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The map label for this gene is comEB [H]

Identifier: 193212376

GI number: 193212376

Start: 760221

End: 760742

Strand: Direct

Name: comEB [H]

Synonym: Cpar_0709

Alternate gene names: 193212376

Gene position: 760221-760742 (Clockwise)

Preceding gene: 193212373

Following gene: 193212377

Centisome position: 33.21

GC content: 57.85

Gene sequence:

>522_bases
ATGCAGGAAGAAAGCAAAAGCGGTTGTGGTTGCAGTTCGCGAGGCGAAAATGGCGCTGGTGAGCAGGCGCGGCTCGGGTG
GCACGAATATTTCATGTGCGTAGCGCACCTCATTTCACGCCGGGCGACCTGCACGCGGGGGCACATCGGTGCGGTGATCG
TGCGCGACAACAACATCCTCTCGACCGGCTACAACGGCGCGCCTTCCGGACTGCCGCACTGCAACGAGACCAACTGCAAA
ATCTACCGCAGTACCCATCCCGACGGCACCGTCGAGGAGAACTGCGTCAACACGATTCACGCCGAAATCAACGCCATCGC
ACAGGCCGCCAAGCACGGTGTATCGATAAAAGATGCCGATATTTACATCACCGCCAGCCCCTGCATCCACTGCCTGAAGG
TGCTCATTAACGTGGGCATCAAAACCATTTATTACGACAAGCCCTACAAGATCGAGCACATCGCCGAGCTGTTGCGCCTG
TCGGGTATCAAGCTGGTGCAGGTGCACGCCGAAAACTGCTGA

Upstream 100 bases:

>100_bases
CCAAGCAAGAAGATGAGGGAGAAGGCTCAGCCGTTCAAAAATATTGCGCAGCCGCTTTCTTTACTCTATTTTCCTGAAAC
AATCTAAAAAGAAGATAACT

Downstream 100 bases:

>100_bases
AGGGGGACGGCGCGATGAATCCAAATGTGGGGATGCGTCCGGAGGACGAAGGCCACATGCGGCGATGCCTTGAACTGGCC
GAGCGCGGCGCGGGCAGCGT

Product: zinc-binding CMP/dCMP deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MQEESKSGCGCSSRGENGAGEQARLGWHEYFMCVAHLISRRATCTRGHIGAVIVRDNNILSTGYNGAPSGLPHCNETNCK
IYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRL
SGIKLVQVHAENC

Sequences:

>Translated_173_residues
MQEESKSGCGCSSRGENGAGEQARLGWHEYFMCVAHLISRRATCTRGHIGAVIVRDNNILSTGYNGAPSGLPHCNETNCK
IYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRL
SGIKLVQVHAENC
>Mature_173_residues
MQEESKSGCGCSSRGENGAGEQARLGWHEYFMCVAHLISRRATCTRGHIGAVIVRDNNILSTGYNGAPSGLPHCNETNCK
IYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRL
SGIKLVQVHAENC

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742821, Length=122, Percent_Identity=33.6065573770492, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI61742819, Length=122, Percent_Identity=33.6065573770492, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321938, Length=154, Percent_Identity=31.1688311688312, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667298, Length=143, Percent_Identity=30.0699300699301, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667302, Length=143, Percent_Identity=30.0699300699301, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 18890; Mature: 18890

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
5.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEESKSGCGCSSRGENGAGEQARLGWHEYFMCVAHLISRRATCTRGHIGAVIVRDNNIL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEE
STGYNGAPSGLPHCNETNCKIYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDAD
ECCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCE
IYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRLSGIKLVQVHAENC
EEEECHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure
MQEESKSGCGCSSRGENGAGEQARLGWHEYFMCVAHLISRRATCTRGHIGAVIVRDNNIL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEE
STGYNGAPSGLPHCNETNCKIYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDAD
ECCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCE
IYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRLSGIKLVQVHAENC
EEEECHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]