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The map label for this gene is clpP [H]

Identifier: 193214418

GI number: 193214418

Start: 819322

End: 820002

Strand: Direct

Name: clpP [H]

Synonym: Ctha_0701

Alternate gene names: 193214418

Gene position: 819322-820002 (Clockwise)

Preceding gene: 193214417

Following gene: 193214419

Centisome position: 24.88

GC content: 48.46

Gene sequence:

>681_bases
ATGGCCAACATTAATTTTGGTTTTGAAAATTTCGCGAAAAAAGAACTCTACTCATCTCGCACTGAAAGTAGCATCAACAA
CATGCTTGTGCCAATGGTTATTGAGACGTCAGGACGTGGCGAACGAGCTTTTGATATTTTTTCAAGGCTTTTAAGAGAAC
GCATTATTTTTCTCGGAACGCCAATAGATGATCACTCAGCAAGCCTCATCATGGCGCAGCTCATTTACCTCGAGTCTGAA
GATCCTGAGCGCGATATTTTCATGTACATCAACTCGCCAGGTGGCAGCGTTTCAGCCGGTCTTGGTCTCTACGATACCAT
GCAATACATTCGCCCCGACGTTTCAACGGTTTGCGTGGGAATGGCTGCCAGCATGGGCGCCTTTTTGCTCGCCAGTGGCA
CCGCCGGAAAACGCGCCAGCTTGCCGCACTCACGCATTATGATTCACCAGCCGTCGGGTGGCGCACAAGGTCAGGAAACC
GACATTGTCATTCAAGCAAGAGAAATTGAGAAAATTCGCCGCTTGCTTGAAGAACTTTTTGCGCAACACACCAAACAGGA
TGTCGTGAAAGTTCGCGAGGATTCCGAACGCGATCGCTGGATGAACGCTCAAGAAGCTAAAGAATACGGCATTATCGACG
AGATTTTTGATCGCCGCAAAGCTCCTGAAGAGGCCAAGTAG

Upstream 100 bases:

>100_bases
TATTTGCGCGAGCTCACCTCGTGCAAATATCCCTCCAAATAGCTTGACAATAATACCACGCTGTGTGGGATTAATTCTTT
GAATTTAAAAATGAGTGATA

Downstream 100 bases:

>100_bases
TATTCGGCTTTTGAAAAAATTCACTATTGATTAGACAGCCATTGCTTGAGAATGCTCAAGCAATGGCTTTTTTTTATTCA
GTGGAAAAGCTCGGTACAAA

Product: endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MANINFGFENFAKKELYSSRTESSINNMLVPMVIETSGRGERAFDIFSRLLRERIIFLGTPIDDHSASLIMAQLIYLESE
DPERDIFMYINSPGGSVSAGLGLYDTMQYIRPDVSTVCVGMAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQET
DIVIQAREIEKIRRLLEELFAQHTKQDVVKVREDSERDRWMNAQEAKEYGIIDEIFDRRKAPEEAK

Sequences:

>Translated_226_residues
MANINFGFENFAKKELYSSRTESSINNMLVPMVIETSGRGERAFDIFSRLLRERIIFLGTPIDDHSASLIMAQLIYLESE
DPERDIFMYINSPGGSVSAGLGLYDTMQYIRPDVSTVCVGMAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQET
DIVIQAREIEKIRRLLEELFAQHTKQDVVKVREDSERDRWMNAQEAKEYGIIDEIFDRRKAPEEAK
>Mature_225_residues
ANINFGFENFAKKELYSSRTESSINNMLVPMVIETSGRGERAFDIFSRLLRERIIFLGTPIDDHSASLIMAQLIYLESED
PERDIFMYINSPGGSVSAGLGLYDTMQYIRPDVSTVCVGMAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETD
IVIQAREIEKIRRLLEELFAQHTKQDVVKVREDSERDRWMNAQEAKEYGIIDEIFDRRKAPEEAK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=59.5744680851064, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=59.8958333333333, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129427, Length=199, Percent_Identity=54.7738693467337, Blast_Score=229, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 25425; Mature: 25294

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINFGFENFAKKELYSSRTESSINNMLVPMVIETSGRGERAFDIFSRLLRERIIFLGT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHEEECC
PIDDHSASLIMAQLIYLESEDPERDIFMYINSPGGSVSAGLGLYDTMQYIRPDVSTVCVG
CCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHH
MAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETDIVIQAREIEKIRRLLEELF
HHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
AQHTKQDVVKVREDSERDRWMNAQEAKEYGIIDEIFDRRKAPEEAK
HHHHHHHHHHHHCCCCHHHCCCHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ANINFGFENFAKKELYSSRTESSINNMLVPMVIETSGRGERAFDIFSRLLRERIIFLGT
CCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHEEECC
PIDDHSASLIMAQLIYLESEDPERDIFMYINSPGGSVSAGLGLYDTMQYIRPDVSTVCVG
CCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHH
MAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETDIVIQAREIEKIRRLLEELF
HHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
AQHTKQDVVKVREDSERDRWMNAQEAKEYGIIDEIFDRRKAPEEAK
HHHHHHHHHHHHCCCCHHHCCCHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]