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The map label for this gene is cysG [H]

Identifier: 193211714

GI number: 193211714

Start: 44314

End: 45693

Strand: Direct

Name: cysG [H]

Synonym: Cpar_0039

Alternate gene names: 193211714

Gene position: 44314-45693 (Clockwise)

Preceding gene: 193211713

Following gene: 193211715

Centisome position: 1.94

GC content: 60.87

Gene sequence:

>1380_bases
ATGACCGATAGAACTCCAGCGGAGCAGGCTCCGCGAAAAGGCTACGTTTATATCGCTGGCGCGGGGCCGGGCGATCCCGA
GCTGATGACCATCAAGGCCGACCGGGCGCTTCGCGAGGCGGACGTGATTCTGTTCGACGATCTGGTGCTTCCGCAGATGC
TCGAAGCCTACAAGGCCGAGAAGATCTATACCGGCAAGCGCAAGGATGCGCACCACTTCGCGCAGGACGAAATCAACCAG
GAGATCGTGCGCCACGCGCTGCTCGGCAAGACGGTGGTGCGGCTCAAGGGCGGCGATCCGTTCATCTTCGGGCGCGGCGG
CGAGGAGATCGAGACGCTCCGGCAGCACGGCATCGACTACGAAATCATCCCCGGCATCACTGCCGCGCACGGGGCGAGCG
CGTACAGCGAAATTCCGCTCACCATGCGCAAGGTCTCCTCGTCGGTGGCCTTCTGTACCGGCCATCCGGTCAACAAGATT
CAGGTGCCCGATACAGATACGATCGTCTATTACATGGTGGCCTCGAACGTGCACGACGTGCTCGACAAGGTGGCCGCGTC
AGGCCGCAGCGGTGAGACGATGGTGGCTGTGGTGCAGAACGCCACCCGCTACAACCAGCGCGTCTTCACCGGTACGCTCG
ACGAGTTCCGCAAGCGCGAGCGGGCGGTCTATTCACCGGCGCTGCTCATCATCGGCCAGAACATCAACCAGTACATCGAA
CAGACCTGGTATTCGCGCAAGAAGAAGGTGCTGATGACCGGCGGCGACGTCAAAAAGTACGACCCGGCAAACTGGATCAC
GGTGCACTTCCCGTGCCGTCAGGTGGCTGGGGCCGACCTCGACGCGGTGAAGCGCTGCATGGGCAAGATCGACGACTTCT
CGATGCTCTTTTTCCAGAACCGTTTCGCCGTCACCTACTTTTTCAAGTACCTCTTCGAGCACGGCAAGGATGTGCGCCAC
CTGGCTCACATGACCATCTGTACCTCCAGCCGCACGGCGGCCAGCGAGCTGCTCGAATACGGTATCATTCCCGATTGCTG
CCTCGAATCGGAGGGGTCATCGACCATTTCCGGACTACTTGGCAAGGAGGGGCTCACCGGCCAGAACATTCTCCTGCCCG
GTGCAGAGAACGTCGATGAGGCCGTTTCTGCCGAACTGAAGTCTGCGGGCAACAGCGTCACGCCGCTGACCGTCTATGTG
CACGGTGCGCAGGACAAGGGTGATGCGATCGACCTCGATTTCATCGACGAAATCTATTTCGCCTCCCCGGCTTGCGTCCG
GAAATTCCGCGAACTGTACGGCGAGATTCCGGCCCGTATCACGGTCGCTCCTGCCGATGCCAACACGAGAGAGGAGTATT
CCAGACTGTTCGGCGCCTGA

Upstream 100 bases:

>100_bases
GGCCAGAACGTCAAGAAGTCCGTCGCGTGGCGCAACCGGCTCCGCGAGATGATCGACGAGGAGTGGCCGGAGACCAATCA
GTAATTTCACTATTCCGATC

Downstream 100 bases:

>100_bases
TTTGGCGGCCCGGCCAGGACGATGATGGGGAAAAAGCCTGAATCTGCTTATATTCAGGCTGTCCCCTAAAAGACACCTCT
AAAAATTATTGCGTGCCCCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTDRTPAEQAPRKGYVYIAGAGPGDPELMTIKADRALREADVILFDDLVLPQMLEAYKAEKIYTGKRKDAHHFAQDEINQ
EIVRHALLGKTVVRLKGGDPFIFGRGGEEIETLRQHGIDYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNKI
QVPDTDTIVYYMVASNVHDVLDKVAASGRSGETMVAVVQNATRYNQRVFTGTLDEFRKRERAVYSPALLIIGQNINQYIE
QTWYSRKKKVLMTGGDVKKYDPANWITVHFPCRQVAGADLDAVKRCMGKIDDFSMLFFQNRFAVTYFFKYLFEHGKDVRH
LAHMTICTSSRTAASELLEYGIIPDCCLESEGSSTISGLLGKEGLTGQNILLPGAENVDEAVSAELKSAGNSVTPLTVYV
HGAQDKGDAIDLDFIDEIYFASPACVRKFRELYGEIPARITVAPADANTREEYSRLFGA

Sequences:

>Translated_459_residues
MTDRTPAEQAPRKGYVYIAGAGPGDPELMTIKADRALREADVILFDDLVLPQMLEAYKAEKIYTGKRKDAHHFAQDEINQ
EIVRHALLGKTVVRLKGGDPFIFGRGGEEIETLRQHGIDYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNKI
QVPDTDTIVYYMVASNVHDVLDKVAASGRSGETMVAVVQNATRYNQRVFTGTLDEFRKRERAVYSPALLIIGQNINQYIE
QTWYSRKKKVLMTGGDVKKYDPANWITVHFPCRQVAGADLDAVKRCMGKIDDFSMLFFQNRFAVTYFFKYLFEHGKDVRH
LAHMTICTSSRTAASELLEYGIIPDCCLESEGSSTISGLLGKEGLTGQNILLPGAENVDEAVSAELKSAGNSVTPLTVYV
HGAQDKGDAIDLDFIDEIYFASPACVRKFRELYGEIPARITVAPADANTREEYSRLFGA
>Mature_458_residues
TDRTPAEQAPRKGYVYIAGAGPGDPELMTIKADRALREADVILFDDLVLPQMLEAYKAEKIYTGKRKDAHHFAQDEINQE
IVRHALLGKTVVRLKGGDPFIFGRGGEEIETLRQHGIDYEIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNKIQ
VPDTDTIVYYMVASNVHDVLDKVAASGRSGETMVAVVQNATRYNQRVFTGTLDEFRKRERAVYSPALLIIGQNINQYIEQ
TWYSRKKKVLMTGGDVKKYDPANWITVHFPCRQVAGADLDAVKRCMGKIDDFSMLFFQNRFAVTYFFKYLFEHGKDVRHL
AHMTICTSSRTAASELLEYGIIPDCCLESEGSSTISGLLGKEGLTGQNILLPGAENVDEAVSAELKSAGNSVTPLTVYVH
GAQDKGDAIDLDFIDEIYFASPACVRKFRELYGEIPARITVAPADANTREEYSRLFGA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=252, Percent_Identity=41.2698412698413, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322922, Length=246, Percent_Identity=30.8943089430894, Blast_Score=111, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 50827; Mature: 50696

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRTPAEQAPRKGYVYIAGAGPGDPELMTIKADRALREADVILFDDLVLPQMLEAYKAE
CCCCCCHHHCCCCCEEEEEECCCCCCCEEEEECCHHHHHCCEEEEHHHHHHHHHHHHHHH
KIYTGKRKDAHHFAQDEINQEIVRHALLGKTVVRLKGGDPFIFGRGGEEIETLRQHGIDY
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCHHHHHHHHCCCCE
EIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNKIQVPDTDTIVYYMVASNVHDV
EECCCCCHHCCCCHHHHCCHHHHHHHCCEEEEECCCCCEEECCCCCCEEEEEECCCHHHH
LDKVAASGRSGETMVAVVQNATRYNQRVFTGTLDEFRKRERAVYSPALLIIGQNINQYIE
HHHHHHCCCCCCEEEEEEHHHHHHCCEEEECCHHHHHHHHHHHCCCEEEEEECCHHHHHH
QTWYSRKKKVLMTGGDVKKYDPANWITVHFPCRQVAGADLDAVKRCMGKIDDFSMLFFQN
HHHHHCCCEEEEECCCCCCCCCCCEEEEECCHHHHCCCCHHHHHHHHCCCCCHHEEHHHC
RFAVTYFFKYLFEHGKDVRHLAHMTICTSSRTAASELLEYGIIPDCCLESEGSSTISGLL
CHHHHHHHHHHHHCCCHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
GKEGLTGQNILLPGAENVDEAVSAELKSAGNSVTPLTVYVHGAQDKGDAIDLDFIDEIYF
CCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEECHHHHHHHHH
ASPACVRKFRELYGEIPARITVAPADANTREEYSRLFGA
CCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TDRTPAEQAPRKGYVYIAGAGPGDPELMTIKADRALREADVILFDDLVLPQMLEAYKAE
CCCCCHHHCCCCCEEEEEECCCCCCCEEEEECCHHHHHCCEEEEHHHHHHHHHHHHHHH
KIYTGKRKDAHHFAQDEINQEIVRHALLGKTVVRLKGGDPFIFGRGGEEIETLRQHGIDY
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCHHHHHHHHCCCCE
EIIPGITAAHGASAYSEIPLTMRKVSSSVAFCTGHPVNKIQVPDTDTIVYYMVASNVHDV
EECCCCCHHCCCCHHHHCCHHHHHHHCCEEEEECCCCCEEECCCCCCEEEEEECCCHHHH
LDKVAASGRSGETMVAVVQNATRYNQRVFTGTLDEFRKRERAVYSPALLIIGQNINQYIE
HHHHHHCCCCCCEEEEEEHHHHHHCCEEEECCHHHHHHHHHHHCCCEEEEEECCHHHHHH
QTWYSRKKKVLMTGGDVKKYDPANWITVHFPCRQVAGADLDAVKRCMGKIDDFSMLFFQN
HHHHHCCCEEEEECCCCCCCCCCCEEEEECCHHHHCCCCHHHHHHHHCCCCCHHEEHHHC
RFAVTYFFKYLFEHGKDVRHLAHMTICTSSRTAASELLEYGIIPDCCLESEGSSTISGLL
CHHHHHHHHHHHHCCCHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
GKEGLTGQNILLPGAENVDEAVSAELKSAGNSVTPLTVYVHGAQDKGDAIDLDFIDEIYF
CCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEECHHHHHHHHH
ASPACVRKFRELYGEIPARITVAPADANTREEYSRLFGA
CCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA