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The map label for this gene is pyrG

Identifier: 193214481

GI number: 193214481

Start: 899871

End: 901544

Strand: Direct

Name: pyrG

Synonym: Ctha_0764

Alternate gene names: 193214481

Gene position: 899871-901544 (Clockwise)

Preceding gene: 193214480

Following gene: 193214483

Centisome position: 27.32

GC content: 45.16

Gene sequence:

>1674_bases
ATGGCGCGTTCCAAAATCGTTAAGCATATTTTTGTGACCGGCGGTGTCGTATCGTCACTTGGCAAAGGCATTCTTTCCGC
CTCGCTTGGCGCACTGCTAAAATCTCGTGGGTTGAGAGTTGCTATTCAAAAATATGACCCATACATCAATGTCGATCCCG
GTACCATGTCGCCCTACCAGCATGGCGAAGTTTATGTGACCGACGACGGCGCAGAAACAGACCTCGATTTAGGACATTAC
GAACGGTTTCTTGATGAAGCGACTTCCCGCGCCAGCAACATGACTATGGGACGGATTTACAAAACAGTTCTGGACAACGA
ACGACGCGGCGACTATCTTGGTGGCACGGTTCAGGTTGTTCCTCATGTTATCGATGAAATTAAAGCACGGATGCTTGACC
TTGCTAAAAAAGGAAGCTTTGATGTTGTGATTACAGAAATTGGCGGCACGGTTGGCGACATTGAATCGCTCCCGTTTCTC
GAAGCTATGCGTCAACTGAAGTTACAATTAGGCTCGAAAAATTTGGTCAACATCCACCTAACGCTCGTTCCTTACATTAA
ATCGGCGGCTGAACTAAAAACAAAACCCACGCAGCACAGCGTTAAAATGCTTCTGGAAATTGGCATTCAACCAGATATTT
TGGTTTGCCGCAGCGAACACCCACTTTCAAAAGATATCAAGCATAAAATTGGCCTTTTCTGTAACCTAAGCGATTCGGAC
GTGGTTGGTCTGTGCGATGCAGAAACCATTTACGAAGTTCCGCTTGTGCTTCACGAAGAAAAGATTGACTCGCTTGTTCT
GAAAAAACTCATGCTCAAATCCCCAAAGCCAGCAGACATCAAAGATTGGAAGGATTTTTCCGGCAAGGTAAAATTCCCAA
AAGACGGCGTTGTGGAAATTGGCGTTTGTGGAAAGTATACCAAATATCCTGATGCTTATAAATCCATTGTTGAATCCTTT
ATCCATGCTGGCGCAGCAAACAATGTAAAAGTGAAAGTTCGCTGGATGCACTCCGAGGATTTGGAGCAGAAAGACTGTAA
GGTAAATGAAATGCTTCAAGGCATTTCGGGGATTTTGGTTGCGCCCGGTTTCGGCGAACGCGGCATTGAAGGAAAAATCG
AGATTGTCAAAATCGCCAGAGAGCGAAATATTCCGTTTTTCGGCATTTGCCTTGGTATGCAATGCGCCACCATTGAATAC
GCCCGAAATGTTTGCGGCATGGAAGGCGCACACTCGACCGAGTTTGTGAAAAAAACAAAATATCCGGTCATTGATTTAAT
GGAGCATCAACGCAGTGTGAAGCAAAAAGGTGGAACGATGCGATTAGGCAGTTATCCCTGTATTTTAGAGGAAAACACCA
ATGCGTTTGCGGCTTATGGAAAAAACTTGATCAATGAACGCCATCGCCATCGCTACGAATTTAACAATCAATTCAAGGAA
GAACTTTCGGCAAAAGGTTTAGTGATTGCAGGCGCATCACCAGATGGGGAACTGGTTGAAATTATAGAACTGAAAGGACA
TCGTTGGTTTGTCGGCGTGCAATTCCATCCTGAGCTCAAGTCAAGGGTTCACAAGCCTCATCCGCTATTCATATCGTTTG
TGGCCGAAGCAAAAAAATTCCGCGACGAAATGGCGGTTCATCATTATGAAACATCATCCGTAGAAACGGTGTAG

Upstream 100 bases:

>100_bases
GATTCTGCCACTTGAGCAAACTGAAGGATTAGGGCAATGCTGGTATTTTTTTTATCTTTTACCTTAAATTTTCCATCCGA
ATAAAATATCCGTAGTACTC

Downstream 100 bases:

>100_bases
TTTCACATTTTCAAAATCCCCCACAGCCCATTTTCTCCAATGCTTTTGTGCCCGAAACAGAAAGTCGCTTGTTTGCGTGC
TAAGATTTTATCTCAATGAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MARSKIVKHIFVTGGVVSSLGKGILSASLGALLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEATSRASNMTMGRIYKTVLDNERRGDYLGGTVQVVPHVIDEIKARMLDLAKKGSFDVVITEIGGTVGDIESLPFL
EAMRQLKLQLGSKNLVNIHLTLVPYIKSAAELKTKPTQHSVKMLLEIGIQPDILVCRSEHPLSKDIKHKIGLFCNLSDSD
VVGLCDAETIYEVPLVLHEEKIDSLVLKKLMLKSPKPADIKDWKDFSGKVKFPKDGVVEIGVCGKYTKYPDAYKSIVESF
IHAGAANNVKVKVRWMHSEDLEQKDCKVNEMLQGISGILVAPGFGERGIEGKIEIVKIARERNIPFFGICLGMQCATIEY
ARNVCGMEGAHSTEFVKKTKYPVIDLMEHQRSVKQKGGTMRLGSYPCILEENTNAFAAYGKNLINERHRHRYEFNNQFKE
ELSAKGLVIAGASPDGELVEIIELKGHRWFVGVQFHPELKSRVHKPHPLFISFVAEAKKFRDEMAVHHYETSSVETV

Sequences:

>Translated_557_residues
MARSKIVKHIFVTGGVVSSLGKGILSASLGALLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEATSRASNMTMGRIYKTVLDNERRGDYLGGTVQVVPHVIDEIKARMLDLAKKGSFDVVITEIGGTVGDIESLPFL
EAMRQLKLQLGSKNLVNIHLTLVPYIKSAAELKTKPTQHSVKMLLEIGIQPDILVCRSEHPLSKDIKHKIGLFCNLSDSD
VVGLCDAETIYEVPLVLHEEKIDSLVLKKLMLKSPKPADIKDWKDFSGKVKFPKDGVVEIGVCGKYTKYPDAYKSIVESF
IHAGAANNVKVKVRWMHSEDLEQKDCKVNEMLQGISGILVAPGFGERGIEGKIEIVKIARERNIPFFGICLGMQCATIEY
ARNVCGMEGAHSTEFVKKTKYPVIDLMEHQRSVKQKGGTMRLGSYPCILEENTNAFAAYGKNLINERHRHRYEFNNQFKE
ELSAKGLVIAGASPDGELVEIIELKGHRWFVGVQFHPELKSRVHKPHPLFISFVAEAKKFRDEMAVHHYETSSVETV
>Mature_556_residues
ARSKIVKHIFVTGGVVSSLGKGILSASLGALLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYE
RFLDEATSRASNMTMGRIYKTVLDNERRGDYLGGTVQVVPHVIDEIKARMLDLAKKGSFDVVITEIGGTVGDIESLPFLE
AMRQLKLQLGSKNLVNIHLTLVPYIKSAAELKTKPTQHSVKMLLEIGIQPDILVCRSEHPLSKDIKHKIGLFCNLSDSDV
VGLCDAETIYEVPLVLHEEKIDSLVLKKLMLKSPKPADIKDWKDFSGKVKFPKDGVVEIGVCGKYTKYPDAYKSIVESFI
HAGAANNVKVKVRWMHSEDLEQKDCKVNEMLQGISGILVAPGFGERGIEGKIEIVKIARERNIPFFGICLGMQCATIEYA
RNVCGMEGAHSTEFVKKTKYPVIDLMEHQRSVKQKGGTMRLGSYPCILEENTNAFAAYGKNLINERHRHRYEFNNQFKEE
LSAKGLVIAGASPDGELVEIIELKGHRWFVGVQFHPELKSRVHKPHPLFISFVAEAKKFRDEMAVHHYETSSVETV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=44.2831215970962, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=43.0909090909091, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=43.0909090909091, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=43.0909090909091, Blast_Score=445, Evalue=1e-125,
Organism=Escherichia coli, GI1789142, Length=548, Percent_Identity=51.8248175182482, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25148299, Length=610, Percent_Identity=37.5409836065574, Blast_Score=390, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=41.563055062167, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319432, Length=564, Percent_Identity=39.8936170212766, Blast_Score=412, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24664469, Length=547, Percent_Identity=44.0585009140768, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI21357815, Length=491, Percent_Identity=42.1588594704684, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHLT3 (B3QWC0)

Other databases:

- EMBL:   CP001100
- RefSeq:   YP_001995680.1
- ProteinModelPortal:   B3QWC0
- GeneID:   6421811
- GenomeReviews:   CP001100_GR
- KEGG:   cts:Ctha_0764
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 62164; Mature: 62033

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 390-390 ACT_SITE 516-516 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSKIVKHIFVTGGVVSSLGKGILSASLGALLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEATSRASNMTMGRIYKTVLDNERRGDYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHH
PHVIDEIKARMLDLAKKGSFDVVITEIGGTVGDIESLPFLEAMRQLKLQLGSKNLVNIHL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
TLVPYIKSAAELKTKPTQHSVKMLLEIGIQPDILVCRSEHPLSKDIKHKIGLFCNLSDSD
EEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCEEEECCCCC
VVGLCDAETIYEVPLVLHEEKIDSLVLKKLMLKSPKPADIKDWKDFSGKVKFPKDGVVEI
EEEECCCHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEECCCCCCEEE
GVCGKYTKYPDAYKSIVESFIHAGAANNVKVKVRWMHSEDLEQKDCKVNEMLQGISGILV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHCCCHHHHHHCCCCEEE
APGFGERGIEGKIEIVKIARERNIPFFGICLGMQCATIEYARNVCGMEGAHSTEFVKKTK
CCCCCCCCCCCCEEEEEEEHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCC
YPVIDLMEHQRSVKQKGGTMRLGSYPCILEENTNAFAAYGKNLINERHRHRYEFNNQFKE
CCHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELSAKGLVIAGASPDGELVEIIELKGHRWFVGVQFHPELKSRVHKPHPLFISFVAEAKKF
HHCCCCEEEECCCCCCCEEEEEEECCCEEEEEEEECHHHHHHCCCCCCHHHHHHHHHHHH
RDEMAVHHYETSSVETV
HHHHHHHEECCCCCCCC
>Mature Secondary Structure 
ARSKIVKHIFVTGGVVSSLGKGILSASLGALLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEATSRASNMTMGRIYKTVLDNERRGDYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHH
PHVIDEIKARMLDLAKKGSFDVVITEIGGTVGDIESLPFLEAMRQLKLQLGSKNLVNIHL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
TLVPYIKSAAELKTKPTQHSVKMLLEIGIQPDILVCRSEHPLSKDIKHKIGLFCNLSDSD
EEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCEEEECCCCC
VVGLCDAETIYEVPLVLHEEKIDSLVLKKLMLKSPKPADIKDWKDFSGKVKFPKDGVVEI
EEEECCCHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEECCCCCCEEE
GVCGKYTKYPDAYKSIVESFIHAGAANNVKVKVRWMHSEDLEQKDCKVNEMLQGISGILV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHCCCHHHHHHCCCCEEE
APGFGERGIEGKIEIVKIARERNIPFFGICLGMQCATIEYARNVCGMEGAHSTEFVKKTK
CCCCCCCCCCCCEEEEEEEHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCC
YPVIDLMEHQRSVKQKGGTMRLGSYPCILEENTNAFAAYGKNLINERHRHRYEFNNQFKE
CCHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELSAKGLVIAGASPDGELVEIIELKGHRWFVGVQFHPELKSRVHKPHPLFISFVAEAKKF
HHCCCCEEEECCCCCCCEEEEEEECCCEEEEEEEECHHHHHHCCCCCCHHHHHHHHHHHH
RDEMAVHHYETSSVETV
HHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA