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The map label for this gene is cbs [H]

Identifier: 193211961

GI number: 193211961

Start: 306071

End: 307441

Strand: Direct

Name: cbs [H]

Synonym: Cpar_0287

Alternate gene names: 193211961

Gene position: 306071-307441 (Clockwise)

Preceding gene: 193211957

Following gene: 193211962

Centisome position: 13.37

GC content: 59.81

Gene sequence:

>1371_bases
ATGACCAACGATATTTTCGACATTTCGGGCAACACTCCGCTGGTTCCCATGAAACAGCTTACCCGCCAGAAAAAAGCGCG
CTTCATGGCGAAGCTTGAATACATGAATCCCTGCATGTCGCACTATTGCCGGGTGTCGACCGCCATCGTCAAGGAGGCTG
AAGAAGAGGGCCTCATCCATCCCGGCATGACGCTGGTGGACTGGACCTTCGGCACGAGCGGCATCGCGCTGGCTATGGTG
GCCGTGAGCAAGGGCTACAAAGTGCTGCTCGCCGCGCCGGACAGCATCTGCCGGGAGAAGCAGGATGTGCTCCGTGCGCT
TGGCGCTGAACTGGTGCTCACCCCGTCCGAAGCTACGGGCGGCAACCTGCACGGGTGCGTAGCCGTGGCTGAAAACCTTG
TCCGGACGATGCCGAACGCCTGGTTCGCCAACATGTACGAAAATCCGGTCAGCCGTCAGGTGCACCAGAGCGGCACCGGC
CCGGAAATTTTCAGCCAAAGCGACGAAAAGGTGACCCACGTGTTCGTGCCGATGGCTTCCGGTGCCATGATTTCCGGCAT
TGGTCGCTACTTCAAATCGGTCAATCCCGACGTGCAGATTATCGGCGTGGAGCCGGTCGGCTCGATCTATCACGACCTGC
ACGAAGGCCGGAGCCAGGGGGGCGTGACCTCGTTTCAGCTTGAGGATATTGGCGCCGTTCAGCCTACCTCGTTCTGGGAA
CCCGAGGTGATCGACCGGATTGTGCAGGTCAGCGACGCCGACGCCTTCAACTGCGGCCGTGAGCTGCTGCGCTCCGAGGG
TGTGTTTGCCGGGGGCGCTTCCGGCGCGGCAATGTGCGCTGCGCTCCGCGAGGGCGAAAGCCTCGGCAGCGATTCGCTGG
TGGTGGTGATGATGACCGATTTCGGCGGCTACGACCTGTCGCGCATGTACAACGACGAGTGGATGCGCCGTCAGGGTTTC
TACCGCAAGGCCAAGACCGCGCTCGACCAGATCACTGCCGACGACATCCTCCTGCGCAAGGCGCGCAAGGATCTGATCTT
CGCCCAGCCCGAGCAGACACTCGCGGACGTGTTCGAAATGATGAAGCAGAACGACGTTTCGCAGATGCCTATCGTCTCTT
TCGGCGCACCCATCGGCAGCATCAGCGAAAACAAGATTCTCTCCATCCTGATCGAGAACGATTCGGCCATGAACGCCAAG
GTGGTGGCCTTTATGGAGAAGCCTTTCCCGGTCTGCCAGCCGGACGCCACCATCAGCGAACTGTCCGGAAAACTTCAGAC
CAATGCGGCCGGTGTGCTTATCAGCCTTAGTGACGGAAGGCTGCAACTGATTACCAAATCTGATCTTATCGATGCGCTGA
CGCACAAGTGA

Upstream 100 bases:

>100_bases
TGTCAAAACCGTATCGATCAGGTCCTTGACACTTTTTAGCGGCACCGTTGTTTATGTATATTAAAAATCAGAACAACACC
GACTCACATCAATCTTCGCC

Downstream 100 bases:

>100_bases
ACGACTGCAGAATAATGTGGTTGTTTTTTTGGACTGATTTACTTATCTAAGCACTCCTGAACGTACAGGTTTCCGGTACT
GCCGATTGGCGGTTCCTGCA

Product: Pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTNDIFDISGNTPLVPMKQLTRQKKARFMAKLEYMNPCMSHYCRVSTAIVKEAEEEGLIHPGMTLVDWTFGTSGIALAMV
AVSKGYKVLLAAPDSICREKQDVLRALGAELVLTPSEATGGNLHGCVAVAENLVRTMPNAWFANMYENPVSRQVHQSGTG
PEIFSQSDEKVTHVFVPMASGAMISGIGRYFKSVNPDVQIIGVEPVGSIYHDLHEGRSQGGVTSFQLEDIGAVQPTSFWE
PEVIDRIVQVSDADAFNCGRELLRSEGVFAGGASGAAMCAALREGESLGSDSLVVVMMTDFGGYDLSRMYNDEWMRRQGF
YRKAKTALDQITADDILLRKARKDLIFAQPEQTLADVFEMMKQNDVSQMPIVSFGAPIGSISENKILSILIENDSAMNAK
VVAFMEKPFPVCQPDATISELSGKLQTNAAGVLISLSDGRLQLITKSDLIDALTHK

Sequences:

>Translated_456_residues
MTNDIFDISGNTPLVPMKQLTRQKKARFMAKLEYMNPCMSHYCRVSTAIVKEAEEEGLIHPGMTLVDWTFGTSGIALAMV
AVSKGYKVLLAAPDSICREKQDVLRALGAELVLTPSEATGGNLHGCVAVAENLVRTMPNAWFANMYENPVSRQVHQSGTG
PEIFSQSDEKVTHVFVPMASGAMISGIGRYFKSVNPDVQIIGVEPVGSIYHDLHEGRSQGGVTSFQLEDIGAVQPTSFWE
PEVIDRIVQVSDADAFNCGRELLRSEGVFAGGASGAAMCAALREGESLGSDSLVVVMMTDFGGYDLSRMYNDEWMRRQGF
YRKAKTALDQITADDILLRKARKDLIFAQPEQTLADVFEMMKQNDVSQMPIVSFGAPIGSISENKILSILIENDSAMNAK
VVAFMEKPFPVCQPDATISELSGKLQTNAAGVLISLSDGRLQLITKSDLIDALTHK
>Mature_455_residues
TNDIFDISGNTPLVPMKQLTRQKKARFMAKLEYMNPCMSHYCRVSTAIVKEAEEEGLIHPGMTLVDWTFGTSGIALAMVA
VSKGYKVLLAAPDSICREKQDVLRALGAELVLTPSEATGGNLHGCVAVAENLVRTMPNAWFANMYENPVSRQVHQSGTGP
EIFSQSDEKVTHVFVPMASGAMISGIGRYFKSVNPDVQIIGVEPVGSIYHDLHEGRSQGGVTSFQLEDIGAVQPTSFWEP
EVIDRIVQVSDADAFNCGRELLRSEGVFAGGASGAAMCAALREGESLGSDSLVVVMMTDFGGYDLSRMYNDEWMRRQGFY
RKAKTALDQITADDILLRKARKDLIFAQPEQTLADVFEMMKQNDVSQMPIVSFGAPIGSISENKILSILIENDSAMNAKV
VAFMEKPFPVCQPDATISELSGKLQTNAAGVLISLSDGRLQLITKSDLIDALTHK

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=439, Percent_Identity=28.0182232346241, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI295821200, Length=439, Percent_Identity=28.0182232346241, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4557415, Length=439, Percent_Identity=28.0182232346241, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=32.2784810126582, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=32.5581395348837, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562970, Length=317, Percent_Identity=33.4384858044164, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32566674, Length=285, Percent_Identity=35.0877192982456, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17535051, Length=336, Percent_Identity=34.2261904761905, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=29.7546012269939, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=31.0030395136778, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=32.2475570032573, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=34.3137254901961, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=29.0178571428571, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=499, Percent_Identity=28.2565130260521, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=26.8072289156627, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24643623, Length=437, Percent_Identity=30.2059496567506, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI20129101, Length=437, Percent_Identity=30.2059496567506, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49675; Mature: 49543

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDIFDISGNTPLVPMKQLTRQKKARFMAKLEYMNPCMSHYCRVSTAIVKEAEEEGLIH
CCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PGMTLVDWTFGTSGIALAMVAVSKGYKVLLAAPDSICREKQDVLRALGAELVLTPSEATG
CCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCC
GNLHGCVAVAENLVRTMPNAWFANMYENPVSRQVHQSGTGPEIFSQSDEKVTHVFVPMAS
CCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCCCCHHHCCCCCCEEEEEEECCC
GAMISGIGRYFKSVNPDVQIIGVEPVGSIYHDLHEGRSQGGVTSFQLEDIGAVQPTSFWE
CHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
PEVIDRIVQVSDADAFNCGRELLRSEGVFAGGASGAAMCAALREGESLGSDSLVVVMMTD
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEC
FGGYDLSRMYNDEWMRRQGFYRKAKTALDQITADDILLRKARKDLIFAQPEQTLADVFEM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHH
MKQNDVSQMPIVSFGAPIGSISENKILSILIENDSAMNAKVVAFMEKPFPVCQPDATISE
HHHCCCCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHH
LSGKLQTNAAGVLISLSDGRLQLITKSDLIDALTHK
HCCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
TNDIFDISGNTPLVPMKQLTRQKKARFMAKLEYMNPCMSHYCRVSTAIVKEAEEEGLIH
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PGMTLVDWTFGTSGIALAMVAVSKGYKVLLAAPDSICREKQDVLRALGAELVLTPSEATG
CCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCC
GNLHGCVAVAENLVRTMPNAWFANMYENPVSRQVHQSGTGPEIFSQSDEKVTHVFVPMAS
CCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCCCCHHHCCCCCCEEEEEEECCC
GAMISGIGRYFKSVNPDVQIIGVEPVGSIYHDLHEGRSQGGVTSFQLEDIGAVQPTSFWE
CHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
PEVIDRIVQVSDADAFNCGRELLRSEGVFAGGASGAAMCAALREGESLGSDSLVVVMMTD
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEC
FGGYDLSRMYNDEWMRRQGFYRKAKTALDQITADDILLRKARKDLIFAQPEQTLADVFEM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHH
MKQNDVSQMPIVSFGAPIGSISENKILSILIENDSAMNAKVVAFMEKPFPVCQPDATISE
HHHCCCCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHH
LSGKLQTNAAGVLISLSDGRLQLITKSDLIDALTHK
HCCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]