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The map label for this gene is purH

Identifier: 194334505

GI number: 194334505

Start: 1855553

End: 1857130

Strand: Reverse

Name: purH

Synonym: Paes_1700

Alternate gene names: 194334505

Gene position: 1857130-1855553 (Counterclockwise)

Preceding gene: 194334508

Following gene: 194334503

Centisome position: 73.9

GC content: 51.14

Gene sequence:

>1578_bases
ATGTCTGATCCTGTTATCAAGCGAGCGTTGGTTTCTGTTTCTGATAAAACCGGCATCGTCGATTTTTGCCGTGAGCTGGG
GGCTATGGGTGTCGAGATTTTTTCAACCGGAGGCACCCTGCGTATTCTTCAGGAGTCCGGTATCGAAGCTGCTTCAATTT
CGACGATAACCGGTTTTCCTGAGATTATGGATGGCCGCGTGAAAACGCTTCACCCGAAAATTCACGGCGGCCTGCTTGCT
GTTCGTGACAACGAGGATCATGTCGGCCAGGCAAAGGCGAATGGTATTGAGTTTATCGATATGGTTGTTGTTAATCTCTA
CCCTTTCGAGGCTACTGTTGCCAAGCCTGATGTGACGTTTGAAGAAGCTATCGAAAATATTGACATCGGCGGTCCGTCGA
TGCTTCGCAGCGCAGCGAAGAATAACGAGTCTGTCACGGTGGTGACCGACAGCGCTGATTATGCAACGGTTCTTGATGAG
ATGCGCTCCAATAATGGTGCGACCCGTCGTGAGACTCGCCTGACCCTTGCAAGAAAGGTGTTTGAACTTACCTCGCGCTA
TGACCGTGCGATTGCTGATTACCTGATCGGTGCCGAGGAGAGTGGCGAAACGGAGGCTCCGGCCGCTATTTCCGTGAAGC
TTGAAAAAGAGCTCGATATGCGTTATGGCGAGAATCCTCATCAGAGCGCCGGTTTCTATCGTCTTGTGGATGGTCAGGGA
TCACGCTGTTTTGATGATTTCTTCGACAAGTTGCACGGTAAGGAGTTGTCGTACAACAATATGCTTGATATTGCCGCTGC
GACTGGACTTGTCGAGGAGTTTCGCGGTGAGGATCCTGCAGTGGTTATCATCAAACACACCAACCCGTGCGGGGTTGCTC
AGGCAGGAACTCTTGTTGACGCGTATCGCAAGGCGTTTTCGACCGATACACAGTCACCGTTTGGCGGTATCATCGCTTTT
AACGTTCCGCTCGATATGGAGACAGCACTTGCCGTCGATGAGATTTTTACCGAGATTCTGATTGCTCCGGCATACGAGGA
TGGGGTGCTGGATATGCTGATGAAGAAGAAAAACCGTCGTCTTGTTCTTCAGAAAAAGGCGCTTCTCCAGGAGGTCATGG
AATACAAGTCGACACAGTTCGGCATGCTCGTTCAGGATCGCGACAGCAAGATTGTTTCTCGTGAGGACCTGAAGGTTGTG
ACGAAACGCCAGCCGGACGAGCAGGAACTTGATGATATGATGTTTGCATGGAAGATCGCCAAGCATGTGAAGTCCAATAC
GATTGTGTATGTGAAAAACGGTCAGACGATTGGTGTGGGAGCAGGTCAGATGTCGCGTATCGATTCGGCAAAAATCGCTC
GTTCCAAGGCTGCCGAGGCCGGTTTGGATATCAAGGGTTCTGCAGTTGCTTCAGATGCGTTTTTCCCGTTTGCAGATGGT
TTGCTTGCCGCTGCTGAAGCCGGTGCGACATCGGTCATACAGCCTGGCGGATCGATCCGCGACGATGAGGTTATTGCCGC
TGCGGACGAGAACAACCTTGCAATGGTCTTTACGTCGATGCGCCACTTCAAGCATTGA

Upstream 100 bases:

>100_bases
GTTTTGTGGTTAGCCATTTAGTGAATATTTGATTAAATTCTCTGGTTTATTGCGTTCAGTATAAGGAACGGTATACAAAC
AAAATCTAATAAATCTACAA

Downstream 100 bases:

>100_bases
GCTTGTTGCACCTGGTTTTGTTTTTTTGATGATAGCCTCCGGTTTGTGCCGGGGGCTTTTTTTGTTGGTGAATGGTGAGG
GATAACAGATTTCAGTCCAC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSDPVIKRALVSVSDKTGIVDFCRELGAMGVEIFSTGGTLRILQESGIEAASISTITGFPEIMDGRVKTLHPKIHGGLLA
VRDNEDHVGQAKANGIEFIDMVVVNLYPFEATVAKPDVTFEEAIENIDIGGPSMLRSAAKNNESVTVVTDSADYATVLDE
MRSNNGATRRETRLTLARKVFELTSRYDRAIADYLIGAEESGETEAPAAISVKLEKELDMRYGENPHQSAGFYRLVDGQG
SRCFDDFFDKLHGKELSYNNMLDIAAATGLVEEFRGEDPAVVIIKHTNPCGVAQAGTLVDAYRKAFSTDTQSPFGGIIAF
NVPLDMETALAVDEIFTEILIAPAYEDGVLDMLMKKKNRRLVLQKKALLQEVMEYKSTQFGMLVQDRDSKIVSREDLKVV
TKRQPDEQELDDMMFAWKIAKHVKSNTIVYVKNGQTIGVGAGQMSRIDSAKIARSKAAEAGLDIKGSAVASDAFFPFADG
LLAAAEAGATSVIQPGGSIRDDEVIAAADENNLAMVFTSMRHFKH

Sequences:

>Translated_525_residues
MSDPVIKRALVSVSDKTGIVDFCRELGAMGVEIFSTGGTLRILQESGIEAASISTITGFPEIMDGRVKTLHPKIHGGLLA
VRDNEDHVGQAKANGIEFIDMVVVNLYPFEATVAKPDVTFEEAIENIDIGGPSMLRSAAKNNESVTVVTDSADYATVLDE
MRSNNGATRRETRLTLARKVFELTSRYDRAIADYLIGAEESGETEAPAAISVKLEKELDMRYGENPHQSAGFYRLVDGQG
SRCFDDFFDKLHGKELSYNNMLDIAAATGLVEEFRGEDPAVVIIKHTNPCGVAQAGTLVDAYRKAFSTDTQSPFGGIIAF
NVPLDMETALAVDEIFTEILIAPAYEDGVLDMLMKKKNRRLVLQKKALLQEVMEYKSTQFGMLVQDRDSKIVSREDLKVV
TKRQPDEQELDDMMFAWKIAKHVKSNTIVYVKNGQTIGVGAGQMSRIDSAKIARSKAAEAGLDIKGSAVASDAFFPFADG
LLAAAEAGATSVIQPGGSIRDDEVIAAADENNLAMVFTSMRHFKH
>Mature_524_residues
SDPVIKRALVSVSDKTGIVDFCRELGAMGVEIFSTGGTLRILQESGIEAASISTITGFPEIMDGRVKTLHPKIHGGLLAV
RDNEDHVGQAKANGIEFIDMVVVNLYPFEATVAKPDVTFEEAIENIDIGGPSMLRSAAKNNESVTVVTDSADYATVLDEM
RSNNGATRRETRLTLARKVFELTSRYDRAIADYLIGAEESGETEAPAAISVKLEKELDMRYGENPHQSAGFYRLVDGQGS
RCFDDFFDKLHGKELSYNNMLDIAAATGLVEEFRGEDPAVVIIKHTNPCGVAQAGTLVDAYRKAFSTDTQSPFGGIIAFN
VPLDMETALAVDEIFTEILIAPAYEDGVLDMLMKKKNRRLVLQKKALLQEVMEYKSTQFGMLVQDRDSKIVSREDLKVVT
KRQPDEQELDDMMFAWKIAKHVKSNTIVYVKNGQTIGVGAGQMSRIDSAKIARSKAAEAGLDIKGSAVASDAFFPFADGL
LAAAEAGATSVIQPGGSIRDDEVIAAADENNLAMVFTSMRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=481, Percent_Identity=37.2141372141372, Blast_Score=273, Evalue=4e-73,
Organism=Escherichia coli, GI1790439, Length=530, Percent_Identity=53.3962264150943, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71985564, Length=615, Percent_Identity=30.8943089430894, Blast_Score=265, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71985574, Length=354, Percent_Identity=25.7062146892655, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=36.1344537815126, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6323056, Length=480, Percent_Identity=35.8333333333333, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24649832, Length=484, Percent_Identity=36.3636363636364, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_PROA2 (B4S3H9)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016365.1
- ProteinModelPortal:   B4S3H9
- SMR:   B4S3H9
- GeneID:   6459862
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1700
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 57197; Mature: 57065

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPVIKRALVSVSDKTGIVDFCRELGAMGVEIFSTGGTLRILQESGIEAASISTITGFP
CCCHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCEEEEEECCCCCEEEEEECCCCH
EIMDGRVKTLHPKIHGGLLAVRDNEDHVGQAKANGIEFIDMVVVNLYPFEATVAKPDVTF
HHHCCCCEEECHHHCCCEEEEECCCCCCCCCCCCCHHEEEEEEHEEECCEEECCCCCCCH
EEAIENIDIGGPSMLRSAAKNNESVTVVTDSADYATVLDEMRSNNGATRRETRLTLARKV
HHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FELTSRYDRAIADYLIGAEESGETEAPAAISVKLEKELDMRYGENPHQSAGFYRLVDGQG
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHHCCCCCCCCCCEEEEECCCC
SRCFDDFFDKLHGKELSYNNMLDIAAATGLVEEFRGEDPAVVIIKHTNPCGVAQAGTLVD
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHH
AYRKAFSTDTQSPFGGIIAFNVPLDMETALAVDEIFTEILIAPAYEDGVLDMLMKKKNRR
HHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCE
LVLQKKALLQEVMEYKSTQFGMLVQDRDSKIVSREDLKVVTKRQPDEQELDDMMFAWKIA
EHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
KHVKSNTIVYVKNGQTIGVGAGQMSRIDSAKIARSKAAEAGLDIKGSAVASDAFFPFADG
HHHCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHH
LLAAAEAGATSVIQPGGSIRDDEVIAAADENNLAMVFTSMRHFKH
HHHHHCCCCCEEECCCCCCCCCCEEEEECCCCEEEEEEHHHHHCC
>Mature Secondary Structure 
SDPVIKRALVSVSDKTGIVDFCRELGAMGVEIFSTGGTLRILQESGIEAASISTITGFP
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCEEEEEECCCCCEEEEEECCCCH
EIMDGRVKTLHPKIHGGLLAVRDNEDHVGQAKANGIEFIDMVVVNLYPFEATVAKPDVTF
HHHCCCCEEECHHHCCCEEEEECCCCCCCCCCCCCHHEEEEEEHEEECCEEECCCCCCCH
EEAIENIDIGGPSMLRSAAKNNESVTVVTDSADYATVLDEMRSNNGATRRETRLTLARKV
HHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FELTSRYDRAIADYLIGAEESGETEAPAAISVKLEKELDMRYGENPHQSAGFYRLVDGQG
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHHCCCCCCCCCCEEEEECCCC
SRCFDDFFDKLHGKELSYNNMLDIAAATGLVEEFRGEDPAVVIIKHTNPCGVAQAGTLVD
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHH
AYRKAFSTDTQSPFGGIIAFNVPLDMETALAVDEIFTEILIAPAYEDGVLDMLMKKKNRR
HHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCE
LVLQKKALLQEVMEYKSTQFGMLVQDRDSKIVSREDLKVVTKRQPDEQELDDMMFAWKIA
EHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
KHVKSNTIVYVKNGQTIGVGAGQMSRIDSAKIARSKAAEAGLDIKGSAVASDAFFPFADG
HHHCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHH
LLAAAEAGATSVIQPGGSIRDDEVIAAADENNLAMVFTSMRHFKH
HHHHHCCCCCEEECCCCCCCCCCEEEEECCCCEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA