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The map label for this gene is aarA [H]

Identifier: 193212039

GI number: 193212039

Start: 395762

End: 397105

Strand: Direct

Name: aarA [H]

Synonym: Cpar_0368

Alternate gene names: 193212039

Gene position: 395762-397105 (Clockwise)

Preceding gene: 193212038

Following gene: 193212040

Centisome position: 17.29

GC content: 58.56

Gene sequence:

>1344_bases
ATGGCCGATCCCAATCACCGCAATTCACTGACGATTACCGACAATCGTACCGGCAAATCGTATGAGCTTCCCATCGAGAA
CGGCACCGTCCGAACCATGGATCTTCGACAGATCAAGGCGTCGGAGGACGATTTCGGGCTTCTCGGTTATGATCCGGCGT
TCCTGAACACCTGCTCCTGCAAAAGCCAGATCACCTTCATCGATGGCGAAAAGGGCATTCTCCGCTACCGGGGCTATCCG
ATCGAGCAGCTTGCCGAGAAGAGCTCGTTCCTCGAAACCGCTTACCTGCTCATTAAGGGTGAACTGCCTGACAAGGAGCG
CCTTGCGGTCTGGACTTACAACATCCGTCACCACACCATGACCCATGCCAACCTGACCAAGTTCATGGATGGGTTCCGCT
ACGACGCGCATCCGATGGGCATTCTCGTAGGTACAGTGGGGGCGCTCTCGACCTTCTATCCCGACGCCAAACAGGTTAGT
GAGGAGGAGTCCCGTAAGCTTCAGGTGCGGCGGCTGATCGGCAAGATCCCGACCCTTGCGGCCATGAGCTTCCGGCACAG
CCTCGGTTTTCCTTACGTGCTGCCGGACAACGATCTGAGCTACGCGGGCAATTTTCTGTCGATGATGTTCCGGATGACGG
AGCAGAAGTACGAACCGAATCCAGTGCTTGAAAAAGCACTCGACGTGCTCTTCATCCTGCACGCCGACCACGAGCAGAAC
TGCTCGACCAACGCCGTGCGCTCGGTCAGCAGCTCGATGGTCGATCCCTACTCAGCTATCGCGGCAGGTTGTGCAGCGCT
CTATGGCCCGCTGCATGGCGGGGCCAACGAGGCGGTCATTCGCATGCTCGAAGGGATTGGCTCGGTCGATAATATCCCCG
CCTTCATCAAATCGGTCAAGAGCGGCGAGGGGCGGCTCATGGGATTCGGCCATCGCGTCTATAAAAATTACGACCCGCGG
GCGCGAATCATCAAGAAGATCGCCTTCGAGGTGTTCGAGGAGACCGGACGGAACCCGCTGCTCGACATCGCCATCGAGCT
GGAACGGATCGCGCTGGAGGACGACTATTTCGTCGGGCGCAAACTCTATCCGAACGTCGATTTCTACTCCGGCCTGATCT
ACCAGGCGATGGGCTTTCCAACCGACATGTTCCCGGTGCTCTTCGCTATCGGGCGCACGCCGGGCTGGCTCGCGCAGTGG
ATCGAGCATGTCAAGGATCCGGAGCAGAGAATTGCCCGTCCGCGCCAGATTTTCCTCGGCGCACCCTCCCGCGATTACGT
GCCGCTTGACGAGCGTCCGAGCAGGGGCGATGACGAAGAGAAGTTTGGCATCTGCAGGCTCTGA

Upstream 100 bases:

>100_bases
GTCCTAATGCCGGGAGTTTCGTAAATTAGTGCTCAATGTGACGGCAACCCCTCGTAAAAGGGGCGTTATGTCTTTGTTAA
CGTTTATCAGTGCAACAAAC

Downstream 100 bases:

>100_bases
TTTTGATCTGCCAAACGTAAGGTATTTGTTTTCATTAAATGGATTTACACTATGTCTGTCACTACAAAAGATGTTGCCTA
TATCGCGGAACTTGCCCGCC

Product: citrate synthase I

Products: NA

Alternate protein names: Acetic acid resistance protein [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MADPNHRNSLTITDNRTGKSYELPIENGTVRTMDLRQIKASEDDFGLLGYDPAFLNTCSCKSQITFIDGEKGILRYRGYP
IEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTMTHANLTKFMDGFRYDAHPMGILVGTVGALSTFYPDAKQVS
EEESRKLQVRRLIGKIPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEQKYEPNPVLEKALDVLFILHADHEQN
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIRMLEGIGSVDNIPAFIKSVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFEVFEETGRNPLLDIAIELERIALEDDYFVGRKLYPNVDFYSGLIYQAMGFPTDMFPVLFAIGRTPGWLAQW
IEHVKDPEQRIARPRQIFLGAPSRDYVPLDERPSRGDDEEKFGICRL

Sequences:

>Translated_447_residues
MADPNHRNSLTITDNRTGKSYELPIENGTVRTMDLRQIKASEDDFGLLGYDPAFLNTCSCKSQITFIDGEKGILRYRGYP
IEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTMTHANLTKFMDGFRYDAHPMGILVGTVGALSTFYPDAKQVS
EEESRKLQVRRLIGKIPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEQKYEPNPVLEKALDVLFILHADHEQN
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIRMLEGIGSVDNIPAFIKSVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFEVFEETGRNPLLDIAIELERIALEDDYFVGRKLYPNVDFYSGLIYQAMGFPTDMFPVLFAIGRTPGWLAQW
IEHVKDPEQRIARPRQIFLGAPSRDYVPLDERPSRGDDEEKFGICRL
>Mature_446_residues
ADPNHRNSLTITDNRTGKSYELPIENGTVRTMDLRQIKASEDDFGLLGYDPAFLNTCSCKSQITFIDGEKGILRYRGYPI
EQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTMTHANLTKFMDGFRYDAHPMGILVGTVGALSTFYPDAKQVSE
EESRKLQVRRLIGKIPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEQKYEPNPVLEKALDVLFILHADHEQNC
STNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIRMLEGIGSVDNIPAFIKSVKSGEGRLMGFGHRVYKNYDPRA
RIIKKIAFEVFEETGRNPLLDIAIELERIALEDDYFVGRKLYPNVDFYSGLIYQAMGFPTDMFPVLFAIGRTPGWLAQWI
EHVKDPEQRIARPRQIFLGAPSRDYVPLDERPSRGDDEEKFGICRL

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=372, Percent_Identity=27.1505376344086, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1786939, Length=412, Percent_Identity=49.7572815533981, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1786527, Length=360, Percent_Identity=32.5, Blast_Score=189, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17555174, Length=383, Percent_Identity=27.9373368146214, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=365, Percent_Identity=26.3013698630137, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=363, Percent_Identity=25.068870523416, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=402, Percent_Identity=24.6268656716418, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640124, Length=373, Percent_Identity=26.8096514745308, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640126, Length=373, Percent_Identity=26.8096514745308, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356863, Length=392, Percent_Identity=25.765306122449, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 50490; Mature: 50359

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPNHRNSLTITDNRTGKSYELPIENGTVRTMDLRQIKASEDDFGLLGYDPAFLNTCSC
CCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEHHHHHCCCCCCCEECCCHHHHCCCCC
KSQITFIDGEKGILRYRGYPIEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTM
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHEEEEEEECCCCCCCCEEEEEEECCHHEE
THANLTKFMDGFRYDAHPMGILVGTVGALSTFYPDAKQVSEEESRKLQVRRLIGKIPTLA
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
AMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEQKYEPNPVLEKALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEEECCCCCC
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIRMLEGIGSVDNIPAFIKSVK
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHC
SGEGRLMGFGHRVYKNYDPRARIIKKIAFEVFEETGRNPLLDIAIELERIALEDDYFVGR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHEEEEEHHEECCCCEECC
KLYPNVDFYSGLIYQAMGFPTDMFPVLFAIGRTPGWLAQWIEHVKDPEQRIARPRQIFLG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCEEEEE
APSRDYVPLDERPSRGDDEEKFGICRL
CCCCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
ADPNHRNSLTITDNRTGKSYELPIENGTVRTMDLRQIKASEDDFGLLGYDPAFLNTCSC
CCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEHHHHHCCCCCCCEECCCHHHHCCCCC
KSQITFIDGEKGILRYRGYPIEQLAEKSSFLETAYLLIKGELPDKERLAVWTYNIRHHTM
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHEEEEEEECCCCCCCCEEEEEEECCHHEE
THANLTKFMDGFRYDAHPMGILVGTVGALSTFYPDAKQVSEEESRKLQVRRLIGKIPTLA
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
AMSFRHSLGFPYVLPDNDLSYAGNFLSMMFRMTEQKYEPNPVLEKALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEEECCCCCC
CSTNAVRSVSSSMVDPYSAIAAGCAALYGPLHGGANEAVIRMLEGIGSVDNIPAFIKSVK
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHC
SGEGRLMGFGHRVYKNYDPRARIIKKIAFEVFEETGRNPLLDIAIELERIALEDDYFVGR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHEEEEEHHEECCCCEECC
KLYPNVDFYSGLIYQAMGFPTDMFPVLFAIGRTPGWLAQWIEHVKDPEQRIARPRQIFLG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCEEEEE
APSRDYVPLDERPSRGDDEEKFGICRL
CCCCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2156811 [H]