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The map label for this gene is fadA [H]

Identifier: 192290296

GI number: 192290296

Start: 2050622

End: 2051797

Strand: Reverse

Name: fadA [H]

Synonym: Rpal_1903

Alternate gene names: 192290296

Gene position: 2051797-2050622 (Counterclockwise)

Preceding gene: 192290305

Following gene: 192290295

Centisome position: 35.72

GC content: 65.39

Gene sequence:

>1176_bases
ATGGCCGAGGCCTATATCGTCGCTGCCGCTCGCACTGCCGGCGGCCGCAAGGGAGGTCGTCTGGCTGGCTGGCATCCGGT
CGACCTCGCCGCCTCCGTCATCAATGCGCTGGTCGACCGTTCGGGCGCCGCGCCGGATCAGATTGAAGACGTGATCATGG
GCTGCGTGGGCCAGGGTGGCGAGCAGGCCGTCAATGTCGGCCGCAACGCAGTGCTGGCCTCGAAGCTGCCGGAAAGCGTG
CCGGGCACGTCGGTCGACCGTCAGTGCGGCTCGTCGCAGCAGGCACTGCATTTCGCCGCACAGGCGGTGATGGCCGGCAC
CATGGACATCGTGATCGCCGCCGGCGTCGAATCGATGACCCGCGTGCCGATGGGCTCGCCGAGCATCCTCGCCGCCAAGG
CCGGGCTCGGTAACTACAAGAGCCCGAAGATGGAAGAGCGCTACCCGAACATCCAGTTCAGCCAGTTTGTCGGCGCCGAG
ATGGTGGCGAACAAGTACAACCTGTCGAAGGACGAGCTCGACGAATTCGCATTCAACAGCCACCAGCGCGCGATCGCCGC
GACGCAAGGAGGCAAGTTCAAGGACGAGATCATCCCACTCGAGATCACCCGCGCCGACGGCTCGACCGACATCCACCACA
TCGACGAAGGCATTCGCTTCGACGCGACGCTCGACGGCATCAAGGGCGTCAAGCTGATCAACGAAAACGGCGGCAAGCTG
ACGGCGGCGACCGCCAGCCAGATCTGCGACGGCGCCTCCGGCGTGGTAGTGGTCAACGAGAAGGGCCTGAAGCAGCTCGG
CGTTCAGCCGCTGGCGCGTGTCCATCACATGACGATGCGCGGCGGCGATCCGGTGATCATGCTGGAAGCCCCCCTGCCCG
CCACCGAATACGCGCTGAAGAAGGCCGGGATGAAGATCGACGACATCGATCTGTTCGAGGTCAATGAAGCGTTCGCCTCG
ATCCCGGCCGCCTGGCTGAAGGCGACCGGTGCCGATCCGGCGCGGCTCAACGTCAATGGCGGCGCGATCGCGCTCGGCCA
TCCGCTCGGCGGCTCCGGCACCAAGCTGATGACTACGCTGATCCACGCGCTGAAGCAGCAGAACAAGCGCTACGGTCTGC
AGACGATGTGCGAAGGCGGCGGCATGGCCAACGTCACCATCGTCGAGCGGCTGTAA

Upstream 100 bases:

>100_bases
GCTCAAGCGTTAATTGATCGATTGACTAAATCCTCCCCCGCCACTTAAATCGCGGCGGTCCGAAACCCGTACCCAACAAC
CATTTTCAGGGAGAGAACAC

Downstream 100 bases:

>100_bases
GCTACCGGGAACGGCTCATCCTGAGGCGCGGCGTGTTCGCCGCGTCTCCCCTTCGTCCCGACCAACAGTCAGTGGATGAA
GACGATCGACGTCATTGCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAEAYIVAAARTAGGRKGGRLAGWHPVDLAASVINALVDRSGAAPDQIEDVIMGCVGQGGEQAVNVGRNAVLASKLPESV
PGTSVDRQCGSSQQALHFAAQAVMAGTMDIVIAAGVESMTRVPMGSPSILAAKAGLGNYKSPKMEERYPNIQFSQFVGAE
MVANKYNLSKDELDEFAFNSHQRAIAATQGGKFKDEIIPLEITRADGSTDIHHIDEGIRFDATLDGIKGVKLINENGGKL
TAATASQICDGASGVVVVNEKGLKQLGVQPLARVHHMTMRGGDPVIMLEAPLPATEYALKKAGMKIDDIDLFEVNEAFAS
IPAAWLKATGADPARLNVNGGAIALGHPLGGSGTKLMTTLIHALKQQNKRYGLQTMCEGGGMANVTIVERL

Sequences:

>Translated_391_residues
MAEAYIVAAARTAGGRKGGRLAGWHPVDLAASVINALVDRSGAAPDQIEDVIMGCVGQGGEQAVNVGRNAVLASKLPESV
PGTSVDRQCGSSQQALHFAAQAVMAGTMDIVIAAGVESMTRVPMGSPSILAAKAGLGNYKSPKMEERYPNIQFSQFVGAE
MVANKYNLSKDELDEFAFNSHQRAIAATQGGKFKDEIIPLEITRADGSTDIHHIDEGIRFDATLDGIKGVKLINENGGKL
TAATASQICDGASGVVVVNEKGLKQLGVQPLARVHHMTMRGGDPVIMLEAPLPATEYALKKAGMKIDDIDLFEVNEAFAS
IPAAWLKATGADPARLNVNGGAIALGHPLGGSGTKLMTTLIHALKQQNKRYGLQTMCEGGGMANVTIVERL
>Mature_390_residues
AEAYIVAAARTAGGRKGGRLAGWHPVDLAASVINALVDRSGAAPDQIEDVIMGCVGQGGEQAVNVGRNAVLASKLPESVP
GTSVDRQCGSSQQALHFAAQAVMAGTMDIVIAAGVESMTRVPMGSPSILAAKAGLGNYKSPKMEERYPNIQFSQFVGAEM
VANKYNLSKDELDEFAFNSHQRAIAATQGGKFKDEIIPLEITRADGSTDIHHIDEGIRFDATLDGIKGVKLINENGGKLT
AATASQICDGASGVVVVNEKGLKQLGVQPLARVHHMTMRGGDPVIMLEAPLPATEYALKKAGMKIDDIDLFEVNEAFASI
PAAWLKATGADPARLNVNGGAIALGHPLGGSGTKLMTTLIHALKQQNKRYGLQTMCEGGGMANVTIVERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=33.7595907928389, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=34.5268542199489, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=35.1485148514851, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=35.1898734177215, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=28.3018867924528, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=27.8481012658228, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=39.2947103274559, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=39.0547263681592, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=37.0558375634518, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1788554, Length=400, Percent_Identity=37.5, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=414, Percent_Identity=28.5024154589372, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=36.2244897959184, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=32.0707070707071, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=29.5739348370927, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=29.5508274231678, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=27.1144278606965, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=32.2660098522167, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=33.587786259542, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=35.3689567430025, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=34.7826086956522, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=28.436018957346, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40978; Mature: 40847

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIVAAARTAGGRKGGRLAGWHPVDLAASVINALVDRSGAAPDQIEDVIMGCVGQGG
CCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
EQAVNVGRNAVLASKLPESVPGTSVDRQCGSSQQALHFAAQAVMAGTMDIVIAAGVESMT
HHHHHHCCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHH
RVPMGSPSILAAKAGLGNYKSPKMEERYPNIQFSQFVGAEMVANKYNLSKDELDEFAFNS
HCCCCCCCEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
HQRAIAATQGGKFKDEIIPLEITRADGSTDIHHIDEGIRFDATLDGIKGVKLINENGGKL
CCCEEEECCCCCCCCCEEEEEEEECCCCCCHHHHCCCCEEEEECCCCCCEEEEECCCCEE
TAATASQICDGASGVVVVNEKGLKQLGVQPLARVHHMTMRGGDPVIMLEAPLPATEYALK
EEHHHHHHCCCCCCEEEECCCCHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
KAGMKIDDIDLFEVNEAFASIPAAWLKATGADPARLNVNGGAIALGHPLGGSGTKLMTTL
HCCCCCCCCEEEEHHHHHHHCCHHHHHCCCCCCEEEEECCCEEEECCCCCCCCHHHHHHH
IHALKQQNKRYGLQTMCEGGGMANVTIVERL
HHHHHHHHHHCCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
AEAYIVAAARTAGGRKGGRLAGWHPVDLAASVINALVDRSGAAPDQIEDVIMGCVGQGG
CCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
EQAVNVGRNAVLASKLPESVPGTSVDRQCGSSQQALHFAAQAVMAGTMDIVIAAGVESMT
HHHHHHCCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHH
RVPMGSPSILAAKAGLGNYKSPKMEERYPNIQFSQFVGAEMVANKYNLSKDELDEFAFNS
HCCCCCCCEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
HQRAIAATQGGKFKDEIIPLEITRADGSTDIHHIDEGIRFDATLDGIKGVKLINENGGKL
CCCEEEECCCCCCCCCEEEEEEEECCCCCCHHHHCCCCEEEEECCCCCCEEEEECCCCEE
TAATASQICDGASGVVVVNEKGLKQLGVQPLARVHHMTMRGGDPVIMLEAPLPATEYALK
EEHHHHHHCCCCCCEEEECCCCHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
KAGMKIDDIDLFEVNEAFASIPAAWLKATGADPARLNVNGGAIALGHPLGGSGTKLMTTL
HCCCCCCCCEEEEHHHHHHHCCHHHHHCCCCCCEEEEECCCEEEECCCCCCCCHHHHHHH
IHALKQQNKRYGLQTMCEGGGMANVTIVERL
HHHHHHHHHHCCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA