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The map label for this gene is kefB [H]

Identifier: 193212350

GI number: 193212350

Start: 728519

End: 730354

Strand: Direct

Name: kefB [H]

Synonym: Cpar_0683

Alternate gene names: 193212350

Gene position: 728519-730354 (Clockwise)

Preceding gene: 193212348

Following gene: 193212351

Centisome position: 31.82

GC content: 57.41

Gene sequence:

>1836_bases
ATGCATCACTATGATTTTCTCGGGCAACTGGTACTGATCGGTACCCTTGCCATAGCCACCATTCTGCTGTTCCAGAGGAT
CCGCATTCCTCCGGTGATCGGTCTGATTTTCACGGGCATCATGCTCGGCCCTACGGGGTTCGGTGTGGTCAGCGACAGCG
GATTGATTTCGATCCTCGCCGAGCTGGGTGTGGTGCTGCTGCTTTTTACCATCGGGCTGGAGTTTTCGCTCGACGACATG
AAGAAGCTCCAGAAGATTGTTTTTGCGGGAGGTCTGGCACAGGTGATGCTGACCGGGATGATTATAGCCGCGCTGGCTTT
CTGGCTGCTGGAGGCGATTGGAAAAAAGATCAGCATCCAAGAGGCGATTGTGCTCGGTTTTTCCTTTTCGGTAAGCAGTA
CCGCCTTGTGCCTGAAGATTCTCTCCGACCGCGATGAACTCAGCTTCGAGCACGGCAAGATTGCGCTCGGCATCCTGATT
TTTCAGGACATGGCCATTGTGCCACTCATGATCGGCTTGACGTTTCTGACGCCCGGTAAGGTCATTTCGCCCGAAGCGAC
CTTTCAGGAGGTGGCGCTGCTGCTGCTGTTCGCCATCGGTATGTTCGGCGGATTCCGGCTTCTGATGCCGAGGATCGTGC
GGATGATTACCGAGCTTCATGCCGGGGAGGTGCTGGTGCTCGGTGCGCTGGTGCTTTGCTTCGGTGCTGCGTGGCTTGCT
TCGCTCATCGGCCTGTCGCTGGCACTCGGCGCGTTCATGGCCGGCATGGTGATTGCCAGCACCGACGGAAGCCACCGCAT
CAGCAGAACCATCGATCCCTTCCGCGAAGCACTGACCAGCATCTTTTTTGTGTCGGTCGGGCTCCTGCTCGATGTGAACA
TGATCGAGCTTCCGTGGCTGATCGGTGTGGCTCTCGTTGTGCTACTCGTCAAAGGCATCGTCATGACGGGCATTTCGATG
GCTCTCGGCTTTTCAACGAGGGTGAGCCTGATGTCGGGCATGGTGCTGGCCCAGATTGGTGAGTTCTCGTTCGTGCTGGC
CGGATCGGCAAAGAATACGGGGCTGCTCGACCAGCACATGTTTCAGTTGATGCTGACCATCATCGTCGTCACCATGATCG
TTACGCCTGCGCTGATCTCGGCGGCTCCGGCATTTGCCGCGCAGATGGCTCCTGTGTTCAGGTTCATGCCGCTGATGCCC
GAGCCGAAACCGAAACAGCCGACGCGCACCACGACAAGCTCAATCGCCTGCAAGGGTGAAATTCATGCGGTCATTATCGG
CTACGGTCTGATCGGCCGGAATGTGGCCGCCGTGATGAACGCCACCAACCTGCTCTACACGGTGCTCGACACCAACCGCA
AGGTGGTCAGCACCATGCGCCGCAAAGGTGAACCGCTTTTTTTCGGCGACTGCACAGAGCGCAAATCGTTGCTTCGTGTC
GGTACCGACCACTGTCGCTCCGTGGTGATCTGCATTCCCGAGATCGAGGCGGCTATTCAGTGCATCCGTCAGGTGCGCAT
CATCAACAGTGAAGCCTTCATCATCGTCCGTGCACGCTCGTTCCAGTCCGCTTCGCAGTTCTACAGAGCCGGAGCCGATG
CGGTCGTGACCGAGATTTTCGAAACCTCGATTCAGATGTTTTCCGAGTTGCTCAGGCATTTCAAAGTCGATCCCGAAACC
ATCTTCGAGCAGCAGGAGATCATCCGGCGTGAGGGCGGCAAGCTGTTTCTGGAGCCGACAGCTGAATCCTCCGCTTCCTC
CAGCAAAAACGGCAAACCCGCTGGACGCAAGTCACCTGTGCCGCCAAAGCCCGCCAGCGATCAGCCACGGTCGTAA

Upstream 100 bases:

>100_bases
TGGCTTCAGCCACTTGTTTCCGGGCATCAGTTGAGACTGTTCGGAGGGTATTGCCGTAGAGTTATTTCGTCCTTCTCCAG
GTTTTTGACCAAGGTGCTGC

Downstream 100 bases:

>100_bases
GCGGTTTTTGCTTCCGGTTCTGACGTTTGCTCTCGCTTGACTGCTGATGAAAAAAGCGTGAAAAAAGCCTTTTTTCTCTA
CATTGAGGGTGTAGCGTGCT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MHHYDFLGQLVLIGTLAIATILLFQRIRIPPVIGLIFTGIMLGPTGFGVVSDSGLISILAELGVVLLLFTIGLEFSLDDM
KKLQKIVFAGGLAQVMLTGMIIAALAFWLLEAIGKKISIQEAIVLGFSFSVSSTALCLKILSDRDELSFEHGKIALGILI
FQDMAIVPLMIGLTFLTPGKVISPEATFQEVALLLLFAIGMFGGFRLLMPRIVRMITELHAGEVLVLGALVLCFGAAWLA
SLIGLSLALGAFMAGMVIASTDGSHRISRTIDPFREALTSIFFVSVGLLLDVNMIELPWLIGVALVVLLVKGIVMTGISM
ALGFSTRVSLMSGMVLAQIGEFSFVLAGSAKNTGLLDQHMFQLMLTIIVVTMIVTPALISAAPAFAAQMAPVFRFMPLMP
EPKPKQPTRTTTSSIACKGEIHAVIIGYGLIGRNVAAVMNATNLLYTVLDTNRKVVSTMRRKGEPLFFGDCTERKSLLRV
GTDHCRSVVICIPEIEAAIQCIRQVRIINSEAFIIVRARSFQSASQFYRAGADAVVTEIFETSIQMFSELLRHFKVDPET
IFEQQEIIRREGGKLFLEPTAESSASSSKNGKPAGRKSPVPPKPASDQPRS

Sequences:

>Translated_611_residues
MHHYDFLGQLVLIGTLAIATILLFQRIRIPPVIGLIFTGIMLGPTGFGVVSDSGLISILAELGVVLLLFTIGLEFSLDDM
KKLQKIVFAGGLAQVMLTGMIIAALAFWLLEAIGKKISIQEAIVLGFSFSVSSTALCLKILSDRDELSFEHGKIALGILI
FQDMAIVPLMIGLTFLTPGKVISPEATFQEVALLLLFAIGMFGGFRLLMPRIVRMITELHAGEVLVLGALVLCFGAAWLA
SLIGLSLALGAFMAGMVIASTDGSHRISRTIDPFREALTSIFFVSVGLLLDVNMIELPWLIGVALVVLLVKGIVMTGISM
ALGFSTRVSLMSGMVLAQIGEFSFVLAGSAKNTGLLDQHMFQLMLTIIVVTMIVTPALISAAPAFAAQMAPVFRFMPLMP
EPKPKQPTRTTTSSIACKGEIHAVIIGYGLIGRNVAAVMNATNLLYTVLDTNRKVVSTMRRKGEPLFFGDCTERKSLLRV
GTDHCRSVVICIPEIEAAIQCIRQVRIINSEAFIIVRARSFQSASQFYRAGADAVVTEIFETSIQMFSELLRHFKVDPET
IFEQQEIIRREGGKLFLEPTAESSASSSKNGKPAGRKSPVPPKPASDQPRS
>Mature_611_residues
MHHYDFLGQLVLIGTLAIATILLFQRIRIPPVIGLIFTGIMLGPTGFGVVSDSGLISILAELGVVLLLFTIGLEFSLDDM
KKLQKIVFAGGLAQVMLTGMIIAALAFWLLEAIGKKISIQEAIVLGFSFSVSSTALCLKILSDRDELSFEHGKIALGILI
FQDMAIVPLMIGLTFLTPGKVISPEATFQEVALLLLFAIGMFGGFRLLMPRIVRMITELHAGEVLVLGALVLCFGAAWLA
SLIGLSLALGAFMAGMVIASTDGSHRISRTIDPFREALTSIFFVSVGLLLDVNMIELPWLIGVALVVLLVKGIVMTGISM
ALGFSTRVSLMSGMVLAQIGEFSFVLAGSAKNTGLLDQHMFQLMLTIIVVTMIVTPALISAAPAFAAQMAPVFRFMPLMP
EPKPKQPTRTTTSSIACKGEIHAVIIGYGLIGRNVAAVMNATNLLYTVLDTNRKVVSTMRRKGEPLFFGDCTERKSLLRV
GTDHCRSVVICIPEIEAAIQCIRQVRIINSEAFIIVRARSFQSASQFYRAGADAVVTEIFETSIQMFSELLRHFKVDPET
IFEQQEIIRREGGKLFLEPTAESSASSSKNGKPAGRKSPVPPKPASDQPRS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=409, Percent_Identity=27.6283618581907, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1789749, Length=574, Percent_Identity=28.2229965156794, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1786685, Length=586, Percent_Identity=30.2047781569966, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1786232, Length=575, Percent_Identity=25.5652173913043, Blast_Score=176, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66091; Mature: 66091

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHYDFLGQLVLIGTLAIATILLFQRIRIPPVIGLIFTGIMLGPTGFGVVSDSGLISILA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCCHHHHHHH
ELGVVLLLFTIGLEFSLDDMKKLQKIVFAGGLAQVMLTGMIIAALAFWLLEAIGKKISIQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EAIVLGFSFSVSSTALCLKILSDRDELSFEHGKIALGILIFQDMAIVPLMIGLTFLTPGK
HHHHEEEECCHHHHHHHHHHHCCCHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCC
VISPEATFQEVALLLLFAIGMFGGFRLLMPRIVRMITELHAGEVLVLGALVLCFGAAWLA
CCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SLIGLSLALGAFMAGMVIASTDGSHRISRTIDPFREALTSIFFVSVGLLLDVNMIELPWL
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
IGVALVVLLVKGIVMTGISMALGFSTRVSLMSGMVLAQIGEFSFVLAGSAKNTGLLDQHM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHH
FQLMLTIIVVTMIVTPALISAAPAFAAQMAPVFRFMPLMPEPKPKQPTRTTTSSIACKGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCC
IHAVIIGYGLIGRNVAAVMNATNLLYTVLDTNRKVVSTMRRKGEPLFFGDCTERKSLLRV
EEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHH
GTDHCRSVVICIPEIEAAIQCIRQVRIINSEAFIIVRARSFQSASQFYRAGADAVVTEIF
CHHHHCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHH
ETSIQMFSELLRHFKVDPETIFEQQEIIRREGGKLFLEPTAESSASSSKNGKPAGRKSPV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
PPKPASDQPRS
CCCCCCCCCCC
>Mature Secondary Structure
MHHYDFLGQLVLIGTLAIATILLFQRIRIPPVIGLIFTGIMLGPTGFGVVSDSGLISILA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCCHHHHHHH
ELGVVLLLFTIGLEFSLDDMKKLQKIVFAGGLAQVMLTGMIIAALAFWLLEAIGKKISIQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EAIVLGFSFSVSSTALCLKILSDRDELSFEHGKIALGILIFQDMAIVPLMIGLTFLTPGK
HHHHEEEECCHHHHHHHHHHHCCCHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCC
VISPEATFQEVALLLLFAIGMFGGFRLLMPRIVRMITELHAGEVLVLGALVLCFGAAWLA
CCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SLIGLSLALGAFMAGMVIASTDGSHRISRTIDPFREALTSIFFVSVGLLLDVNMIELPWL
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
IGVALVVLLVKGIVMTGISMALGFSTRVSLMSGMVLAQIGEFSFVLAGSAKNTGLLDQHM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHH
FQLMLTIIVVTMIVTPALISAAPAFAAQMAPVFRFMPLMPEPKPKQPTRTTTSSIACKGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCC
IHAVIIGYGLIGRNVAAVMNATNLLYTVLDTNRKVVSTMRRKGEPLFFGDCTERKSLLRV
EEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHH
GTDHCRSVVICIPEIEAAIQCIRQVRIINSEAFIIVRARSFQSASQFYRAGADAVVTEIF
CHHHHCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHH
ETSIQMFSELLRHFKVDPETIFEQQEIIRREGGKLFLEPTAESSASSSKNGKPAGRKSPV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
PPKPASDQPRS
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA