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The map label for this gene is hemE [H]

Identifier: 192290094

GI number: 192290094

Start: 1819636

End: 1820652

Strand: Reverse

Name: hemE [H]

Synonym: Rpal_1696

Alternate gene names: 192290094

Gene position: 1820652-1819636 (Counterclockwise)

Preceding gene: 192290100

Following gene: 192290093

Centisome position: 31.7

GC content: 65.49

Gene sequence:

>1017_bases
ATGGAAGTGCTTTCCGGCAACCGGCAGGCCTCTCCTCCGATGTGGATGATGCGGCAGGCCGGACGTTACCTGCCGGAATA
CCGCGCAACGCGGGCGCAAGCCGGTAGTTTCCTCGATCTGTGCTTTAATGCGGAGCTCGCCGCCGAGGTGACGCTGCAGC
CGATCCGGCGATTCGGCTTCGACGCGGCGATCATCTTCTCCGACATTCTGGTGGTGCCTTACGCGCTCGGCCGCTCGGTG
CGGTTCGAAGTCGGCGAAGGCCCGCGGCTCGACCCGCTGAATTCGCCCGATCTGGTCGGCACGCTGAACAACGCGATCGA
TCTCTCCAAGCTCGAGCCGGTATTCGAAGCGCTGCGCATCGTTCGCCGCGAACTGAAGCCGGAGACCACGCTGATCGGCT
TCTGCGGCTCACCGTTCACGGTCGCGACCTACATGGTGGCCGGCCAGGGCACCTCGGATCAACATCCGGCACGACTGATG
GCGTATCAGCACCCCGGCGCGTTCGCCAAGATCATCGACGTGCTGGTCGAGAGCTCGATTCAGTATCTGCTCAGGCAGCT
CGATGCCGGCGCCGACGTGCTGCAGATCTTCGACACCTGGGCCGGCATCCTGCCGCCGCGCGAATTCGAGAAGTGGTGCA
TCGAGCCGACCCGCCGGATCGTCGAGGGCATCCGCAAGGTCAAGCCGGGCACCAAGATCATCGGCTTCCCGCGCGGCGCC
GGCGCGCTGCTGCCGGCGTTCGTCGAACGCACCGGCGTCGACGCCGTCAGCATCGACTGGACCGCCGAACCGGCGTTCGT
GCGCGAGAAGGTGCAGACCAAGGTCGCAATTCAGGGCAACCTCGATCCGCTGCTGCTGATCGCCGGCGGCTCGGCGCTCG
ACCAGGGGGTCGACGACGTCCTGAACAACTTCTCGTCGGGCCGTCACATCTTCAATCTCGGCCACGGCATCACGCCGGAC
GCGCCGATCGCTCACGTCGAGCAGATGATCAAGCGCGTCCGCGACTACAAGGCCTGA

Upstream 100 bases:

>100_bases
GTGGTCAAGACGGTGCGCGCAGTGTATCAGACCGTCAAGAAGACTTGTCGTACAACAGTGGGTAGCTCTCTTGACACAGA
ATCTGGTGACCAAACCGTTC

Downstream 100 bases:

>100_bases
GGCGCCCTCGCCTCTCGCCGTCCGACCTGATCGAAGAGCCGGTGCAGCCCGCACCGGCTCTTTTGTTTTGCGGATTGCGA
CGAGCGATCACCACAACTCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MEVLSGNRQASPPMWMMRQAGRYLPEYRATRAQAGSFLDLCFNAELAAEVTLQPIRRFGFDAAIIFSDILVVPYALGRSV
RFEVGEGPRLDPLNSPDLVGTLNNAIDLSKLEPVFEALRIVRRELKPETTLIGFCGSPFTVATYMVAGQGTSDQHPARLM
AYQHPGAFAKIIDVLVESSIQYLLRQLDAGADVLQIFDTWAGILPPREFEKWCIEPTRRIVEGIRKVKPGTKIIGFPRGA
GALLPAFVERTGVDAVSIDWTAEPAFVREKVQTKVAIQGNLDPLLLIAGGSALDQGVDDVLNNFSSGRHIFNLGHGITPD
APIAHVEQMIKRVRDYKA

Sequences:

>Translated_338_residues
MEVLSGNRQASPPMWMMRQAGRYLPEYRATRAQAGSFLDLCFNAELAAEVTLQPIRRFGFDAAIIFSDILVVPYALGRSV
RFEVGEGPRLDPLNSPDLVGTLNNAIDLSKLEPVFEALRIVRRELKPETTLIGFCGSPFTVATYMVAGQGTSDQHPARLM
AYQHPGAFAKIIDVLVESSIQYLLRQLDAGADVLQIFDTWAGILPPREFEKWCIEPTRRIVEGIRKVKPGTKIIGFPRGA
GALLPAFVERTGVDAVSIDWTAEPAFVREKVQTKVAIQGNLDPLLLIAGGSALDQGVDDVLNNFSSGRHIFNLGHGITPD
APIAHVEQMIKRVRDYKA
>Mature_338_residues
MEVLSGNRQASPPMWMMRQAGRYLPEYRATRAQAGSFLDLCFNAELAAEVTLQPIRRFGFDAAIIFSDILVVPYALGRSV
RFEVGEGPRLDPLNSPDLVGTLNNAIDLSKLEPVFEALRIVRRELKPETTLIGFCGSPFTVATYMVAGQGTSDQHPARLM
AYQHPGAFAKIIDVLVESSIQYLLRQLDAGADVLQIFDTWAGILPPREFEKWCIEPTRRIVEGIRKVKPGTKIIGFPRGA
GALLPAFVERTGVDAVSIDWTAEPAFVREKVQTKVAIQGNLDPLLLIAGGSALDQGVDDVLNNFSSGRHIFNLGHGITPD
APIAHVEQMIKRVRDYKA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=340, Percent_Identity=40, Blast_Score=224, Evalue=8e-59,
Organism=Escherichia coli, GI2367337, Length=326, Percent_Identity=46.319018404908, Blast_Score=278, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6320252, Length=328, Percent_Identity=35.3658536585366, Blast_Score=202, Evalue=4e-53,
Organism=Drosophila melanogaster, GI19921920, Length=328, Percent_Identity=37.8048780487805, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI221330099, Length=328, Percent_Identity=37.8048780487805, Blast_Score=224, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37194; Mature: 37194

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVLSGNRQASPPMWMMRQAGRYLPEYRATRAQAGSFLDLCFNAELAAEVTLQPIRRFGF
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCC
DAAIIFSDILVVPYALGRSVRFEVGEGPRLDPLNSPDLVGTLNNAIDLSKLEPVFEALRI
CHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VRRELKPETTLIGFCGSPFTVATYMVAGQGTSDQHPARLMAYQHPGAFAKIIDVLVESSI
HHHHCCCCCEEEEECCCCHHHHHEEEECCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHH
QYLLRQLDAGADVLQIFDTWAGILPPREFEKWCIEPTRRIVEGIRKVKPGTKIIGFPRGA
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
GALLPAFVERTGVDAVSIDWTAEPAFVREKVQTKVAIQGNLDPLLLIAGGSALDQGVDDV
CHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHEEEEECCCCEEEEEECCCHHHHHHHHH
LNNFSSGRHIFNLGHGITPDAPIAHVEQMIKRVRDYKA
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEVLSGNRQASPPMWMMRQAGRYLPEYRATRAQAGSFLDLCFNAELAAEVTLQPIRRFGF
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCC
DAAIIFSDILVVPYALGRSVRFEVGEGPRLDPLNSPDLVGTLNNAIDLSKLEPVFEALRI
CHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VRRELKPETTLIGFCGSPFTVATYMVAGQGTSDQHPARLMAYQHPGAFAKIIDVLVESSI
HHHHCCCCCEEEEECCCCHHHHHEEEECCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHH
QYLLRQLDAGADVLQIFDTWAGILPPREFEKWCIEPTRRIVEGIRKVKPGTKIIGFPRGA
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
GALLPAFVERTGVDAVSIDWTAEPAFVREKVQTKVAIQGNLDPLLLIAGGSALDQGVDDV
CHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHEEEEECCCCEEEEEECCCHHHHHHHHH
LNNFSSGRHIFNLGHGITPDAPIAHVEQMIKRVRDYKA
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA