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The map label for this gene is nat [H]

Identifier: 193212033

GI number: 193212033

Start: 389562

End: 390335

Strand: Direct

Name: nat [H]

Synonym: Cpar_0362

Alternate gene names: 193212033

Gene position: 389562-390335 (Clockwise)

Preceding gene: 193212032

Following gene: 193212038

Centisome position: 17.02

GC content: 59.95

Gene sequence:

>774_bases
ATGAACGCAGCCAATTTCGATCTTTCGTCCTATCTGTCACGCATTGGCTTCAACGGCAATCCGGTTGGGGATTTCGAGAC
GCTGAAGCGTTTGATGCGCTGCCAGCTCTTTTCGGTGCCGTTCGAAAATCTCGATGTGCAGGCCGGGCAGGTGCCGTCGC
TTGTGCCTGAAGAGATTTGCGACAAGATCGTCAAACGGCGGCGCGGCGGGTACTGCTACGAAGTGAACGCTATCTTCGCA
ATGGCGCTGGAGGCTCTCGGCATTCCGTACCGCTTCGTGGCGGCGCGGCCCATGACCTACGCCGTCCGCCGCCCCAAAAC
CCACATGGCGATCATCGCCTCCATCGACGGCGCGGAGTGGCTCTGCGACCTCGGTTTTGGCAGTTACGGCATCCGCGAGC
CGATCAACCTCGAATGGCTCGACCGGCAGATCGTCCAGGAGTGCGACACCTTCAGGCTCACGATGGTTTCGGAGCGCGAC
TACCGGTTGCAGTCGATGAGTGATGGCGAGTGGAAAGCGCTTTACGAGTTCAACCTCTGTCCGCAAGAGCTTGTGGATTT
CGAGCCGGCCAACTGGCTCAACGCGACCCATCCCGACTCGATTTTCGTGCAGGCGCCGATCGTGGTGTTGCAGCACGCAT
CGGGCAAAACGGTGCTCAGCGGCGAGCGTTTCCGGGCGGTCTCCGAAGAAGGCCAGGTGGAGGAGAGGCGTGTTGGCGAG
AATGAGATTGAGGAATTGCTGCGGGCGCGCTTTGGGCTTGATTGGCATCCTTGA

Upstream 100 bases:

>100_bases
CATCGACGAACTGCACAGCGCGTTGACGGCACTGCTGGAAGAGGATCGGGCGGCCATGAAGAATAATCTTTAAGAGCAAC
CACGTGATCGTTTCCTTTCC

Downstream 100 bases:

>100_bases
GGCGTCAGTGCGGCGAGCAAAATGGTTCTGGCGACATCGTGTGTGCTGAGGCCGCCAGAACAGGAGAGAAGCTTAAAAAA
CAAGGTAGGCGCGTGCCTGA

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MNAANFDLSSYLSRIGFNGNPVGDFETLKRLMRCQLFSVPFENLDVQAGQVPSLVPEEICDKIVKRRRGGYCYEVNAIFA
MALEALGIPYRFVAARPMTYAVRRPKTHMAIIASIDGAEWLCDLGFGSYGIREPINLEWLDRQIVQECDTFRLTMVSERD
YRLQSMSDGEWKALYEFNLCPQELVDFEPANWLNATHPDSIFVQAPIVVLQHASGKTVLSGERFRAVSEEGQVEERRVGE
NEIEELLRARFGLDWHP

Sequences:

>Translated_257_residues
MNAANFDLSSYLSRIGFNGNPVGDFETLKRLMRCQLFSVPFENLDVQAGQVPSLVPEEICDKIVKRRRGGYCYEVNAIFA
MALEALGIPYRFVAARPMTYAVRRPKTHMAIIASIDGAEWLCDLGFGSYGIREPINLEWLDRQIVQECDTFRLTMVSERD
YRLQSMSDGEWKALYEFNLCPQELVDFEPANWLNATHPDSIFVQAPIVVLQHASGKTVLSGERFRAVSEEGQVEERRVGE
NEIEELLRARFGLDWHP
>Mature_257_residues
MNAANFDLSSYLSRIGFNGNPVGDFETLKRLMRCQLFSVPFENLDVQAGQVPSLVPEEICDKIVKRRRGGYCYEVNAIFA
MALEALGIPYRFVAARPMTYAVRRPKTHMAIIASIDGAEWLCDLGFGSYGIREPINLEWLDRQIVQECDTFRLTMVSERD
YRLQSMSDGEWKALYEFNLCPQELVDFEPANWLNATHPDSIFVQAPIVVLQHASGKTVLSGERFRAVSEEGQVEERRVGE
NEIEELLRARFGLDWHP

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649130, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649128, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649126, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649124, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649122, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649119, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI42741671, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI237649009, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI116295260, Length=235, Percent_Identity=28.936170212766, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1787736, Length=255, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 29346; Mature: 29346

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAANFDLSSYLSRIGFNGNPVGDFETLKRLMRCQLFSVPFENLDVQAGQVPSLVPEEIC
CCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
DKIVKRRRGGYCYEVNAIFAMALEALGIPYRFVAARPMTYAVRRPKTHMAIIASIDGAEW
HHHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCEEEEEEECCCHHH
LCDLGFGSYGIREPINLEWLDRQIVQECDTFRLTMVSERDYRLQSMSDGEWKALYEFNLC
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCC
PQELVDFEPANWLNATHPDSIFVQAPIVVLQHASGKTVLSGERFRAVSEEGQVEERRVGE
HHHHHCCCCCCCCCCCCCCCEEEECCEEEEECCCCCEEECCHHHHHHCCCCCHHHHHCCH
NEIEELLRARFGLDWHP
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNAANFDLSSYLSRIGFNGNPVGDFETLKRLMRCQLFSVPFENLDVQAGQVPSLVPEEIC
CCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
DKIVKRRRGGYCYEVNAIFAMALEALGIPYRFVAARPMTYAVRRPKTHMAIIASIDGAEW
HHHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCEEEEEEECCCHHH
LCDLGFGSYGIREPINLEWLDRQIVQECDTFRLTMVSERDYRLQSMSDGEWKALYEFNLC
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCC
PQELVDFEPANWLNATHPDSIFVQAPIVVLQHASGKTVLSGERFRAVSEEGQVEERRVGE
HHHHHCCCCCCCCCCCCCCCEEEECCEEEEECCCCCEEECCHHHHHHCCCCCHHHHHCCH
NEIEELLRARFGLDWHP
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]