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The map label for this gene is basS [H]

Identifier: 194733917

GI number: 194733917

Start: 4423227

End: 4424306

Strand: Reverse

Name: basS [H]

Synonym: SeSA_A4546

Alternate gene names: 194733917

Gene position: 4424306-4423227 (Counterclockwise)

Preceding gene: 194734993

Following gene: 194735822

Centisome position: 93.95

GC content: 54.35

Gene sequence:

>1080_bases
GTGAGCCTGATGCGTTTTCAGCGAAGAGCGATGACCCTTCGCCAGCGTTTAATGCTGACAATTGGTCTTATTCTGCTGGT
GTTCCAGTTAATCAGTACCTTCTGGTTATGGCATGAAAGCACTGAGCAAATTCAATTGTTCGAGCAGGCGCTGCGGGATA
ATCGCAACAACGATCGCCATATCATGCACGAAATTCGCGAGGCGGTCGCCAGCCTGATCGTCCCCGGCGTATTTATGGTT
AGCCTGACTCTGCTAATTTGTTACCAGGCGGTACGGCGTATTACCCGTCCGCTCGCCGAACTGCAAAAAGAGCTGGAAGC
ACGGACGGCGGATAATCTGGCGCCGATCGCCATTCACAGCTCCACGCTTGAGATTGAGTCCGTCGTCTCGGCGATCAATC
AACTGGTTACGCGTTTGACCACCACGCTCGACAATGAACGCCTTTTTACCGCCGATGTGGCCCATGAGCTACGCACGCCG
CTGTCGGGGGTGCGTTTGCATCTGGAATTATTGTCAAAAACCCACAATGTTGATGTCGCGCCGCTTATCGCCCGTCTTGA
CCAGATGATGGATAGCGTCTCCCAGCTTCTGCAACTGGCGCGCGTGGGCCAGTCATTCTCTTCCGGGAATTATCAGGAAG
TAAAACTGCTGGAAGATGTGATCCTCCCCTCCTACGATGAGCTGAACACCATGCTGGAAACGCGTCAGCAAACTCTGTTG
CTGCCGGAAAGCGCGGCGGACGTGGTGGTGCGCGGTGACGCGACGTTACTGCGTATGCTGCTGCGAAATCTGGTGGAAAA
CGCGCATCGCTATAGCCCTGAAGGAACCCATATCACTATCCACATTAGCGCCGACCCCAACGCTATTATGGCGGTCGAAG
ACGAGGGGCCGGGTATTGATGAAAGCAAATGCGGGAAGCTAAGCGAAGCGTTCGTGCGGATGGACAGCCGTTATGGCGGA
ATTGGCCTGGGGCTGAGTATCGTCAGCCGCATCACCCAACTACATCAGGGACAGTTTTTCCTGCAAAACCGTACGGAAAG
AACAGGCACCCGTGCCTGGGTGCTGTTGAAAAAGGCATAA

Upstream 100 bases:

>100_bases
GGAAGTGCATATACATAATTTGCGCGACAAAGTCGGCAAGTCGCGCATTCGCACGGTTCGCGGGTTTGGCTACATGCTGG
TTGCCACTGAGGAAAGCTAA

Downstream 100 bases:

>100_bases
CAGGCGTTTAATACGTCGTGACCCACACATAGATAAAACTGCTGACAATCAGCACACTACACAGGGTCGTCAAACTTTTA
TAAATATAGCTTTTCATGAC

Product: sensor protein BasS/PmrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSLMRFQRRAMTLRQRLMLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRHIMHEIREAVASLIVPGVFMV
SLTLLICYQAVRRITRPLAELQKELEARTADNLAPIAIHSSTLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTP
LSGVRLHLELLSKTHNVDVAPLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPNAIMAVEDEGPGIDESKCGKLSEAFVRMDSRYGG
IGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA

Sequences:

>Translated_359_residues
MSLMRFQRRAMTLRQRLMLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRHIMHEIREAVASLIVPGVFMV
SLTLLICYQAVRRITRPLAELQKELEARTADNLAPIAIHSSTLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTP
LSGVRLHLELLSKTHNVDVAPLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPNAIMAVEDEGPGIDESKCGKLSEAFVRMDSRYGG
IGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA
>Mature_358_residues
SLMRFQRRAMTLRQRLMLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRHIMHEIREAVASLIVPGVFMVS
LTLLICYQAVRRITRPLAELQKELEARTADNLAPIAIHSSTLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTPL
SGVRLHLELLSKTHNVDVAPLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLLL
PESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPNAIMAVEDEGPGIDESKCGKLSEAFVRMDSRYGGI
GLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA

Specific function: Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virul

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790551, Length=355, Percent_Identity=85.9154929577465, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1789403, Length=276, Percent_Identity=32.2463768115942, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789808, Length=269, Percent_Identity=29.368029739777, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=30.8370044052863, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=28.0528052805281, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=29.8701298701299, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=27.9661016949153, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=29.0540540540541, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=245, Percent_Identity=28.9795918367347, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=354, Percent_Identity=24.5762711864407, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=278, Percent_Identity=24.8201438848921, Blast_Score=61, Evalue=9e-11,
Organism=Escherichia coli, GI1787374, Length=277, Percent_Identity=24.9097472924188, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40594; Mature: 40462

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMRFQRRAMTLRQRLMLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHH
IMHEIREAVASLIVPGVFMVSLTLLICYQAVRRITRPLAELQKELEARTADNLAPIAIHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
STLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTPLSGVRLHLELLSKTHNVDVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHH
PLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPNAIMAVEDEGPGID
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCC
ESKCGKLSEAFVRMDSRYGGIGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SLMRFQRRAMTLRQRLMLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHH
IMHEIREAVASLIVPGVFMVSLTLLICYQAVRRITRPLAELQKELEARTADNLAPIAIHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
STLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTPLSGVRLHLELLSKTHNVDVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHH
PLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPNAIMAVEDEGPGID
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCC
ESKCGKLSEAFVRMDSRYGGIGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8391535; 11677609 [H]