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The map label for this gene is dnaX [H]

Identifier: 194334277

GI number: 194334277

Start: 1608902

End: 1610755

Strand: Reverse

Name: dnaX [H]

Synonym: Paes_1470

Alternate gene names: 194334277

Gene position: 1610755-1608902 (Counterclockwise)

Preceding gene: 194334278

Following gene: 194334276

Centisome position: 64.1

GC content: 50.81

Gene sequence:

>1854_bases
ATGAGCTATCAGGTTATAGCCAGAAAATACAGACCGAGTAAATTCGCCGATATTACCGCTCAGGAGCATATCACGCACAC
CATCCAGAATGCGCTTCGTCTCGACAGGGTTGGCCATGGCTATATTTTTTCGGGACTTCGGGGAGTCGGCAAGACAACCG
CGGCGAGGGTATTTGCCAAAGCGGTCAACTGTCAGAAAATGATTGATGACCCTGTCTACCGTCAGGAGGTCACCGAACCT
TGCGGAGAATGCGAAAGCTGCCTTGATTTCGATGCGGGAACAAGTCTCAATATTTCAGAGTTTGACGCTGCCTCAAACAA
TAGTGTTGACGATATCCGCCAGTTACGCGAAAACGTACGCTACGGGCCTCAGAAAGGTCGTTACCGTGTCTATATCATCG
ATGAGGTTCACATGCTTTCAACTGCGGCCTTCAACGCTTTTCTCAAGACGCTTGAGGAACCGCCGTCCCACGCTATTTTC
ATTTTCGCCACGACGGAGCTGCACAAAATACCGGCGACTATTTCTTCTCGCTGTCAGCGTTTTAATTTCAAACGTATTCC
GATCGGAGAGATCCAGTCGCAGTTGCAGATGATCTGCAGGGCCGAAACGCTTCAGATTTCAGATGATGCCCTTCTGCTTA
TAGCGCGCAAGGCTCAGGGGTCGATGCGCGACGCGCAGAGCATTCTCGATCAGGTGATAGCTTTTTCTGTTGGAAACGAC
GCTGAAAAAGTGATCGCATACCAGGGGGTTGCAGAGTTGTTGAACTATATCGATGACGATCAGTTTTTTGATGTCAGCGA
CGCTGTAGCGGAAAACGATCCGGTGAAGATGCTTCAGGTTGCCCGTTTTGTTATTGATAACGGTTATGACGAGCAGGATT
TTCTCGAAAAACTCATTGAGCATTTCAGAAACTTTCTTGTGCTCTACAACCTGCGTTCTACCCGTCTCATTGAACGGACG
GAAAGTGTTAAGGAGCGCTATCAGCAGAGTGCAGGGGGCTTGAGTGCCCCGCTTGTCATGCAATTGATCGATTTGTTGAT
GAAGGAGTCCGGTGAACTGAAGTTTCAGTTCGAGTACCAGTTCCGCTTTGAACTGACACTGCTGCGTCTGATCGAACTTG
TTCACAACGATGGAGGTGTCGCAGCCTCTGTAGCTGGAGGGCCGCCGGTAAAAAAAAAAGCCCCTGAACCGGATCTGAAA
CAGCCGGACAGGCATCCCGGACCAGCAGGGAGGTCTGCTCCTGGGGCCCGACCGGCAGAATTGCCTTCTCCTGCATCGAC
GCCGGAGCAACAGCCTCCATCAGCCAGGTCAGCCTCATTGCCCCCTTCCCCGCAACAGTCTGCACCACGCAATGTCGCGT
CCGGGAAACCGGGGGTTGATTTCAGCGCATGGCAGGGCAAGCTTATGAATTTCACCAGAAACGGTTCTCGCAAGCAGCCT
GTTCAGGCCTCTTCGTCCGACGCTCGTCAGTCCGGCGTTTTTGAGGGCGTTGTCGAGGTTGAAAAGTTCCGGATGGAGTG
GAACCAGTTTCTTGAAATGCTTCTGAAGAAACGACAGAAGGTGCTTGTGACTCATCTTCGTTCATGCGAACTGACATCCT
GTTCTCATGGAGTGCTCGTCATGACCTGCGGCAAGAAGTTTTCCTATGAAGAACTGATGCAGGATGCTGCTCTGCTCAGC
AAGGAGATCGAGTCATTTTACGGCATTGCGGTCAAACTCCAGATCTGTTATGATGCTGCCAGAGATGCTCAGACGCGGGA
ACAAACCATTTTTACCCTTTTCAGGGATCTTGCCGAAACCAATGATGTGATGAAGTATATCATTAAGGAGTTTGGCGGCG
AACTCGTGTATTGA

Upstream 100 bases:

>100_bases
GACAGGATCTTTCCGGACTCGAACAGAATATCATCCAATGCCTGCAGCATGCGATGCATCAGCCGCTTGCTGCGTTTTTG
AACACAGCGACCCGTACACT

Downstream 100 bases:

>100_bases
CGCGGGAAGAACTGTTTCCATAATCTGTAAAAATTCATCATATTCAGTGTTTTCGACACGTTTAACATCTCGTTACCACT
ATCTATGAGCTTAGCGCCTG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MSYQVIARKYRPSKFADITAQEHITHTIQNALRLDRVGHGYIFSGLRGVGKTTAARVFAKAVNCQKMIDDPVYRQEVTEP
CGECESCLDFDAGTSLNISEFDAASNNSVDDIRQLRENVRYGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPSHAIF
IFATTELHKIPATISSRCQRFNFKRIPIGEIQSQLQMICRAETLQISDDALLLIARKAQGSMRDAQSILDQVIAFSVGND
AEKVIAYQGVAELLNYIDDDQFFDVSDAVAENDPVKMLQVARFVIDNGYDEQDFLEKLIEHFRNFLVLYNLRSTRLIERT
ESVKERYQQSAGGLSAPLVMQLIDLLMKESGELKFQFEYQFRFELTLLRLIELVHNDGGVAASVAGGPPVKKKAPEPDLK
QPDRHPGPAGRSAPGARPAELPSPASTPEQQPPSARSASLPPSPQQSAPRNVASGKPGVDFSAWQGKLMNFTRNGSRKQP
VQASSSDARQSGVFEGVVEVEKFRMEWNQFLEMLLKKRQKVLVTHLRSCELTSCSHGVLVMTCGKKFSYEELMQDAALLS
KEIESFYGIAVKLQICYDAARDAQTREQTIFTLFRDLAETNDVMKYIIKEFGGELVY

Sequences:

>Translated_617_residues
MSYQVIARKYRPSKFADITAQEHITHTIQNALRLDRVGHGYIFSGLRGVGKTTAARVFAKAVNCQKMIDDPVYRQEVTEP
CGECESCLDFDAGTSLNISEFDAASNNSVDDIRQLRENVRYGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPSHAIF
IFATTELHKIPATISSRCQRFNFKRIPIGEIQSQLQMICRAETLQISDDALLLIARKAQGSMRDAQSILDQVIAFSVGND
AEKVIAYQGVAELLNYIDDDQFFDVSDAVAENDPVKMLQVARFVIDNGYDEQDFLEKLIEHFRNFLVLYNLRSTRLIERT
ESVKERYQQSAGGLSAPLVMQLIDLLMKESGELKFQFEYQFRFELTLLRLIELVHNDGGVAASVAGGPPVKKKAPEPDLK
QPDRHPGPAGRSAPGARPAELPSPASTPEQQPPSARSASLPPSPQQSAPRNVASGKPGVDFSAWQGKLMNFTRNGSRKQP
VQASSSDARQSGVFEGVVEVEKFRMEWNQFLEMLLKKRQKVLVTHLRSCELTSCSHGVLVMTCGKKFSYEELMQDAALLS
KEIESFYGIAVKLQICYDAARDAQTREQTIFTLFRDLAETNDVMKYIIKEFGGELVY
>Mature_616_residues
SYQVIARKYRPSKFADITAQEHITHTIQNALRLDRVGHGYIFSGLRGVGKTTAARVFAKAVNCQKMIDDPVYRQEVTEPC
GECESCLDFDAGTSLNISEFDAASNNSVDDIRQLRENVRYGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPSHAIFI
FATTELHKIPATISSRCQRFNFKRIPIGEIQSQLQMICRAETLQISDDALLLIARKAQGSMRDAQSILDQVIAFSVGNDA
EKVIAYQGVAELLNYIDDDQFFDVSDAVAENDPVKMLQVARFVIDNGYDEQDFLEKLIEHFRNFLVLYNLRSTRLIERTE
SVKERYQQSAGGLSAPLVMQLIDLLMKESGELKFQFEYQFRFELTLLRLIELVHNDGGVAASVAGGPPVKKKAPEPDLKQ
PDRHPGPAGRSAPGARPAELPSPASTPEQQPPSARSASLPPSPQQSAPRNVASGKPGVDFSAWQGKLMNFTRNGSRKQPV
QASSSDARQSGVFEGVVEVEKFRMEWNQFLEMLLKKRQKVLVTHLRSCELTSCSHGVLVMTCGKKFSYEELMQDAALLSK
EIESFYGIAVKLQICYDAARDAQTREQTIFTLFRDLAETNDVMKYIIKEFGGELVY

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=371, Percent_Identity=37.466307277628, Blast_Score=265, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17541988, Length=278, Percent_Identity=24.1007194244604, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=252, Percent_Identity=26.5873015873016, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324478, Length=232, Percent_Identity=22.8448275862069, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 69211; Mature: 69079

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVIARKYRPSKFADITAQEHITHTIQNALRLDRVGHGYIFSGLRGVGKTTAARVFAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHH
AVNCQKMIDDPVYRQEVTEPCGECESCLDFDAGTSLNISEFDAASNNSVDDIRQLRENVR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCC
YGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPSHAIFIFATTELHKIPATISSRCQR
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHH
FNFKRIPIGEIQSQLQMICRAETLQISDDALLLIARKAQGSMRDAQSILDQVIAFSVGND
CCCCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
AEKVIAYQGVAELLNYIDDDQFFDVSDAVAENDPVKMLQVARFVIDNGYDEQDFLEKLIE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
HFRNFLVLYNLRSTRLIERTESVKERYQQSAGGLSAPLVMQLIDLLMKESGELKFQFEYQ
HHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
FRFELTLLRLIELVHNDGGVAASVAGGPPVKKKAPEPDLKQPDRHPGPAGRSAPGARPAE
EEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LPSPASTPEQQPPSARSASLPPSPQQSAPRNVASGKPGVDFSAWQGKLMNFTRNGSRKQP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
VQASSSDARQSGVFEGVVEVEKFRMEWNQFLEMLLKKRQKVLVTHLRSCELTSCSHGVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
MTCGKKFSYEELMQDAALLSKEIESFYGIAVKLQICYDAARDAQTREQTIFTLFRDLAET
EECCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHH
NDVMKYIIKEFGGELVY
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SYQVIARKYRPSKFADITAQEHITHTIQNALRLDRVGHGYIFSGLRGVGKTTAARVFAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHH
AVNCQKMIDDPVYRQEVTEPCGECESCLDFDAGTSLNISEFDAASNNSVDDIRQLRENVR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCC
YGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPSHAIFIFATTELHKIPATISSRCQR
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHH
FNFKRIPIGEIQSQLQMICRAETLQISDDALLLIARKAQGSMRDAQSILDQVIAFSVGND
CCCCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
AEKVIAYQGVAELLNYIDDDQFFDVSDAVAENDPVKMLQVARFVIDNGYDEQDFLEKLIE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
HFRNFLVLYNLRSTRLIERTESVKERYQQSAGGLSAPLVMQLIDLLMKESGELKFQFEYQ
HHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
FRFELTLLRLIELVHNDGGVAASVAGGPPVKKKAPEPDLKQPDRHPGPAGRSAPGARPAE
EEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LPSPASTPEQQPPSARSASLPPSPQQSAPRNVASGKPGVDFSAWQGKLMNFTRNGSRKQP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
VQASSSDARQSGVFEGVVEVEKFRMEWNQFLEMLLKKRQKVLVTHLRSCELTSCSHGVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
MTCGKKFSYEELMQDAALLSKEIESFYGIAVKLQICYDAARDAQTREQTIFTLFRDLAET
EECCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHH
NDVMKYIIKEFGGELVY
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]