATGTTCAAAAGT
AACCGCTGGATGACAGGGTTAATCTTCGCGTTAGCGCTGTGCATATGCATCGTGCTGGTGCCGCTGGTTCAGGATACCTC
TTACACCCTCACCGCGATTCTGTTCACCATCATGGGCTTCGCCTTATACGGACCGCATATGCTTTTTGCCGTCGGCTGTC
TGGATGTGACCCATAAGGATGCGGCGGGATCGATTACCGGCTTTCGGGGATTGTTCAGCTATGTCGGCGCGGCAATGGCC
GGTGTGCCGGTAATTATGGTGAAAAATAGCTGGGCGTGGTCGGGCGTTTATATCTATGCGTTAATCGCCATTCTGTTAAC
GACTCTGTCGCTGGCGCTGCTCTCCAGGCTGCATCGGTTATAA

Upstream 100 bases:

>100_bases
AAATCCACCATCAGATTAATTATCACGGTTTCGAATTGCTTCTTTTTCTTATTGAAGATGAATTATAACGCGACTCACCT
CGCCGGAAGGGAATTTTAAA

Downstream 100 bases:

>100_bases
CATTCTGGCGACAGCGGCAAAACGCGGCTGTCGCCAGTCTCTGTCAGAAACGGTAATCCACCGCCATAAAGTAACGACGT
CCGTCTTCGGTGTAACCGTA

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSIKTFIFSQPDKPIVKEKKEIDQTYKKFRFEIIASVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILY
GAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAI
VEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNL
SFWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKS
NRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMA
GVPVIMVKNSWAWSGVYIYALIAILLTTLSLALLSRLHRL

Sequences:

>Translated_440_residues
MSIKTFIFSQPDKPIVKEKKEIDQTYKKFRFEIIASVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILY
GAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAI
VEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNL
SFWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKS
NRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMA
GVPVIMVKNSWAWSGVYIYALIAILLTTLSLALLSRLHRL
>Mature_439_residues
SIKTFIFSQPDKPIVKEKKEIDQTYKKFRFEIIASVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYG
AMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIV
EAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNLS
FWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSN
RWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAG
VPVIMVKNSWAWSGVYIYALIAILLTTLSLALLSRLHRL

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=425, Percent_Identity=29.8823529411765, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4503847, Length=425, Percent_Identity=29.8823529411765, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI256219483, Length=425, Percent_Identity=29.8823529411765, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI256219543, Length=447, Percent_Identity=29.082774049217, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI256219564, Length=345, Percent_Identity=30.1449275362319, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI46361976, Length=494, Percent_Identity=20.8502024291498, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082310, Length=426, Percent_Identity=39.906103286385, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1788573, Length=428, Percent_Identity=32.0093457943925, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI2367259, Length=415, Percent_Identity=27.9518072289157, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789515, Length=371, Percent_Identity=27.4932614555256, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI2367379, Length=397, Percent_Identity=21.4105793450882, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542316, Length=445, Percent_Identity=22.9213483146067, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI133901856, Length=459, Percent_Identity=21.7864923747277, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI133901854, Length=459, Percent_Identity=21.7864923747277, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133930953, Length=445, Percent_Identity=24.0449438202247, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17564202, Length=331, Percent_Identity=22.9607250755287, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17564204, Length=261, Percent_Identity=23.7547892720307, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24656866, Length=397, Percent_Identity=20.4030226700252, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45550478, Length=397, Percent_Identity=20.4030226700252, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656861, Length=397, Percent_Identity=20.4030226700252, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48525; Mature: 48394

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKTFIFSQPDKPIVKEKKEIDQTYKKFRFEIIASVFISYAVFYLTRKNFSAAMPAMLT
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHH
AAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHH
AFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNL
HCCCCCEEEEECCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCH
SFWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFE
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
AGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGF
HCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSGVYIYA
HHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
LIAILLTTLSLALLSRLHRL
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIKTFIFSQPDKPIVKEKKEIDQTYKKFRFEIIASVFISYAVFYLTRKNFSAAMPAMLT
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHH
AAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHH
AFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNL
HCCCCCEEEEECCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCH
SFWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFE
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
AGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGF
HCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSGVYIYA
HHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
LIAILLTTLSLALLSRLHRL
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]