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The map label for this gene is glmS [H]

Identifier: 193214263

GI number: 193214263

Start: 642697

End: 644529

Strand: Direct

Name: glmS [H]

Synonym: Ctha_0544

Alternate gene names: 193214263

Gene position: 642697-644529 (Clockwise)

Preceding gene: 193214262

Following gene: 193214264

Centisome position: 19.51

GC content: 44.52

Gene sequence:

>1833_bases
ATGTGTGGTATAGTTGGCTATATCGGTAAAAAAAATGCCTCGCCTATTTTGATTGACGGCTTAAAACGGCTGGAATATCG
TGGATATGACTCCGCTGGAATTGCGCTTTTAAATGGCACGCTGCACATACATAAGAAAAAAGGAAAAGTTGCCGATCTTG
AGCAAATTCTTCCTGAATTTTCCGATAGCCTTACAATTGGAATCGGGCATACCCGCTGGGCAACTCATGGAGAACCCAAT
GACGTAAATGCCCATCCTCATACAAATGAAGCAGGCGATATTGCCGTTATTCATAACGGGATTATTGAAAATTATGGCGC
AATTCGTGCAGAATTACAGCGAAAAGGCCACAAATTTAAGGGCGATACGGACACCGAAGTTCTGGCTCACTTGATCGATG
AAATCTGGAACGAAGCCGACTGCGATTTTGAAACGGCTATTCGTTTAGCATTAAAAGAAGTGGATGGAACCTATGGCCTT
TGCGCAATTACATCCCGCGAGCCCGACAAAATTGTAACGGCACGCAATGGGAGCCCTCTCATTATCGGTGTTGGCGAAGA
TGAATTTCTTATTGGCTCGGATGCCAGTCCGATTGTCTCTCATACGCGGAAAGTCATTTACCTAAACGACGGCGAAATGG
CGATACTTACGCGTGATAGCTACACGATAAAGACGATTGAAAATGTCACGATGCCCAAGGCCATTGACGAACTCACTTTC
GGCATTGCTGAGATTGAAAAAGCAGGGTTTGACCATTTCATGCTTAAGGAAATTTTCGAACAGCCGGAAGCCATTGAAAA
TTCAATGCGTGGCCGCGCGCTGCCTAATGAAGGACAAGTGCGTCTTGGCGGCATTCGCGAACACATTGATCGATTGAGAA
ATGCTAAGCGAATTATCATTTGCGCTTGTGGCACAAGCTGGCATTCAGGTCTGGTAGGTGAATATCTGATAGAAGAATAT
GCGCGCATCCCGGTTGAAGTTGAATATGCTTCCGAGTTTCGCTACCGACATCCGATTTTGAGCAAAGATGATGTTGTGAT
TGCTATTTCCCAATCTGGAGAAACGGCTGATACCTTGGCTGCAATTCGTGAGGCAAAAGCAAAAGGGGCCCTTGTTTTGG
GCATTTGTAATGTAGTCGGCTCATCCATTGCAAGAGAAACAGATTGCGGTATTTACACTCACGCTGGTCCTGAAATTGGC
GTTGCATCCACAAAAGCCTTCACTGCGCAGGTCACCGTTTTGGTGCTGCTTGCTCTTGCGTTAAGCCAAAAACGGACGCT
TTCGGACGAGCAAACCAAGGATATTATTCAAGACCTGTATCAACTTCCAAAAAAAGTACAGGAAATATTAAACTTAAATG
AAGAGATTTTCGAAATGGCCAAAGTCTTTAAAGATGCACGGAACTTCCTGTATCTTGGCCGCGGCTTCAATTTCCCTGTT
GCTTTAGAAGGCGCGCTAAAACTCAAGGAAATTTCTTACATCCATGCAGAAGGCTATCCTGCCGCTGAAATGAAACACGG
CCCAATTGCTCTCATCGATGAAAATATGCCGGTTGTTTTCATTGCGAACAAAGATAGTTCCTATCAAAAAATCATTAGCA
ATATTGAAGAAGTCCGCAGCAGAAAAGGACGCGTTATTGTGATTGCTTCTGAAGGCGACAATGACATCGATAAACTTGCG
GAGTTTGTCATCCACATTCCAGATGCAATGATGCCACTTATGCCACTTTTAACAGTTATTCCGCTTCAGCTTTTGGCCTA
TCATATCGCTGTGCTTCGCGGTTGCGATGTTGATCAGCCAAGAAATTTAGCGAAATCGGTAACTGTGGAGTAA

Upstream 100 bases:

>100_bases
GTCACAACTCTTCCCCCAAAAAAAATTAAATTCATCAGGCAAGAGTGCTTTCACTCGTATCTGAACTCACTCATACCTGT
AAATTCTAAATGATATTAAT

Downstream 100 bases:

>100_bases
AAATTGCTGTTTTGCGTGCTGCGCAAAATTGAAATTTATAGAAAAAGGCTGTTGAAAAAGCAGCCTTTTTTCATTGCATC
ATCACGCGTCATGACTGTAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGYIGKKNASPILIDGLKRLEYRGYDSAGIALLNGTLHIHKKKGKVADLEQILPEFSDSLTIGIGHTRWATHGEPN
DVNAHPHTNEAGDIAVIHNGIIENYGAIRAELQRKGHKFKGDTDTEVLAHLIDEIWNEADCDFETAIRLALKEVDGTYGL
CAITSREPDKIVTARNGSPLIIGVGEDEFLIGSDASPIVSHTRKVIYLNDGEMAILTRDSYTIKTIENVTMPKAIDELTF
GIAEIEKAGFDHFMLKEIFEQPEAIENSMRGRALPNEGQVRLGGIREHIDRLRNAKRIIICACGTSWHSGLVGEYLIEEY
ARIPVEVEYASEFRYRHPILSKDDVVIAISQSGETADTLAAIREAKAKGALVLGICNVVGSSIARETDCGIYTHAGPEIG
VASTKAFTAQVTVLVLLALALSQKRTLSDEQTKDIIQDLYQLPKKVQEILNLNEEIFEMAKVFKDARNFLYLGRGFNFPV
ALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPVVFIANKDSSYQKIISNIEEVRSRKGRVIVIASEGDNDIDKLA
EFVIHIPDAMMPLMPLLTVIPLQLLAYHIAVLRGCDVDQPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGYIGKKNASPILIDGLKRLEYRGYDSAGIALLNGTLHIHKKKGKVADLEQILPEFSDSLTIGIGHTRWATHGEPN
DVNAHPHTNEAGDIAVIHNGIIENYGAIRAELQRKGHKFKGDTDTEVLAHLIDEIWNEADCDFETAIRLALKEVDGTYGL
CAITSREPDKIVTARNGSPLIIGVGEDEFLIGSDASPIVSHTRKVIYLNDGEMAILTRDSYTIKTIENVTMPKAIDELTF
GIAEIEKAGFDHFMLKEIFEQPEAIENSMRGRALPNEGQVRLGGIREHIDRLRNAKRIIICACGTSWHSGLVGEYLIEEY
ARIPVEVEYASEFRYRHPILSKDDVVIAISQSGETADTLAAIREAKAKGALVLGICNVVGSSIARETDCGIYTHAGPEIG
VASTKAFTAQVTVLVLLALALSQKRTLSDEQTKDIIQDLYQLPKKVQEILNLNEEIFEMAKVFKDARNFLYLGRGFNFPV
ALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPVVFIANKDSSYQKIISNIEEVRSRKGRVIVIASEGDNDIDKLA
EFVIHIPDAMMPLMPLLTVIPLQLLAYHIAVLRGCDVDQPRNLAKSVTVE
>Mature_610_residues
MCGIVGYIGKKNASPILIDGLKRLEYRGYDSAGIALLNGTLHIHKKKGKVADLEQILPEFSDSLTIGIGHTRWATHGEPN
DVNAHPHTNEAGDIAVIHNGIIENYGAIRAELQRKGHKFKGDTDTEVLAHLIDEIWNEADCDFETAIRLALKEVDGTYGL
CAITSREPDKIVTARNGSPLIIGVGEDEFLIGSDASPIVSHTRKVIYLNDGEMAILTRDSYTIKTIENVTMPKAIDELTF
GIAEIEKAGFDHFMLKEIFEQPEAIENSMRGRALPNEGQVRLGGIREHIDRLRNAKRIIICACGTSWHSGLVGEYLIEEY
ARIPVEVEYASEFRYRHPILSKDDVVIAISQSGETADTLAAIREAKAKGALVLGICNVVGSSIARETDCGIYTHAGPEIG
VASTKAFTAQVTVLVLLALALSQKRTLSDEQTKDIIQDLYQLPKKVQEILNLNEEIFEMAKVFKDARNFLYLGRGFNFPV
ALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPVVFIANKDSSYQKIISNIEEVRSRKGRVIVIASEGDNDIDKLA
EFVIHIPDAMMPLMPLLTVIPLQLLAYHIAVLRGCDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=41.2280701754386, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI205277386, Length=681, Percent_Identity=40.3817914831131, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=46.5798045602606, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI87082251, Length=314, Percent_Identity=22.9299363057325, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788651, Length=218, Percent_Identity=28.4403669724771, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=45.2873563218391, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=45.2873563218391, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17539970, Length=454, Percent_Identity=44.0528634361233, Blast_Score=379, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322745, Length=445, Percent_Identity=44.7191011235955, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=38.0841121495327, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI21357745, Length=683, Percent_Identity=41.5812591508053, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67263; Mature: 67263

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGKKNASPILIDGLKRLEYRGYDSAGIALLNGTLHIHKKKGKVADLEQILPEF
CCCCEECCCCCCCCCEEHHHHHHHHCCCCCCCCEEEEECEEEEEECCCCHHHHHHHHHHC
SDSLTIGIGHTRWATHGEPNDVNAHPHTNEAGDIAVIHNGIIENYGAIRAELQRKGHKFK
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCC
GDTDTEVLAHLIDEIWNEADCDFETAIRLALKEVDGTYGLCAITSREPDKIVTARNGSPL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEE
IIGVGEDEFLIGSDASPIVSHTRKVIYLNDGEMAILTRDSYTIKTIENVTMPKAIDELTF
EEECCCCCEEECCCCCHHHHCCEEEEEEECCCEEEEECCCEEEEEHHCCCCHHHHHHHHH
GIAEIEKAGFDHFMLKEIFEQPEAIENSMRGRALPNEGQVRLGGIREHIDRLRNAKRIII
HHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEECHHHHHHHHHCCCCEEEE
CACGTSWHSGLVGEYLIEEYARIPVEVEYASEFRYRHPILSKDDVVIAISQSGETADTLA
EECCCCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHH
AIREAKAKGALVLGICNVVGSSIARETDCGIYTHAGPEIGVASTKAFTAQVTVLVLLALA
HHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LSQKRTLSDEQTKDIIQDLYQLPKKVQEILNLNEEIFEMAKVFKDARNFLYLGRGFNFPV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCEEEECCCCCCCE
ALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPVVFIANKDSSYQKIISNIEEVRS
EECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHH
RKGRVIVIASEGDNDIDKLAEFVIHIPDAMMPLMPLLTVIPLQLLAYHIAVLRGCDVDQP
CCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RNLAKSVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGKKNASPILIDGLKRLEYRGYDSAGIALLNGTLHIHKKKGKVADLEQILPEF
CCCCEECCCCCCCCCEEHHHHHHHHCCCCCCCCEEEEECEEEEEECCCCHHHHHHHHHHC
SDSLTIGIGHTRWATHGEPNDVNAHPHTNEAGDIAVIHNGIIENYGAIRAELQRKGHKFK
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCC
GDTDTEVLAHLIDEIWNEADCDFETAIRLALKEVDGTYGLCAITSREPDKIVTARNGSPL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEE
IIGVGEDEFLIGSDASPIVSHTRKVIYLNDGEMAILTRDSYTIKTIENVTMPKAIDELTF
EEECCCCCEEECCCCCHHHHCCEEEEEEECCCEEEEECCCEEEEEHHCCCCHHHHHHHHH
GIAEIEKAGFDHFMLKEIFEQPEAIENSMRGRALPNEGQVRLGGIREHIDRLRNAKRIII
HHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEECHHHHHHHHHCCCCEEEE
CACGTSWHSGLVGEYLIEEYARIPVEVEYASEFRYRHPILSKDDVVIAISQSGETADTLA
EECCCCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHH
AIREAKAKGALVLGICNVVGSSIARETDCGIYTHAGPEIGVASTKAFTAQVTVLVLLALA
HHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LSQKRTLSDEQTKDIIQDLYQLPKKVQEILNLNEEIFEMAKVFKDARNFLYLGRGFNFPV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCEEEECCCCCCCE
ALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPVVFIANKDSSYQKIISNIEEVRS
EECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHH
RKGRVIVIASEGDNDIDKLAEFVIHIPDAMMPLMPLLTVIPLQLLAYHIAVLRGCDVDQP
CCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RNLAKSVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]