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The map label for this gene is dxs [C]

Identifier: 193212496

GI number: 193212496

Start: 906159

End: 907142

Strand: Direct

Name: dxs [C]

Synonym: Cpar_0833

Alternate gene names: 193212496

Gene position: 906159-907142 (Clockwise)

Preceding gene: 193212488

Following gene: 193212497

Centisome position: 39.58

GC content: 58.94

Gene sequence:

>984_bases
ATGGGAGAGAAAAATATCGTCGAGGAGACCGAGAAGTACGCTTCCCGGGGCAACAAGGCTACCCGCACGGGATTCGGTGA
AGCGCTGCTCGAAGCCGGACGCGAAAACCCTTCGGTTGTCGCGCTTTGCGCCGACCTGACTGGCTCGCTGAACATGAACC
TCTTCCGCAAAGAGTTTCCGGAACGCTTCATCCAGACCGGTATTGCCGAGGCGAACATGATTTCGATGGCCGCCGGTCTT
GCTACCACCGGCAAAACGCCTGTGGCTTCGACCTTCGCTGTTTTTGCTACCGGCCGCGTGTTCGACCAGATCCGCCAGTC
GGTCTGCTATTCGAATCTCAACGTTAAAATCTGCGCATCGCACGCCGGCCTGACGCTCGGCGAGGACGGTGCGACCCACC
AGATTCTTGAAGATATCGGTCTGATGCGCAGTCTTCCGCGCATGACTGTTGTCGTACCGTGCGACTACAGCGAAACCAAA
CGTGCCACCAAGGCGATCATCGAGCACGAAGGCCCGGTTTATCTCCGCTTCGGCCGTCCGAATGTCCCGGACTTCACCTC
CGACGAGGATGGGTTCGAGCTCGGCAAGTCTATCGAGCTGCATCCCGGCAAGGATGTGACCGTCATCGCTTGCGGCATCA
TGGTCTGGAAAGCGCTCGAAGCGGCGCGGATCCTCGAAAAGGAGGGCGTTTCGGTGCGCGTCATCAACATGCACACCATC
AAGCCGATCGACACGCTGGCCATCGTCCGCGCGGCTCACGACACCGGCGCGATCGTCACCGCCGAGGAGCACCAGATGTA
CACCGGTCTCGGTGAAGCTGTGGCCAACGTCTGCGCCCGCAACATTCCGGTGCCGATCGAAATGGTCGCTGTCGAGGACT
CCTTCGGCGAGTCCGGCAAGCCGGACGATCTGCTCCGCAAGTACAAACTGACCACCGAGGATATTCTGGAGAAGATTTAC
CTGGTGCTCAGAAGAAAAGATTAA

Upstream 100 bases:

>100_bases
CCTGTGCTCTGGAATCGCAACTCGATAAGTGGGCAGAGGTTAACCCGGAGGTCATCCGGGTCCTGCATAAGTTTTTCTAA
TCTAAGGTATTCTGTCATTA

Downstream 100 bases:

>100_bases
ATAATGGGGAACAGGTCTTGCAGGAATCCCGCAAGACTTTTTTGAAATACCGGAGCCTGATGTCATAAAAAGCTGTCAGG
CTCTGACTTTTCAGACAGTT

Product: Transketolase central region

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MGEKNIVEETEKYASRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMNLFRKEFPERFIQTGIAEANMISMAAGL
ATTGKTPVASTFAVFATGRVFDQIRQSVCYSNLNVKICASHAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETK
RATKAIIEHEGPVYLRFGRPNVPDFTSDEDGFELGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
KPIDTLAIVRAAHDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDSFGESGKPDDLLRKYKLTTEDILEKIY
LVLRRKD

Sequences:

>Translated_327_residues
MGEKNIVEETEKYASRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMNLFRKEFPERFIQTGIAEANMISMAAGL
ATTGKTPVASTFAVFATGRVFDQIRQSVCYSNLNVKICASHAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETK
RATKAIIEHEGPVYLRFGRPNVPDFTSDEDGFELGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
KPIDTLAIVRAAHDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDSFGESGKPDDLLRKYKLTTEDILEKIY
LVLRRKD
>Mature_326_residues
GEKNIVEETEKYASRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMNLFRKEFPERFIQTGIAEANMISMAAGLA
TTGKTPVASTFAVFATGRVFDQIRQSVCYSNLNVKICASHAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETKR
ATKAIIEHEGPVYLRFGRPNVPDFTSDEDGFELGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTIK
PIDTLAIVRAAHDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDSFGESGKPDDLLRKYKLTTEDILEKIYL
VLRRKD

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=309, Percent_Identity=38.1877022653722, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4507521, Length=309, Percent_Identity=38.1877022653722, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI225637463, Length=313, Percent_Identity=38.9776357827476, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI225637461, Length=313, Percent_Identity=38.9776357827476, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI225637459, Length=313, Percent_Identity=38.9776357827476, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI133778974, Length=313, Percent_Identity=36.1022364217252, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI291084858, Length=234, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156564403, Length=239, Percent_Identity=27.6150627615063, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786622, Length=299, Percent_Identity=27.4247491638796, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788808, Length=357, Percent_Identity=26.890756302521, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI48994911, Length=327, Percent_Identity=25.6880733944954, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539652, Length=309, Percent_Identity=34.6278317152104, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17538422, Length=238, Percent_Identity=25.6302521008403, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325331, Length=312, Percent_Identity=24.6794871794872, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319593, Length=245, Percent_Identity=27.3469387755102, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666278, Length=313, Percent_Identity=34.5047923322684, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24645119, Length=311, Percent_Identity=34.4051446945338, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45551847, Length=311, Percent_Identity=34.4051446945338, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45550715, Length=311, Percent_Identity=34.4051446945338, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21358145, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650940, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 35701; Mature: 35570

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKNIVEETEKYASRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMNLFRKEFP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHH
ERFIQTGIAEANMISMAAGLATTGKTPVASTFAVFATGRVFDQIRQSVCYSNLNVKICAS
HHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETKRATKAIIEHEGPVYLRFGRP
CCCCEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCC
NVPDFTSDEDGFELGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
CCCCCCCCCCHHHCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
KPIDTLAIVRAAHDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDSFGESGK
CCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
PDDLLRKYKLTTEDILEKIYLVLRRKD
CHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GEKNIVEETEKYASRGNKATRTGFGEALLEAGRENPSVVALCADLTGSLNMNLFRKEFP
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHH
ERFIQTGIAEANMISMAAGLATTGKTPVASTFAVFATGRVFDQIRQSVCYSNLNVKICAS
HHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HAGLTLGEDGATHQILEDIGLMRSLPRMTVVVPCDYSETKRATKAIIEHEGPVYLRFGRP
CCCCEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCC
NVPDFTSDEDGFELGKSIELHPGKDVTVIACGIMVWKALEAARILEKEGVSVRVINMHTI
CCCCCCCCCCHHHCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
KPIDTLAIVRAAHDTGAIVTAEEHQMYTGLGEAVANVCARNIPVPIEMVAVEDSFGESGK
CCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
PDDLLRKYKLTTEDILEKIYLVLRRKD
CHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]