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The map label for this gene is manC [H]

Identifier: 194334831

GI number: 194334831

Start: 2231461

End: 2232579

Strand: Reverse

Name: manC [H]

Synonym: Paes_2034

Alternate gene names: 194334831

Gene position: 2232579-2231461 (Counterclockwise)

Preceding gene: 194334833

Following gene: 194334829

Centisome position: 88.84

GC content: 52.1

Gene sequence:

>1119_bases
ATGGATGAAGCCGTTCAGCATCTCTATGCCATCATCATGGCCGGAGGCCAGGGGTCGGGTCTGTGGCCACTGTCGCGCAG
GGATATGCCTCGTCAGTTTGTCGATATATTCGGTATTGGTACCATGATCGAGAGAACGGTTCAGCGCCTTTCCGGAATTG
TTCCGCCCGATCATATCTATATCGTTACCAGCTCCAGAGGTCAAGCGCTCGTGAGCACCCTTCTGCCAGGTTTTCCAATG
TCCAATGTGCTGGCCGAGCCGTTGGGGCGAAAAACGGCTCCCTGTATAGCACTGGCGACGGCCTTTGTAAAAAAGCGTGA
TCCTGACGCCGTTACCCTGGTCGTGCCCTCTGATCATCTGGTAGAGGATAATGCAACATTTGAAAAAACCATCAGAGAAG
GGGTGCAGCTTGCGCTGCAAAAAAAGGAGCTGGTGACTATCGGTATACGCCCTGACCGTCCTGAGACGACATATGGCTAT
ATGCAGGTGGATATCCCCGCTTCTCAAAGATCCCTCTCGCCCGGACAGACGACAACCCTTCATCACGTGAGGGCATTTGC
AGAAAAGCCGGACAGTCGAACTGCTCAGGAATTTGTCGATAGTGGAGATTTTTTCTGGAACAGCGGGATCTTTATCTGGC
ATATCGATGTGATCTGTCGCGAACTCGAGCATTGGATGCCGGATCTCTATCGTGACCTTCTCTATATGTACGAGGCTATC
GGTTCGTCCAAGGAGCAGGAGGTGATTGAAGACGTTTACAGCTGGCAGCATCCAGTCGCCATCGATTGCGGTGTTATGGA
AAAATCTGAATCGGTCGTCATGCTCGAAGGGCAGTTCGGCTGGATGGATCTTGGTAACTGGGACGACATGCTCTCCGCGC
AGCAAGTATCGTCAATCCCTGATGCATCAGGCAGGGTTCAGAATCTTATCGAAGTCGATACCGTCAATACGATTGTTCAC
AAACCGTCCTCTAAAGCAGTATGTCTTGTCGGCGTGACTGATCTGATTGTGGTCGAAACCGACGACGCGCTGCTGATTTG
CCGTAAAGGTGATTCTCGCGGTGTGCGCAAGGCGGTCGATATCATGCGCAGGAATGACGGGATGGAGGGGTATTTGTAG

Upstream 100 bases:

>100_bases
GAAATGCGCTCAGGAAGGGATCGTCCTTAAAATAATCGTAATTTCATTATAATGAACAGAGAACTCTTCTACTGTTTTCA
GAATTCCTACTCATGTTATC

Downstream 100 bases:

>100_bases
CTATAATCATGACCTGCTCCATTCGGTGCCTTCGCGAGTGTCTTTCATAGTGATGCCCGCTTCGGCGAGTTTGTCGCGGA
TCAGATCGCTCAGTTCATAA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MDEAVQHLYAIIMAGGQGSGLWPLSRRDMPRQFVDIFGIGTMIERTVQRLSGIVPPDHIYIVTSSRGQALVSTLLPGFPM
SNVLAEPLGRKTAPCIALATAFVKKRDPDAVTLVVPSDHLVEDNATFEKTIREGVQLALQKKELVTIGIRPDRPETTYGY
MQVDIPASQRSLSPGQTTTLHHVRAFAEKPDSRTAQEFVDSGDFFWNSGIFIWHIDVICRELEHWMPDLYRDLLYMYEAI
GSSKEQEVIEDVYSWQHPVAIDCGVMEKSESVVMLEGQFGWMDLGNWDDMLSAQQVSSIPDASGRVQNLIEVDTVNTIVH
KPSSKAVCLVGVTDLIVVETDDALLICRKGDSRGVRKAVDIMRRNDGMEGYL

Sequences:

>Translated_372_residues
MDEAVQHLYAIIMAGGQGSGLWPLSRRDMPRQFVDIFGIGTMIERTVQRLSGIVPPDHIYIVTSSRGQALVSTLLPGFPM
SNVLAEPLGRKTAPCIALATAFVKKRDPDAVTLVVPSDHLVEDNATFEKTIREGVQLALQKKELVTIGIRPDRPETTYGY
MQVDIPASQRSLSPGQTTTLHHVRAFAEKPDSRTAQEFVDSGDFFWNSGIFIWHIDVICRELEHWMPDLYRDLLYMYEAI
GSSKEQEVIEDVYSWQHPVAIDCGVMEKSESVVMLEGQFGWMDLGNWDDMLSAQQVSSIPDASGRVQNLIEVDTVNTIVH
KPSSKAVCLVGVTDLIVVETDDALLICRKGDSRGVRKAVDIMRRNDGMEGYL
>Mature_372_residues
MDEAVQHLYAIIMAGGQGSGLWPLSRRDMPRQFVDIFGIGTMIERTVQRLSGIVPPDHIYIVTSSRGQALVSTLLPGFPM
SNVLAEPLGRKTAPCIALATAFVKKRDPDAVTLVVPSDHLVEDNATFEKTIREGVQLALQKKELVTIGIRPDRPETTYGY
MQVDIPASQRSLSPGQTTTLHHVRAFAEKPDSRTAQEFVDSGDFFWNSGIFIWHIDVICRELEHWMPDLYRDLLYMYEAI
GSSKEQEVIEDVYSWQHPVAIDCGVMEKSESVVMLEGQFGWMDLGNWDDMLSAQQVSSIPDASGRVQNLIEVDTVNTIVH
KPSSKAVCLVGVTDLIVVETDDALLICRKGDSRGVRKAVDIMRRNDGMEGYL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=368, Percent_Identity=33.695652173913, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 41466; Mature: 41466

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEAVQHLYAIIMAGGQGSGLWPLSRRDMPRQFVDIFGIGTMIERTVQRLSGIVPPDHIY
CCHHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IVTSSRGQALVSTLLPGFPMSNVLAEPLGRKTAPCIALATAFVKKRDPDAVTLVVPSDHL
EEECCCCHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCE
VEDNATFEKTIREGVQLALQKKELVTIGIRPDRPETTYGYMQVDIPASQRSLSPGQTTTL
ECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
HHVRAFAEKPDSRTAQEFVDSGDFFWNSGIFIWHIDVICRELEHWMPDLYRDLLYMYEAI
HHHHHHHCCCCCHHHHHHHCCCCCEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
GSSKEQEVIEDVYSWQHPVAIDCGVMEKSESVVMLEGQFGWMDLGNWDDMLSAQQVSSIP
CCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCEEECCCHHHHHHHHHHHCCC
DASGRVQNLIEVDTVNTIVHKPSSKAVCLVGVTDLIVVETDDALLICRKGDSRGVRKAVD
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCEEEEEECCCCCHHHHHHH
IMRRNDGMEGYL
HHHHCCCCCCCC
>Mature Secondary Structure
MDEAVQHLYAIIMAGGQGSGLWPLSRRDMPRQFVDIFGIGTMIERTVQRLSGIVPPDHIY
CCHHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IVTSSRGQALVSTLLPGFPMSNVLAEPLGRKTAPCIALATAFVKKRDPDAVTLVVPSDHL
EEECCCCHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCE
VEDNATFEKTIREGVQLALQKKELVTIGIRPDRPETTYGYMQVDIPASQRSLSPGQTTTL
ECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
HHVRAFAEKPDSRTAQEFVDSGDFFWNSGIFIWHIDVICRELEHWMPDLYRDLLYMYEAI
HHHHHHHCCCCCHHHHHHHCCCCCEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
GSSKEQEVIEDVYSWQHPVAIDCGVMEKSESVVMLEGQFGWMDLGNWDDMLSAQQVSSIP
CCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCEEECCCHHHHHHHHHHHCCC
DASGRVQNLIEVDTVNTIVHKPSSKAVCLVGVTDLIVVETDDALLICRKGDSRGVRKAVD
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCEEEEEECCCCCHHHHHHH
IMRRNDGMEGYL
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]