Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 194333871

GI number: 194333871

Start: 1148162

End: 1149136

Strand: Reverse

Name: fba [H]

Synonym: Paes_1045

Alternate gene names: 194333871

Gene position: 1149136-1148162 (Counterclockwise)

Preceding gene: 194333873

Following gene: 194333865

Centisome position: 45.73

GC content: 48.31

Gene sequence:

>975_bases
ATGCAACAGCCTCATATCAGCTATAAAGAACTCGGACTTCAGAACAGCAAGGAACTCTTTGCTAAAGCTGTCAAAGGCGG
ATATGCTATTCCTGCATACAATTTCAACAATCTCGAACAACTTCAGGCCATCATCATGGCATGTGTGGAAACAAATTCTC
CAGTCATTCTTCAGGTTTCCAAAGGAGCGAGAAACTACGCAAATCAGACCCTGTTGCGCAACCTTGCCCGAGGAGCCGTC
GAATATGCGGCCGAACTCGGAAACCCGGTTCCTATCGTTCTTCACCTCGACCATGGCGACAGTTTCGAACTCTGCAAGGA
CTGTATTCAAACAGGCTTCTCTTCTGTCATGATCGACGGGTCCCATCTCAGCTATGAAGACAACGTTACATTGACCCGTC
AGGTTGTAGACTACGCTCACCAGTATGATGTCACCGTTGAAGGAGAACTCGGCGTTCTGGCCGGTGTCGAAGATGAGGTT
GCATCAGAAACCCATACATACACCCAACCGGAAGAGGTCGAAGATTTTGTCACCAGAACAGGTGTAGACAGTCTGGCCAT
CGCTATAGGAACATCGCATGGTGCTTTTAAGTTCAAACCCGGGGAAGATCATAAAATACGTCTGGATATCCTGTCTGAAA
TAGAGAAAAGAATACCAGGATTTCCTATCGTTCTCCACGGCTCATCATCCGTTCCGCAGGATCTGGTTAAAACCATCAAT
GAACATGGCGGTAAACTCAAGGATGCAATCGGCATCAGTGAAGAACAGCTTCGCAAAGCGGCTCAATCAGCTGTCTGCAA
AATCAATATCGACTCCGACGGCAGACTTGCCATGACCGCAGCCATCCGCAAGGTCCTTGACGAAAAACCCGAAGAGTTTG
ATCCTCGAAAATATCTCGGCCCTGCCAGAGACGCACTCAAGGAGCTCTACAAGCACAAAAACATCAACGTACTCGGCTCC
AACGACAAAGCCTGA

Upstream 100 bases:

>100_bases
ATAGCATTGAATGCGACAACCAAATATATTATATTTAAAAACACTTGCTTCGGCAAAACATCATTAATCAGACCTCAAAA
TACATCAGGGAGACCTTTTC

Downstream 100 bases:

>100_bases
GCGGCAAGGAACAAAACCACACAAAAAAAGCCGGCACTTTTAGGTTGCCGGCTTTTTCTGTCTCCACCAATCACCAATCA
CCTCTGTGGGCAAAAATCTT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQQPHISYKELGLQNSKELFAKAVKGGYAIPAYNFNNLEQLQAIIMACVETNSPVILQVSKGARNYANQTLLRNLARGAV
EYAAELGNPVPIVLHLDHGDSFELCKDCIQTGFSSVMIDGSHLSYEDNVTLTRQVVDYAHQYDVTVEGELGVLAGVEDEV
ASETHTYTQPEEVEDFVTRTGVDSLAIAIGTSHGAFKFKPGEDHKIRLDILSEIEKRIPGFPIVLHGSSSVPQDLVKTIN
EHGGKLKDAIGISEEQLRKAAQSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLGPARDALKELYKHKNINVLGS
NDKA

Sequences:

>Translated_324_residues
MQQPHISYKELGLQNSKELFAKAVKGGYAIPAYNFNNLEQLQAIIMACVETNSPVILQVSKGARNYANQTLLRNLARGAV
EYAAELGNPVPIVLHLDHGDSFELCKDCIQTGFSSVMIDGSHLSYEDNVTLTRQVVDYAHQYDVTVEGELGVLAGVEDEV
ASETHTYTQPEEVEDFVTRTGVDSLAIAIGTSHGAFKFKPGEDHKIRLDILSEIEKRIPGFPIVLHGSSSVPQDLVKTIN
EHGGKLKDAIGISEEQLRKAAQSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLGPARDALKELYKHKNINVLGS
NDKA
>Mature_324_residues
MQQPHISYKELGLQNSKELFAKAVKGGYAIPAYNFNNLEQLQAIIMACVETNSPVILQVSKGARNYANQTLLRNLARGAV
EYAAELGNPVPIVLHLDHGDSFELCKDCIQTGFSSVMIDGSHLSYEDNVTLTRQVVDYAHQYDVTVEGELGVLAGVEDEV
ASETHTYTQPEEVEDFVTRTGVDSLAIAIGTSHGAFKFKPGEDHKIRLDILSEIEKRIPGFPIVLHGSSSVPQDLVKTIN
EHGGKLKDAIGISEEQLRKAAQSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLGPARDALKELYKHKNINVLGS
NDKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=315, Percent_Identity=35.8730158730159, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87082041, Length=298, Percent_Identity=33.2214765100671, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1788072, Length=300, Percent_Identity=31, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789293, Length=300, Percent_Identity=25.3333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322790, Length=340, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 35584; Mature: 35584

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQPHISYKELGLQNSKELFAKAVKGGYAIPAYNFNNLEQLQAIIMACVETNSPVILQVS
CCCCCCCHHHHCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
KGARNYANQTLLRNLARGAVEYAAELGNPVPIVLHLDHGDSFELCKDCIQTGFSSVMIDG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCHHEEECC
SHLSYEDNVTLTRQVVDYAHQYDVTVEGELGVLAGVEDEVASETHTYTQPEEVEDFVTRT
CCCCCCCCCHHHHHHHHHHHHCCEEECCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHC
GVDSLAIAIGTSHGAFKFKPGEDHKIRLDILSEIEKRIPGFPIVLHGSSSVPQDLVKTIN
CCCCEEEEEECCCCEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
EHGGKLKDAIGISEEQLRKAAQSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLG
HCCCHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCC
PARDALKELYKHKNINVLGSNDKA
HHHHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure
MQQPHISYKELGLQNSKELFAKAVKGGYAIPAYNFNNLEQLQAIIMACVETNSPVILQVS
CCCCCCCHHHHCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
KGARNYANQTLLRNLARGAVEYAAELGNPVPIVLHLDHGDSFELCKDCIQTGFSSVMIDG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCHHEEECC
SHLSYEDNVTLTRQVVDYAHQYDVTVEGELGVLAGVEDEVASETHTYTQPEEVEDFVTRT
CCCCCCCCCHHHHHHHHHHHHCCEEECCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHC
GVDSLAIAIGTSHGAFKFKPGEDHKIRLDILSEIEKRIPGFPIVLHGSSSVPQDLVKTIN
CCCCEEEEEECCCCEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
EHGGKLKDAIGISEEQLRKAAQSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLG
HCCCHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCC
PARDALKELYKHKNINVLGSNDKA
HHHHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]