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The map label for this gene is thrB [H]

Identifier: 194734054

GI number: 194734054

Start: 2801

End: 3730

Strand: Direct

Name: thrB [H]

Synonym: SeSA_A0003

Alternate gene names: 194734054

Gene position: 2801-3730 (Clockwise)

Preceding gene: 194737774

Following gene: 194736906

Centisome position: 0.06

GC content: 57.96

Gene sequence:

>930_bases
ATGGTGAAAGTGTATGCCCCGGCTTCCAGCGCGAACATGAGCGTCGGTTTCGACGTGTTGGGCGCGGCCGTCACACCCGT
TGACGGCACGTTGCTGGGCGATGTGGTATCCGTTGAAGCAGCGGACCATTTCCGTCTGCATAACCTGGGGCGATTTGCCG
ATAAACTGCCGCCGGAGCCGCGTGAAAATATTGTTTATCAGTGCTGGGAACGTTTTTGCCAGGCATTGGGGAAAACCATC
CCGGTGGCGATGACGCTGGAAAAAAATATGCCGATTGGTTCCGGGTTAGGGTCCAGCGCCTGTTCCGTCGTTGCTGCGCT
GGTCGCGATGAATGAGCACTGCGGCAAACCGTTAAACGACACGCGTCTGTTGGCGCTGATGGGCGAGCTGGAAGGCCGTA
TCTCCGGCAGCATCCATTACGATAACGTCGCGCCGTGCTTTCTTGGCGGTATGCAGCTGATGATTGAAGAAAACGGCATT
ATTAGTCAGCAGGTGCCGGGCTTTGATGAGTGGCTATGGGTACTGGCTTATCCGGGCATTAAAGTTTCCACCGCAGAAGC
ACGGGCCATTTTGCCTGCGCAGTATCGCCGTCAGGATTGCATTGCGCATGGACGGCATCTGGCCGGTTTTATTCACGCCT
GTTACTCGCGGCAGCCGCAGCTTGCCGCCGCGCTGATGAAAGATGTTATTGCCGAACCATACCGCGCGCGTTTACTGCCG
GGCTTTAGCCAGGCGCGGCAGGCGGTATCGGAGATCGGCGCGCTGGCGAGCGGGATTTCCGGGTCGGGGCCGACGCTGTT
TGCGCTATGCGATAAACCGGAGACGGCGCAGCGCGTCGCGGACTGGCTGAGCAAACATTATCTGCAAAATCAGGAAGGCT
TCGTTCATATTTGCCGGCTGGATACGGCGGGCGCACGAGTAGTGGGATAA

Upstream 100 bases:

>100_bases
CCGTTGGTGCTGCGCGGCTACGGCGCAGGCAATGATGTGACGGCGGCGGGCGTGTTTGCCGATCTGTTACGGACCCTCTC
ATGGAAGTTAGGAGTTTAAC

Downstream 100 bases:

>100_bases
TCAATGAAACTCTATAATCTGAAAGACCATAATGAGCAGGTCAGCTTTGCGCAGGCCGTCACGCAAGGACTGGGCAAACA
GCAGGGACTTTTTTTTCCGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEPRENIVYQCWERFCQALGKTI
PVAMTLEKNMPIGSGLGSSACSVVAALVAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGI
ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLP
GFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRLDTAGARVVG

Sequences:

>Translated_309_residues
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEPRENIVYQCWERFCQALGKTI
PVAMTLEKNMPIGSGLGSSACSVVAALVAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGI
ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLP
GFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRLDTAGARVVG
>Mature_309_residues
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEPRENIVYQCWERFCQALGKTI
PVAMTLEKNMPIGSGLGSSACSVVAALVAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGI
ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLP
GFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRLDTAGARVVG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=308, Percent_Identity=93.5064935064935, Blast_Score=599, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33287; Mature: 33287

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEP
CEEEECCCCCCCCEECHHHHHCCCCCCCCHHHHHHHEECCHHHHHHHHHHHHHHHCCCCC
RENIVYQCWERFCQALGKTIPVAMTLEKNMPIGSGLGSSACSVVAALVAMNEHCGKPLND
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
TRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGI
HHHHHHHHHHCCCCCCCEEECCCCHHHHCCEEEEEECCCCCCCCCCCHHHHHHHEECCCC
KVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLP
EEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHCC
GFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRL
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
DTAGARVVG
CCCCCCCCC
>Mature Secondary Structure
MVKVYAPASSANMSVGFDVLGAAVTPVDGTLLGDVVSVEAADHFRLHNLGRFADKLPPEP
CEEEECCCCCCCCEECHHHHHCCCCCCCCHHHHHHHEECCHHHHHHHHHHHHHHHCCCCC
RENIVYQCWERFCQALGKTIPVAMTLEKNMPIGSGLGSSACSVVAALVAMNEHCGKPLND
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
TRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENGIISQQVPGFDEWLWVLAYPGI
HHHHHHHHHHCCCCCCCEEECCCCHHHHCCEEEEEECCCCCCCCCCCHHHHHHHEECCCC
KVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPQLAAALMKDVIAEPYRARLLP
EEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHCC
GFSQARQAVSEIGALASGISGSGPTLFALCDKPETAQRVADWLSKHYLQNQEGFVHICRL
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
DTAGARVVG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA