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The map label for this gene is 193212282

Identifier: 193212282

GI number: 193212282

Start: 658258

End: 659667

Strand: Direct

Name: 193212282

Synonym: Cpar_0615

Alternate gene names: NA

Gene position: 658258-659667 (Clockwise)

Preceding gene: 193212281

Following gene: 193212283

Centisome position: 28.75

GC content: 59.86

Gene sequence:

>1410_bases
ATGGAAATTGAATTCTACGGGGCGACGAAAAGGGTGACGGGTTCCTGTCACATTTTGCGGGCTGGCGGCTACACGGTGCT
GCTCGATTGCGGACTGGTGCAGGGGAGCCACGACGTTGAGGTGCTGAACCGTGAGCCTTTTCCGTTTGAGCCTTCCGACA
TCGATGCCGTGGTGCTCAGTCACGGCCATATCGACCACTCAGGACGCCTGCCGCAACTGGTCAAACGGGGCTTCAAGGGG
CCGATCTACACCCATCACGGCACGATCGATCTGTGCAGAGTTCTGCTCAGGGATTCGGCGATGCTTTCAGAGCACGACGC
CCGGTTCATGCGAAAGCACGGCCATCAGCATGCCGAGCCGCTCTACACGGTCGATGAGGCGCTGCAATGCGTCAGAAACA
TGACCGGCGTGGGCTACGGCGAGCGGCGCGAAATTCTGCCGGGCATTGCCGTGACGCTCTATGATGCGGGCCACATTCTC
GCTTCGGCGTTCGTCAAGCTTGAGATCACGGAGGGCGAAAACACTCGCACCGTGGTGTTCAGCGGCGACCTCGGCCAGTA
CGATTCGCCGATTCTCAACGATCCGGAAGCTATCGGTCAGGCCGATACGGTGATCGTCGAAAGCACCTACGGCGACCGGC
TGCACCGCGATTTCGACAAGACTGTGACCGAGCTCGGCGAGATCATCGAAACGGCATGTCGCGACTGCGGCAACATCTTG
ATCCCAGCCTTTTCAATCGGCCGCAGCCAGGAGTTGCTCTACCTGTTCGGCGAGCATTACAAAGAGTGGGGGCTTGACAA
ATGGCAGGTGTTCCTCGACAGCCCGATGGCGATCGAGGCGAGCCGCATTTACTGGCATTACGAAGAGTTGTGGGATGCGG
AGGCGCGGCTTTTCCGCAGTCAGATGCGAAGGATGCCGCCTGTCGATAACCTTCATATGACCCGCACGGTGGAGGAATCG
ATGAAGATCAACGAACTCCATCAGGGGGCCATCATCATCGCAGGCAGTGGCATGTGCAACGGCGGCCGCATCCTGCATCA
TCTGAAACGCAATATCGAACGCTCCGAGTGCCACCTCATCATCACCGGCTTTCAGGCCGAAGGCACGCTTGGCAGGGAGA
TCGTGGCTGGAAACAAGGAGGTGTCGCTGCACGGGAGAATGTATCGCGTGCAGGTGCAACTGCACACGGTCGGCGGCCTG
TCGGCGCATGGCGATCGCGCCGACCTCCTGCGCTGGCTGAAGACAAGGGCCGGGTCGCCGAAGGTGATGATCGTGCATGG
CGAAGATGGAGCCAAGCAGTCGTTCCAGGGGTTTCTGCACGACGAACTTGCCGTTGACGCGCTCATTCCGCAGCCCGGCG
ACCGGCTCGATCTGCTCTCGAACGTGCTAAGCCGGGCGGAGTCTGAATAA

Upstream 100 bases:

>100_bases
GGCTTTTTGCTTTTCCACACCGGGGCTTCGTACATTTTAAAAAGGCTCTTGGCTCATCCGGTCTGCCGGAAAACCGGTTC
ATCAAAACACGGGGGCGATC

Downstream 100 bases:

>100_bases
CATATTCAATACCAATGACCATCAAGACCATTCACGAACTGGTTCCCGTTCTGCAAACCGCCATAGGCCCGGTGATTCTG
ATCTCCGGGCTCGGTCTGCT

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MEIEFYGATKRVTGSCHILRAGGYTVLLDCGLVQGSHDVEVLNREPFPFEPSDIDAVVLSHGHIDHSGRLPQLVKRGFKG
PIYTHHGTIDLCRVLLRDSAMLSEHDARFMRKHGHQHAEPLYTVDEALQCVRNMTGVGYGERREILPGIAVTLYDAGHIL
ASAFVKLEITEGENTRTVVFSGDLGQYDSPILNDPEAIGQADTVIVESTYGDRLHRDFDKTVTELGEIIETACRDCGNIL
IPAFSIGRSQELLYLFGEHYKEWGLDKWQVFLDSPMAIEASRIYWHYEELWDAEARLFRSQMRRMPPVDNLHMTRTVEES
MKINELHQGAIIIAGSGMCNGGRILHHLKRNIERSECHLIITGFQAEGTLGREIVAGNKEVSLHGRMYRVQVQLHTVGGL
SAHGDRADLLRWLKTRAGSPKVMIVHGEDGAKQSFQGFLHDELAVDALIPQPGDRLDLLSNVLSRAESE

Sequences:

>Translated_469_residues
MEIEFYGATKRVTGSCHILRAGGYTVLLDCGLVQGSHDVEVLNREPFPFEPSDIDAVVLSHGHIDHSGRLPQLVKRGFKG
PIYTHHGTIDLCRVLLRDSAMLSEHDARFMRKHGHQHAEPLYTVDEALQCVRNMTGVGYGERREILPGIAVTLYDAGHIL
ASAFVKLEITEGENTRTVVFSGDLGQYDSPILNDPEAIGQADTVIVESTYGDRLHRDFDKTVTELGEIIETACRDCGNIL
IPAFSIGRSQELLYLFGEHYKEWGLDKWQVFLDSPMAIEASRIYWHYEELWDAEARLFRSQMRRMPPVDNLHMTRTVEES
MKINELHQGAIIIAGSGMCNGGRILHHLKRNIERSECHLIITGFQAEGTLGREIVAGNKEVSLHGRMYRVQVQLHTVGGL
SAHGDRADLLRWLKTRAGSPKVMIVHGEDGAKQSFQGFLHDELAVDALIPQPGDRLDLLSNVLSRAESE
>Mature_469_residues
MEIEFYGATKRVTGSCHILRAGGYTVLLDCGLVQGSHDVEVLNREPFPFEPSDIDAVVLSHGHIDHSGRLPQLVKRGFKG
PIYTHHGTIDLCRVLLRDSAMLSEHDARFMRKHGHQHAEPLYTVDEALQCVRNMTGVGYGERREILPGIAVTLYDAGHIL
ASAFVKLEITEGENTRTVVFSGDLGQYDSPILNDPEAIGQADTVIVESTYGDRLHRDFDKTVTELGEIIETACRDCGNIL
IPAFSIGRSQELLYLFGEHYKEWGLDKWQVFLDSPMAIEASRIYWHYEELWDAEARLFRSQMRRMPPVDNLHMTRTVEES
MKINELHQGAIIIAGSGMCNGGRILHHLKRNIERSECHLIITGFQAEGTLGREIVAGNKEVSLHGRMYRVQVQLHTVGGL
SAHGDRADLLRWLKTRAGSPKVMIVHGEDGAKQSFQGFLHDELAVDALIPQPGDRLDLLSNVLSRAESE

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=449, Percent_Identity=26.2806236080178, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI33300633, Length=476, Percent_Identity=25, Blast_Score=132, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32566029, Length=471, Percent_Identity=27.3885350318471, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32564696, Length=476, Percent_Identity=25, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323307, Length=439, Percent_Identity=25.9681093394077, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24648013, Length=463, Percent_Identity=26.3498920086393, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21358523, Length=481, Percent_Identity=25.3638253638254, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52499; Mature: 52499

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEFYGATKRVTGSCHILRAGGYTVLLDCGLVQGSHDVEVLNREPFPFEPSDIDAVVLS
CEEEEECCCEEECCCEEEEEECCEEEEEEECEECCCCCEEEECCCCCCCCCCCCCEEEEE
HGHIDHSGRLPQLVKRGFKGPIYTHHGTIDLCRVLLRDSAMLSEHDARFMRKHGHQHAEP
CCCCCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
LYTVDEALQCVRNMTGVGYGERREILPGIAVTLYDAGHILASAFVKLEITEGENTRTVVF
HHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCHHHHEEEEEEEEEECCCCEEEEEE
SGDLGQYDSPILNDPEAIGQADTVIVESTYGDRLHRDFDKTVTELGEIIETACRDCGNIL
ECCCCCCCCCCCCCHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IPAFSIGRSQELLYLFGEHYKEWGLDKWQVFLDSPMAIEASRIYWHYEELWDAEARLFRS
EEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHEEEEHHHHHHHHHHHHHH
QMRRMPPVDNLHMTRTVEESMKINELHQGAIIIAGSGMCNGGRILHHLKRNIERSECHLI
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEE
ITGFQAEGTLGREIVAGNKEVSLHGRMYRVQVQLHTVGGLSAHGDRADLLRWLKTRAGSP
EEEEECCCCCCCCEECCCCEEEECCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCC
KVMIVHGEDGAKQSFQGFLHDELAVDALIPQPGDRLDLLSNVLSRAESE
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIEFYGATKRVTGSCHILRAGGYTVLLDCGLVQGSHDVEVLNREPFPFEPSDIDAVVLS
CEEEEECCCEEECCCEEEEEECCEEEEEEECEECCCCCEEEECCCCCCCCCCCCCEEEEE
HGHIDHSGRLPQLVKRGFKGPIYTHHGTIDLCRVLLRDSAMLSEHDARFMRKHGHQHAEP
CCCCCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
LYTVDEALQCVRNMTGVGYGERREILPGIAVTLYDAGHILASAFVKLEITEGENTRTVVF
HHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCHHHHEEEEEEEEEECCCCEEEEEE
SGDLGQYDSPILNDPEAIGQADTVIVESTYGDRLHRDFDKTVTELGEIIETACRDCGNIL
ECCCCCCCCCCCCCHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IPAFSIGRSQELLYLFGEHYKEWGLDKWQVFLDSPMAIEASRIYWHYEELWDAEARLFRS
EEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHEEEEHHHHHHHHHHHHHH
QMRRMPPVDNLHMTRTVEESMKINELHQGAIIIAGSGMCNGGRILHHLKRNIERSECHLI
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEE
ITGFQAEGTLGREIVAGNKEVSLHGRMYRVQVQLHTVGGLSAHGDRADLLRWLKTRAGSP
EEEEECCCCCCCCEECCCCEEEECCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCC
KVMIVHGEDGAKQSFQGFLHDELAVDALIPQPGDRLDLLSNVLSRAESE
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA