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The map label for this gene is argH

Identifier: 194333873

GI number: 194333873

Start: 1151402

End: 1152784

Strand: Reverse

Name: argH

Synonym: Paes_1047

Alternate gene names: 194333873

Gene position: 1152784-1151402 (Counterclockwise)

Preceding gene: 194333877

Following gene: 194333871

Centisome position: 45.87

GC content: 48.88

Gene sequence:

>1383_bases
ATGAGCAAGAAAAAAGAACTCTTGTGGCAAAGCCGCTTTTCAGAGCCGTTTGATCGTGAGGCTCTCCTCTTTTCCTCCTC
CGTGGATGTCGATAAAGAACTCTATCAGGAAGACATCACAGGCTCTATTGCCCATGTCACCATGCTTTCCGAAGAAGCGA
TCATTCCGGCAGAAGAGGCCAGACTGATTATCGAAGGTCTGCAGGAGATCGAAGAGGAAATCAGCACAGGAAGTCTTGTC
CCGCATTGGGAGGATGAGGATATTCACACCGTGATAGAAAATCGCCTGAAAGAAAAGATCGGCCCTATCGCAGGCAAGAT
CCATTCAGGCAGAAGCCGTAACGACCAGGTAGCCACTGATACCAGGCTTTATCTCAAACGCTCTATCGAAGAGATCCGCC
AGGCCCTGAAAGAGCTGAAAACTGTTCTGGTGGACAAAGCCGAAGCCTACCGCAGAACAATCATCTTCGGTTATACCCAT
CTTCAAAGAGCACAACCTATTTCAGCAGGGCACTACTACCTCGCCTATTTCAACATGTTCGACCGGGATAATCAACGCCT
TCAGGACCTTTATAAACGGGTCGATATCTCTCCTCTGGGTGCTGCTGCATTTGCAGGAAGCACGTTAGCGCTCAATGCGG
AGAGAAGCCGTGATCTGCTCGAATTTGAGGGGCTGTTTCACAACAGCATTGACGCCGTCAGTGACCGCGACATCATTATA
GAATTCGTCTCGGCATGCTCAATTATCATGATGCACCTGTCGAGATTTGCTGAAGACCTTATCCTCTGGAGCTCCTACGA
ATTCAACTATCTTGAAATCAGTGACGCTTTTGCCACCGGTTCATCGATCATGCCGCAGAAAAAAAACGCCGATATCGCAG
AACTGGTCAGAGGGAAAACAGGACGGGTCTATGGCGATCTCATGGCTATGCTGACCATCATGAAAGGTCTGCCGCTCTCC
TACAACCGTGACATGCAGGAAGACAAACCGCCGCTCTTCGATGCATCAAAAACGACACGTTCATCTGTACGGATTTTCAC
AAAAATGCTCGAAAACACGTCGATTAAAGAGAACCGCCTCTCATCACTCGTAGCAAAAGACCTGAGCCTTGCAACGGAAA
TAGCCGAATATCTGGTACAAAAAAACATGCCGTTCCGAGACGCTCACCGGGTCACAGGAAAAATAGTCAGCCATGTCATC
GAATCGGGAACAACGCTTCCTGACATGACTCTCGAAACCTACCGGACGTTTTCAGACCTCTTTGACGAAGACCTCTATGA
TGCGCTGAAACCCGAAGCGAGCGTCAATGCAAAAAAAACCCACGGGAGCACATCATTCGCATCGGTTGAAGAACAGATCG
TCTCAGCAAGAACACGGATCTGA

Upstream 100 bases:

>100_bases
AATCCTCTACCACAGCCATAGTGGCCGAAGCGTCCGGGCGATCAGCTCTCTTTTGCCTATAAAACATTTCTAATTAATAC
CTTATCAAGAAAGAAACTAT

Downstream 100 bases:

>100_bases
AACACACAAAAAGGGGAGCTTACTCCCCTTTTTGTGCATTATTGCTGTGAATGCCATGGCGCCGACGCAGCCCCTCTCGG
AATCTGACCAGCCCCAACAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSKKKELLWQSRFSEPFDREALLFSSSVDVDKELYQEDITGSIAHVTMLSEEAIIPAEEARLIIEGLQEIEEEISTGSLV
PHWEDEDIHTVIENRLKEKIGPIAGKIHSGRSRNDQVATDTRLYLKRSIEEIRQALKELKTVLVDKAEAYRRTIIFGYTH
LQRAQPISAGHYYLAYFNMFDRDNQRLQDLYKRVDISPLGAAAFAGSTLALNAERSRDLLEFEGLFHNSIDAVSDRDIII
EFVSACSIIMMHLSRFAEDLILWSSYEFNYLEISDAFATGSSIMPQKKNADIAELVRGKTGRVYGDLMAMLTIMKGLPLS
YNRDMQEDKPPLFDASKTTRSSVRIFTKMLENTSIKENRLSSLVAKDLSLATEIAEYLVQKNMPFRDAHRVTGKIVSHVI
ESGTTLPDMTLETYRTFSDLFDEDLYDALKPEASVNAKKTHGSTSFASVEEQIVSARTRI

Sequences:

>Translated_460_residues
MSKKKELLWQSRFSEPFDREALLFSSSVDVDKELYQEDITGSIAHVTMLSEEAIIPAEEARLIIEGLQEIEEEISTGSLV
PHWEDEDIHTVIENRLKEKIGPIAGKIHSGRSRNDQVATDTRLYLKRSIEEIRQALKELKTVLVDKAEAYRRTIIFGYTH
LQRAQPISAGHYYLAYFNMFDRDNQRLQDLYKRVDISPLGAAAFAGSTLALNAERSRDLLEFEGLFHNSIDAVSDRDIII
EFVSACSIIMMHLSRFAEDLILWSSYEFNYLEISDAFATGSSIMPQKKNADIAELVRGKTGRVYGDLMAMLTIMKGLPLS
YNRDMQEDKPPLFDASKTTRSSVRIFTKMLENTSIKENRLSSLVAKDLSLATEIAEYLVQKNMPFRDAHRVTGKIVSHVI
ESGTTLPDMTLETYRTFSDLFDEDLYDALKPEASVNAKKTHGSTSFASVEEQIVSARTRI
>Mature_459_residues
SKKKELLWQSRFSEPFDREALLFSSSVDVDKELYQEDITGSIAHVTMLSEEAIIPAEEARLIIEGLQEIEEEISTGSLVP
HWEDEDIHTVIENRLKEKIGPIAGKIHSGRSRNDQVATDTRLYLKRSIEEIRQALKELKTVLVDKAEAYRRTIIFGYTHL
QRAQPISAGHYYLAYFNMFDRDNQRLQDLYKRVDISPLGAAAFAGSTLALNAERSRDLLEFEGLFHNSIDAVSDRDIIIE
FVSACSIIMMHLSRFAEDLILWSSYEFNYLEISDAFATGSSIMPQKKNADIAELVRGKTGRVYGDLMAMLTIMKGLPLSY
NRDMQEDKPPLFDASKTTRSSVRIFTKMLENTSIKENRLSSLVAKDLSLATEIAEYLVQKNMPFRDAHRVTGKIVSHVIE
SGTTLPDMTLETYRTFSDLFDEDLYDALKPEASVNAKKTHGSTSFASVEEQIVSARTRI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=457, Percent_Identity=40.9190371991247, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303542, Length=457, Percent_Identity=40.9190371991247, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=38.9496717724289, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI68303549, Length=457, Percent_Identity=38.9496717724289, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=40.9691629955947, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17553882, Length=243, Percent_Identity=26.7489711934156, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=40.6047516198704, Blast_Score=355, Evalue=1e-98,
Organism=Drosophila melanogaster, GI221473854, Length=446, Percent_Identity=34.5291479820628, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI78706858, Length=446, Percent_Identity=34.5291479820628, Blast_Score=298, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PROA2 (B4S7P9)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015733.1
- ProteinModelPortal:   B4S7P9
- SMR:   B4S7P9
- GeneID:   6459898
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1047
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52191; Mature: 52060

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKKELLWQSRFSEPFDREALLFSSSVDVDKELYQEDITGSIAHVTMLSEEAIIPAEEA
CCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHCCCHHHEEEECCCCCCCHHHH
RLIIEGLQEIEEEISTGSLVPHWEDEDIHTVIENRLKEKIGPIAGKIHSGRSRNDQVATD
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
TRLYLKRSIEEIRQALKELKTVLVDKAEAYRRTIIFGYTHLQRAQPISAGHYYLAYFNMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHCCCCCCCCEEEEEEHHH
DRDNQRLQDLYKRVDISPLGAAAFAGSTLALNAERSRDLLEFEGLFHNSIDAVSDRDIII
CCCCHHHHHHHHHCCCCCCCHHHHCCCEEEECCHHCCHHHHHHHHHHCCCCCCCCHHHHH
EFVSACSIIMMHLSRFAEDLILWSSYEFNYLEISDAFATGSSIMPQKKNADIAELVRGKT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCCCC
GRVYGDLMAMLTIMKGLPLSYNRDMQEDKPPLFDASKTTRSSVRIFTKMLENTSIKENRL
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
SSLVAKDLSLATEIAEYLVQKNMPFRDAHRVTGKIVSHVIESGTTLPDMTLETYRTFSDL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FDEDLYDALKPEASVNAKKTHGSTSFASVEEQIVSARTRI
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKKELLWQSRFSEPFDREALLFSSSVDVDKELYQEDITGSIAHVTMLSEEAIIPAEEA
CCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHCCCHHHEEEECCCCCCCHHHH
RLIIEGLQEIEEEISTGSLVPHWEDEDIHTVIENRLKEKIGPIAGKIHSGRSRNDQVATD
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
TRLYLKRSIEEIRQALKELKTVLVDKAEAYRRTIIFGYTHLQRAQPISAGHYYLAYFNMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHCCCCCCCCEEEEEEHHH
DRDNQRLQDLYKRVDISPLGAAAFAGSTLALNAERSRDLLEFEGLFHNSIDAVSDRDIII
CCCCHHHHHHHHHCCCCCCCHHHHCCCEEEECCHHCCHHHHHHHHHHCCCCCCCCHHHHH
EFVSACSIIMMHLSRFAEDLILWSSYEFNYLEISDAFATGSSIMPQKKNADIAELVRGKT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCCCC
GRVYGDLMAMLTIMKGLPLSYNRDMQEDKPPLFDASKTTRSSVRIFTKMLENTSIKENRL
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
SSLVAKDLSLATEIAEYLVQKNMPFRDAHRVTGKIVSHVIESGTTLPDMTLETYRTFSDL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FDEDLYDALKPEASVNAKKTHGSTSFASVEEQIVSARTRI
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA