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The map label for this gene is cobB [H]

Identifier: 193212715

GI number: 193212715

Start: 1169799

End: 1170491

Strand: Direct

Name: cobB [H]

Synonym: Cpar_1060

Alternate gene names: 193212715

Gene position: 1169799-1170491 (Clockwise)

Preceding gene: 193212713

Following gene: 193212717

Centisome position: 51.1

GC content: 57.14

Gene sequence:

>693_bases
ATGAAAAAGATCAACCCGACAGCATATCAGCGAATTGTCTTCTTTACCGGTGCAGGCATGTCCGCCGAAAGCGGCATTCC
CACCTATCGGGGCAAAGGAGGCTTCTGGAGCCAGTGCGACTATGAGGAGTATGCCTGCCAGGAAGCCTTCGAGCGCCAGC
CCGAAAAGGTGTTGCATTTTCACGAACTGCGGCGTCAGGCGGTGCTCGATTGCGAGCCGCACGAGGGGCACCGGGTGATC
TCCGGAATGCCGGAGACTTTCGTGATTACACAGAATATCGACGGTATGCACCAGCGCGCGGGCTCGAAAAAGGTCATCGA
ACTGCACGGAAGCCTGTGGCAATTGCGATGCGAGGAGTGTGAAACGATGAAAGAAGATTTCGGGCGAGAGTACGAAACGT
TACGATGCGACTGCGGCTGCTGGCTCCGACCCGCAATCACCTGGTTCGGCGACAGGCTCGATGAAGTCGTGATGCAGCAA
GCCTCGGAAATCATCGCATCGTGCGATCTGTTCATCAGCATCGGCACCTCGGGAACCGTGTGGCCAGCTGCAGGATTTCC
CGAACTTGCCCGGCAATCCGGAGCCTATTGCATTGAAATCAACCCCGAGCCATCGGGCGCAACCAGTTACCACCAAACCA
TTCGGGGCAAAGCCGGACGCGTGCTGCCAGAGCTGTTTGCGCGGGAAACATAA

Upstream 100 bases:

>100_bases
CAAAGAAAAAGGTCAGGAAAAGCTCAAATCACGGCAAACCTGTATTTTGGAACTATGCATTGCAACCATGTTCTGACAAT
AATCGAGAACTGATCAACCG

Downstream 100 bases:

>100_bases
AGGGCGCGTTTTCTGACCGGCAGCAAAGCCTATCACGAAAAAGCGCCCTGAAAAAATTATCCGAGAGGATCAGTACGTCA
ACAGCTTGATGCCCTCTTCA

Product: Silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKKINPTAYQRIVFFTGAGMSAESGIPTYRGKGGFWSQCDYEEYACQEAFERQPEKVLHFHELRRQAVLDCEPHEGHRVI
SGMPETFVITQNIDGMHQRAGSKKVIELHGSLWQLRCEECETMKEDFGREYETLRCDCGCWLRPAITWFGDRLDEVVMQQ
ASEIIASCDLFISIGTSGTVWPAAGFPELARQSGAYCIEINPEPSGATSYHQTIRGKAGRVLPELFARET

Sequences:

>Translated_230_residues
MKKINPTAYQRIVFFTGAGMSAESGIPTYRGKGGFWSQCDYEEYACQEAFERQPEKVLHFHELRRQAVLDCEPHEGHRVI
SGMPETFVITQNIDGMHQRAGSKKVIELHGSLWQLRCEECETMKEDFGREYETLRCDCGCWLRPAITWFGDRLDEVVMQQ
ASEIIASCDLFISIGTSGTVWPAAGFPELARQSGAYCIEINPEPSGATSYHQTIRGKAGRVLPELFARET
>Mature_230_residues
MKKINPTAYQRIVFFTGAGMSAESGIPTYRGKGGFWSQCDYEEYACQEAFERQPEKVLHFHELRRQAVLDCEPHEGHRVI
SGMPETFVITQNIDGMHQRAGSKKVIELHGSLWQLRCEECETMKEDFGREYETLRCDCGCWLRPAITWFGDRLDEVVMQQ
ASEIIASCDLFISIGTSGTVWPAAGFPELARQSGAYCIEINPEPSGATSYHQTIRGKAGRVLPELFARET

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=236, Percent_Identity=36.864406779661, Blast_Score=160, Evalue=7e-40,
Organism=Homo sapiens, GI6912664, Length=252, Percent_Identity=34.9206349206349, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI13787215, Length=233, Percent_Identity=35.1931330472103, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI308199517, Length=232, Percent_Identity=35.7758620689655, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17567771, Length=240, Percent_Identity=25, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990482, Length=241, Percent_Identity=24.4813278008299, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25994; Mature: 25994

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKINPTAYQRIVFFTGAGMSAESGIPTYRGKGGFWSQCDYEEYACQEAFERQPEKVLHF
CCCCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
HELRRQAVLDCEPHEGHRVISGMPETFVITQNIDGMHQRAGSKKVIELHGSLWQLRCEEC
HHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCHHHHHCCCCCEEEHHHHHHHHHHHHH
ETMKEDFGREYETLRCDCGCWLRPAITWFGDRLDEVVMQQASEIIASCDLFISIGTSGTV
HHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
WPAAGFPELARQSGAYCIEINPEPSGATSYHQTIRGKAGRVLPELFARET
CCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHCCCC
>Mature Secondary Structure
MKKINPTAYQRIVFFTGAGMSAESGIPTYRGKGGFWSQCDYEEYACQEAFERQPEKVLHF
CCCCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
HELRRQAVLDCEPHEGHRVISGMPETFVITQNIDGMHQRAGSKKVIELHGSLWQLRCEEC
HHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCHHHHHCCCCCEEEHHHHHHHHHHHHH
ETMKEDFGREYETLRCDCGCWLRPAITWFGDRLDEVVMQQASEIIASCDLFISIGTSGTV
HHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
WPAAGFPELARQSGAYCIEINPEPSGATSYHQTIRGKAGRVLPELFARET
CCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]