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The map label for this gene is gyaR [H]

Identifier: 192288899

GI number: 192288899

Start: 504677

End: 505663

Strand: Reverse

Name: gyaR [H]

Synonym: Rpal_0468

Alternate gene names: 192288899

Gene position: 505663-504677 (Counterclockwise)

Preceding gene: 192288900

Following gene: 192288898

Centisome position: 8.8

GC content: 65.65

Gene sequence:

>987_bases
ATGCCGGGGGAAACGGGCGCGTCGAAGCCGATCGATCTCTTGATCTATGGCCCGCGCAAGGAGGTTATCGATCAGGGTTT
CCCGGCCGGCTATGTGCTGCACAAATGTGAGCGCGCCGACGACCTCGAGAAGCTGAGCGACGAAGCTCGCGGCCGTATCC
GCGGTATCGCGGTCACCGGCCTGGTGCCGACCGGTGCAGCAATGCTGGCGCGGTTTCCGAAACTCGAAATCGTGGCGAGC
TTCGGCGTCGGCTACGACCATGTCGATTCCGCCTGGGCGGCGCAGCATGGCATCATCGTCACCAATACCCCCGACGTGCT
GACCGAAGAAGTCGCCGATACCGCGCTCGGGCTGCTGATCGCGACGTTGCGCGAGTTCATTCGTGCCGACAAATACGTCC
GCGCCGGACAATGGCAGACCCAGGACTATCCGCTCAGCACCGGGTCGCTGCGCGACCGCAAGGTCGGTATGGTCGGCATG
GGCCGGATCGGCCAGGCGATTGCCCGCCGGCTCGACGCCGCACTGGTGCCGGTGGTGTATCACTCGCGCAATCCGGCGCC
CGGCGTCGCCTACAAGCACTATCCGAACCTGATCGAGATGGCCAAGGAGGTCGACACCCTGGTGGTGATCACCCCGGGCG
GCCCCACCACCGCCAAGCTGATCAACGCCGAGGTGCTCGATGCGCTCGGGCCGCGCGGCGTGGTGATCAACGTCGCGCGC
GGCTCGGTGATCGACGAAGCGGCCCTGATTGAGGCCCTGAAATCCGGCAAGATTCTCGCTGCCGGCCTCGACGTATTCGC
GGCCGAACCGACCGTGCCCGAAGAGCTGCGCGCGATGGACAATGTCGTGTTGCTGCCGCATATCGGCTCGGCCTCGGTGG
TGACGCGCAACGCGATGAACCAGCTCGTGGTCGACAATCTGAAAGCCTGGTTCTCCGGCCGTCCGCCGCTGACGCCGGTG
GCCGAAACTCCGGTGAAAGGCCGCTGA

Upstream 100 bases:

>100_bases
TGCTGTCGACGGCGGGCATTGTGATCTATCTGCTACTGGCGCTGATTTCGCATCTGCTGCTGCGGCGCTGGCACGAAAGC
GCGTTGGGAAAGGATAATTG

Downstream 100 bases:

>100_bases
CCATGTGGCGCGCGTTCGGCACGGTGATCCTCTCGGCGCTGCTCGCGTCCGCTGCCGCGGCACAGGACGCAGCTTCGATG
AAGAAGGACATGGTCGGCCA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPGETGASKPIDLLIYGPRKEVIDQGFPAGYVLHKCERADDLEKLSDEARGRIRGIAVTGLVPTGAAMLARFPKLEIVAS
FGVGYDHVDSAWAAQHGIIVTNTPDVLTEEVADTALGLLIATLREFIRADKYVRAGQWQTQDYPLSTGSLRDRKVGMVGM
GRIGQAIARRLDAALVPVVYHSRNPAPGVAYKHYPNLIEMAKEVDTLVVITPGGPTTAKLINAEVLDALGPRGVVINVAR
GSVIDEAALIEALKSGKILAAGLDVFAAEPTVPEELRAMDNVVLLPHIGSASVVTRNAMNQLVVDNLKAWFSGRPPLTPV
AETPVKGR

Sequences:

