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The map label for this gene is nadC [H]

Identifier: 194334754

GI number: 194334754

Start: 2137681

End: 2138559

Strand: Reverse

Name: nadC [H]

Synonym: Paes_1955

Alternate gene names: 194334754

Gene position: 2138559-2137681 (Counterclockwise)

Preceding gene: 194334757

Following gene: 194334751

Centisome position: 85.1

GC content: 52.45

Gene sequence:

>879_bases
ATGAAACAGCGCGATTTTAACGATTTTTTCGAGATGTGCAGAGTTCGCACCATCATGCAGGCTCTTGAGGAGGATCGATA
TGATGGGGATGTGACGACTATGGCGACAATTGATCCTCAGCAGGAAGGTACGGCGGTCATTCGCGCCAAGGCGCGCGGGG
TTCTGGCCGGTGTCGATGTGGCACGTCAGGTGTTTGCACTCATGGATCCGACGATTGTCACGACTGTGCTCAAGGAGGAC
GGCGCTCTTTCTGAAGAGGGGGAGACGGTACTGGAAGTCAGGGGAAAGGTTGCATCGCTGCTCGTCGCGGAGCGTACCGC
GCTCAATTTTATGCAGCGCATGTCGGGGATTGCAACAAGAACGCGAGCCTATGTGGATCTGATTGCTCATACGGGAACTC
AAATTCTCGATACCCGCAAGACAGCTCCCGGGTTACGGTATTTTGATAAAGAAGCGGTGAAAATCGGCAGCGGGCGGAAT
CATCGTTTCGGTTTATTCGATCTCGTACTCATCAAAGATAACCATATTGATGCGGCTGGAGGTATTGTGGCTGCGATCGA
AAGGGCTCGTGAATATCTTACCGGGAGGGGCCTTTCGATGAAGATCGAGGCTGAGGTCCGTTCCATGGATGAGTTGAAGC
AGGCTCTTTCAGCACGACCCGATATTGTGCTTCTTGATAATTTTGCACTTGAGACGACACGCGATGCTGTAGGCTATGTG
CGTCAGCATGCGCCGCAAACCGTTCTCGAGGCTTCGGGAAATGTGGGATTGCACAATGTTGTCGCTTTGGCGGAGACCGG
TGTCGATTTCATTTCTATCGGCGAACTGACCCATACTGTGACGGCCCTTGACCTGTCGATGACGATATCATTTGTCTGA

Upstream 100 bases:

>100_bases
GCGGTCCATTGAATGTAAAACTTCAAAAATTGTTACTTTAAGCAATAACATGTTGGTGCCTCTATGCCAACCACTCAGCG
ACTATAAGGCTTAACGTATT

Downstream 100 bases:

>100_bases
ATCAGGGGAAGACCGGTCAGGAAGGGTTGCTTGCCGGGGTCTGAAGATGGTGGCTCTCGATTCAAAGAGAGTAGATGGCA
GTAAAAAAAGCAGGTATGGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKQRDFNDFFEMCRVRTIMQALEEDRYDGDVTTMATIDPQQEGTAVIRAKARGVLAGVDVARQVFALMDPTIVTTVLKED
GALSEEGETVLEVRGKVASLLVAERTALNFMQRMSGIATRTRAYVDLIAHTGTQILDTRKTAPGLRYFDKEAVKIGSGRN
HRFGLFDLVLIKDNHIDAAGGIVAAIERAREYLTGRGLSMKIEAEVRSMDELKQALSARPDIVLLDNFALETTRDAVGYV
RQHAPQTVLEASGNVGLHNVVALAETGVDFISIGELTHTVTALDLSMTISFV

Sequences:

>Translated_292_residues
MKQRDFNDFFEMCRVRTIMQALEEDRYDGDVTTMATIDPQQEGTAVIRAKARGVLAGVDVARQVFALMDPTIVTTVLKED
GALSEEGETVLEVRGKVASLLVAERTALNFMQRMSGIATRTRAYVDLIAHTGTQILDTRKTAPGLRYFDKEAVKIGSGRN
HRFGLFDLVLIKDNHIDAAGGIVAAIERAREYLTGRGLSMKIEAEVRSMDELKQALSARPDIVLLDNFALETTRDAVGYV
RQHAPQTVLEASGNVGLHNVVALAETGVDFISIGELTHTVTALDLSMTISFV
>Mature_292_residues
MKQRDFNDFFEMCRVRTIMQALEEDRYDGDVTTMATIDPQQEGTAVIRAKARGVLAGVDVARQVFALMDPTIVTTVLKED
GALSEEGETVLEVRGKVASLLVAERTALNFMQRMSGIATRTRAYVDLIAHTGTQILDTRKTAPGLRYFDKEAVKIGSGRN
HRFGLFDLVLIKDNHIDAAGGIVAAIERAREYLTGRGLSMKIEAEVRSMDELKQALSARPDIVLLDNFALETTRDAVGYV
RQHAPQTVLEASGNVGLHNVVALAETGVDFISIGELTHTVTALDLSMTISFV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=247, Percent_Identity=36.8421052631579, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1786299, Length=277, Percent_Identity=41.5162454873646, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=256, Percent_Identity=33.203125, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32013; Mature: 32013

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRDFNDFFEMCRVRTIMQALEEDRYDGDVTTMATIDPQQEGTAVIRAKARGVLAGVDV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEHHCCHHHHHHH
ARQVFALMDPTIVTTVLKEDGALSEEGETVLEVRGKVASLLVAERTALNFMQRMSGIATR
HHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRAYVDLIAHTGTQILDTRKTAPGLRYFDKEAVKIGSGRNHRFGLFDLVLIKDNHIDAAG
HHHHHHHHHHCCCHHHHCCCCCCCCHHHCHHHHEECCCCCCCCEEEEEEEEECCCCCCHH
GIVAAIERAREYLTGRGLSMKIEAEVRSMDELKQALSARPDIVLLDNFALETTRDAVGYV
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
RQHAPQTVLEASGNVGLHNVVALAETGVDFISIGELTHTVTALDLSMTISFV
HHHCCHHHHHCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHEEEEEEEEEEC
>Mature Secondary Structure
MKQRDFNDFFEMCRVRTIMQALEEDRYDGDVTTMATIDPQQEGTAVIRAKARGVLAGVDV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEHHCCHHHHHHH
ARQVFALMDPTIVTTVLKEDGALSEEGETVLEVRGKVASLLVAERTALNFMQRMSGIATR
HHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRAYVDLIAHTGTQILDTRKTAPGLRYFDKEAVKIGSGRNHRFGLFDLVLIKDNHIDAAG
HHHHHHHHHHCCCHHHHCCCCCCCCHHHCHHHHEECCCCCCCCEEEEEEEEECCCCCCHH
GIVAAIERAREYLTGRGLSMKIEAEVRSMDELKQALSARPDIVLLDNFALETTRDAVGYV
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
RQHAPQTVLEASGNVGLHNVVALAETGVDFISIGELTHTVTALDLSMTISFV
HHHCCHHHHHCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]