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The map label for this gene is guaB [H]

Identifier: 194334240

GI number: 194334240

Start: 1558558

End: 1560048

Strand: Reverse

Name: guaB [H]

Synonym: Paes_1433

Alternate gene names: 194334240

Gene position: 1560048-1558558 (Counterclockwise)

Preceding gene: 194334241

Following gene: 194334239

Centisome position: 62.08

GC content: 51.04

Gene sequence:

>1491_bases
ATGGCAAAAATTCTTTATGAAGCGCTGACGTTTGACGATGTTCTGCTCGTTCCTGCGTATTCTGCGGTCCTGCCCAAGGA
AACCAAAGTCTCAACCAGACTCACCAAAAATATCACTCTTCATATGCCCTTGGTCAGTGCGGCCATGGATACCGTTACTG
AATCTGAACTTGCTATCGCCCTGGCTCGTTCGGGCGGGATAGGCTTTATTCATAAAAATCTTACCGTGGAACAGCAGGCT
CGTGAGGTTGCAAGGGTAAAGCGCTACGAAAGCGGCATCATCCGCAATCCGATCTCACTTTATGAGACTGCAACGGTGCA
GGATGCTCTGGACCTTATGCAGAAACATTCCATTTCAGGTATTCCTATTATCGAGCAGCCTCTTGATTCCAATGATGCAT
CACTGAAACTCAAAGGGATCATCACCAACCGCGACCTTCGCTTCAAACCGGCTCCTCAGCAGCCGATTTCGACCATCATG
ACGGTCAATAACCTTATTACGGCGGGTGAAGACATCGACCTTGAAGATGCCGAGGAGATTCTGCTTTCCAACAAAATCGA
AAAGCTGCTGATTACCGATAATGACGGTAATCTTAAAGGCCTGATCACCTTCAAAGATATTCAGAAAAGAAAGCAATACC
CGAACGCATGTAAAGATGAGCAGGGACGGTTGTGTGTCGGCGCTGCAGTCGGTATCCGCTCCAATACGCTGACAAGGGTC
CAGGCTCTTGTTGACGCCGGTGTGGACGTGATCGCAGTCGACACGGCTCATGGGCACAGTAAAGCGGTTGGAGATATGGT
CAAAACCATCAAGCAGCACTATCCCGATCTGCAAATCGTCGCAGGAAACGTCGCCACTCCTGAAGCTGTCCGGGATCTTA
TTGCGGCTGGTGCTGATGCAGTGAAAGTCGGTATCGGCCCGGGAAGTATCTGCACGACCAGGATTGTTGCAGGTGTCGGC
ATGCCGCAGCTGACGGCTATCATGAACTGCTCTGAAGAGGCTGCCAAAACCGGTACACCTATCATTGCTGATGGCGGCAT
CAAATACAGCGGGGATCTCGCAAAAGCTATTGCGGCCGGCGCGGACTCGGTCATGATCGGCAGTATTTTTGCCGGTACCG
ATGAAAGCCCCGGGGAAACAATTCTTTACGAAGGAAGACGCTTCAAGGCGTATCGCGGCATGGGCTCACTCGGAGCAATG
TCCGAACCGGAGGGCAGCAGCGACCGTTACTTCCAGGACGCTTCCAGCGAAAGCAAAAAGTATGTGCCTGAAGGTATCGA
AGGACGTATCCCTGCAAAAGGCAAGCTCGAAGAGGTCATCTATCAGCTGATCGGCGGTCTGAAATCGTCAATGGGCTACT
GCGGTGTTAAAAACATCGAAGAGATGAAACACAATACCTGTTTTGTGCGCATCACATCCGCTGGTCTGCGTGAAAGCCAT
CCTCATGACGTCATGATCACCAAAGAAGCCCCGAACTACTCGATGTCGTAA

Upstream 100 bases:

>100_bases
AAGAAATAAAAACGCTTTTTGCCTACAGATTGTCTTTCAGCCTCCACTTTTGTAAATTGGCAGAATTCTTTCGCGCCTAA
TCATATAAACTGATCTCCGT

Downstream 100 bases:

>100_bases
AAAAATTCTTACACATCAACAAAAAAGCGGCCATCGTCATGAGCCGCTTTTTTGTTAGACCCTCGAGCCCTTCACTGCCC
CTCATACGAGGGTACCTCGC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MAKILYEALTFDDVLLVPAYSAVLPKETKVSTRLTKNITLHMPLVSAAMDTVTESELAIALARSGGIGFIHKNLTVEQQA
REVARVKRYESGIIRNPISLYETATVQDALDLMQKHSISGIPIIEQPLDSNDASLKLKGIITNRDLRFKPAPQQPISTIM
TVNNLITAGEDIDLEDAEEILLSNKIEKLLITDNDGNLKGLITFKDIQKRKQYPNACKDEQGRLCVGAAVGIRSNTLTRV
QALVDAGVDVIAVDTAHGHSKAVGDMVKTIKQHYPDLQIVAGNVATPEAVRDLIAAGADAVKVGIGPGSICTTRIVAGVG
MPQLTAIMNCSEEAAKTGTPIIADGGIKYSGDLAKAIAAGADSVMIGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAM
SEPEGSSDRYFQDASSESKKYVPEGIEGRIPAKGKLEEVIYQLIGGLKSSMGYCGVKNIEEMKHNTCFVRITSAGLRESH
PHDVMITKEAPNYSMS

Sequences:

>Translated_496_residues
MAKILYEALTFDDVLLVPAYSAVLPKETKVSTRLTKNITLHMPLVSAAMDTVTESELAIALARSGGIGFIHKNLTVEQQA
REVARVKRYESGIIRNPISLYETATVQDALDLMQKHSISGIPIIEQPLDSNDASLKLKGIITNRDLRFKPAPQQPISTIM
TVNNLITAGEDIDLEDAEEILLSNKIEKLLITDNDGNLKGLITFKDIQKRKQYPNACKDEQGRLCVGAAVGIRSNTLTRV
QALVDAGVDVIAVDTAHGHSKAVGDMVKTIKQHYPDLQIVAGNVATPEAVRDLIAAGADAVKVGIGPGSICTTRIVAGVG
MPQLTAIMNCSEEAAKTGTPIIADGGIKYSGDLAKAIAAGADSVMIGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAM
SEPEGSSDRYFQDASSESKKYVPEGIEGRIPAKGKLEEVIYQLIGGLKSSMGYCGVKNIEEMKHNTCFVRITSAGLRESH
PHDVMITKEAPNYSMS
>Mature_495_residues
AKILYEALTFDDVLLVPAYSAVLPKETKVSTRLTKNITLHMPLVSAAMDTVTESELAIALARSGGIGFIHKNLTVEQQAR
EVARVKRYESGIIRNPISLYETATVQDALDLMQKHSISGIPIIEQPLDSNDASLKLKGIITNRDLRFKPAPQQPISTIMT
VNNLITAGEDIDLEDAEEILLSNKIEKLLITDNDGNLKGLITFKDIQKRKQYPNACKDEQGRLCVGAAVGIRSNTLTRVQ
ALVDAGVDVIAVDTAHGHSKAVGDMVKTIKQHYPDLQIVAGNVATPEAVRDLIAAGADAVKVGIGPGSICTTRIVAGVGM
PQLTAIMNCSEEAAKTGTPIIADGGIKYSGDLAKAIAAGADSVMIGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAMS
EPEGSSDRYFQDASSESKKYVPEGIEGRIPAKGKLEEVIYQLIGGLKSSMGYCGVKNIEEMKHNTCFVRITSAGLRESHP
HDVMITKEAPNYSMS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=460, Percent_Identity=41.7391304347826, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI217035146, Length=460, Percent_Identity=41.7391304347826, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI34328930, Length=460, Percent_Identity=41.7391304347826, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI156616279, Length=460, Percent_Identity=41.7391304347826, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI34328928, Length=460, Percent_Identity=41.7391304347826, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI217035152, Length=454, Percent_Identity=41.8502202643172, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI217035148, Length=460, Percent_Identity=41.0869565217391, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI217035150, Length=460, Percent_Identity=38.2608695652174, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=39.3574297188755, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=39.3574297188755, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=39.3574297188755, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=39.3574297188755, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=38.5542168674699, Blast_Score=179, Evalue=7e-45,
Organism=Escherichia coli, GI1788855, Length=500, Percent_Identity=54.4, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=228, Percent_Identity=37.280701754386, Blast_Score=165, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=479, Percent_Identity=36.3256784968685, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=37.9391100702576, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=244, Percent_Identity=39.7540983606557, Blast_Score=185, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322012, Length=463, Percent_Identity=40.3887688984881, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=463, Percent_Identity=42.3326133909287, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=463, Percent_Identity=40.3887688984881, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=41.6422287390029, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=38.4615384615385, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641071, Length=461, Percent_Identity=42.7331887201735, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24641073, Length=461, Percent_Identity=42.7331887201735, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI28571163, Length=419, Percent_Identity=42.7207637231504, Blast_Score=308, Evalue=7e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53231; Mature: 53100

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILYEALTFDDVLLVPAYSAVLPKETKVSTRLTKNITLHMPLVSAAMDTVTESELAIA
CHHHHHHHHCCCCEEEECCHHHHCCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHEEEE
LARSGGIGFIHKNLTVEQQAREVARVKRYESGIIRNPISLYETATVQDALDLMQKHSISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
IPIIEQPLDSNDASLKLKGIITNRDLRFKPAPQQPISTIMTVNNLITAGEDIDLEDAEEI
CCEECCCCCCCCCCEEEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
LLSNKIEKLLITDNDGNLKGLITFKDIQKRKQYPNACKDEQGRLCVGAAVGIRSNTLTRV
HHHCCCCEEEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHH
QALVDAGVDVIAVDTAHGHSKAVGDMVKTIKQHYPDLQIVAGNVATPEAVRDLIAAGADA
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCE
VKVGIGPGSICTTRIVAGVGMPQLTAIMNCSEEAAKTGTPIIADGGIKYSGDLAKAIAAG
EEEECCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHCCCCEEECCCEEECCHHHHHHHCC
ADSVMIGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDASSESKK
CCCEEEEEEEECCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
YVPEGIEGRIPAKGKLEEVIYQLIGGLKSSMGYCGVKNIEEMKHNTCFVRITSAGLRESH
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEEEECCCCCCCC
PHDVMITKEAPNYSMS
CCCEEEEECCCCCCCC
>Mature Secondary Structure 
AKILYEALTFDDVLLVPAYSAVLPKETKVSTRLTKNITLHMPLVSAAMDTVTESELAIA
HHHHHHHHCCCCEEEECCHHHHCCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHEEEE
LARSGGIGFIHKNLTVEQQAREVARVKRYESGIIRNPISLYETATVQDALDLMQKHSISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
IPIIEQPLDSNDASLKLKGIITNRDLRFKPAPQQPISTIMTVNNLITAGEDIDLEDAEEI
CCEECCCCCCCCCCEEEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
LLSNKIEKLLITDNDGNLKGLITFKDIQKRKQYPNACKDEQGRLCVGAAVGIRSNTLTRV
HHHCCCCEEEEECCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHH
QALVDAGVDVIAVDTAHGHSKAVGDMVKTIKQHYPDLQIVAGNVATPEAVRDLIAAGADA
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCE
VKVGIGPGSICTTRIVAGVGMPQLTAIMNCSEEAAKTGTPIIADGGIKYSGDLAKAIAAG
EEEECCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHCCCCEEECCCEEECCHHHHHHHCC
ADSVMIGSIFAGTDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDASSESKK
CCCEEEEEEEECCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
YVPEGIEGRIPAKGKLEEVIYQLIGGLKSSMGYCGVKNIEEMKHNTCFVRITSAGLRESH
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEEEECCCCCCCC
PHDVMITKEAPNYSMS
CCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA