Click here to switch to the map view.

The map label for this gene is gcvT

Identifier: 193212088

GI number: 193212088

Start: 451930

End: 453027

Strand: Direct

Name: gcvT

Synonym: Cpar_0418

Alternate gene names: 193212088

Gene position: 451930-453027 (Clockwise)

Preceding gene: 193212087

Following gene: 193212092

Centisome position: 19.74

GC content: 60.66

Gene sequence:

>1098_bases
ATGAAAAAGACAGCGCTCTCTGCCTGGCATGAAGGTGCCGGTGCGAAAATGATCGATTTCGGCGGCTTTCTGATGCCGGT
GCAGTATTCCGGAATCATCGCCGAACACAAGGCGGTGCGTGAAGCTGCCGGACTGTTCGATGTTTCGCACATGGGGAATT
TCTACGTCAGGGGCGAGCGTGCGCTGGAGTTTCTCCAGTACGTCACCACCAACGATCTCGGCAAGATCGTGGACGGGCAG
GCGCAGTACACGCTGATGCTTTATCCGGACGGCGGCATCGTCGATGACCTCATCATCTACCGCGTCAGCGCCGACACCTT
TTTCCTGATCGTCAACGCGAGCAACTGCGAAAAGGATTTCGCCTGGCTCAGCGACCATGTCGGCGGCTTCGAGGGCGTGA
CGCTCGAAAACCGCACCAGCGAGCTGTCGCTGATCGCTCTGCAGGGCCCGAAAGCGTTCGAGGTACTCGGGCGTGTATTT
CCGGAGGCCGGGCTCGACAAGCTGGCTTCGTTCCATTTCGCGACCGTGCCTTTCGGTGGCGCGGAGGCCATGGTAGCCCG
CACCGGCTACACCGGCGAGGCTGGCGTGGAGATCTGCCTGCCGAACGAAGAGGCTGAGGCGTTGTGGACGGCTCTTATGG
CCGCCGGAAAAAATGACGGCATTCAGCCCATCGGCCTCGGCGCGCGCGACACCCTTCGCCTTGAAATGGGTTATTCGCTC
TATGGCCACGAGATCGACCAGACGGTGAACCCGCTCGAAGCGCGTTTGAAATGGGTGGTCAAGATGGACAAGCCCAACTT
CATCGGCAAGCAGGCCTGCCAGCAGGTCGAGCTTGATCCGCGCAAGAGCGTGGTCGGTTTCAGCCTCGACGGCCGTGCCA
TTCCGCGCCAGCATTTCAAGGTCTACAACTCCGACAAGCAGGAGATCGGCGAGGTGTGCAGCGGCACGGTTTCGCCGACG
CTTCAGGAGCCTATCGGTACGGCCAGCCTTCTGCGCGACTATGCGAAAACCGGCACGCCGATCTTCGTTGAGATTCGCGG
CACCTTTCAACCCGGTACGGTCAGGCGTCTTCCGTTCGTGCATGCCGACCGTCCCTGA

Upstream 100 bases:

>100_bases
ACCTGTTACGGGGCTTGCGAAAAAGTGCTTTGAACTTTACGGCTAAATGTTTTTTTAGAAGGCATTCCAACATATTCATC
CAATCAGGTAAAGGAGATTA

Downstream 100 bases:

>100_bases
TCCGGCAAATTGACGATGCCCAGATCGAAAAACAAAACGACGCCGAAGTCTGTGCGCAGGAGTGGCTTCGGCCTGGAAAT
CGGGGGTATCGTCCTGATGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKKTALSAWHEGAGAKMIDFGGFLMPVQYSGIIAEHKAVREAAGLFDVSHMGNFYVRGERALEFLQYVTTNDLGKIVDGQ
AQYTLMLYPDGGIVDDLIIYRVSADTFFLIVNASNCEKDFAWLSDHVGGFEGVTLENRTSELSLIALQGPKAFEVLGRVF
PEAGLDKLASFHFATVPFGGAEAMVARTGYTGEAGVEICLPNEEAEALWTALMAAGKNDGIQPIGLGARDTLRLEMGYSL
YGHEIDQTVNPLEARLKWVVKMDKPNFIGKQACQQVELDPRKSVVGFSLDGRAIPRQHFKVYNSDKQEIGEVCSGTVSPT
LQEPIGTASLLRDYAKTGTPIFVEIRGTFQPGTVRRLPFVHADRP

Sequences:

>Translated_365_residues
MKKTALSAWHEGAGAKMIDFGGFLMPVQYSGIIAEHKAVREAAGLFDVSHMGNFYVRGERALEFLQYVTTNDLGKIVDGQ
AQYTLMLYPDGGIVDDLIIYRVSADTFFLIVNASNCEKDFAWLSDHVGGFEGVTLENRTSELSLIALQGPKAFEVLGRVF
PEAGLDKLASFHFATVPFGGAEAMVARTGYTGEAGVEICLPNEEAEALWTALMAAGKNDGIQPIGLGARDTLRLEMGYSL
YGHEIDQTVNPLEARLKWVVKMDKPNFIGKQACQQVELDPRKSVVGFSLDGRAIPRQHFKVYNSDKQEIGEVCSGTVSPT
LQEPIGTASLLRDYAKTGTPIFVEIRGTFQPGTVRRLPFVHADRP
>Mature_365_residues
MKKTALSAWHEGAGAKMIDFGGFLMPVQYSGIIAEHKAVREAAGLFDVSHMGNFYVRGERALEFLQYVTTNDLGKIVDGQ
AQYTLMLYPDGGIVDDLIIYRVSADTFFLIVNASNCEKDFAWLSDHVGGFEGVTLENRTSELSLIALQGPKAFEVLGRVF
PEAGLDKLASFHFATVPFGGAEAMVARTGYTGEAGVEICLPNEEAEALWTALMAAGKNDGIQPIGLGARDTLRLEMGYSL
YGHEIDQTVNPLEARLKWVVKMDKPNFIGKQACQQVELDPRKSVVGFSLDGRAIPRQHFKVYNSDKQEIGEVCSGTVSPT
LQEPIGTASLLRDYAKTGTPIFVEIRGTFQPGTVRRLPFVHADRP

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=374, Percent_Identity=33.6898395721925, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=33.4261838440111, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI257796256, Length=323, Percent_Identity=33.1269349845201, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI257796254, Length=372, Percent_Identity=31.4516129032258, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI24797151, Length=333, Percent_Identity=28.8288288288288, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI194306651, Length=258, Percent_Identity=30.6201550387597, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI197927446, Length=309, Percent_Identity=26.537216828479, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI21361378, Length=309, Percent_Identity=26.537216828479, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=39.945652173913, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=34.7480106100796, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32563613, Length=274, Percent_Identity=28.1021897810219, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71994045, Length=319, Percent_Identity=27.8996865203762, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71994052, Length=319, Percent_Identity=27.8996865203762, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=36.8831168831169, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=33.42175066313, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28571104, Length=257, Percent_Identity=28.7937743190661, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20130091, Length=268, Percent_Identity=23.8805970149254, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_CHLP8 (B3QLF1)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998041.1
- ProteinModelPortal:   B3QLF1
- GeneID:   6419332
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0418
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39958; Mature: 39958

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTALSAWHEGAGAKMIDFGGFLMPVQYSGIIAEHKAVREAAGLFDVSHMGNFYVRGER
CCCCHHHHHHCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHCCEEHHHCCCEEEEHHH
ALEFLQYVTTNDLGKIVDGQAQYTLMLYPDGGIVDDLIIYRVSADTFFLIVNASNCEKDF
HHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCEEEEEEECCCCCHHH
AWLSDHVGGFEGVTLENRTSELSLIALQGPKAFEVLGRVFPEAGLDKLASFHFATVPFGG
HHHHHCCCCCCCEEECCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHCEEEECCCCC
AEAMVARTGYTGEAGVEICLPNEEAEALWTALMAAGKNDGIQPIGLGARDTLRLEMGYSL
CCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEECCEE
YGHEIDQTVNPLEARLKWVVKMDKPNFIGKQACQQVELDPRKSVVGFSLDGRAIPRQHFK
ECCHHHHCCCHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHE
VYNSDKQEIGEVCSGTVSPTLQEPIGTASLLRDYAKTGTPIFVEIRGTFQPGTVRRLPFV
ECCCCHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCEE
HADRP
ECCCC
>Mature Secondary Structure
MKKTALSAWHEGAGAKMIDFGGFLMPVQYSGIIAEHKAVREAAGLFDVSHMGNFYVRGER
CCCCHHHHHHCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHCCEEHHHCCCEEEEHHH
ALEFLQYVTTNDLGKIVDGQAQYTLMLYPDGGIVDDLIIYRVSADTFFLIVNASNCEKDF
HHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCEEEEEEECCCCCHHH
AWLSDHVGGFEGVTLENRTSELSLIALQGPKAFEVLGRVFPEAGLDKLASFHFATVPFGG
HHHHHCCCCCCCEEECCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHCEEEECCCCC
AEAMVARTGYTGEAGVEICLPNEEAEALWTALMAAGKNDGIQPIGLGARDTLRLEMGYSL
CCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEEECCEE
YGHEIDQTVNPLEARLKWVVKMDKPNFIGKQACQQVELDPRKSVVGFSLDGRAIPRQHFK
ECCHHHHCCCHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHE
VYNSDKQEIGEVCSGTVSPTLQEPIGTASLLRDYAKTGTPIFVEIRGTFQPGTVRRLPFV
ECCCCHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCEE
HADRP
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA