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The map label for this gene is gyaR [H]

Identifier: 192288857

GI number: 192288857

Start: 456977

End: 457978

Strand: Reverse

Name: gyaR [H]

Synonym: Rpal_0426

Alternate gene names: 192288857

Gene position: 457978-456977 (Counterclockwise)

Preceding gene: 192288859

Following gene: 192288856

Centisome position: 7.97

GC content: 65.47

Gene sequence:

>1002_bases
ATGTCGGTTAAGAAAAAGCCTCTGGTCGTCGTCACCCGCAAGCTTCCGGACTCGATCGAAACCCGGATGCGTGAGCTGTT
CGACGCCCGGCTGAATCTCGACGATGTCCCGATGACCGCCGAGCAGCTCGCCGAAGCGGCACGCACTGCCGACGTGCTGG
TACCAACGGTGACCGACGAGATCACCGCCGCGATGGTCAATCAGCCCGATTGTAAGCTGCGGCTGATCGCACATTTTGGC
AACGGCATCGACAATCTCGACGTGGCCGCAGCGCATGCGCGCGGCATCACCGTCACCAACACCCCCAAAGTTCTGACCGA
AGACACCGCCGACATGACCATGGCGCTCATCCTCGCGGTGCCGCGCCGGATGATCGAGGGTGCCGCGCTCCTGACCGACG
GCGGCGAATGGCCCGGCTGGTCGCCGACCTGGATGCTCGGCCGCAGGCTCGGCGGCAAGCGGCTCGGCATCATCGGCATG
GGCCGGATCGGCCAGGCGGTGGCGCGCCGCGCCCGCGCCTTCGGGCTGCAGATCCACTATCACAACCGCAAGCCGGTCGC
GCCGCGGATCGCCGACGAACTCGGGGCGACCTACTGGGATTCACTCGACCAGATGCTGGCGCGGATGGACATCATCTCGG
TGAACTGTCCGCACACCCCGGCGACGTTCCATTTGTTGTCAGCGCGGCGGCTGAAACTGGTCCGCAAGGACGCCTTCATC
GTCAACACCGCGCGCGGCGAGGTGATCGACGAAGAAACCCTGACCAAGCTGATCGAAGCCGGCGACATCGCCGGCGCCGG
CCTCGACGTCTACGAGCACGAGCCGGCGGTCAATCCGAAGCTGGTCCGGCTCGCCAAGCACGGCAAGGTGGTGCTGCTGC
CGCACATGGGCTCGGCCACGATCGAGGGCCGTGTCGAGATGGGCGAGAAGGTGATCATCAACATCCGCACCTTCCTGGAT
AATCACAAGCCGCCGGATCGCGTCCTGCCCGGGATGCTCTGA

Upstream 100 bases:

>100_bases
GGTCGGGACCGGCCCCTGTGGTCACGCTGCTGCGGGAGTGTCGAACAGCTGAGTTAACGGGGACTAAACGATCTCGTTAA
GCTCGTCAGAGAGCGTTGGA

Downstream 100 bases:

>100_bases
TCTCCGTTTCCAAGCGGTCTGCTGCGGCCTAACGCCTCGCGCGTGGGTTCCGCCGGCGCCTTCTCCCTGCCCGTTTCCCA
CACTACCTTCGTTGAACAAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSVKKKPLVVVTRKLPDSIETRMRELFDARLNLDDVPMTAEQLAEAARTADVLVPTVTDEITAAMVNQPDCKLRLIAHFG
NGIDNLDVAAAHARGITVTNTPKVLTEDTADMTMALILAVPRRMIEGAALLTDGGEWPGWSPTWMLGRRLGGKRLGIIGM
GRIGQAVARRARAFGLQIHYHNRKPVAPRIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLVRKDAFI
VNTARGEVIDEETLTKLIEAGDIAGAGLDVYEHEPAVNPKLVRLAKHGKVVLLPHMGSATIEGRVEMGEKVIINIRTFLD
NHKPPDRVLPGML

Sequences:

>Translated_333_residues
MSVKKKPLVVVTRKLPDSIETRMRELFDARLNLDDVPMTAEQLAEAARTADVLVPTVTDEITAAMVNQPDCKLRLIAHFG
NGIDNLDVAAAHARGITVTNTPKVLTEDTADMTMALILAVPRRMIEGAALLTDGGEWPGWSPTWMLGRRLGGKRLGIIGM
GRIGQAVARRARAFGLQIHYHNRKPVAPRIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLVRKDAFI
VNTARGEVIDEETLTKLIEAGDIAGAGLDVYEHEPAVNPKLVRLAKHGKVVLLPHMGSATIEGRVEMGEKVIINIRTFLD
NHKPPDRVLPGML
>Mature_332_residues
SVKKKPLVVVTRKLPDSIETRMRELFDARLNLDDVPMTAEQLAEAARTADVLVPTVTDEITAAMVNQPDCKLRLIAHFGN
GIDNLDVAAAHARGITVTNTPKVLTEDTADMTMALILAVPRRMIEGAALLTDGGEWPGWSPTWMLGRRLGGKRLGIIGMG
RIGQAVARRARAFGLQIHYHNRKPVAPRIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLVRKDAFIV
NTARGEVIDEETLTKLIEAGDIAGAGLDVYEHEPAVNPKLVRLAKHGKVVLLPHMGSATIEGRVEMGEKVIINIRTFLDN
HKPPDRVLPGML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=303, Percent_Identity=34.983498349835, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI23308577, Length=311, Percent_Identity=30.5466237942122, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=33.8645418326693, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=33.8645418326693, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=34.251968503937, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=34.251968503937, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=34.251968503937, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI87082289, Length=313, Percent_Identity=37.0607028753994, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789279, Length=292, Percent_Identity=30.1369863013699, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787645, Length=336, Percent_Identity=24.702380952381, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17532191, Length=268, Percent_Identity=31.7164179104478, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=204, Percent_Identity=34.3137254901961, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=313, Percent_Identity=32.9073482428115, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=30, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=260, Percent_Identity=29.2307692307692, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=219, Percent_Identity=29.6803652968037, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=153, Percent_Identity=32.6797385620915, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=149, Percent_Identity=28.8590604026846, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571528, Length=289, Percent_Identity=36.3321799307958, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=36.2903225806452, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=36.2903225806452, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=36.2903225806452, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=36.2903225806452, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=36.2903225806452, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574284, Length=278, Percent_Identity=31.6546762589928, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=31.5412186379928, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24585514, Length=278, Percent_Identity=31.6546762589928, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574282, Length=278, Percent_Identity=31.6546762589928, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI45551003, Length=278, Percent_Identity=31.6546762589928, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=30.9963099630996, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=310, Percent_Identity=30.9677419354839, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585516, Length=276, Percent_Identity=27.1739130434783, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36575; Mature: 36444

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKKKPLVVVTRKLPDSIETRMRELFDARLNLDDVPMTAEQLAEAARTADVLVPTVTDE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEECHHHH
ITAAMVNQPDCKLRLIAHFGNGIDNLDVAAAHARGITVTNTPKVLTEDTADMTMALILAV
HHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEEECCCCCEEECCHHHHHHHHHHHH
PRRMIEGAALLTDGGEWPGWSPTWMLGRRLGGKRLGIIGMGRIGQAVARRARAFGLQIHY
HHHHHCCCEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHEEEEEE
HNRKPVAPRIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLVRKDAFI
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCEEE
VNTARGEVIDEETLTKLIEAGDIAGAGLDVYEHEPAVNPKLVRLAKHGKVVLLPHMGSAT
EECCCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCEEEEECCCCCE
IEGRVEMGEKVIINIRTFLDNHKPPDRVLPGML
ECCHHCCCCEEEEEEEHHHCCCCCHHHCCCCCC
>Mature Secondary Structure 
SVKKKPLVVVTRKLPDSIETRMRELFDARLNLDDVPMTAEQLAEAARTADVLVPTVTDE
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEECHHHH
ITAAMVNQPDCKLRLIAHFGNGIDNLDVAAAHARGITVTNTPKVLTEDTADMTMALILAV
HHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEEECCCCCEEECCHHHHHHHHHHHH
PRRMIEGAALLTDGGEWPGWSPTWMLGRRLGGKRLGIIGMGRIGQAVARRARAFGLQIHY
HHHHHCCCEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHEEEEEE
HNRKPVAPRIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLVRKDAFI
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCEEE
VNTARGEVIDEETLTKLIEAGDIAGAGLDVYEHEPAVNPKLVRLAKHGKVVLLPHMGSAT
EECCCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCEEEEECCCCCE
IEGRVEMGEKVIINIRTFLDNHKPPDRVLPGML
ECCHHCCCCEEEEEEEHHHCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA