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The map label for this gene is moaE [H]

Identifier: 194334913

GI number: 194334913

Start: 2300861

End: 2301253

Strand: Reverse

Name: moaE [H]

Synonym: Paes_2122

Alternate gene names: 194334913

Gene position: 2301253-2300861 (Counterclockwise)

Preceding gene: 194334914

Following gene: 194334900

Centisome position: 91.58

GC content: 50.13

Gene sequence:

>393_bases
ATGATATCAGTACACATTACATCGGAGAAGATTGACGGGTGGCGTGGCGAATTTCCGGGAGATCCGTCTGAAGGATCTGA
AGTGATCTTTACCGGCCTTGTCCGTGACAAAGAAAACGGGCGTCGTATAGCTGCATTGGTCTACGAACACTATGAAGGGA
TGGCTCAGAAGGAGCTTGAAAAGCTTGCCCGGGGAGCTGTGGATCGGTTTGCTATCGCTTCTCTCTGCTGTCGTCACCGC
ATAGGAACCATTCCTGTGGGAGAGGCCGCCATTGTGGTGATTATGCGTTCATCGCACCGAAAAGAAGGTTTTGCGGCCAT
GAGCTGGTTTATGGACGAGTTGAAAAAGGTTGTTCCTATCTGGAAGGTTGGAAGCATCGAAGCTGAAGAGTAA

Upstream 100 bases:

>100_bases
CGTTTATGCTTGCTCTGAATATGTCGTATCCATCGAGGGAGACTGTTGTCAGAGAAGGTGACGAGGTTGCCATCATTCCA
CCGGTCAGCGGAGGATAGCC

Downstream 100 bases:

>100_bases
GTTTTTCCGCCCTTTTTCTGAGCTGCTCTGTTTCGTTAGTGTTCTTTTTTCCTGGCGAAAAATCGGCCATGTCGAGGGCG
TCGAGCAGCGATAGGAGCTC

Product: molybdopterin biosynthesis MoaE protein

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MISVHITSEKIDGWRGEFPGDPSEGSEVIFTGLVRDKENGRRIAALVYEHYEGMAQKELEKLARGAVDRFAIASLCCRHR
IGTIPVGEAAIVVIMRSSHRKEGFAAMSWFMDELKKVVPIWKVGSIEAEE

Sequences:

>Translated_130_residues
MISVHITSEKIDGWRGEFPGDPSEGSEVIFTGLVRDKENGRRIAALVYEHYEGMAQKELEKLARGAVDRFAIASLCCRHR
IGTIPVGEAAIVVIMRSSHRKEGFAAMSWFMDELKKVVPIWKVGSIEAEE
>Mature_130_residues
MISVHITSEKIDGWRGEFPGDPSEGSEVIFTGLVRDKENGRRIAALVYEHYEGMAQKELEKLARGAVDRFAIASLCCRHR
IGTIPVGEAAIVVIMRSSHRKEGFAAMSWFMDELKKVVPIWKVGSIEAEE

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=101, Percent_Identity=34.6534653465347, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1787003, Length=99, Percent_Identity=37.3737373737374, Blast_Score=73, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356259, Length=99, Percent_Identity=37.3737373737374, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 14532; Mature: 14532

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVHITSEKIDGWRGEFPGDPSEGSEVIFTGLVRDKENGRRIAALVYEHYEGMAQKELE
CEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHH
KLARGAVDRFAIASLCCRHRIGTIPVGEAAIVVIMRSSHRKEGFAAMSWFMDELKKVVPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
WKVGSIEAEE
CCCCCCCCCC
>Mature Secondary Structure
MISVHITSEKIDGWRGEFPGDPSEGSEVIFTGLVRDKENGRRIAALVYEHYEGMAQKELE
CEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCHHHHHHH
KLARGAVDRFAIASLCCRHRIGTIPVGEAAIVVIMRSSHRKEGFAAMSWFMDELKKVVPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
WKVGSIEAEE
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]