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The map label for this gene is lysA [H]

Identifier: 193212450

GI number: 193212450

Start: 850657

End: 851952

Strand: Direct

Name: lysA [H]

Synonym: Cpar_0787

Alternate gene names: 193212450

Gene position: 850657-851952 (Clockwise)

Preceding gene: 193212447

Following gene: 193212451

Centisome position: 37.16

GC content: 55.32

Gene sequence:

>1296_bases
ATGTTCCTTCTAATCGCCAATGAACCATCAAATTACCAGCGCATCGTGCTCGACAGTCACTTTTTTTCATACTCCGACGG
AACCCTTTCATGTGAATCTCTAAAGCTTGACGAACTTGCCCGGCAGTACGGCACGCCACTGTTCGTGACCAGCCGCCAGA
GCCTGATCAGCCAGTACCGGGCCTTCGAGGAGGCATTTGCCGCTCTTCCGCATTTCACCTGTTATTCAGTCAAGGCTAAC
TTCAATCTTGAGGTTATCCGCACGCTTGCTGCCGAAGGTTGCGGATGCGACGTCAATTCCGGAGGTGAACTCTATCGTGC
ACTGAAAGCCGGCGTACCTGCCGAGAAAATCATCATGGCTGGAGTTGGTAAAACCGAGGAGGAGATCGAGTATGGCCTGA
ACTCGGGCGTGATGATGATCAAGGCCGAGTCGACTGCCGAGCTCAAGGCGATCAATCGTGTGGCTGCTCGCCTTGGCAAG
GTCGCACAGGTCGGCGTCAGGGTTACTCCCAACGTGACCGCCGAGACCCATCCCTACATCACCACGGGCGACAGTAAGGA
GAAGTTCGGCATCGACGAGGCCGGGCTGGCCGAGGTGTTCGACTTGTTTAAAGCATTAACGAACCTTGAGCTTCACGGTC
TCGACATGCACATCGGCTCGCAGATTTTCGATCCGGAGTACTACGTGGCCGCCACGCAGAAGCTGCTCGAGGTGCTTGAA
TCGGCGCGTCATCTTGGCTTCGATATCAAATGGCTCGATCTCGGTGGAGGTTTCCCGGCAACCTACGATCCGCAGAAACC
AGCTACGCCGATCACCAAGTTTGCCGAAAAGCTTATTCCGATGCTCGACGACAAAGGCGTGACGGTTATTTTCGAGCCGG
GCCGGTTCATTGCCGCCAACTCGTCGGTGCTGGTCACCAAAATTCTCTATCGCAAGAAAAACCATGCGGGCAAAGAGTTC
TTCATTGTCGATGCCGGTATGACCGAACTGATCCGCCCTGCGCTCTATCAGTCGCACCACGAAGTGCTCACGGTCAAGCA
GCACGACAAGAGCGTTGTGGCTGACGTGGTAGGGCCGGTTTGCGAATCAAGCGACTTCTTCGTCCGCCACCGCACTATCG
GCGATGCTCCTGAAGGTGAATTGCTCGCCGTACTCTCTTCCGGAGCTTATGGCGCAGTCATGGGCACCAACTACAATGGT
CGCCGTCGTCCCGCAGAAGTAATGGTTGACGGCAGCGAAGCCAAGCTGATTCGCCGCCGTGAAACCTACGAGCAGCTCGT
GCAGAACGAAATTTAA

Upstream 100 bases:

>100_bases
GTCGATCAGTTGATTATTAAATGAGCAACGAATATACACCTTGGACTCCTATTATGCAAGGTCTGCTGTTTTTTTGTTTC
AGGAATGAAGAAAGGCTATT

Downstream 100 bases:

>100_bases
GAGCATGGACTAATACGGACGAAGTGGATTGGAATGTTCTCCTGATCCGCTTCGTCCGTTGATGAGCCGAGCCTCCACGC
TATACTTCGCCCTTTTACCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MFLLIANEPSNYQRIVLDSHFFSYSDGTLSCESLKLDELARQYGTPLFVTSRQSLISQYRAFEEAFAALPHFTCYSVKAN
FNLEVIRTLAAEGCGCDVNSGGELYRALKAGVPAEKIIMAGVGKTEEEIEYGLNSGVMMIKAESTAELKAINRVAARLGK
VAQVGVRVTPNVTAETHPYITTGDSKEKFGIDEAGLAEVFDLFKALTNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLE
SARHLGFDIKWLDLGGGFPATYDPQKPATPITKFAEKLIPMLDDKGVTVIFEPGRFIAANSSVLVTKILYRKKNHAGKEF
FIVDAGMTELIRPALYQSHHEVLTVKQHDKSVVADVVGPVCESSDFFVRHRTIGDAPEGELLAVLSSGAYGAVMGTNYNG
RRRPAEVMVDGSEAKLIRRRETYEQLVQNEI

Sequences:

