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The map label for this gene is msrAB [H]

Identifier: 194334202

GI number: 194334202

Start: 1512757

End: 1513761

Strand: Reverse

Name: msrAB [H]

Synonym: Paes_1394

Alternate gene names: 194334202

Gene position: 1513761-1512757 (Counterclockwise)

Preceding gene: 194334204

Following gene: 194334194

Centisome position: 60.24

GC content: 46.87

Gene sequence:

>1005_bases
ATGAAGGGATTCAAGACAGTGCTGGTCATGGTCATGTGTAGCATGTTTTCGTTTATCATCATTTCCTGTGCTACAGCAGG
AGATGATAATGATAGTAGCATGAAACAGGCAAACAATGGTTTAAAGGAGAGTGAGATGGGATACAGAGTATTGACATCTG
AAGAGGAGAGGGTTATTGTCGGAAAGGGGACCGAAATGCCATTCAGTGGCAAGTATGTTGATTTTCATGAAGAGGGCACG
TACGTTTGCAGACGATGCGACGCACCGTTGTTCCGTTCATCTGATAAATTTGAGTCCGGGACCGGATGGCCGAGTTTTGA
CGATGAAATTCCCGGAGCGGTCACACGAAAAACTGATGCAGATGGAAGGAGAACTGAAATTCTCTGTGCCAATTGCGGTG
CACATCTGGGTCATGTGTTTCTTAACGAAGGGCTTACCGGAAAAAATGTCCGTCATTGCGTCAATTCCATAAGTCTTGAT
TTCAAAGGCGCTGATGACAGGGCGATAAAGCCTGCTCAGGTTTCTGAGAAAGCGATTTTTGCAGGGGGTTGCTTCTGGGG
AATGGAGTACCATTTCGGAAAGGTCAATGGCGTTCTCGGCACGACTGTGGGCTATACCGGGGGTTCCAAAGAGGATCCGA
CATACAGAGAAGTGTGTTCAGGTAAAACGGGCCACGCTGAAGCCATGGAAGTGGAATTTGATCCGGCGGTTGTTACTTAT
GAAGAGCTTGCCAGGTTGTTTTTTGAAATTCACGATCCTACCCAGGTTAATCGTCAGGGACCTGATATCGGTACACAGTA
CCGCTCGGCAGTTTATTATGTGGATGATACCCAGAAGGCTATAGCCGAAAAGCTTATTGGGCAGCTGAAGGAGAACGGCT
ATGCTGTTGTTACCGAGCTGGAAAAAGCCAACGCATTTTATCCGGCTGAAGAGTATCATCAGGACTATTATGAAAAGACG
GGTCATCAGCCTTATTGCCACATCTACCAGAAGCGTTTCAAGTAG

Upstream 100 bases:

>100_bases
ATTAATTTTGTCCGAATAAGAAACCCTCAATGCTCAGAATTGGTTATACTTTCATGGTCTATTAATGAGATGGAGGTTCC
ATGCTGAAAAAAAATGTGTC

Downstream 100 bases:

>100_bases
TTGGAAGCGCCAGTATTGCCGCCATGGTCAATGGCGGCTTTTTTTTGCATGGATTCAGCGTCAGGTGACGGGAGTGAAGT
CTTATCCTGCATCGATATGA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKGFKTVLVMVMCSMFSFIIISCATAGDDNDSSMKQANNGLKESEMGYRVLTSEEERVIVGKGTEMPFSGKYVDFHEEGT
YVCRRCDAPLFRSSDKFESGTGWPSFDDEIPGAVTRKTDADGRRTEILCANCGAHLGHVFLNEGLTGKNVRHCVNSISLD
FKGADDRAIKPAQVSEKAIFAGGCFWGMEYHFGKVNGVLGTTVGYTGGSKEDPTYREVCSGKTGHAEAMEVEFDPAVVTY
EELARLFFEIHDPTQVNRQGPDIGTQYRSAVYYVDDTQKAIAEKLIGQLKENGYAVVTELEKANAFYPAEEYHQDYYEKT
GHQPYCHIYQKRFK

Sequences:

>Translated_334_residues
MKGFKTVLVMVMCSMFSFIIISCATAGDDNDSSMKQANNGLKESEMGYRVLTSEEERVIVGKGTEMPFSGKYVDFHEEGT
YVCRRCDAPLFRSSDKFESGTGWPSFDDEIPGAVTRKTDADGRRTEILCANCGAHLGHVFLNEGLTGKNVRHCVNSISLD
FKGADDRAIKPAQVSEKAIFAGGCFWGMEYHFGKVNGVLGTTVGYTGGSKEDPTYREVCSGKTGHAEAMEVEFDPAVVTY
EELARLFFEIHDPTQVNRQGPDIGTQYRSAVYYVDDTQKAIAEKLIGQLKENGYAVVTELEKANAFYPAEEYHQDYYEKT
GHQPYCHIYQKRFK
>Mature_334_residues
MKGFKTVLVMVMCSMFSFIIISCATAGDDNDSSMKQANNGLKESEMGYRVLTSEEERVIVGKGTEMPFSGKYVDFHEEGT
YVCRRCDAPLFRSSDKFESGTGWPSFDDEIPGAVTRKTDADGRRTEILCANCGAHLGHVFLNEGLTGKNVRHCVNSISLD
FKGADDRAIKPAQVSEKAIFAGGCFWGMEYHFGKVNGVLGTTVGYTGGSKEDPTYREVCSGKTGHAEAMEVEFDPAVVTY
EELARLFFEIHDPTQVNRQGPDIGTQYRSAVYYVDDTQKAIAEKLIGQLKENGYAVVTELEKANAFYPAEEYHQDYYEKT
GHQPYCHIYQKRFK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=44.375, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=44.375, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI117606353, Length=124, Percent_Identity=45.1612903225806, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI301336164, Length=120, Percent_Identity=42.5, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI301336162, Length=120, Percent_Identity=42.5, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI73089054, Length=120, Percent_Identity=42.5, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI37620216, Length=120, Percent_Identity=42.5, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=44.6601941747573, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=49.3333333333333, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788077, Length=112, Percent_Identity=44.6428571428571, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=38.0281690140845, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17553450, Length=120, Percent_Identity=39.1666666666667, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=39.1666666666667, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=40.2439024390244, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319816, Length=121, Percent_Identity=45.4545454545455, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=40.9722222222222, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=41.0071942446043, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=39.5833333333333, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45553335, Length=132, Percent_Identity=40.9090909090909, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356369, Length=132, Percent_Identity=40.9090909090909, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221378664, Length=132, Percent_Identity=42.4242424242424, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24645799, Length=132, Percent_Identity=40.9090909090909, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221378662, Length=139, Percent_Identity=40.2877697841727, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645804, Length=143, Percent_Identity=37.7622377622378, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24645801, Length=143, Percent_Identity=37.7622377622378, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 37250; Mature: 37250

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGFKTVLVMVMCSMFSFIIISCATAGDDNDSSMKQANNGLKESEMGYRVLTSEEERVIV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCEEEECCCCCEEEE
GKGTEMPFSGKYVDFHEEGTYVCRRCDAPLFRSSDKFESGTGWPSFDDEIPGAVTRKTDA
ECCCCCCCCCCEEEECCCCCHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEECCCC
DGRRTEILCANCGAHLGHVFLNEGLTGKNVRHCVNSISLDFKGADDRAIKPAQVSEKAIF
CCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCCCCCCCCCHHCCCEEE
AGGCFWGMEYHFGKVNGVLGTTVGYTGGSKEDPTYREVCSGKTGHAEAMEVEFDPAVVTY
ECCEEECCEEECCCCCCEEECEEECCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCEECH
EELARLFFEIHDPTQVNRQGPDIGTQYRSAVYYVDDTQKAIAEKLIGQLKENGYAVVTEL
HHHHHHHHHCCCCHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEE
EKANAFYPAEEYHQDYYEKTGHQPYCHIYQKRFK
HHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKGFKTVLVMVMCSMFSFIIISCATAGDDNDSSMKQANNGLKESEMGYRVLTSEEERVIV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCEEEECCCCCEEEE
GKGTEMPFSGKYVDFHEEGTYVCRRCDAPLFRSSDKFESGTGWPSFDDEIPGAVTRKTDA
ECCCCCCCCCCEEEECCCCCHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEECCCC
DGRRTEILCANCGAHLGHVFLNEGLTGKNVRHCVNSISLDFKGADDRAIKPAQVSEKAIF
CCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCCCCCCCCCHHCCCEEE
AGGCFWGMEYHFGKVNGVLGTTVGYTGGSKEDPTYREVCSGKTGHAEAMEVEFDPAVVTY
ECCEEECCEEECCCCCCEEECEEECCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCEECH
EELARLFFEIHDPTQVNRQGPDIGTQYRSAVYYVDDTQKAIAEKLIGQLKENGYAVVTEL
HHHHHHHHHCCCCHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEE
EKANAFYPAEEYHQDYYEKTGHQPYCHIYQKRFK
HHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]