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The map label for this gene is degP [H]

Identifier: 194334370

GI number: 194334370

Start: 1703133

End: 1704641

Strand: Reverse

Name: degP [H]

Synonym: Paes_1565

Alternate gene names: 194334370

Gene position: 1704641-1703133 (Counterclockwise)

Preceding gene: 194334371

Following gene: 194334369

Centisome position: 67.83

GC content: 50.96

Gene sequence:

>1509_bases
ATGAAAAGAAAATATACCTACTTGTTTCTTGTGCTCGCCGGTGTGCTGGTTGGCGCGCTTGCTTTTTCTCATATTGATGT
CACTGTACCGGTTGCCGAGAAAAAGATCGCGGTCACGAGTTTTTCGAATGATGCTGCTGCGTCGCCGGGGGTCGAGCATC
AGCCTATCCGTTCGCTGAAGGACCTGAACGAAGCATTTGTCCAGTTGGCTGAGTCTGCGACACCTTCCGTTGTGACGATT
TTTACCGAAAAGACGGTCAACAGAAAAACCATTTCTCCGTTTGATCTTTTCGGCAGTCCCTTTGACGATTTTTTCAATGT
TCCACGTGACAGGGGAGGGCAGAATGGATCCAAGGAGGTGCTCAGAGGACTCGGCTCAGGGGTGGTCGTCAGTGCGGATG
GTTATATCCTTACCAACAACCATGTTGTCGATAATGCCGATGTGATCTACATTCGTACGTATGAAAATAATAAAGTGGCG
GCCAAAGTGGTCGGCAAGGACCCGAAGACAGATCTGGCGGTTATCAAGGCTGACGTCAAAGGATTGAAGCCTATCGCTAT
CGGCGACAGTGACGCACTGAGGGTTGGTGAGTGGGTGATCGCTATTGGCAGTCCGCTCGGAGAGAACCTTGCCCGCACAG
TAACGCAGGGTATTGTCAGCGCTAAAGGCCGCGCCAATGTCGGACTTGCTGATTATGAAGATTTTATTCAGACAGACGCT
GCCATCAATCCCGGCAATTCCGGTGGTCCCCTGGTCAATATCAACGGTGAACTTGTCGGGATCAACACTGCTATTGCAAG
TCGGACAGGTGGTTTTGAAGGGATCGGCTTTGCTGTTCCTTCGAATATGGCAAAAAAAGTGATGCAGTCGCTCATCAGCA
ACGGCAAGGTTACAAGAGGATGGCTGGGCGTCACCATTCAGGATGTCGATGAAAATATCGCCAAGGGGCTGCAGCTTGAT
CCGCCAGAGGGTGTTCTTGTCGGAACGGTTGTTGACGATGGTCCTGCTGCATCGGCAGGGGTGAAGACGGGAGATGTGAT
CATTGCCATCGATGGTAAAAAAGTGACCGATACCATTGAACTTCGTAACGGCATTGCAGAGACACCTCCGGGGACGACTG
TAAAACTCAGGGTGTGGCGAAACGGGCAGGTAAAGCTCTTGAGCGTGCGGTTGAGCGAGCTTCCCGGAAAGGAGGAGGTT
GCTGTCGAAGAGAAGGCTGAAATCACTGATCTCCTGGGTTTCAGTGTTTCGGAACTGACCTCCGAGCTGGCTTCACGATA
CAGGCTGAGTCGGGATAAGGGTGCTGTTCTTGTGACCGGTATCGATCCATCGAGCAAGGCGTATCGAGCTGGTTTGCGAC
AGGGAGATCTCATTCTTTCCGTCAACAAGAAAAACGTAAGCACCTACAAGGAGTTTCTTGCGGTGGCCGGCTCAGTGAAA
AAAGGCGATCTCCTCTTTCTCTTGATCGAACGTCAGGGCAGCAAAGTGTATTTTGCCTTTAACATTTAA

Upstream 100 bases:

>100_bases
CGACGAGACCATGAACAAAATGAGAGCGGGGCTCAGAACGCTCGAAGCGCTCGAGCATGTTTCAAACGATTGATGTGTAA
CGATTAATTCATTGAGAACC

Downstream 100 bases:

>100_bases
TGGCTCTTTGCTTGCAGACTAAAGAATTGTACATTTAAAAGACATACAGGTTAAAGTCAGCGCCCGGCGCTGACTTTACT
TGTTTATGGTTATGAACATA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKRKYTYLFLVLAGVLVGALAFSHIDVTVPVAEKKIAVTSFSNDAAASPGVEHQPIRSLKDLNEAFVQLAESATPSVVTI
FTEKTVNRKTISPFDLFGSPFDDFFNVPRDRGGQNGSKEVLRGLGSGVVVSADGYILTNNHVVDNADVIYIRTYENNKVA
AKVVGKDPKTDLAVIKADVKGLKPIAIGDSDALRVGEWVIAIGSPLGENLARTVTQGIVSAKGRANVGLADYEDFIQTDA
AINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAKKVMQSLISNGKVTRGWLGVTIQDVDENIAKGLQLD
PPEGVLVGTVVDDGPAASAGVKTGDVIIAIDGKKVTDTIELRNGIAETPPGTTVKLRVWRNGQVKLLSVRLSELPGKEEV
AVEEKAEITDLLGFSVSELTSELASRYRLSRDKGAVLVTGIDPSSKAYRAGLRQGDLILSVNKKNVSTYKEFLAVAGSVK
KGDLLFLLIERQGSKVYFAFNI

Sequences:

>Translated_502_residues
MKRKYTYLFLVLAGVLVGALAFSHIDVTVPVAEKKIAVTSFSNDAAASPGVEHQPIRSLKDLNEAFVQLAESATPSVVTI
FTEKTVNRKTISPFDLFGSPFDDFFNVPRDRGGQNGSKEVLRGLGSGVVVSADGYILTNNHVVDNADVIYIRTYENNKVA
AKVVGKDPKTDLAVIKADVKGLKPIAIGDSDALRVGEWVIAIGSPLGENLARTVTQGIVSAKGRANVGLADYEDFIQTDA
AINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAKKVMQSLISNGKVTRGWLGVTIQDVDENIAKGLQLD
PPEGVLVGTVVDDGPAASAGVKTGDVIIAIDGKKVTDTIELRNGIAETPPGTTVKLRVWRNGQVKLLSVRLSELPGKEEV
AVEEKAEITDLLGFSVSELTSELASRYRLSRDKGAVLVTGIDPSSKAYRAGLRQGDLILSVNKKNVSTYKEFLAVAGSVK
KGDLLFLLIERQGSKVYFAFNI
>Mature_502_residues
MKRKYTYLFLVLAGVLVGALAFSHIDVTVPVAEKKIAVTSFSNDAAASPGVEHQPIRSLKDLNEAFVQLAESATPSVVTI
FTEKTVNRKTISPFDLFGSPFDDFFNVPRDRGGQNGSKEVLRGLGSGVVVSADGYILTNNHVVDNADVIYIRTYENNKVA
AKVVGKDPKTDLAVIKADVKGLKPIAIGDSDALRVGEWVIAIGSPLGENLARTVTQGIVSAKGRANVGLADYEDFIQTDA
AINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAKKVMQSLISNGKVTRGWLGVTIQDVDENIAKGLQLD
PPEGVLVGTVVDDGPAASAGVKTGDVIIAIDGKKVTDTIELRNGIAETPPGTTVKLRVWRNGQVKLLSVRLSELPGKEEV
AVEEKAEITDLLGFSVSELTSELASRYRLSRDKGAVLVTGIDPSSKAYRAGLRQGDLILSVNKKNVSTYKEFLAVAGSVK
KGDLLFLLIERQGSKVYFAFNI

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=292, Percent_Identity=37.3287671232877, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308541, Length=262, Percent_Identity=37.0229007633588, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI22129776, Length=266, Percent_Identity=34.5864661654135, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI7019477, Length=258, Percent_Identity=37.984496124031, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786356, Length=446, Percent_Identity=40.1345291479821, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789629, Length=436, Percent_Identity=37.1559633027523, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=41.2186379928315, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=32.9545454545455, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53292; Mature: 53292

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKYTYLFLVLAGVLVGALAFSHIDVTVPVAEKKIAVTSFSNDAAASPGVEHQPIRSLK
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHH
DLNEAFVQLAESATPSVVTIFTEKTVNRKTISPFDLFGSPFDDFFNVPRDRGGQNGSKEV
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCCCCHHHH
LRGLGSGVVVSADGYILTNNHVVDNADVIYIRTYENNKVAAKVVGKDPKTDLAVIKADVK
HHHCCCCEEEECCCEEEECCEEECCCCEEEEEEECCCEEEEEEECCCCCCCEEEEEECCC
GLKPIAIGDSDALRVGEWVIAIGSPLGENLARTVTQGIVSAKGRANVGLADYEDFIQTDA
CCCEEEECCCCCEEECEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
AINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAKKVMQSLISNGKVTRG
CCCCCCCCCCEEEECCEEEEEEHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEE
WLGVTIQDVDENIAKGLQLDPPEGVLVGTVVDDGPAASAGVKTGDVIIAIDGKKVTDTIE
EEEEEEEHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHH
LRNGIAETPPGTTVKLRVWRNGQVKLLSVRLSELPGKEEVAVEEKAEITDLLGFSVSELT
HHCCCCCCCCCCEEEEEEECCCCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHCCCHHHHH
SELASRYRLSRDKGAVLVTGIDPSSKAYRAGLRQGDLILSVNKKNVSTYKEFLAVAGSVK
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
KGDLLFLLIERQGSKVYFAFNI
CCCEEEEEEECCCCEEEEEEEC
>Mature Secondary Structure
MKRKYTYLFLVLAGVLVGALAFSHIDVTVPVAEKKIAVTSFSNDAAASPGVEHQPIRSLK
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHH
DLNEAFVQLAESATPSVVTIFTEKTVNRKTISPFDLFGSPFDDFFNVPRDRGGQNGSKEV
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCCCCHHHH
LRGLGSGVVVSADGYILTNNHVVDNADVIYIRTYENNKVAAKVVGKDPKTDLAVIKADVK
HHHCCCCEEEECCCEEEECCEEECCCCEEEEEEECCCEEEEEEECCCCCCCEEEEEECCC
GLKPIAIGDSDALRVGEWVIAIGSPLGENLARTVTQGIVSAKGRANVGLADYEDFIQTDA
CCCEEEECCCCCEEECEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
AINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAKKVMQSLISNGKVTRG
CCCCCCCCCCEEEECCEEEEEEHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEE
WLGVTIQDVDENIAKGLQLDPPEGVLVGTVVDDGPAASAGVKTGDVIIAIDGKKVTDTIE
EEEEEEEHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHH
LRNGIAETPPGTTVKLRVWRNGQVKLLSVRLSELPGKEEVAVEEKAEITDLLGFSVSELT
HHCCCCCCCCCCEEEEEEECCCCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHCCCHHHHH
SELASRYRLSRDKGAVLVTGIDPSSKAYRAGLRQGDLILSVNKKNVSTYKEFLAVAGSVK
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
KGDLLFLLIERQGSKVYFAFNI
CCCEEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]