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The map label for this gene is gltS [H]

Identifier: 194733970

GI number: 194733970

Start: 3824160

End: 3825365

Strand: Reverse

Name: gltS [H]

Synonym: SeSA_A3953

Alternate gene names: 194733970

Gene position: 3825365-3824160 (Counterclockwise)

Preceding gene: 194737559

Following gene: 194734322

Centisome position: 81.23

GC content: 56.88

Gene sequence:

>1206_bases
ATGTTTGAACTCGATACCTTATCGACCCTTGTCGCCGCCACGCTGGTGCTGCTACTGGGTCGCAAGCTGGTCCAGTCTGT
CTCCTTACTGAAGAAATATACGATTCCGGAGCCGGTGGCGGGGGGGTTACTGGTCGCGGTTGCGCTGCTGGTGCTGAAAA
AAAGCGTCGGTTGGGAGGTCAACTTTGATATGACCCTGCGCGATCCGTTGATGCTGGCGTTTTTCGCGACGATCGGCCTT
AACGCTAACCTTGCCAGCCTGCGCAAGGGGGGACGCGTTGTTGGCGTCTTCCTGGTCGTCGTGGTCGGATTACTGCTGAT
GCAGAATGCCATCGGTATCGGCATGGCGAGTCTGTTGGGGCTGGACCCGTTAATGGGGCTGATTGCCGGGTCAATTACGC
TGTCCGGCGGACACGGTACCGGCGCGGCGTGGAGTAAACTGTTTGTCGAACGTTATGGTTTTGCCAATGCCACCGAAGTT
GCGATGGCATGTGCAACCTTTGGCCTGGTGCTGGGCGGGTTGATAGGCGGCCCGGTAGCGCGTTATCTGGTGAAACACTC
CACCACGCCGGATGGAATGCCTGACGATCAGGCCGTGCCGACAGCCTTTGAAAAGCCGGATGTGGGCCGTATGATCACTT
CTCTGGTGCTAATCGAAACCATCGCCCTGATTGCTATCTGTCTGACCGTGGGCAAAATCGTAGCGCAGCTACTGGCGGGA
ACGGTGCTTGAACTGCCGGTCTTCGTTTGTGTGCTATTTGTTGGGGTGATCCTCAGCAATGGCCTGGCGCTGGTGGGTTT
TTATCGCGTATTTGAGCGTGCTGTTTCGGTGCTGGGGAACGTGAGTCTGTCACTGTTCCTGGCAATGGCGCTGATGAGCC
TGAAGCTGTGGGAACTGGCGTCGCTGGCGCTGCCGATGCTGGCGATTCTGGTGGTACAGACCATCTTCATGGCGCTGTAC
GCGATCTTCGTCACCTGGCGCATGATGGGGAAAAACTACGATGCAGCGGTGTTGGCGGCGGGTCACTGCGGTTTTGGCCT
GGGCGCAACGCCGACCGCCATTGCTAATATGCAGGCGATTACCGACCGTTTTGGCCCCTCGCATATGGCGTTCCTGGTGG
TGCCGATGGTTGGTGCGTTCTTTATCGATATCGTTAATGCGTTGGTAATCAAGCTGTACCTGCTGTTACCGATTTTCGCG
CAATAA

Upstream 100 bases:

>100_bases
TTTCTGCTTAAAATCCATGCCGAAGACTCGCAAAGAGCTAAAAAACTGACTCAGGAAATGATTTGTGCGCACATGTCACA
GCGCACTACAGGAGCTTTAA

Downstream 100 bases:

>100_bases
TAGTTTGTACGGCGGCATTAAAGCCGCCGTGCTCATTAGGCGTTGGAATAACGTTCGGTTTCCGGCATCCAGCGCTCAAT
CAGCGCTTGTGCCTGCTGCG

Product: sodium/glutamate symporter

Products: Na (I) [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate permease [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MFELDTLSTLVAATLVLLLGRKLVQSVSLLKKYTIPEPVAGGLLVAVALLVLKKSVGWEVNFDMTLRDPLMLAFFATIGL
NANLASLRKGGRVVGVFLVVVVGLLLMQNAIGIGMASLLGLDPLMGLIAGSITLSGGHGTGAAWSKLFVERYGFANATEV
AMACATFGLVLGGLIGGPVARYLVKHSTTPDGMPDDQAVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG
TVLELPVFVCVLFVGVILSNGLALVGFYRVFERAVSVLGNVSLSLFLAMALMSLKLWELASLALPMLAILVVQTIFMALY
AIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITDRFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLLLPIFA
Q

Sequences:

>Translated_401_residues
MFELDTLSTLVAATLVLLLGRKLVQSVSLLKKYTIPEPVAGGLLVAVALLVLKKSVGWEVNFDMTLRDPLMLAFFATIGL
NANLASLRKGGRVVGVFLVVVVGLLLMQNAIGIGMASLLGLDPLMGLIAGSITLSGGHGTGAAWSKLFVERYGFANATEV
AMACATFGLVLGGLIGGPVARYLVKHSTTPDGMPDDQAVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG
TVLELPVFVCVLFVGVILSNGLALVGFYRVFERAVSVLGNVSLSLFLAMALMSLKLWELASLALPMLAILVVQTIFMALY
AIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITDRFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLLLPIFA
Q
>Mature_401_residues
MFELDTLSTLVAATLVLLLGRKLVQSVSLLKKYTIPEPVAGGLLVAVALLVLKKSVGWEVNFDMTLRDPLMLAFFATIGL
NANLASLRKGGRVVGVFLVVVVGLLLMQNAIGIGMASLLGLDPLMGLIAGSITLSGGHGTGAAWSKLFVERYGFANATEV
AMACATFGLVLGGLIGGPVARYLVKHSTTPDGMPDDQAVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG
TVLELPVFVCVLFVGVILSNGLALVGFYRVFERAVSVLGNVSLSLFLAMALMSLKLWELASLALPMLAILVVQTIFMALY
AIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITDRFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLLLPIFA
Q

Specific function: Catalyzes the sodium-dependent uptake of extracellular glutamate [H]

COG id: COG0786

COG function: function code E; Na+/glutamate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gltS symporter family [H]

Homologues:

Organism=Escherichia coli, GI1790085, Length=400, Percent_Identity=93, Blast_Score=673, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004445 [H]

Pfam domain/function: PF03616 Glt_symporter [H]

EC number: NA

Molecular weight: Translated: 42330; Mature: 42330

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELDTLSTLVAATLVLLLGRKLVQSVSLLKKYTIPEPVAGGLLVAVALLVLKKSVGWEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
NFDMTLRDPLMLAFFATIGLNANLASLRKGGRVVGVFLVVVVGLLLMQNAIGIGMASLLG
EECCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDPLMGLIAGSITLSGGHGTGAAWSKLFVERYGFANATEVAMACATFGLVLGGLIGGPVA
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RYLVKHSTTPDGMPDDQAVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLELPVFVCVLFVGVILSNGLALVGFYRVFERAVSVLGNVSLSLFLAMALMSLKLWELA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLALPMLAILVVQTIFMALYAIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCHHHHHHHHHH
TDRFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLLLPIFAQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFELDTLSTLVAATLVLLLGRKLVQSVSLLKKYTIPEPVAGGLLVAVALLVLKKSVGWEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEE
NFDMTLRDPLMLAFFATIGLNANLASLRKGGRVVGVFLVVVVGLLLMQNAIGIGMASLLG
EECCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDPLMGLIAGSITLSGGHGTGAAWSKLFVERYGFANATEVAMACATFGLVLGGLIGGPVA
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RYLVKHSTTPDGMPDDQAVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVLELPVFVCVLFVGVILSNGLALVGFYRVFERAVSVLGNVSLSLFLAMALMSLKLWELA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLALPMLAILVVQTIFMALYAIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCHHHHHHHHHH
TDRFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLLLPIFAQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + L-glutamate [Periplasm] = Na (I) [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2254324; 2017136; 7686882; 9278503; 1544582 [H]