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The map label for this gene is sdhA [H]

Identifier: 194335043

GI number: 194335043

Start: 2432157

End: 2433911

Strand: Reverse

Name: sdhA [H]

Synonym: Paes_2255

Alternate gene names: 194335043

Gene position: 2433911-2432157 (Counterclockwise)

Preceding gene: 194335044

Following gene: 194335042

Centisome position: 96.86

GC content: 54.7

Gene sequence:

>1755_bases
ATGGATGTTGTTTATCATGATGTGATCATTGTCGGCGCAGGGCTTGCCGGCCTGCGTGCAGCGGTGGAACTTGCAGGATC
AGCCGATGTGGCGGTGCTATCCAAGCTGCACCCCCTTCGTTCTCATTCCGGTGCTGCTCAGGGAGGGATATCTGCAGCTC
TCGGAAATGTTGAAGAGGATAACCCTGACTGGCATGCCTATGATACGATCAAGGGTTCGGATTATCTTGCTGATCAGTAT
GCTGTCCAGGTGATGTGCAATGACGCTCCGAGAGCGATTATCGAGATGGAGCATCTGGGAGTTCCTTTTTCCCGTCTCGA
TGACGGGCGTATAGCCCAGCGTCCATTTGGCGGCCATACCCGGAATTTCGGTCAGGCGCCTGTTCGCAGGACCTGTTTTG
CTGCGGATCGAACAGGACATGTCTGCCTGCATACGCTCTACGAGCAGTCGCTCAAGCAGGGCGTTAGGTTTTATGATGAA
ATTCAGGTGCTCGATCTGTGTATGGAGGATGGCTCGGTTAACGGTGTCGTTGCCATGGAGCTTCTGACCGGCCGCATAGT
GCTCATGCATGCAAAAGCGGTGATGTTTGCGACCGGAGGTTATGGTAAGGCATGGAAGACGACCTCGAACGCTTTTGCCA
ATACCGGTGATGGTTTGGGGATCGTGCTTCGTAACGGTCTTCCTCTTCAGGATATGGAGTTTGTCCAGTTTCATCCGACA
GGACTCTATCAGTTGGGGATTCTTATTACCGAGGCGGCAAGAGGAGAGGGCGGCATATTGCTCAACGGCAACGGAGAGCG
GTTTATGGAACGCTATGCACCCAGTATCAAGGACCTTGCTCCGCGAGATATTGTAAGTCGGAGTATTTATGATGAGCTGA
AAGCCGGCAGGGGCGCTGGTCCCGAAAAAGATCATGTGCTGTTGGACCTGACATCGCTTTCGCATGAGAAAATCGCAAGC
CGTCTGCCCGAGATCGAGTCTTTTGCGAAAGTCTATCTGGGCATCGATCCTTCACGAGCGCCTATTCCTGTACTTCCTAC
CTGCCACTATGCCATGGGCGGCATTCCCACCTCGGTGGATGGTCGCGTTCTCGGCGATGCTGAGGGTCGTGAGGTTCCGG
GTTTCTGGGCGGCAGGAGAGGTCGCCTGTGTTTCGGTGCATGGCGCCAATCGTCTCGGATCAAACTCTCTTCTGGATCTT
ATTGTGTTTGGCCGGCGCAGCGGAAAGGATATTGCTCAATTCCTGAAGAAGAGCGGGCCGGCGTTGCCTCTCGACATGCA
TGCCGCTGATCGCGTCAAGGGGGTTATCAGCACGCTTCTGGATCGTCAGAGCGGTGAATCCGTTGCCGCAGTGCGCCGTG
ATCTTCAGCGGGTTATGATGGATGACGTATCGGTGTTCCGCCAGGAGTCATGCCTGGCCGATGCGGTCAGCAAGCTGCGC
GAACTGCAGCAGCGGGCATCGTTGATCCGGGTCAGGGACAGGACAAGAAATTTCAACCAGGAGCTTACCGACGCTCTTGA
GCTGCAGCACATGGTCAATTATTCTCTGACGGTTGCGCTTTCAGCGCTCAATCGTCGTGAATCGCGGGGCGCGCACAGCA
GGGAGGATTATCCCGACCGGGACGACGCCAATTGGCTGAAGCATTCAATGTGCCGTATGGATGAAGAGGGTGGCGTGCAG
CTTTTTGATAGGCCTGTCGATCTCTCATTAGCGGCGGCAAATCCTGTGTTTGTTCCGAAAGAAAGAAAGTACTGA

Upstream 100 bases:

>100_bases
TGCAGGAAGTCTTGCCGTCTGTCTTTTCCTCTCTGTTCAGGGAATTGCCTCTATTCTTGCTGCCGGGTCTGGCGCGTAAT
CCGATGTAAAATTGAAGTTT

Downstream 100 bases:

>100_bases
TCGTCAAACAGCGCATTGAGTGTTTGATGTTTGGTTTGATAGTTGATGTAATGAATTGTTAAGCGCGAAGCGTGATATAA
AGGAGTTTATTTATGAAATA

Product: succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MDVVYHDVIIVGAGLAGLRAAVELAGSADVAVLSKLHPLRSHSGAAQGGISAALGNVEEDNPDWHAYDTIKGSDYLADQY
AVQVMCNDAPRAIIEMEHLGVPFSRLDDGRIAQRPFGGHTRNFGQAPVRRTCFAADRTGHVCLHTLYEQSLKQGVRFYDE
IQVLDLCMEDGSVNGVVAMELLTGRIVLMHAKAVMFATGGYGKAWKTTSNAFANTGDGLGIVLRNGLPLQDMEFVQFHPT
GLYQLGILITEAARGEGGILLNGNGERFMERYAPSIKDLAPRDIVSRSIYDELKAGRGAGPEKDHVLLDLTSLSHEKIAS
RLPEIESFAKVYLGIDPSRAPIPVLPTCHYAMGGIPTSVDGRVLGDAEGREVPGFWAAGEVACVSVHGANRLGSNSLLDL
IVFGRRSGKDIAQFLKKSGPALPLDMHAADRVKGVISTLLDRQSGESVAAVRRDLQRVMMDDVSVFRQESCLADAVSKLR
ELQQRASLIRVRDRTRNFNQELTDALELQHMVNYSLTVALSALNRRESRGAHSREDYPDRDDANWLKHSMCRMDEEGGVQ
LFDRPVDLSLAAANPVFVPKERKY

Sequences:

>Translated_584_residues
MDVVYHDVIIVGAGLAGLRAAVELAGSADVAVLSKLHPLRSHSGAAQGGISAALGNVEEDNPDWHAYDTIKGSDYLADQY
AVQVMCNDAPRAIIEMEHLGVPFSRLDDGRIAQRPFGGHTRNFGQAPVRRTCFAADRTGHVCLHTLYEQSLKQGVRFYDE
IQVLDLCMEDGSVNGVVAMELLTGRIVLMHAKAVMFATGGYGKAWKTTSNAFANTGDGLGIVLRNGLPLQDMEFVQFHPT
GLYQLGILITEAARGEGGILLNGNGERFMERYAPSIKDLAPRDIVSRSIYDELKAGRGAGPEKDHVLLDLTSLSHEKIAS
RLPEIESFAKVYLGIDPSRAPIPVLPTCHYAMGGIPTSVDGRVLGDAEGREVPGFWAAGEVACVSVHGANRLGSNSLLDL
IVFGRRSGKDIAQFLKKSGPALPLDMHAADRVKGVISTLLDRQSGESVAAVRRDLQRVMMDDVSVFRQESCLADAVSKLR
ELQQRASLIRVRDRTRNFNQELTDALELQHMVNYSLTVALSALNRRESRGAHSREDYPDRDDANWLKHSMCRMDEEGGVQ
LFDRPVDLSLAAANPVFVPKERKY
>Mature_584_residues
MDVVYHDVIIVGAGLAGLRAAVELAGSADVAVLSKLHPLRSHSGAAQGGISAALGNVEEDNPDWHAYDTIKGSDYLADQY
AVQVMCNDAPRAIIEMEHLGVPFSRLDDGRIAQRPFGGHTRNFGQAPVRRTCFAADRTGHVCLHTLYEQSLKQGVRFYDE
IQVLDLCMEDGSVNGVVAMELLTGRIVLMHAKAVMFATGGYGKAWKTTSNAFANTGDGLGIVLRNGLPLQDMEFVQFHPT
GLYQLGILITEAARGEGGILLNGNGERFMERYAPSIKDLAPRDIVSRSIYDELKAGRGAGPEKDHVLLDLTSLSHEKIAS
RLPEIESFAKVYLGIDPSRAPIPVLPTCHYAMGGIPTSVDGRVLGDAEGREVPGFWAAGEVACVSVHGANRLGSNSLLDL
IVFGRRSGKDIAQFLKKSGPALPLDMHAADRVKGVISTLLDRQSGESVAAVRRDLQRVMMDDVSVFRQESCLADAVSKLR
ELQQRASLIRVRDRTRNFNQELTDALELQHMVNYSLTVALSALNRRESRGAHSREDYPDRDDANWLKHSMCRMDEEGGVQ
LFDRPVDLSLAAANPVFVPKERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=573, Percent_Identity=46.4223385689354, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1786942, Length=560, Percent_Identity=48.5714285714286, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1790597, Length=548, Percent_Identity=40.5109489051095, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788928, Length=548, Percent_Identity=32.4817518248175, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=584, Percent_Identity=46.4041095890411, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17505833, Length=588, Percent_Identity=45.578231292517, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71986328, Length=78, Percent_Identity=48.7179487179487, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322701, Length=563, Percent_Identity=47.6021314387211, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6322416, Length=526, Percent_Identity=49.6197718631179, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320788, Length=475, Percent_Identity=29.8947368421053, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17137288, Length=578, Percent_Identity=47.4048442906574, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24655642, Length=578, Percent_Identity=47.4048442906574, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24655647, Length=578, Percent_Identity=47.4048442906574, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24663005, Length=580, Percent_Identity=43.7931034482759, Blast_Score=460, Evalue=1e-129,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63808; Mature: 63808

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVVYHDVIIVGAGLAGLRAAVELAGSADVAVLSKLHPLRSHSGAAQGGISAALGNVEED
CCEEEEEHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCC
NPDWHAYDTIKGSDYLADQYAVQVMCNDAPRAIIEMEHLGVPFSRLDDGRIAQRPFGGHT
CCCCEEEECCCCCCHHHHCEEEEEEECCCCCHHEEHHHCCCCHHHCCCCCCCCCCCCCCC
RNFGQAPVRRTCFAADRTGHVCLHTLYEQSLKQGVRFYDEIQVLDLCMEDGSVNGVVAME
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LLTGRIVLMHAKAVMFATGGYGKAWKTTSNAFANTGDGLGIVLRNGLPLQDMEFVQFHPT
HHHCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCC
GLYQLGILITEAARGEGGILLNGNGERFMERYAPSIKDLAPRDIVSRSIYDELKAGRGAG
CCEEHHEEEEECCCCCCCEEECCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCCC
PEKDHVLLDLTSLSHEKIASRLPEIESFAKVYLGIDPSRAPIPVLPTCHYAMGGIPTSVD
CCCCCEEEEEHHCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCC
GRVLGDAEGREVPGFWAAGEVACVSVHGANRLGSNSLLDLIVFGRRSGKDIAQFLKKSGP
CEEECCCCCCCCCCEECCCCEEEEEEECCCCCCCCHHEEHHEECCCCCHHHHHHHHHCCC
ALPLDMHAADRVKGVISTLLDRQSGESVAAVRRDLQRVMMDDVSVFRQESCLADAVSKLR
CCEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELQQRASLIRVRDRTRNFNQELTDALELQHMVNYSLTVALSALNRRESRGAHSREDYPDR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DDANWLKHSMCRMDEEGGVQLFDRPVDLSLAAANPVFVPKERKY
CCHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCCEECCCCCCC
>Mature Secondary Structure
MDVVYHDVIIVGAGLAGLRAAVELAGSADVAVLSKLHPLRSHSGAAQGGISAALGNVEED
CCEEEEEHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCC
NPDWHAYDTIKGSDYLADQYAVQVMCNDAPRAIIEMEHLGVPFSRLDDGRIAQRPFGGHT
CCCCEEEECCCCCCHHHHCEEEEEEECCCCCHHEEHHHCCCCHHHCCCCCCCCCCCCCCC
RNFGQAPVRRTCFAADRTGHVCLHTLYEQSLKQGVRFYDEIQVLDLCMEDGSVNGVVAME
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LLTGRIVLMHAKAVMFATGGYGKAWKTTSNAFANTGDGLGIVLRNGLPLQDMEFVQFHPT
HHHCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCC
GLYQLGILITEAARGEGGILLNGNGERFMERYAPSIKDLAPRDIVSRSIYDELKAGRGAG
CCEEHHEEEEECCCCCCCEEECCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCCC
PEKDHVLLDLTSLSHEKIASRLPEIESFAKVYLGIDPSRAPIPVLPTCHYAMGGIPTSVD
CCCCCEEEEEHHCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCC
GRVLGDAEGREVPGFWAAGEVACVSVHGANRLGSNSLLDLIVFGRRSGKDIAQFLKKSGP
CEEECCCCCCCCCCEECCCCEEEEEEECCCCCCCCHHEEHHEECCCCCHHHHHHHHHCCC
ALPLDMHAADRVKGVISTLLDRQSGESVAAVRRDLQRVMMDDVSVFRQESCLADAVSKLR
CCEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELQQRASLIRVRDRTRNFNQELTDALELQHMVNYSLTVALSALNRRESRGAHSREDYPDR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DDANWLKHSMCRMDEEGGVQLFDRPVDLSLAAANPVFVPKERKY
CCHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA