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The map label for this gene is fdh [H]

Identifier: 192290754

GI number: 192290754

Start: 2554537

End: 2555706

Strand: Reverse

Name: fdh [H]

Synonym: Rpal_2370

Alternate gene names: 192290754

Gene position: 2555706-2554537 (Counterclockwise)

Preceding gene: 192290756

Following gene: 192290752

Centisome position: 44.49

GC content: 63.16

Gene sequence:

>1170_bases
ATGAAAGCTCTGACCTGGCACGGCAAGAACGACATCCGCTGCGAGAACGTGCCGGATCCGAAAATCCAACACGGCCGCGA
TGCGATCATCAAGGTGACGGCGTGCGCGATCTGCGGTTCGGACCTGCACCTGATGGACGGCGTCATGCCGTCGATGCAGA
GCGGTGACGTGCTCGGTCACGAGACCATGGGTGAAGTCGTCGAGGTCGGCTCCGAGAATACCAAGCTGAAGGTCGGCGAT
CGCGTGGTGGTTCCGTTTACGATCTCCTGCGGCGAGTGCTTCTTCTGTCAGCGCGGCTTCTATTCAGGCTGCGAGCGATC
GAACCCGAACGCCAAGATGGCCGAGAAGATGTGGGGCCATTCGCCGGCCGGCCTGTTCGGCTATTCGCACATGCTCGGCG
GCTATGCGGGAGGCCAGGCCGAGTATCTGCGTATCCCTTACGCAGATGTCGGGCCGATCAAGGTGCCGGATGGTTTGACC
GACGAACAGGTGCTGTTCCTGTCCGACATCTTCCCCACCGGCTTCATGGCGGCGGACTTCTGCAACCTGAAGGGCGGCGA
GACCGTCGCGGTGTGGGGCTGCGGCCCGGTCGGACAGATGGCGATCAAGAGCGCCTTCCTGCTCGGCGCCGAGCGTGTGA
TCGCGATCGACACCGTGCCGGAGCGGATGGAATTAGCGCGGCAGTCCGGCGCGATCGTCATCAACTTCATGGACGACGAC
GTCTATGACAAGATCCAGGATCTCACCAACGGCCGCGGCGCCGACGCCTGCATCGACGCGGTCGGAACCGAAGCCGCCGC
GACCGCGAGCCTCGACTCGATGATCGACCGCGTGAAAGTGGCGACCTTCATGGGCACCGACAGGCCGCACGTGCTGCGCC
AGGCGATCCACTGCTGCCGCAACTTCGGCACGGTGTCGATCGTCGGCGTTTATGGCGGGCTGCTCGACAAGATCCCGATG
GGCTCGGCCATCAACAGAGGCCTGACGATGCGGATGGCGCAGACCCCGGTGCAACACTATCTGCCGCAACTGCTCGGCCG
TATCCAACAGGGCGAGATCGACCCGTCCTTCGTGATCACCCACCGCGCTACGCTCGACGAAGGCCCAGAACTCTACAAGA
CCTTCCGCGACAAGAAGGACGGCTGCATCAAGGTGGTGATGAGGCCGTAA

Upstream 100 bases:

>100_bases
CGAGCGATGGCAGCCAAGAGGGATACTCCCTCGTCAGCAGCGCAGGAACATCCGAACGGCCGAGGCTTTCTCCCTCACCA
TTCACGACGAGGGACCGCAG

Downstream 100 bases:

>100_bases
GCGACGTCTGGACGTCGCCGAACGATCTCGCTCATGATGGCCGGGCCTTGTCCCGGCCATCTACGTCCTTTCACTTGTCG
ACATAGCGACGCATTGGATG

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKALTWHGKNDIRCENVPDPKIQHGRDAIIKVTACAICGSDLHLMDGVMPSMQSGDVLGHETMGEVVEVGSENTKLKVGD
RVVVPFTISCGECFFCQRGFYSGCERSNPNAKMAEKMWGHSPAGLFGYSHMLGGYAGGQAEYLRIPYADVGPIKVPDGLT
DEQVLFLSDIFPTGFMAADFCNLKGGETVAVWGCGPVGQMAIKSAFLLGAERVIAIDTVPERMELARQSGAIVINFMDDD
VYDKIQDLTNGRGADACIDAVGTEAAATASLDSMIDRVKVATFMGTDRPHVLRQAIHCCRNFGTVSIVGVYGGLLDKIPM
GSAINRGLTMRMAQTPVQHYLPQLLGRIQQGEIDPSFVITHRATLDEGPELYKTFRDKKDGCIKVVMRP

Sequences:

>Translated_389_residues
MKALTWHGKNDIRCENVPDPKIQHGRDAIIKVTACAICGSDLHLMDGVMPSMQSGDVLGHETMGEVVEVGSENTKLKVGD
RVVVPFTISCGECFFCQRGFYSGCERSNPNAKMAEKMWGHSPAGLFGYSHMLGGYAGGQAEYLRIPYADVGPIKVPDGLT
DEQVLFLSDIFPTGFMAADFCNLKGGETVAVWGCGPVGQMAIKSAFLLGAERVIAIDTVPERMELARQSGAIVINFMDDD
VYDKIQDLTNGRGADACIDAVGTEAAATASLDSMIDRVKVATFMGTDRPHVLRQAIHCCRNFGTVSIVGVYGGLLDKIPM
GSAINRGLTMRMAQTPVQHYLPQLLGRIQQGEIDPSFVITHRATLDEGPELYKTFRDKKDGCIKVVMRP
>Mature_389_residues
MKALTWHGKNDIRCENVPDPKIQHGRDAIIKVTACAICGSDLHLMDGVMPSMQSGDVLGHETMGEVVEVGSENTKLKVGD
RVVVPFTISCGECFFCQRGFYSGCERSNPNAKMAEKMWGHSPAGLFGYSHMLGGYAGGQAEYLRIPYADVGPIKVPDGLT
DEQVLFLSDIFPTGFMAADFCNLKGGETVAVWGCGPVGQMAIKSAFLLGAERVIAIDTVPERMELARQSGAIVINFMDDD
VYDKIQDLTNGRGADACIDAVGTEAAATASLDSMIDRVKVATFMGTDRPHVLRQAIHCCRNFGTVSIVGVYGGLLDKIPM
GSAINRGLTMRMAQTPVQHYLPQLLGRIQQGEIDPSFVITHRATLDEGPELYKTFRDKKDGCIKVVMRP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=382, Percent_Identity=25.9162303664921, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=26.2872628726287, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71565154, Length=289, Percent_Identity=28.3737024221453, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71565152, Length=295, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI34577061, Length=278, Percent_Identity=29.4964028776978, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501929, Length=278, Percent_Identity=29.8561151079137, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501933, Length=278, Percent_Identity=28.7769784172662, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI71743840, Length=313, Percent_Identity=27.7955271565495, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI262073058, Length=313, Percent_Identity=27.7955271565495, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=44.7837150127226, Blast_Score=334, Evalue=5e-93,
Organism=Escherichia coli, GI87082125, Length=280, Percent_Identity=31.7857142857143, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790045, Length=398, Percent_Identity=28.643216080402, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788073, Length=390, Percent_Identity=25.8974358974359, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI226510992, Length=373, Percent_Identity=24.6648793565684, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=232, Percent_Identity=34.051724137931, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=29.5392953929539, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788075, Length=395, Percent_Identity=26.5822784810127, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787863, Length=391, Percent_Identity=21.9948849104859, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788407, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790718, Length=217, Percent_Identity=24.4239631336406, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=390, Percent_Identity=26.1538461538462, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=247, Percent_Identity=30.3643724696356, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=384, Percent_Identity=26.0416666666667, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=383, Percent_Identity=25.3263707571802, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=366, Percent_Identity=25.1366120218579, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=302, Percent_Identity=29.1390728476821, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=408, Percent_Identity=26.4705882352941, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=365, Percent_Identity=26.5753424657534, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=371, Percent_Identity=25.6064690026954, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=352, Percent_Identity=25.5681818181818, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=392, Percent_Identity=25.5102040816327, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137530, Length=392, Percent_Identity=25.2551020408163, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737895, Length=283, Percent_Identity=30.3886925795053, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42187; Mature: 42187

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTWHGKNDIRCENVPDPKIQHGRDAIIKVTACAICGSDLHLMDGVMPSMQSGDVLGH
CCCEEECCCCCCCCCCCCCCCHHCCCCCEEEEEEHHHCCCCHHHHHCCCCCCCCCCCCCH
ETMGEVVEVGSENTKLKVGDRVVVPFTISCGECFFCQRGFYSGCERSNPNAKMAEKMWGH
HHHHHHHHCCCCCCEEEECCEEEEEEEECCCCEEEECCCHHCCCCCCCCCHHHHHHHCCC
SPAGLFGYSHMLGGYAGGQAEYLRIPYADVGPIKVPDGLTDEQVLFLSDIFPTGFMAADF
CCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCCCCCEEEEEHHCCCCHHHHHH
CNLKGGETVAVWGCGPVGQMAIKSAFLLGAERVIAIDTVPERMELARQSGAIVINFMDDD
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCEEEEECCCH
VYDKIQDLTNGRGADACIDAVGTEAAATASLDSMIDRVKVATFMGTDRPHVLRQAIHCCR
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NFGTVSIVGVYGGLLDKIPMGSAINRGLTMRMAQTPVQHYLPQLLGRIQQGEIDPSFVIT
CCCCEEEEEHHHHHHHHCCCCHHHHCCEEEHHHHCCHHHHHHHHHHHHHCCCCCCCEEEE
HRATLDEGPELYKTFRDKKDGCIKVVMRP
EECCCCCCHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKALTWHGKNDIRCENVPDPKIQHGRDAIIKVTACAICGSDLHLMDGVMPSMQSGDVLGH
CCCEEECCCCCCCCCCCCCCCHHCCCCCEEEEEEHHHCCCCHHHHHCCCCCCCCCCCCCH
ETMGEVVEVGSENTKLKVGDRVVVPFTISCGECFFCQRGFYSGCERSNPNAKMAEKMWGH
HHHHHHHHCCCCCCEEEECCEEEEEEEECCCCEEEECCCHHCCCCCCCCCHHHHHHHCCC
SPAGLFGYSHMLGGYAGGQAEYLRIPYADVGPIKVPDGLTDEQVLFLSDIFPTGFMAADF
CCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCCCCCEEEEEHHCCCCHHHHHH
CNLKGGETVAVWGCGPVGQMAIKSAFLLGAERVIAIDTVPERMELARQSGAIVINFMDDD
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCEEEEECCCH
VYDKIQDLTNGRGADACIDAVGTEAAATASLDSMIDRVKVATFMGTDRPHVLRQAIHCCR
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NFGTVSIVGVYGGLLDKIPMGSAINRGLTMRMAQTPVQHYLPQLLGRIQQGEIDPSFVIT
CCCCEEEEEHHHHHHHHCCCCHHHHCCEEEHHHHCCHHHHHHHHHHHHHCCCCCCCEEEE
HRATLDEGPELYKTFRDKKDGCIKVVMRP
EECCCCCCHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]