Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 194334322

GI number: 194334322

Start: 1655816

End: 1657270

Strand: Reverse

Name: glpK [H]

Synonym: Paes_1515

Alternate gene names: 194334322

Gene position: 1657270-1655816 (Counterclockwise)

Preceding gene: 194334325

Following gene: 194334321

Centisome position: 65.95

GC content: 53.61

Gene sequence:

>1455_bases
ATGGCGATTCTTGCTCTGGATCAGGGTACGACAGGAACGACATGTATGCTTTTTGACGCAGCCGGAGAGGTTCTGGCAAG
AAGTTATCGTGAACTCAACCAGATCTATCCCTGTGAAGGGTGGGTTGAGCACGATCCGGAAGCGATATGGCAGAGCGTTC
TTGATACGATCGATGATCTCGGCGATGCGTTACGCTTTTCGTCGGTGAAGGCAATCGGGATAACGAATCAGCGAGAGACG
ACGGTTGTCTGGGATGCAAAGACGGGCAGGCCTGTGTGCAACGCTATTGTCTGGCAGTGCAGACGGACCTCGGAGATGTG
TACCCGTTACCGGGATCAGAGCGCGATGATTACCGCTAAAACCGGTTTGCCTCTCGATGCCTATTTCAGTGCCACAAAGA
TTCGCTGGATTCTGGAGCATTGTGCTGCTGATGAGAGTCAGGATCTTCTTTTCGGAACCGTCGACAGCTGGCTGTTATGG
AAGCTGACGGGCGGCAGTGTGCACGCCACTGATATGACCAATGCGTCCAGAACGCTGCTTTTCAATATCGAGGAGCGACG
CTGGGATGATGAGTTGCTTGAACTCTTCGATATACCTCGTTCGATGCTTCCGGAAGTGAGAAATTCCATGGCGGATTTCG
GGCGTGTGAGCGCAATCGATCTTCTTCAGGGGGTCCCGGTTACAGGGATTGCCGGTGATCAGCAGGCGGCGTTGTTCGGT
CAGTGCTGCTTTGAGCCGGGTAGTCTCAAGAACACCTACGGGACTGGATGCTTTATGGTCATGAACACCGGCCGGGAGCG
TATCCGTTCACAAAACGGTCTCTTGTCAACGCTTGCTCTCGATGCATCCGCCAGGCCCTGCTATGCGCTGGAAGGTTCAG
TATTTGTTGCAGGAGCCGTTATTCAGTGGCTGCGCGATGAATTGCAGCTTATCTCCTCTGCTTCCGAATCTGAAATACTT
GCTGCGCAGATCGCATCGAATGGCGGCGTCTATATCGTTCCAGCCTTTGCTGGTCTCGGAGCACCTCACTGGCGGATGGA
TGCCCGCGGTACGATTGTCGGCCTGACCCGTGGCGTTAACAAAAAGCATATTGTCAGGGCGGCACTTGAGTCTATTGCCT
ATCAGTCCTACGATGTTTTCAGGGCGATGGCTGCTGATACAGGTATGATGCCGAAGGCCCTGATTGTTGATGGGGGAGCG
GTCAGCAACGACTTTTTAATGCAGTTTCAGGCAGATATTCTTGATATTGCGGTACACAGACCCCGACATATCGAGTCGAC
CGTGCTCGGAGCAGCTTTTCTTGCTGGTTTGCAGTCCGGTTTCTGGACCTCAGTCGATGAGTTGAAGGGGTTGCGGGAGA
TAGCCTTCGGGTTTACGCCAGCCATGGATCCCGATGTCAGAGAGCGATATCTCTCCGGTTGGCAGAAAGCCCTGCGTCAG
ACGCTTAGCGTATAG

Upstream 100 bases:

>100_bases
AGTTCATTTTTTTAATTTTACCGTATCTTTTTACCTGTCTGTCTGTGGCAGACGCAGGAGGTGGAGCGTGCGGCATTAAC
GATAAAAAGAAGGTCAATCG

Downstream 100 bases:

>100_bases
CGTGATGCATTAACTCTGGAATGAAGAACTATGAATCACAGCAGTCACGAGGGGTCAGGAGGCCCGAAATCCGTTACCTG
TCCCCGATGCGGGAAAGCGT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAILALDQGTTGTTCMLFDAAGEVLARSYRELNQIYPCEGWVEHDPEAIWQSVLDTIDDLGDALRFSSVKAIGITNQRET
TVVWDAKTGRPVCNAIVWQCRRTSEMCTRYRDQSAMITAKTGLPLDAYFSATKIRWILEHCAADESQDLLFGTVDSWLLW
KLTGGSVHATDMTNASRTLLFNIEERRWDDELLELFDIPRSMLPEVRNSMADFGRVSAIDLLQGVPVTGIAGDQQAALFG
QCCFEPGSLKNTYGTGCFMVMNTGRERIRSQNGLLSTLALDASARPCYALEGSVFVAGAVIQWLRDELQLISSASESEIL
AAQIASNGGVYIVPAFAGLGAPHWRMDARGTIVGLTRGVNKKHIVRAALESIAYQSYDVFRAMAADTGMMPKALIVDGGA
VSNDFLMQFQADILDIAVHRPRHIESTVLGAAFLAGLQSGFWTSVDELKGLREIAFGFTPAMDPDVRERYLSGWQKALRQ
TLSV

Sequences:

>Translated_484_residues
MAILALDQGTTGTTCMLFDAAGEVLARSYRELNQIYPCEGWVEHDPEAIWQSVLDTIDDLGDALRFSSVKAIGITNQRET
TVVWDAKTGRPVCNAIVWQCRRTSEMCTRYRDQSAMITAKTGLPLDAYFSATKIRWILEHCAADESQDLLFGTVDSWLLW
KLTGGSVHATDMTNASRTLLFNIEERRWDDELLELFDIPRSMLPEVRNSMADFGRVSAIDLLQGVPVTGIAGDQQAALFG
QCCFEPGSLKNTYGTGCFMVMNTGRERIRSQNGLLSTLALDASARPCYALEGSVFVAGAVIQWLRDELQLISSASESEIL
AAQIASNGGVYIVPAFAGLGAPHWRMDARGTIVGLTRGVNKKHIVRAALESIAYQSYDVFRAMAADTGMMPKALIVDGGA
VSNDFLMQFQADILDIAVHRPRHIESTVLGAAFLAGLQSGFWTSVDELKGLREIAFGFTPAMDPDVRERYLSGWQKALRQ
TLSV
>Mature_483_residues
AILALDQGTTGTTCMLFDAAGEVLARSYRELNQIYPCEGWVEHDPEAIWQSVLDTIDDLGDALRFSSVKAIGITNQRETT
VVWDAKTGRPVCNAIVWQCRRTSEMCTRYRDQSAMITAKTGLPLDAYFSATKIRWILEHCAADESQDLLFGTVDSWLLWK
LTGGSVHATDMTNASRTLLFNIEERRWDDELLELFDIPRSMLPEVRNSMADFGRVSAIDLLQGVPVTGIAGDQQAALFGQ
CCFEPGSLKNTYGTGCFMVMNTGRERIRSQNGLLSTLALDASARPCYALEGSVFVAGAVIQWLRDELQLISSASESEILA
AQIASNGGVYIVPAFAGLGAPHWRMDARGTIVGLTRGVNKKHIVRAALESIAYQSYDVFRAMAADTGMMPKALIVDGGAV
SNDFLMQFQADILDIAVHRPRHIESTVLGAAFLAGLQSGFWTSVDELKGLREIAFGFTPAMDPDVRERYLSGWQKALRQT
LSV

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=498, Percent_Identity=46.1847389558233, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI189409120, Length=498, Percent_Identity=46.1847389558233, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI42794763, Length=503, Percent_Identity=45.5268389662028, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI41393575, Length=444, Percent_Identity=47.2972972972973, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI88196792, Length=505, Percent_Identity=32.8712871287129, Blast_Score=295, Evalue=7e-80,
Organism=Escherichia coli, GI1790361, Length=491, Percent_Identity=53.5641547861507, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1789987, Length=461, Percent_Identity=26.2472885032538, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789168, Length=484, Percent_Identity=22.7272727272727, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1787789, Length=518, Percent_Identity=23.5521235521236, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=498, Percent_Identity=39.5582329317269, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71986140, Length=517, Percent_Identity=24.5647969052224, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71986147, Length=301, Percent_Identity=27.906976744186, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321755, Length=485, Percent_Identity=36.9072164948454, Blast_Score=286, Evalue=7e-78,
Organism=Drosophila melanogaster, GI17864214, Length=453, Percent_Identity=42.3841059602649, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24655555, Length=472, Percent_Identity=40.6779661016949, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24655560, Length=472, Percent_Identity=40.6779661016949, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24655570, Length=472, Percent_Identity=40.6779661016949, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24655574, Length=472, Percent_Identity=40.6779661016949, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24655565, Length=472, Percent_Identity=40.6779661016949, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24654573, Length=387, Percent_Identity=44.1860465116279, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI19922058, Length=510, Percent_Identity=34.5098039215686, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24652871, Length=490, Percent_Identity=34.0816326530612, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24656367, Length=484, Percent_Identity=29.1322314049587, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21357867, Length=500, Percent_Identity=28.6, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24656372, Length=325, Percent_Identity=32, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI45552909, Length=286, Percent_Identity=27.6223776223776, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 53175; Mature: 53044

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILALDQGTTGTTCMLFDAAGEVLARSYRELNQIYPCEGWVEHDPEAIWQSVLDTIDDL
CEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
GDALRFSSVKAIGITNQRETTVVWDAKTGRPVCNAIVWQCRRTSEMCTRYRDQSAMITAK
HHHHHHCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
TGLPLDAYFSATKIRWILEHCAADESQDLLFGTVDSWLLWKLTGGSVHATDMTNASRTLL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCEEEEECCCCCCEEEE
FNIEERRWDDELLELFDIPRSMLPEVRNSMADFGRVSAIDLLQGVPVTGIAGDQQAALFG
EEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHH
QCCFEPGSLKNTYGTGCFMVMNTGRERIRSQNGLLSTLALDASARPCYALEGSVFVAGAV
HHHCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHHHHH
IQWLRDELQLISSASESEILAAQIASNGGVYIVPAFAGLGAPHWRMDARGTIVGLTRGVN
HHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEECHHCCCCCCEEECCCCEEEEEECCCC
KKHIVRAALESIAYQSYDVFRAMAADTGMMPKALIVDGGAVSNDFLMQFQADILDIAVHR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
PRHIESTVLGAAFLAGLQSGFWTSVDELKGLREIAFGFTPAMDPDVRERYLSGWQKALRQ
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
TLSV
HHCC
>Mature Secondary Structure 
AILALDQGTTGTTCMLFDAAGEVLARSYRELNQIYPCEGWVEHDPEAIWQSVLDTIDDL
EEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
GDALRFSSVKAIGITNQRETTVVWDAKTGRPVCNAIVWQCRRTSEMCTRYRDQSAMITAK
HHHHHHCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
TGLPLDAYFSATKIRWILEHCAADESQDLLFGTVDSWLLWKLTGGSVHATDMTNASRTLL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCEEEEECCCCCCEEEE
FNIEERRWDDELLELFDIPRSMLPEVRNSMADFGRVSAIDLLQGVPVTGIAGDQQAALFG
EEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHH
QCCFEPGSLKNTYGTGCFMVMNTGRERIRSQNGLLSTLALDASARPCYALEGSVFVAGAV
HHHCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHHHHH
IQWLRDELQLISSASESEILAAQIASNGGVYIVPAFAGLGAPHWRMDARGTIVGLTRGVN
HHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEECHHCCCCCCEEECCCCEEEEEECCCC
KKHIVRAALESIAYQSYDVFRAMAADTGMMPKALIVDGGAVSNDFLMQFQADILDIAVHR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
PRHIESTVLGAAFLAGLQSGFWTSVDELKGLREIAFGFTPAMDPDVRERYLSGWQKALRQ
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
TLSV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA