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The map label for this gene is acsA [H]

Identifier: 193214180

GI number: 193214180

Start: 541289

End: 543121

Strand: Direct

Name: acsA [H]

Synonym: Ctha_0461

Alternate gene names: 193214180

Gene position: 541289-543121 (Clockwise)

Preceding gene: 193214174

Following gene: 193214181

Centisome position: 16.44

GC content: 50.25

Gene sequence:

>1833_bases
ATGATCAACATCACCGAAACAAACCGCTTGATAAAACCGCCAGCTTATTTACGCGACGCCGCCCATATTCAAAACTACGA
ATCCACTTATGCGCGATCGATTGAAAACCCGGATGCGTTCTGGGACGAAATCGCTTCAGGGTTCATCTGGGAAAATAAAT
GGACGAAAGTTTGTGAGGTTCAACCGCCCTATCATCGTTGGTTTGTGGGTGGAACGACCAACATCACGCTAAACATGTTA
GACCGGCATATTGTCGGCCATCGGAGAAACAAAGTGGCGCTGCTTTGGGCATCTGAAAACGGACGAGAAGTTGTCGTCAC
TTACGATCGATTGCTTCGGCGCGTTTGCCAGCTGGCCAATGCGTTGACGATGAGTGGGGTTCGAAAAGGCGACACGGTTT
TAATTTATATGCCGAACACGGTGGAGTTCGTGTATGCGATGCTGGCTTGTGCGAGAATCGGTGCGATTCACGCTTCCGTT
CATACAGGTTTAGGTGTGCAAGCCTTGCGCGAACGCATTGAATCGGTTCGTCCAAAAGTGGTCTTTTGTGCCGACGCCAC
GCTCAGCGGCGGAAAAGTGATCGCTTTAAAACCGATGCTGGACGACGCGCTTCAAGGGAACGATTGCGTTGAAAAAATCG
TGGTTTTGCGCCGTCAAGAACCCAAAATTGAACTTTACTCTGGCCTTGAAGTTGATTTTTATGACTTCTTAATCGGAATG
CCTCAATGGATAAATCCTGAAATTGTGGAATCCTCGCATCCATTGTTTGTGTACTTCACGACGGACGCCGCCGGTGCGCC
AAAAGGAATCGTACAAGCCCAAGGCGGATACATGGTTGGCTCGGCATATTACACACGCATTTTCTTTGATTTGCAAGATT
CCGATATTTTGTGGAACACCTCCGATTTGAGCTGGATAACGGGTCACACAAACGGCATTTACGGGCCGCTCTTGAACGGC
GCAACCCTCTATTTCCGCGAAGGCGCATTGACAACCCCAAACACTGAAGCAACTTGGGCGGCGATCGAACGACATGGCAT
TAACATTCTTTCCACCATGCCCACAACACTTCGCATTTTAAAATCCTTTGGCGCTGCGTTTTCGGAAAAATATGATTTAT
CCACGCTTCGGCTGGTTGCATCTACTGGAGAACCGCTGCCTGCGGAGCTTTATAGTTGGGCATCGGAATTTGTGGCTGGG
CGAAATGGCTTTGTGGCCAATAGTTGGTGGGAAGCCGAGCTTGGCGCGCCGATGCTCGGCACGCTCATGGCAAACGAGGC
CAAACTGAACTTCGTTGGAAAGCCATTTCCTGGCGTTGCGTTGGAAGTGGTGCAAACCGACGGTTCATCAGCCGCGCCAA
ATCAACCGGGAAAGCTGGCCATTTTGCGTCCTGTCCCAACGATGCTTAGTGAAACCTGGCAAAACCAGGAACAATATTCT
GCTTATTGGTCGCAAATTCCAGGTCGGTTTGCAACCGGCGACGATGCGCTGAAAGATGAAGATGGATTTTTTGCCATTTT
AGGCCGTCACGACGATGCGCTCATCATTGGCGGATTTCGAATCGGAGTACATGAAATTGAACAGACACTCGCCAAACATC
CAGCGGTCAAAGAAGCGGCGATCTTTGGCGTGCCGGATAGCGTCACTGGAACGAAACTCAAAGCTTGGGTTGTGCTGCAT
CAAGAAACATCTGCGCCTGAACGCACGCGCTCAATGCTCTATGGATATATTTTTCATGAACTGGGCAGAATGGCTGTGCC
TGGCGAAATTGTTTTTTGCGATGCGCTGCCTCAACTCGGCGATGGCTCGCGCGCACTGCAACATCCACGATAG

Upstream 100 bases:

>100_bases
TTGCTCGTGTGCTTCGGAATTTTGGCTGCGCGAAACCTGTTTCATTCTGCATAAAAATAGCAACCAGCTTGAGGGAACTT
TATTCAAAAATGCGTCCAAC

Downstream 100 bases:

>100_bases
CCAGTGGACGCCATAACTTCGTATGTTTCTACGTAAAACATTCTGATTTTTTTTAGCAGCGAATGTTATATTAATAGCTC
TTTTTTTTTAATGAACCCTG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MINITETNRLIKPPAYLRDAAHIQNYESTYARSIENPDAFWDEIASGFIWENKWTKVCEVQPPYHRWFVGGTTNITLNML
DRHIVGHRRNKVALLWASENGREVVVTYDRLLRRVCQLANALTMSGVRKGDTVLIYMPNTVEFVYAMLACARIGAIHASV
HTGLGVQALRERIESVRPKVVFCADATLSGGKVIALKPMLDDALQGNDCVEKIVVLRRQEPKIELYSGLEVDFYDFLIGM
PQWINPEIVESSHPLFVYFTTDAAGAPKGIVQAQGGYMVGSAYYTRIFFDLQDSDILWNTSDLSWITGHTNGIYGPLLNG
ATLYFREGALTTPNTEATWAAIERHGINILSTMPTTLRILKSFGAAFSEKYDLSTLRLVASTGEPLPAELYSWASEFVAG
RNGFVANSWWEAELGAPMLGTLMANEAKLNFVGKPFPGVALEVVQTDGSSAAPNQPGKLAILRPVPTMLSETWQNQEQYS
AYWSQIPGRFATGDDALKDEDGFFAILGRHDDALIIGGFRIGVHEIEQTLAKHPAVKEAAIFGVPDSVTGTKLKAWVVLH
QETSAPERTRSMLYGYIFHELGRMAVPGEIVFCDALPQLGDGSRALQHPR

Sequences:

>Translated_610_residues
MINITETNRLIKPPAYLRDAAHIQNYESTYARSIENPDAFWDEIASGFIWENKWTKVCEVQPPYHRWFVGGTTNITLNML
DRHIVGHRRNKVALLWASENGREVVVTYDRLLRRVCQLANALTMSGVRKGDTVLIYMPNTVEFVYAMLACARIGAIHASV
HTGLGVQALRERIESVRPKVVFCADATLSGGKVIALKPMLDDALQGNDCVEKIVVLRRQEPKIELYSGLEVDFYDFLIGM
PQWINPEIVESSHPLFVYFTTDAAGAPKGIVQAQGGYMVGSAYYTRIFFDLQDSDILWNTSDLSWITGHTNGIYGPLLNG
ATLYFREGALTTPNTEATWAAIERHGINILSTMPTTLRILKSFGAAFSEKYDLSTLRLVASTGEPLPAELYSWASEFVAG
RNGFVANSWWEAELGAPMLGTLMANEAKLNFVGKPFPGVALEVVQTDGSSAAPNQPGKLAILRPVPTMLSETWQNQEQYS
AYWSQIPGRFATGDDALKDEDGFFAILGRHDDALIIGGFRIGVHEIEQTLAKHPAVKEAAIFGVPDSVTGTKLKAWVVLH
QETSAPERTRSMLYGYIFHELGRMAVPGEIVFCDALPQLGDGSRALQHPR
>Mature_610_residues
MINITETNRLIKPPAYLRDAAHIQNYESTYARSIENPDAFWDEIASGFIWENKWTKVCEVQPPYHRWFVGGTTNITLNML
DRHIVGHRRNKVALLWASENGREVVVTYDRLLRRVCQLANALTMSGVRKGDTVLIYMPNTVEFVYAMLACARIGAIHASV
HTGLGVQALRERIESVRPKVVFCADATLSGGKVIALKPMLDDALQGNDCVEKIVVLRRQEPKIELYSGLEVDFYDFLIGM
PQWINPEIVESSHPLFVYFTTDAAGAPKGIVQAQGGYMVGSAYYTRIFFDLQDSDILWNTSDLSWITGHTNGIYGPLLNG
ATLYFREGALTTPNTEATWAAIERHGINILSTMPTTLRILKSFGAAFSEKYDLSTLRLVASTGEPLPAELYSWASEFVAG
RNGFVANSWWEAELGAPMLGTLMANEAKLNFVGKPFPGVALEVVQTDGSSAAPNQPGKLAILRPVPTMLSETWQNQEQYS
AYWSQIPGRFATGDDALKDEDGFFAILGRHDDALIIGGFRIGVHEIEQTLAKHPAVKEAAIFGVPDSVTGTKLKAWVVLH
QETSAPERTRSMLYGYIFHELGRMAVPGEIVFCDALPQLGDGSRALQHPR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=587, Percent_Identity=34.0715502555366, Blast_Score=345, Evalue=9e-95,
Organism=Homo sapiens, GI8923896, Length=639, Percent_Identity=32.2378716744914, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI253970489, Length=652, Percent_Identity=31.7484662576687, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI13375727, Length=596, Percent_Identity=31.3758389261745, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI31982927, Length=539, Percent_Identity=27.8293135435993, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI38505220, Length=523, Percent_Identity=25.2390057361377, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI122937307, Length=542, Percent_Identity=25.4612546125461, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI42544132, Length=529, Percent_Identity=23.2514177693762, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI115511026, Length=530, Percent_Identity=24.3396226415094, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI58082049, Length=533, Percent_Identity=24.202626641651, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI157311624, Length=529, Percent_Identity=24.7637051039698, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI157311622, Length=529, Percent_Identity=24.7637051039698, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI195947378, Length=477, Percent_Identity=22.8511530398323, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI156151445, Length=526, Percent_Identity=25.8555133079848, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI187761345, Length=375, Percent_Identity=23.2, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI187761343, Length=375, Percent_Identity=23.2, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1790505, Length=602, Percent_Identity=34.0531561461794, Blast_Score=348, Evalue=6e-97,
Organism=Escherichia coli, GI1786529, Length=596, Percent_Identity=30.7046979865772, Blast_Score=280, Evalue=3e-76,
Organism=Escherichia coli, GI1788107, Length=539, Percent_Identity=24.6753246753247, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786801, Length=464, Percent_Identity=22.6293103448276, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=625, Percent_Identity=30.56, Blast_Score=282, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71982997, Length=617, Percent_Identity=30.7941653160454, Blast_Score=282, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17569507, Length=565, Percent_Identity=23.5398230088496, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=535, Percent_Identity=21.6822429906542, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=532, Percent_Identity=24.0601503759398, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=507, Percent_Identity=22.879684418146, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=494, Percent_Identity=22.6720647773279, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=527, Percent_Identity=21.8216318785579, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=547, Percent_Identity=21.9378427787934, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=600, Percent_Identity=33.3333333333333, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319264, Length=602, Percent_Identity=33.2225913621262, Blast_Score=342, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6319699, Length=307, Percent_Identity=23.7785016286645, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24667955, Length=628, Percent_Identity=31.2101910828025, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI62472339, Length=515, Percent_Identity=32.8155339805825, Blast_Score=285, Evalue=9e-77,
Organism=Drosophila melanogaster, GI21355225, Length=548, Percent_Identity=30.4744525547445, Blast_Score=281, Evalue=8e-76,
Organism=Drosophila melanogaster, GI24667959, Length=484, Percent_Identity=31.404958677686, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI19922652, Length=510, Percent_Identity=23.3333333333333, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24656500, Length=503, Percent_Identity=22.2664015904573, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358303, Length=466, Percent_Identity=23.8197424892704, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648260, Length=507, Percent_Identity=22.6824457593688, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24581924, Length=509, Percent_Identity=22.2003929273084, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648253, Length=490, Percent_Identity=20.8163265306122, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648255, Length=495, Percent_Identity=21.6161616161616, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859661, Length=162, Percent_Identity=30.2469135802469, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 67603; Mature: 67603

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINITETNRLIKPPAYLRDAAHIQNYESTYARSIENPDAFWDEIASGFIWENKWTKVCEV
CEEECCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCCCEEEEC
QPPYHRWFVGGTTNITLNMLDRHIVGHRRNKVALLWASENGREVVVTYDRLLRRVCQLAN
CCCHHEEEECCCCEEEEEEHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHH
ALTMSGVRKGDTVLIYMPNTVEFVYAMLACARIGAIHASVHTGLGVQALRERIESVRPKV
HHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
VFCADATLSGGKVIALKPMLDDALQGNDCVEKIVVLRRQEPKIELYSGLEVDFYDFLIGM
EEEECCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHCC
PQWINPEIVESSHPLFVYFTTDAAGAPKGIVQAQGGYMVGSAYYTRIFFDLQDSDILWNT
CCCCCCHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEECCEEEEEEEEEECCCCEEEEC
SDLSWITGHTNGIYGPLLNGATLYFREGALTTPNTEATWAAIERHGINILSTMPTTLRIL
CCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHH
KSFGAAFSEKYDLSTLRLVASTGEPLPAELYSWASEFVAGRNGFVANSWWEAELGAPMLG
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEECCEECCCCCCCHHH
TLMANEAKLNFVGKPFPGVALEVVQTDGSSAAPNQPGKLAILRPVPTMLSETWQNQEQYS
HHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHCCHHHHH
AYWSQIPGRFATGDDALKDEDGFFAILGRHDDALIIGGFRIGVHEIEQTLAKHPAVKEAA
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEHHHHHHHHHHHHCCCCCHHE
IFGVPDSVTGTKLKAWVVLHQETSAPERTRSMLYGYIFHELGRMAVPGEIVFCDALPQLG
EECCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
DGSRALQHPR
CCCCCCCCCC
>Mature Secondary Structure
MINITETNRLIKPPAYLRDAAHIQNYESTYARSIENPDAFWDEIASGFIWENKWTKVCEV
CEEECCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCCCEEEEC
QPPYHRWFVGGTTNITLNMLDRHIVGHRRNKVALLWASENGREVVVTYDRLLRRVCQLAN
CCCHHEEEECCCCEEEEEEHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHH
ALTMSGVRKGDTVLIYMPNTVEFVYAMLACARIGAIHASVHTGLGVQALRERIESVRPKV
HHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
VFCADATLSGGKVIALKPMLDDALQGNDCVEKIVVLRRQEPKIELYSGLEVDFYDFLIGM
EEEECCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHCC
PQWINPEIVESSHPLFVYFTTDAAGAPKGIVQAQGGYMVGSAYYTRIFFDLQDSDILWNT
CCCCCCHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEECCEEEEEEEEEECCCCEEEEC
SDLSWITGHTNGIYGPLLNGATLYFREGALTTPNTEATWAAIERHGINILSTMPTTLRIL
CCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHH
KSFGAAFSEKYDLSTLRLVASTGEPLPAELYSWASEFVAGRNGFVANSWWEAELGAPMLG
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEECCEECCCCCCCHHH
TLMANEAKLNFVGKPFPGVALEVVQTDGSSAAPNQPGKLAILRPVPTMLSETWQNQEQYS
HHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHCCHHHHH
AYWSQIPGRFATGDDALKDEDGFFAILGRHDDALIIGGFRIGVHEIEQTLAKHPAVKEAA
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEHHHHHHHHHHHHCCCCCHHE
IFGVPDSVTGTKLKAWVVLHQETSAPERTRSMLYGYIFHELGRMAVPGEIVFCDALPQLG
EECCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
DGSRALQHPR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]