>Translated_328_residues
MPGETGASKPIDLLIYGPRKEVIDQGFPAGYVLHKCERADDLEKLSDEARGRIRGIAVTGLVPTGAAMLARFPKLEIVAS
FGVGYDHVDSAWAAQHGIIVTNTPDVLTEEVADTALGLLIATLREFIRADKYVRAGQWQTQDYPLSTGSLRDRKVGMVGM
GRIGQAIARRLDAALVPVVYHSRNPAPGVAYKHYPNLIEMAKEVDTLVVITPGGPTTAKLINAEVLDALGPRGVVINVAR
GSVIDEAALIEALKSGKILAAGLDVFAAEPTVPEELRAMDNVVLLPHIGSASVVTRNAMNQLVVDNLKAWFSGRPPLTPV
AETPVKGR
>Mature_327_residues
PGETGASKPIDLLIYGPRKEVIDQGFPAGYVLHKCERADDLEKLSDEARGRIRGIAVTGLVPTGAAMLARFPKLEIVASF
GVGYDHVDSAWAAQHGIIVTNTPDVLTEEVADTALGLLIATLREFIRADKYVRAGQWQTQDYPLSTGSLRDRKVGMVGMG
RIGQAIARRLDAALVPVVYHSRNPAPGVAYKHYPNLIEMAKEVDTLVVITPGGPTTAKLINAEVLDALGPRGVVINVARG
SVIDEAALIEALKSGKILAAGLDVFAAEPTVPEELRAMDNVVLLPHIGSASVVTRNAMNQLVVDNLKAWFSGRPPLTPVA
ETPVKGR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=38.7096774193548, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI23308577, Length=224, Percent_Identity=32.5892857142857, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=28.1853281853282, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=28.1853281853282, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=27.7992277992278, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=27.7992277992278, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=27.7992277992278, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082289, Length=256, Percent_Identity=38.28125, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789279, Length=294, Percent_Identity=28.9115646258503, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081824, Length=234, Percent_Identity=29.9145299145299, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787645, Length=269, Percent_Identity=25.6505576208178, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=29.1828793774319, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=260, Percent_Identity=23.8461538461538, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=37.9746835443038, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=286, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=284, Percent_Identity=25.3521126760563, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=261, Percent_Identity=27.9693486590038, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=24.2753623188406, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=316, Percent_Identity=25.3164556962025, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571528, Length=252, Percent_Identity=40.8730158730159, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585514, Length=290, Percent_Identity=34.8275862068965, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574282, Length=290, Percent_Identity=34.8275862068965, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45552429, Length=290, Percent_Identity=34.8275862068965, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574284, Length=291, Percent_Identity=34.7079037800687, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45551003, Length=291, Percent_Identity=34.7079037800687, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=33.8582677165354, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=32.2709163346614, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=27.4131274131274, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=27.4131274131274, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=27.4131274131274, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=27.4131274131274, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=27.4131274131274, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921140, Length=261, Percent_Identity=28.735632183908, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35029; Mature: 34898

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGETGASKPIDLLIYGPRKEVIDQGFPAGYVLHKCERADDLEKLSDEARGRIRGIAVTG
CCCCCCCCCCEEEEEECCHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHCCEEEEEEEEC
LVPTGAAMLARFPKLEIVASFGVGYDHVDSAWAAQHGIIVTNTPDVLTEEVADTALGLLI
CCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHH
ATLREFIRADKYVRAGQWQTQDYPLSTGSLRDRKVGMVGMGRIGQAIARRLDAALVPVVY
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHEEE
HSRNPAPGVAYKHYPNLIEMAKEVDTLVVITPGGPTTAKLINAEVLDALGPRGVVINVAR
ECCCCCCCCCHHHCCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
GSVIDEAALIEALKSGKILAAGLDVFAAEPTVPEELRAMDNVVLLPHIGSASVVTRNAMN
CCHHHHHHHHHHHHCCCEEEECCHHEECCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHH
QLVVDNLKAWFSGRPPLTPVAETPVKGR
HHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PGETGASKPIDLLIYGPRKEVIDQGFPAGYVLHKCERADDLEKLSDEARGRIRGIAVTG
CCCCCCCCCEEEEEECCHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHCCEEEEEEEEC
LVPTGAAMLARFPKLEIVASFGVGYDHVDSAWAAQHGIIVTNTPDVLTEEVADTALGLLI
CCCCCHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHH
ATLREFIRADKYVRAGQWQTQDYPLSTGSLRDRKVGMVGMGRIGQAIARRLDAALVPVVY
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHEEE
HSRNPAPGVAYKHYPNLIEMAKEVDTLVVITPGGPTTAKLINAEVLDALGPRGVVINVAR
ECCCCCCCCCHHHCCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
GSVIDEAALIEALKSGKILAAGLDVFAAEPTVPEELRAMDNVVLLPHIGSASVVTRNAMN
CCHHHHHHHHHHHHCCCEEEECCHHEECCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHH
QLVVDNLKAWFSGRPPLTPVAETPVKGR
HHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA