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The map label for this gene is manC [H]

Identifier: 193211881

GI number: 193211881

Start: 205900

End: 207021

Strand: Direct

Name: manC [H]

Synonym: Cpar_0207

Alternate gene names: 193211881

Gene position: 205900-207021 (Clockwise)

Preceding gene: 193211879

Following gene: 193211884

Centisome position: 8.99

GC content: 55.97

Gene sequence:

>1122_bases
ATGGGCACGACAAAGAATTTCTGCAGCCATGTCTATGCCGTGGTCATGGCTGGGGGCATAGGCAGCAAGCTCTGGCCGCT
TTCGCGCAAGCGCTATCCCAAGCAGTTTCTCCATTTTTTTGATGGCGGAACCATGATCCGCAAAACCGTCGAGCGGATTG
CCCGCATCGTCAGGAAAGAGAACATCCTCATCATCACCAGCAAGCAGCACTGGCGTCTTGTGCTCGACTCGCTACCCGAT
TTCGATGCCGACAACATCATCATCGAACCCACCATCAGGGATACGGCTACCTGTATCGCCCTGGCGACCACCTTCATCCG
GAAACGCAATCCCGATGCCGTGACTGTCGTGCTTCCGGCTGACCACCTCGTGCACAATGAGGGGCGCTTTCTGGAAACCG
TCGAGAAGGGAATTTGCATGGCGCGGGAAAAACAGGGGCTGATCACCATCGGCATCAAGCCGGATCGGCCTGAGACGCGC
TACGGCTATATTCAGGTGGAAGCGTCGGTCATGATGGAGGATGAGACAGATGATGACGACATTCCCCTGTTTCGGGTAAA
AACCTTTGCCGAAAAGCCTGACATTGCCACCGCCGAACAGTTTCTGCAAAGCTGTGACTTCTGGTGGAACAGCGGGGTCT
TGATTTGGCACGTTGATGACATCAACCGGGAGTTCCGCCGCTCGTTGCCCGACCTGTACGAAGACATGCAGAACGTGCAT
GCCTTCATCGGAACCGATCGGCAGGAGTCGGTTATCGAGGATGTCTATAGTTGGGTTCATCCGGTTTCGATCGCTTACGG
CATTATGGAAAAGGCCGAAAAGGTCTACATGCTGGCCGGTGATTTCGGGTGGACCGATCTGGGATGCTGGGACGAGGTGA
TCAAGGTGGGACTCGGCCTCGAAGGTCGCGATATGGACGGCAGCGAGGCGATCATGATCGATTCGAACCAGGTCTTCGTC
CGCAAGCCTCACGGCAAGGCAGTGGTGACCATCGGCGTGGACGACATCATCGTGATCGATACGCCCGATGCGCTGCTGAT
CTGTCGAAAGGGGCAGTCGGGTGATGTTGCCAAGGCTGTTGAGGTGATGAGGCGCGAGGAGGGGCTGGACAAGTTTTTAT
GA

Upstream 100 bases:

>100_bases
AACGATTCGTCTGTACAGAATGACGGGCATCTCATCGGGAGCTGAATCGGCTGTTGCCGGAATCATGACGGTGAGGGCTC
GAAGGTAGAGAAAGAAAAGT

Downstream 100 bases:

>100_bases
GGCGCTGACCCGCTCCCCGGCTTGAAAGCCGGGGCAACATGAATGTAAGAGGAGATGAATATCCGTTGGGCTGAAGCCCT
CCTGAATGTGGGAGAGCCGG

Product: Mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MGTTKNFCSHVYAVVMAGGIGSKLWPLSRKRYPKQFLHFFDGGTMIRKTVERIARIVRKENILIITSKQHWRLVLDSLPD
FDADNIIIEPTIRDTATCIALATTFIRKRNPDAVTVVLPADHLVHNEGRFLETVEKGICMAREKQGLITIGIKPDRPETR
YGYIQVEASVMMEDETDDDDIPLFRVKTFAEKPDIATAEQFLQSCDFWWNSGVLIWHVDDINREFRRSLPDLYEDMQNVH
AFIGTDRQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGDFGWTDLGCWDEVIKVGLGLEGRDMDGSEAIMIDSNQVFV
RKPHGKAVVTIGVDDIIVIDTPDALLICRKGQSGDVAKAVEVMRREEGLDKFL

Sequences:

>Translated_373_residues
MGTTKNFCSHVYAVVMAGGIGSKLWPLSRKRYPKQFLHFFDGGTMIRKTVERIARIVRKENILIITSKQHWRLVLDSLPD
FDADNIIIEPTIRDTATCIALATTFIRKRNPDAVTVVLPADHLVHNEGRFLETVEKGICMAREKQGLITIGIKPDRPETR
YGYIQVEASVMMEDETDDDDIPLFRVKTFAEKPDIATAEQFLQSCDFWWNSGVLIWHVDDINREFRRSLPDLYEDMQNVH
AFIGTDRQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGDFGWTDLGCWDEVIKVGLGLEGRDMDGSEAIMIDSNQVFV
RKPHGKAVVTIGVDDIIVIDTPDALLICRKGQSGDVAKAVEVMRREEGLDKFL
>Mature_372_residues
GTTKNFCSHVYAVVMAGGIGSKLWPLSRKRYPKQFLHFFDGGTMIRKTVERIARIVRKENILIITSKQHWRLVLDSLPDF
DADNIIIEPTIRDTATCIALATTFIRKRNPDAVTVVLPADHLVHNEGRFLETVEKGICMAREKQGLITIGIKPDRPETRY
GYIQVEASVMMEDETDDDDIPLFRVKTFAEKPDIATAEQFLQSCDFWWNSGVLIWHVDDINREFRRSLPDLYEDMQNVHA
FIGTDRQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGDFGWTDLGCWDEVIKVGLGLEGRDMDGSEAIMIDSNQVFVR
KPHGKAVVTIGVDDIIVIDTPDALLICRKGQSGDVAKAVEVMRREEGLDKFL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=361, Percent_Identity=33.2409972299169, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 42340; Mature: 42209

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTTKNFCSHVYAVVMAGGIGSKLWPLSRKRYPKQFLHFFDGGTMIRKTVERIARIVRKE
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
NILIITSKQHWRLVLDSLPDFDADNIIIEPTIRDTATCIALATTFIRKRNPDAVTVVLPA
CEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
DHLVHNEGRFLETVEKGICMAREKQGLITIGIKPDRPETRYGYIQVEASVMMEDETDDDD
HHHCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCCEEEEEEEEEEEEEECCCCCCC
IPLFRVKTFAEKPDIATAEQFLQSCDFWWNSGVLIWHVDDINREFRRSLPDLYEDMQNVH
CCEEEEEHHCCCCCHHHHHHHHHHCCCEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
AFIGTDRQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGDFGWTDLGCWDEVIKVGLGL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCC
EGRDMDGSEAIMIDSNQVFVRKPHGKAVVTIGVDDIIVIDTPDALLICRKGQSGDVAKAV
CCCCCCCCCEEEEECCEEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCHHHHH
EVMRREEGLDKFL
HHHHHHHHHHHCC
>Mature Secondary Structure 
GTTKNFCSHVYAVVMAGGIGSKLWPLSRKRYPKQFLHFFDGGTMIRKTVERIARIVRKE
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
NILIITSKQHWRLVLDSLPDFDADNIIIEPTIRDTATCIALATTFIRKRNPDAVTVVLPA
CEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
DHLVHNEGRFLETVEKGICMAREKQGLITIGIKPDRPETRYGYIQVEASVMMEDETDDDD
HHHCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCCEEEEEEEEEEEEEECCCCCCC
IPLFRVKTFAEKPDIATAEQFLQSCDFWWNSGVLIWHVDDINREFRRSLPDLYEDMQNVH
CCEEEEEHHCCCCCHHHHHHHHHHCCCEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
AFIGTDRQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGDFGWTDLGCWDEVIKVGLGL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCC
EGRDMDGSEAIMIDSNQVFVRKPHGKAVVTIGVDDIIVIDTPDALLICRKGQSGDVAKAV
CCCCCCCCCEEEEECCEEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCHHHHH
EVMRREEGLDKFL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]