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The map label for this gene is rihC [H]

Identifier: 194734027

GI number: 194734027

Start: 60168

End: 61088

Strand: Direct

Name: rihC [H]

Synonym: SeSA_A0057

Alternate gene names: 194734027

Gene position: 60168-61088 (Clockwise)

Preceding gene: 194734594

Following gene: 194734877

Centisome position: 1.28

GC content: 58.09

Gene sequence:

>921_bases
ATGGCAGCATCCCTACACATTATTCTTGATACCGATCCAGGCATTGATGACGCCGCCGCGATTGCCGCTGCGCTGTTTGC
CCCCGAGCTGGATCTGCAACTGATGACCACCGTTGCCGGCAACGTTTCGGTCGAAAAAACCACCCGTAACGGCTTACAGC
TCCTGCATTTCTGGGACGCCGATGTGCCACTTGCCCAGGGGGCCGCGACGCCGCTGCTGCGTCCGTTACGCGATGCGGCA
TACGTCCACGGCGAATCCGGCATGGAAGGCTATGATTTTGTCGACCATCAGCGCCAACCGTTGGCGAAGCCAGCGTTTAT
CGCTATCCGGGATGTGCTGATGAACGCCCCGGAGCCCATGACATTGGTGGCGATAGGGCCATTGACCAATATTGCGTTGC
TACTGATGCACTATCCGGAGTGCCGCTTCAACATTCACCGGCTGGTGATTATGGGCGGTTCCGCAGGGCGCGGCAATTTT
ACGCCTAATGCTGAATTTAACATTGCTGTCGATCCGGAAGCCGCCGCCCACGTATTTCGTAGCGGCATTGAGATTGTGAT
GTGTGGGCTGGACGTCACCAATCAGGCCGTGTTGACGCCGGAGTATCTGGCTACGCTTCCTGCGCTTAATAAAACCGGCG
GCATGCTGCATGCATTGTTCAGCCATTACCGCAGCGGCAGTATGCAAAGCGGTCTGCGGATGCACGATCTCTGCGCTATC
GCCTGGCTGGTGCGTCCGGAGCTTTTTACCCTGCAATCCTGTTTTGTGGCCGTAGAAACGCAGGGGCAATATACCGCAGG
TACCACGGTGGTGGATATTGAAGGGCGTCTGGGGCAGCCCGCCAACGCGCAGGTGGCGCTGGCGCTGGATGTGGACGGTT
TTCGTCAGTGGGTGGCTGAGGTGTTTGCCTGTGCGCCGTAA

Upstream 100 bases:

>100_bases
TAAGCTAAGTCCGCGTCTGGTGACGGATGACGATGTGCCTGATACCTGTATCAGTCGCGCTGAGTACGAAGATATAAAAC
AATAGGTCAGGAGAGCGTTA

Downstream 100 bases:

>100_bases
TTACATGTTGGCGCCATAATCTCATACTTTGCCGCGATAGAGTCTCTCCGGCCTGCCCACTTTCCCGTAGCTGATCTCCG
CTTCGAGAAAGTTATTTTTC

Product: ribonucleoside hydrolase RihC

Products: uracil; ribose; xanthine; hypoxanthine; adenine; cytosine; guanine [C]

Alternate protein names: Purine/pyrimidine ribonucleoside hydrolase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAASLHIILDTDPGIDDAAAIAAALFAPELDLQLMTTVAGNVSVEKTTRNGLQLLHFWDADVPLAQGAATPLLRPLRDAA
YVHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPMTLVAIGPLTNIALLLMHYPECRFNIHRLVIMGGSAGRGNF
TPNAEFNIAVDPEAAAHVFRSGIEIVMCGLDVTNQAVLTPEYLATLPALNKTGGMLHALFSHYRSGSMQSGLRMHDLCAI
AWLVRPELFTLQSCFVAVETQGQYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAEVFACAP

Sequences:

>Translated_306_residues
MAASLHIILDTDPGIDDAAAIAAALFAPELDLQLMTTVAGNVSVEKTTRNGLQLLHFWDADVPLAQGAATPLLRPLRDAA
YVHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPMTLVAIGPLTNIALLLMHYPECRFNIHRLVIMGGSAGRGNF
TPNAEFNIAVDPEAAAHVFRSGIEIVMCGLDVTNQAVLTPEYLATLPALNKTGGMLHALFSHYRSGSMQSGLRMHDLCAI
AWLVRPELFTLQSCFVAVETQGQYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAEVFACAP
>Mature_305_residues
AASLHIILDTDPGIDDAAAIAAALFAPELDLQLMTTVAGNVSVEKTTRNGLQLLHFWDADVPLAQGAATPLLRPLRDAAY
VHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPMTLVAIGPLTNIALLLMHYPECRFNIHRLVIMGGSAGRGNFT
PNAEFNIAVDPEAAAHVFRSGIEIVMCGLDVTNQAVLTPEYLATLPALNKTGGMLHALFSHYRSGSMQSGLRMHDLCAIA
WLVRPELFTLQSCFVAVETQGQYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAEVFACAP

Specific function: Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786213, Length=301, Percent_Identity=82.0598006644518, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1786871, Length=304, Percent_Identity=45.3947368421053, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI1788486, Length=303, Percent_Identity=40.2640264026403, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32565474, Length=200, Percent_Identity=30.5, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565698, Length=189, Percent_Identity=32.8042328042328, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320608, Length=215, Percent_Identity=33.0232558139535, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641837, Length=328, Percent_Identity=31.7073170731707, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24641839, Length=184, Percent_Identity=34.2391304347826, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583915, Length=185, Percent_Identity=34.5945945945946, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022976 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 32914; Mature: 32783

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASLHIILDTDPGIDDAAAIAAALFAPELDLQLMTTVAGNVSVEKTTRNGLQLLHFWDA
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCEEEEEEECC
DVPLAQGAATPLLRPLRDAAYVHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPM
CCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCE
TLVAIGPLTNIALLLMHYPECRFNIHRLVIMGGSAGRGNFTPNAEFNIAVDPEAAAHVFR
EEEEECCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHH
SGIEIVMCGLDVTNQAVLTPEYLATLPALNKTGGMLHALFSHYRSGSMQSGLRMHDLCAI
CCCEEEEECCCCCCCEEECHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHCCCHHHHHHHH
AWLVRPELFTLQSCFVAVETQGQYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAE
HHHHCCHHHEEEEEEEEEECCCCEECCCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHH
VFACAP
HHHCCC
>Mature Secondary Structure 
AASLHIILDTDPGIDDAAAIAAALFAPELDLQLMTTVAGNVSVEKTTRNGLQLLHFWDA
CCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCEEEEEEECC
DVPLAQGAATPLLRPLRDAAYVHGESGMEGYDFVDHQRQPLAKPAFIAIRDVLMNAPEPM
CCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCE
TLVAIGPLTNIALLLMHYPECRFNIHRLVIMGGSAGRGNFTPNAEFNIAVDPEAAAHVFR
EEEEECCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHH
SGIEIVMCGLDVTNQAVLTPEYLATLPALNKTGGMLHALFSHYRSGSMQSGLRMHDLCAI
CCCEEEEECCCCCCCEEECHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHCCCHHHHHHHH
AWLVRPELFTLQSCFVAVETQGQYTAGTTVVDIEGRLGQPANAQVALALDVDGFRQWVAE
HHHHCCHHHEEEEEEEEEECCCCEECCCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHH
VFACAP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine; H2O; xanthosine; inosine; adenosine; cytidine; guanosine [C]

Specific reaction: uridine + H2O = uracil + ribose xanthosine + H2O = xanthine + ribose inosine + H2O = hypoxanthine + ribose adenosine + H2O = adenine + ribose cytidine + H2O = cytosine + ribose guanosine + H2O = guanine + ribose [C]

General reaction: Nonspecific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA