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The map label for this gene is lpxD [H]

Identifier: 193212460

GI number: 193212460

Start: 861994

End: 863061

Strand: Direct

Name: lpxD [H]

Synonym: Cpar_0797

Alternate gene names: 193212460

Gene position: 861994-863061 (Clockwise)

Preceding gene: 193212454

Following gene: 193212467

Centisome position: 37.65

GC content: 57.21

Gene sequence:

>1068_bases
ATGAACATTGCAGACATCAATGCCTTTCTCGGGCGTTATTTCAGCTCCGTCGAGCTTGTCGGTTCGGATCAGACCGAAAT
CACCGGTCCGGCTAAAATTGAAGAGGCCGTCTCCGGGCAGGTCAGTTTCGTCTCTAATGAAAAGTATTACCGACACATTG
CGCAAAGTGGCGCTTCGCTGCTGATTGTGCACCCCAAAGCTCCTGTCGATGATGCGCCTGAGGGAATGAGTTTCCTGAAG
GTCGAAGACCCTTACACCGCGTTTGTGTTCATCCTGCGGCACTTTGCAGGAGCGCGTCGGATTGCGGAGTCTGGCGTGGC
CGCATCGGCGTCGATTGCGCCATCGGCGCGTCTCGGTCGGAACGTTTCGGTTGGCGAGCATGCGGTCATCGGGGAGCGCT
GCGTGATTGGCGACAATACAGTGATCGGCCCCAACACCGTACTGCTCGACGAGGTGACGATTGGTTCAGAGTGTACGCTG
TTTCCACAGGTGACCATGTATGATGGCACGTTGATAGGAGATCGGGTCACGATTCACAGCGGGACGGTCATCGGAGCCGA
CGGTTTCGGTTTTGCGCCGCAGAAAGATGGCTCCTACGTAAAGATTCCCCAGATGGGTACGGTGCGCATCGAGGATGATG
TCGAAATCGGCGCGAACACGACGATTGACCGTGCGACGATGGGGGAGACCGTCATCGAAAAAGGGGTCAAGATCGACAAT
CTTGTGCAGATTGCGCATAACTGCCGGATCGGTGGCGATACGGTCATCGCTTCGCAGGCTGGCATTTCCGGCAGCGTGAA
GATCGGCCGCAACTGCCTTATCGGCGGGCAGGCGGGCTTTGCAGGCCATCTTGAACTTGCCGACAAGATTTCGGTGGCGG
CCAAGGCCGGCATCTCCAAATCCTTCATGCAGTCAGGCCAAGCCATTCGCGGCGTGCCGGCCCAGCCCATGCGTGACCAG
CTCCGCCAGGAAGCCCAGATTCGCTCACTCGGGGAGATGAAGGCAAAAATCGAAGCGCTTGAAACGAAATTGCAGGAGTT
GTGGGAGCGGCTTGACGGTTTAGCTTGA

Upstream 100 bases:

>100_bases
GTACGCTGTCGCATCCGGCGCGATTTAGGATTTTGAATATAGCAAAATGGATTGAATTACTAAGTAAATTTTCTGGCTTT
CTCCGGCCATCGCATACAGT

Downstream 100 bases:

>100_bases
TAATCGCGCTTACGTTTCGCCCAATCTGCGGTTGAGATCCCAGTTGTAGGGCAGATAGCGTATGCGTAGTTGCGTCCTCA
TCGACACAATCCTTTCGCGG

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNIADINAFLGRYFSSVELVGSDQTEITGPAKIEEAVSGQVSFVSNEKYYRHIAQSGASLLIVHPKAPVDDAPEGMSFLK
VEDPYTAFVFILRHFAGARRIAESGVAASASIAPSARLGRNVSVGEHAVIGERCVIGDNTVIGPNTVLLDEVTIGSECTL
FPQVTMYDGTLIGDRVTIHSGTVIGADGFGFAPQKDGSYVKIPQMGTVRIEDDVEIGANTTIDRATMGETVIEKGVKIDN
LVQIAHNCRIGGDTVIASQAGISGSVKIGRNCLIGGQAGFAGHLELADKISVAAKAGISKSFMQSGQAIRGVPAQPMRDQ
LRQEAQIRSLGEMKAKIEALETKLQELWERLDGLA

Sequences:

>Translated_355_residues
MNIADINAFLGRYFSSVELVGSDQTEITGPAKIEEAVSGQVSFVSNEKYYRHIAQSGASLLIVHPKAPVDDAPEGMSFLK
VEDPYTAFVFILRHFAGARRIAESGVAASASIAPSARLGRNVSVGEHAVIGERCVIGDNTVIGPNTVLLDEVTIGSECTL
FPQVTMYDGTLIGDRVTIHSGTVIGADGFGFAPQKDGSYVKIPQMGTVRIEDDVEIGANTTIDRATMGETVIEKGVKIDN
LVQIAHNCRIGGDTVIASQAGISGSVKIGRNCLIGGQAGFAGHLELADKISVAAKAGISKSFMQSGQAIRGVPAQPMRDQ
LRQEAQIRSLGEMKAKIEALETKLQELWERLDGLA
>Mature_355_residues
MNIADINAFLGRYFSSVELVGSDQTEITGPAKIEEAVSGQVSFVSNEKYYRHIAQSGASLLIVHPKAPVDDAPEGMSFLK
VEDPYTAFVFILRHFAGARRIAESGVAASASIAPSARLGRNVSVGEHAVIGERCVIGDNTVIGPNTVLLDEVTIGSECTL
FPQVTMYDGTLIGDRVTIHSGTVIGADGFGFAPQKDGSYVKIPQMGTVRIEDDVEIGANTTIDRATMGETVIEKGVKIDN
LVQIAHNCRIGGDTVIASQAGISGSVKIGRNCLIGGQAGFAGHLELADKISVAAKAGISKSFMQSGQAIRGVPAQPMRDQ
LRQEAQIRSLGEMKAKIEALETKLQELWERLDGLA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=330, Percent_Identity=38.1818181818182, Blast_Score=214, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37668; Mature: 37668

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIADINAFLGRYFSSVELVGSDQTEITGPAKIEEAVSGQVSFVSNEKYYRHIAQSGASL
CCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHCCCEEEEECHHHHHHHHHCCCEE
LIVHPKAPVDDAPEGMSFLKVEDPYTAFVFILRHFAGARRIAESGVAASASIAPSARLGR
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCC
NVSVGEHAVIGERCVIGDNTVIGPNTVLLDEVTIGSECTLFPQVTMYDGTLIGDRVTIHS
CCCCCCEEEECCEEEECCCEEECCCEEEEEEEEECCCEEEECEEEEECCEEECCEEEEEC
GTVIGADGFGFAPQKDGSYVKIPQMGTVRIEDDVEIGANTTIDRATMGETVIEKGVKIDN
CEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCEECCCCCCCHHHHHHHHHHCCCCHHH
LVQIAHNCRIGGDTVIASQAGISGSVKIGRNCLIGGQAGFAGHLELADKISVAAKAGISK
HHHHHHHCCCCCCEEEEECCCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHCCCH
SFMQSGQAIRGVPAQPMRDQLRQEAQIRSLGEMKAKIEALETKLQELWERLDGLA
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIADINAFLGRYFSSVELVGSDQTEITGPAKIEEAVSGQVSFVSNEKYYRHIAQSGASL
CCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHCCCEEEEECHHHHHHHHHCCCEE
LIVHPKAPVDDAPEGMSFLKVEDPYTAFVFILRHFAGARRIAESGVAASASIAPSARLGR
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCC
NVSVGEHAVIGERCVIGDNTVIGPNTVLLDEVTIGSECTLFPQVTMYDGTLIGDRVTIHS
CCCCCCEEEECCEEEECCCEEECCCEEEEEEEEECCCEEEECEEEEECCEEECCEEEEEC
GTVIGADGFGFAPQKDGSYVKIPQMGTVRIEDDVEIGANTTIDRATMGETVIEKGVKIDN
CEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCEECCCCCCCHHHHHHHHHHCCCCHHH
LVQIAHNCRIGGDTVIASQAGISGSVKIGRNCLIGGQAGFAGHLELADKISVAAKAGISK
HHHHHHHCCCCCCEEEEECCCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHCCCH
SFMQSGQAIRGVPAQPMRDQLRQEAQIRSLGEMKAKIEALETKLQELWERLDGLA
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]