>Translated_431_residues
MFLLIANEPSNYQRIVLDSHFFSYSDGTLSCESLKLDELARQYGTPLFVTSRQSLISQYRAFEEAFAALPHFTCYSVKAN
FNLEVIRTLAAEGCGCDVNSGGELYRALKAGVPAEKIIMAGVGKTEEEIEYGLNSGVMMIKAESTAELKAINRVAARLGK
VAQVGVRVTPNVTAETHPYITTGDSKEKFGIDEAGLAEVFDLFKALTNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLE
SARHLGFDIKWLDLGGGFPATYDPQKPATPITKFAEKLIPMLDDKGVTVIFEPGRFIAANSSVLVTKILYRKKNHAGKEF
FIVDAGMTELIRPALYQSHHEVLTVKQHDKSVVADVVGPVCESSDFFVRHRTIGDAPEGELLAVLSSGAYGAVMGTNYNG
RRRPAEVMVDGSEAKLIRRRETYEQLVQNEI
>Mature_431_residues
MFLLIANEPSNYQRIVLDSHFFSYSDGTLSCESLKLDELARQYGTPLFVTSRQSLISQYRAFEEAFAALPHFTCYSVKAN
FNLEVIRTLAAEGCGCDVNSGGELYRALKAGVPAEKIIMAGVGKTEEEIEYGLNSGVMMIKAESTAELKAINRVAARLGK
VAQVGVRVTPNVTAETHPYITTGDSKEKFGIDEAGLAEVFDLFKALTNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLE
SARHLGFDIKWLDLGGGFPATYDPQKPATPITKFAEKLIPMLDDKGVTVIFEPGRFIAANSSVLVTKILYRKKNHAGKEF
FIVDAGMTELIRPALYQSHHEVLTVKQHDKSVVADVVGPVCESSDFFVRHRTIGDAPEGELLAVLSSGAYGAVMGTNYNG
RRRPAEVMVDGSEAKLIRRRETYEQLVQNEI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=366, Percent_Identity=29.2349726775956, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI22538418, Length=378, Percent_Identity=23.8095238095238, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI21361583, Length=378, Percent_Identity=23.8095238095238, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI16506287, Length=402, Percent_Identity=22.3880597014925, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789203, Length=438, Percent_Identity=29.2237442922374, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789307, Length=264, Percent_Identity=24.6212121212121, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=412, Percent_Identity=26.2135922330097, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24586472, Length=390, Percent_Identity=25.8974358974359, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=376, Percent_Identity=26.063829787234, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47486; Mature: 47486

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLLIANEPSNYQRIVLDSHFFSYSDGTLSCESLKLDELARQYGTPLFVTSRQSLISQYR
CEEEEECCCCCCEEEEEECCEEECCCCCEEECCCCHHHHHHHHCCCEEEECHHHHHHHHH
AFEEAFAALPHFTCYSVKANFNLEVIRTLAAEGCGCDVNSGGELYRALKAGVPAEKIIMA
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHEEEE
GVGKTEEEIEYGLNSGVMMIKAESTAELKAINRVAARLGKVAQVGVRVTPNVTAETHPYI
CCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEE
TTGDSKEKFGIDEAGLAEVFDLFKALTNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLE
ECCCCCHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
SARHLGFDIKWLDLGGGFPATYDPQKPATPITKFAEKLIPMLDDKGVTVIFEPGRFIAAN
HHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEC
SSVLVTKILYRKKNHAGKEFFIVDAGMTELIRPALYQSHHEVLTVKQHDKSVVADVVGPV
CCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
CESSDFFVRHRTIGDAPEGELLAVLSSGAYGAVMGTNYNGRRRPAEVMVDGSEAKLIRRR
CCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHH
ETYEQLVQNEI
HHHHHHHHCCC
>Mature Secondary Structure
MFLLIANEPSNYQRIVLDSHFFSYSDGTLSCESLKLDELARQYGTPLFVTSRQSLISQYR
CEEEEECCCCCCEEEEEECCEEECCCCCEEECCCCHHHHHHHHCCCEEEECHHHHHHHHH
AFEEAFAALPHFTCYSVKANFNLEVIRTLAAEGCGCDVNSGGELYRALKAGVPAEKIIMA
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHEEEE
GVGKTEEEIEYGLNSGVMMIKAESTAELKAINRVAARLGKVAQVGVRVTPNVTAETHPYI
CCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEE
TTGDSKEKFGIDEAGLAEVFDLFKALTNLELHGLDMHIGSQIFDPEYYVAATQKLLEVLE
ECCCCCHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
SARHLGFDIKWLDLGGGFPATYDPQKPATPITKFAEKLIPMLDDKGVTVIFEPGRFIAAN
HHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEC
SSVLVTKILYRKKNHAGKEFFIVDAGMTELIRPALYQSHHEVLTVKQHDKSVVADVVGPV
CCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHH
CESSDFFVRHRTIGDAPEGELLAVLSSGAYGAVMGTNYNGRRRPAEVMVDGSEAKLIRRR
CCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHH
ETYEQLVQNEI
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]