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The map label for this gene is gcvT

Identifier: 193214226

GI number: 193214226

Start: 600681

End: 601769

Strand: Direct

Name: gcvT

Synonym: Ctha_0507

Alternate gene names: 193214226

Gene position: 600681-601769 (Clockwise)

Preceding gene: 193214224

Following gene: 193214227

Centisome position: 18.24

GC content: 43.71

Gene sequence:

>1089_bases
ATGAAATACACGCCATTACATAAAATTCATCAACAGCTTGGGGCAAAATTGGTTGATTTTGCCGGCTTTGAAATGCCCGT
TCAATATGACGGAATCCTGGTTGAGCACAAAGCAGTCAGAGAGGCCGTTGGGCTATTTGATGTCTCGCACATGGGCGAGT
TTGAAGTCAAAGGAAAAGGGGCGAAAGCGTTCCTTCAAAACATGACAACAAACGACGTTGAAAGCCTTTGCGACGGCAAA
GCCCAATACTCGCTATTGCTCTATGAAGATGGCGGGGTTGTTGATGATCTGCTCGTATATAAAATTGCCGACGAGCACTA
TTTTTTAATTGTCAATGCAAGCAATATTGAAAAGGATTTCGATTGGCTAAAACAACACCAACCTGATGATGAGGTTGTTT
TGGAAAATCGCTCCGATGAGCTTTCACTTATTGCCATTCAAGGGCCAAAAGCGGAAGCCGTTTTGTCGAAACTCACCGAT
GTGCCACTGGATGCCATCAAGTATTATCACTTCGTATTTGGCGATGTTTGTGGCAAGCGTACCCTGATTTCACGCACAGG
CTACACTGGCGAAGCTGGCTTTGAACTTTGCATGGCAAACGAGCACGCTGAAGAAATTTGGCACGCCCTTATCGAAGCAG
GCCTGCCATTTGGCATTGTCCCCGTAGGGCTTGGCGCTCGCGATACGCTTCGTCTTGAAATGGGATATAGCTTATACGGT
CACGAGATTGATCACCAAACCAATCCCTATGAAGCGCAATTAGGCTGGATTACAAAACTGCAAAAAGGTGATTTTATTGG
AAAAAATGCCTGCGTCGAGAAAAAATTGCATTTGGAACAAACGCTGGTTGGATTTACTTTAACCGGAAAAAACATTCCTC
GTCAAGGCTATAAAATCCAAGACTTAAGTGGGACAGACATAGGCGTTGTTTGTAGTGGAACGCTCTCCCCAACTTTGGGA
AAGCCGATTGGAACAGGATATGTAAAATCTTCATTTTCAAAAATTGACTCGAAAGTTTATATAAACATCAGAGGAAAATT
ACAAGAAGCAGCGGTGGTAAAAGTACCGTTTCTCCATAAAAACCGGTAA

Upstream 100 bases:

>100_bases
ATTGCATAAAATTTCGTATCTTCGTCTCCCCATAGGGAAAGGCTAAATTATTGTTATTTTTTTCATTATTAGCGACGGTG
AAAACATTTTGTTGACTCGA

Downstream 100 bases:

>100_bases
GGGTGATATAGAGAACGAAAAAAAATTTTATAAAATCACCAAAAAACTTGACTAATGAAAGTTGACGTTTTTTTAACCCC
TGCTGGGATTGATGAGCATC

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKYTPLHKIHQQLGAKLVDFAGFEMPVQYDGILVEHKAVREAVGLFDVSHMGEFEVKGKGAKAFLQNMTTNDVESLCDGK
AQYSLLLYEDGGVVDDLLVYKIADEHYFLIVNASNIEKDFDWLKQHQPDDEVVLENRSDELSLIAIQGPKAEAVLSKLTD
VPLDAIKYYHFVFGDVCGKRTLISRTGYTGEAGFELCMANEHAEEIWHALIEAGLPFGIVPVGLGARDTLRLEMGYSLYG
HEIDHQTNPYEAQLGWITKLQKGDFIGKNACVEKKLHLEQTLVGFTLTGKNIPRQGYKIQDLSGTDIGVVCSGTLSPTLG
KPIGTGYVKSSFSKIDSKVYINIRGKLQEAAVVKVPFLHKNR

Sequences:

>Translated_362_residues
MKYTPLHKIHQQLGAKLVDFAGFEMPVQYDGILVEHKAVREAVGLFDVSHMGEFEVKGKGAKAFLQNMTTNDVESLCDGK
AQYSLLLYEDGGVVDDLLVYKIADEHYFLIVNASNIEKDFDWLKQHQPDDEVVLENRSDELSLIAIQGPKAEAVLSKLTD
VPLDAIKYYHFVFGDVCGKRTLISRTGYTGEAGFELCMANEHAEEIWHALIEAGLPFGIVPVGLGARDTLRLEMGYSLYG
HEIDHQTNPYEAQLGWITKLQKGDFIGKNACVEKKLHLEQTLVGFTLTGKNIPRQGYKIQDLSGTDIGVVCSGTLSPTLG
KPIGTGYVKSSFSKIDSKVYINIRGKLQEAAVVKVPFLHKNR
>Mature_362_residues
MKYTPLHKIHQQLGAKLVDFAGFEMPVQYDGILVEHKAVREAVGLFDVSHMGEFEVKGKGAKAFLQNMTTNDVESLCDGK
AQYSLLLYEDGGVVDDLLVYKIADEHYFLIVNASNIEKDFDWLKQHQPDDEVVLENRSDELSLIAIQGPKAEAVLSKLTD
VPLDAIKYYHFVFGDVCGKRTLISRTGYTGEAGFELCMANEHAEEIWHALIEAGLPFGIVPVGLGARDTLRLEMGYSLYG
HEIDHQTNPYEAQLGWITKLQKGDFIGKNACVEKKLHLEQTLVGFTLTGKNIPRQGYKIQDLSGTDIGVVCSGTLSPTLG
KPIGTGYVKSSFSKIDSKVYINIRGKLQEAAVVKVPFLHKNR

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=33.2409972299169, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=30.7277628032345, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI257796256, Length=315, Percent_Identity=33.015873015873, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI24797151, Length=342, Percent_Identity=28.9473684210526, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI194306651, Length=262, Percent_Identity=29.0076335877863, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI197927446, Length=331, Percent_Identity=26.5861027190332, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI21361378, Length=331, Percent_Identity=26.5861027190332, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=39.1304347826087, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=36.096256684492, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71994045, Length=363, Percent_Identity=25.6198347107438, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994052, Length=363, Percent_Identity=25.6198347107438, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32563613, Length=316, Percent_Identity=23.4177215189873, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=35.0649350649351, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=34.9206349206349, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28571104, Length=264, Percent_Identity=29.5454545454545, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI20130091, Length=337, Percent_Identity=25.5192878338279, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_CHLT3 (B3QV24)

Other databases:

- EMBL:   CP001100
- RefSeq:   YP_001995425.1
- ProteinModelPortal:   B3QV24
- GeneID:   6421551
- GenomeReviews:   CP001100_GR
- KEGG:   cts:Ctha_0507
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40180; Mature: 40180

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTPLHKIHQQLGAKLVDFAGFEMPVQYDGILVEHKAVREAVGLFDVSHMGEFEVKGKG
CCCCCHHHHHHHHCCCEEHHCCCCCCEEECCEEEEHHHHHHHHHHHHHCCCCCEEECCCC
AKAFLQNMTTNDVESLCDGKAQYSLLLYEDGGVVDDLLVYKIADEHYFLIVNASNIEKDF
HHHHHHCCCCHHHHHHHCCCCEEEEEEEECCCCHHHEEEEEEECCEEEEEEECCCCCHHH
DWLKQHQPDDEVVLENRSDELSLIAIQGPKAEAVLSKLTDVPLDAIKYYHFVFGDVCGKR
HHHHHCCCCCCEEEECCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
TLISRTGYTGEAGFELCMANEHAEEIWHALIEAGLPFGIVPVGLGARDTLRLEMGYSLYG
EEEECCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCEEEC
HEIDHQTNPYEAQLGWITKLQKGDFIGKNACVEKKLHLEQTLVGFTLTGKNIPRQGYKIQ
CCCCCCCCCCEEHHHHHEEECCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCEEE
DLSGTDIGVVCSGTLSPTLGKPIGTGYVKSSFSKIDSKVYINIRGKLQEAAVVKVPFLHK
ECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCEEC
NR
CC
>Mature Secondary Structure
MKYTPLHKIHQQLGAKLVDFAGFEMPVQYDGILVEHKAVREAVGLFDVSHMGEFEVKGKG
CCCCCHHHHHHHHCCCEEHHCCCCCCEEECCEEEEHHHHHHHHHHHHHCCCCCEEECCCC
AKAFLQNMTTNDVESLCDGKAQYSLLLYEDGGVVDDLLVYKIADEHYFLIVNASNIEKDF
HHHHHHCCCCHHHHHHHCCCCEEEEEEEECCCCHHHEEEEEEECCEEEEEEECCCCCHHH
DWLKQHQPDDEVVLENRSDELSLIAIQGPKAEAVLSKLTDVPLDAIKYYHFVFGDVCGKR
HHHHHCCCCCCEEEECCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
TLISRTGYTGEAGFELCMANEHAEEIWHALIEAGLPFGIVPVGLGARDTLRLEMGYSLYG
EEEECCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCEEEC
HEIDHQTNPYEAQLGWITKLQKGDFIGKNACVEKKLHLEQTLVGFTLTGKNIPRQGYKIQ
CCCCCCCCCCEEHHHHHEEECCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCEEE
DLSGTDIGVVCSGTLSPTLGKPIGTGYVKSSFSKIDSKVYINIRGKLQEAAVVKVPFLHK
ECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCEEC
NR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA