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The map label for this gene is kefC [H]

Identifier: 192290390

GI number: 192290390

Start: 2159141

End: 2160871

Strand: Reverse

Name: kefC [H]

Synonym: Rpal_1997

Alternate gene names: 192290390

Gene position: 2160871-2159141 (Counterclockwise)

Preceding gene: 192290393

Following gene: 192290388

Centisome position: 37.62

GC content: 64.93

Gene sequence:

>1731_bases
ATGCACGAACTGATTGGCGATATCACGCTGAGCATCCTGTTCGCCTGGCTGCTCGGACTGGCGGCGCATTTTTTCCGTCA
GCCATTGATCCTCGCCTACCTTATCGGCGGTTTCGTCATCGGTCCATTCGGCCTTGGCTGGGTGAAATCCGAGAACTCGA
TCTCGGTGATCTCCGAGCTCGGGCTGATCTTCATGCTGTTCATGATCGGTCTCGAGATCGATCTGAAGAAGATCATCCGG
GCTGGTCCCGTTATCCTGGTGGCGGCCGGCGGACAGATCGCCGGCGGCGTGCTGCTCGGCCTCGCCTTCTTCGTCGGCAT
CGGCCTTAGTCTCGGCGGCGGCCATTTTGACGCGCTGTATCTGACGGTGGCGTGCGCGCTGTCCTCCACCGTGATCATCG
TCAAGGTGCTGTACGAGAAGCGCGAGCTCGACACCCTGCCCGGCCGCATCACGCTCGGCATCCTGGTGCTGCAGGACATC
TTCGCGATCCTGTTCTTGGCGGTGCAGCCAAGTCTCGCCGACCTGCAGATCTCGGTGCTGCTGCTGTCGATCGCGCGGGT
CGTCGCGCTGGTCGCCACTGCGCTGGCGCTGTCGCGCTACGTGCTGCCCTGGCTGTTTCACCGCATTGCCCGCACGCCCG
AACTGGTGCTTCTCGGCGCATTGGCGTGGTGCTTCCTGATCGGCGAAATCGCCGAGCGGCTGCATCTGTCGCGCGAGATG
GGCGCACTGGTCGCCGGCGTGTCGCTGTCGACCTTCCCCTACGCGCTCGACGTCACCGCCAAGGTGACGACGCTGCGGGA
CTTCTTCATCACGCTGTTCTTCGTCGCGCTCGGCATGACGATCCCGATCCCGAACGGCTCGGTGATCGGACTGGCGCTGG
CGATCGCGGTATTCACGCTGGCGAGCCGGCTGCTCACCACCTTCCTGCCGCTGTATCTGATGAAGCAGGGCCTGCGTGCC
AGCCTGCTGCCGGCGCTGAACCTGGCGCAGATCAGCGAGTTCTCGCTGGTGGTGATCCAGACCGGCGTCGCCGCCGGACA
TATCGGCACCCAGACCGCGAGCGCGGCGTCGTTCGCTTTCGTGCTCCTGGCGGTGCTGTCGACCTTCGTGATCATGCGCA
GCGATCCGATCACCCGCCGCGCGATCGGGACACTGACCAAATTCGGCTTCCGTGATCTCGGCCAGCAGCAGAGCGGCGCC
GAGGCCGCCGCCGAGGCTGGCCATGGCGCGGTGCATCGCATCGTGATCCTGGGCTTCTTCCGCGCCGCCAGCGCGCTGGT
CAGCGAGATCGAGCAGCACACCCCGGAGCTGCTCAAGCAGATCAGCGTGATCGACTTCAACCCGATGGTGTATCGCACCC
TCACCGAGCGTGGCATGCACGTGATCTACGGCGATATCAGCAACGTCGACACGCTGCTGCACGCCGGCGTCGCCAAGGCC
GAGATCATCATTCTCAGCGTGCCGGACTCGCTGCTGAAGGGCGCCACCAACGAACGGCTGGTGCGCCACGTCCGCGCGCT
CAATCCCAACGCACAGATCGTCGCAACCGCCGACCTGCTCGCCGATGTCGAGGCGATGTATCAGGCGGGTGCGGACTACG
TCACCGTCACCCGGCTGGCCGACGCCCGCGAGCTGTTCGAAGTGATCGAAGCCGCCGACAATGGCCTGCTGTCCGATAAG
CGCGCCGCCCTCGACGCCCGTCTCGCCGAGCGCCGGGAAGTATTGCCGTAA

Upstream 100 bases:

>100_bases
CGTAATGGCGTCTCGTTCCGCGAGCCAGGCTCCCGATGCATTGTCTCAGCATGGCTGTCCCTTTAGTGTTCGCGCCAAGG
CATTCCACGGCGGAAGGTGC

Downstream 100 bases:

>100_bases
CGCTATCGCGCGGGCGAATTCGCCTCACAATTGCGCCGACAAAAGATACGGCCTAGCGCCACTCGGCGCTAACTTGTCGA
CCCATGCGATCACAACGGTC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MHELIGDITLSILFAWLLGLAAHFFRQPLILAYLIGGFVIGPFGLGWVKSENSISVISELGLIFMLFMIGLEIDLKKIIR
AGPVILVAAGGQIAGGVLLGLAFFVGIGLSLGGGHFDALYLTVACALSSTVIIVKVLYEKRELDTLPGRITLGILVLQDI
FAILFLAVQPSLADLQISVLLLSIARVVALVATALALSRYVLPWLFHRIARTPELVLLGALAWCFLIGEIAERLHLSREM
GALVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALAIAVFTLASRLLTTFLPLYLMKQGLRA
SLLPALNLAQISEFSLVVIQTGVAAGHIGTQTASAASFAFVLLAVLSTFVIMRSDPITRRAIGTLTKFGFRDLGQQQSGA
EAAAEAGHGAVHRIVILGFFRAASALVSEIEQHTPELLKQISVIDFNPMVYRTLTERGMHVIYGDISNVDTLLHAGVAKA
EIIILSVPDSLLKGATNERLVRHVRALNPNAQIVATADLLADVEAMYQAGADYVTVTRLADARELFEVIEAADNGLLSDK
RAALDARLAERREVLP

Sequences:

>Translated_576_residues
MHELIGDITLSILFAWLLGLAAHFFRQPLILAYLIGGFVIGPFGLGWVKSENSISVISELGLIFMLFMIGLEIDLKKIIR
AGPVILVAAGGQIAGGVLLGLAFFVGIGLSLGGGHFDALYLTVACALSSTVIIVKVLYEKRELDTLPGRITLGILVLQDI
FAILFLAVQPSLADLQISVLLLSIARVVALVATALALSRYVLPWLFHRIARTPELVLLGALAWCFLIGEIAERLHLSREM
GALVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALAIAVFTLASRLLTTFLPLYLMKQGLRA
SLLPALNLAQISEFSLVVIQTGVAAGHIGTQTASAASFAFVLLAVLSTFVIMRSDPITRRAIGTLTKFGFRDLGQQQSGA
EAAAEAGHGAVHRIVILGFFRAASALVSEIEQHTPELLKQISVIDFNPMVYRTLTERGMHVIYGDISNVDTLLHAGVAKA
EIIILSVPDSLLKGATNERLVRHVRALNPNAQIVATADLLADVEAMYQAGADYVTVTRLADARELFEVIEAADNGLLSDK
RAALDARLAERREVLP
>Mature_576_residues
MHELIGDITLSILFAWLLGLAAHFFRQPLILAYLIGGFVIGPFGLGWVKSENSISVISELGLIFMLFMIGLEIDLKKIIR
AGPVILVAAGGQIAGGVLLGLAFFVGIGLSLGGGHFDALYLTVACALSSTVIIVKVLYEKRELDTLPGRITLGILVLQDI
FAILFLAVQPSLADLQISVLLLSIARVVALVATALALSRYVLPWLFHRIARTPELVLLGALAWCFLIGEIAERLHLSREM
GALVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALAIAVFTLASRLLTTFLPLYLMKQGLRA
SLLPALNLAQISEFSLVVIQTGVAAGHIGTQTASAASFAFVLLAVLSTFVIMRSDPITRRAIGTLTKFGFRDLGQQQSGA
EAAAEAGHGAVHRIVILGFFRAASALVSEIEQHTPELLKQISVIDFNPMVYRTLTERGMHVIYGDISNVDTLLHAGVAKA
EIIILSVPDSLLKGATNERLVRHVRALNPNAQIVATADLLADVEAMYQAGADYVTVTRLADARELFEVIEAADNGLLSDK
RAALDARLAERREVLP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=387, Percent_Identity=25.8397932816537, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786232, Length=555, Percent_Identity=30.6306306306306, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786685, Length=578, Percent_Identity=26.8166089965398, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789749, Length=536, Percent_Identity=24.4402985074627, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 61815; Mature: 61815

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELIGDITLSILFAWLLGLAAHFFRQPLILAYLIGGFVIGPFGLGWVKSENSISVISEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHH
GLIFMLFMIGLEIDLKKIIRAGPVILVAAGGQIAGGVLLGLAFFVGIGLSLGGGHFDALY
HHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LTVACALSSTVIIVKVLYEKRELDTLPGRITLGILVLQDIFAILFLAVQPSLADLQISVL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LLSIARVVALVATALALSRYVLPWLFHRIARTPELVLLGALAWCFLIGEIAERLHLSREM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALAIAVFTL
HHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHH
ASRLLTTFLPLYLMKQGLRASLLPALNLAQISEFSLVVIQTGVAAGHIGTQTASAASFAF
HHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHH
VLLAVLSTFVIMRSDPITRRAIGTLTKFGFRDLGQQQSGAEAAAEAGHGAVHRIVILGFF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHH
RAASALVSEIEQHTPELLKQISVIDFNPMVYRTLTERGMHVIYGDISNVDTLLHAGVAKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCEE
EIIILSVPDSLLKGATNERLVRHVRALNPNAQIVATADLLADVEAMYQAGADYVTVTRLA
EEEEEECCHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCEEEHHHHH
DARELFEVIEAADNGLLSDKRAALDARLAERREVLP
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHELIGDITLSILFAWLLGLAAHFFRQPLILAYLIGGFVIGPFGLGWVKSENSISVISEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHH
GLIFMLFMIGLEIDLKKIIRAGPVILVAAGGQIAGGVLLGLAFFVGIGLSLGGGHFDALY
HHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LTVACALSSTVIIVKVLYEKRELDTLPGRITLGILVLQDIFAILFLAVQPSLADLQISVL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LLSIARVVALVATALALSRYVLPWLFHRIARTPELVLLGALAWCFLIGEIAERLHLSREM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALAIAVFTL
HHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHH
ASRLLTTFLPLYLMKQGLRASLLPALNLAQISEFSLVVIQTGVAAGHIGTQTASAASFAF
HHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHH
VLLAVLSTFVIMRSDPITRRAIGTLTKFGFRDLGQQQSGAEAAAEAGHGAVHRIVILGFF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHH
RAASALVSEIEQHTPELLKQISVIDFNPMVYRTLTERGMHVIYGDISNVDTLLHAGVAKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCEE
EIIILSVPDSLLKGATNERLVRHVRALNPNAQIVATADLLADVEAMYQAGADYVTVTRLA
EEEEEECCHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCEEEHHHHH
DARELFEVIEAADNGLLSDKRAALDARLAERREVLP
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA