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The map label for this gene is sucD [H]

Identifier: 192288618

GI number: 192288618

Start: 202934

End: 203818

Strand: Reverse

Name: sucD [H]

Synonym: Rpal_0185

Alternate gene names: 192288618

Gene position: 203818-202934 (Counterclockwise)

Preceding gene: 192288619

Following gene: 192288617

Centisome position: 3.55

GC content: 66.44

Gene sequence:

>885_bases
ATGTCCATTCTGATCGACAGCAACACCCGCGTTATCTGCCAGGGCTTCACCGGCAAGAACGGTACCTTCCATTCCGAGGC
AGCGATCGCCTACGGCACCAAGATGGTCGGCGGCACCTCGCCGGGCAAAGGCGGCTCGACCCACCTCGGCCTGCCGGTGT
TCGACACCGTCCGTGAGGCGCGCGACAAGACCGGGGCGGATGCGTCGGTGATCTACGTGCCGCCGCCGGGCGCCGCGGAC
GCGATCTGCGAGGCGATCGACGCCGAGATCCCGCTGATCGTCTGCATCACCGAGGGCATCCCGGTGCTCGACATGGTGCG
GGTGAAGCGGTCGCTGAATGGCTCGAAGTCGCGCCTGATCGGGCCGAACTGCCCGGGCGTGATGACCGCCGGCGAGTGCA
AGATCGGCATCATGCCGGCCAACATCTTCAAGCCGGGCTCGGTCGGCATCGTGTCGCGCTCCGGCACCCTGACCTATGAG
GCGGTGTTCCAGACCTCGGCCGAGGGCCTCGGCCAGACCACCGCGGTCGGCATCGGCGGCGACCCGGTCAAGGGCACCGA
ATTCATCGACGTGCTGGAGATGTTCCTGGCCGACGACAAGACCGAGTCGATCATCATGATCGGTGAGATCGGCGGTTCGG
CCGAAGAAGACGCCGCCCAGTTCCTGATCGACGAGGCCAAGCGCGGCCGCAAGAAACCGATGGTCGGATTCATCGCCGGC
GTCACTGCCCCTCCCGGCCGCCGCATGGGCCACGCCGGTGCGATCATTTCGGGCGGCAAGGGCGATGCGGCCTCGAAGAC
CGCAGCCATGGAAGCGGCTGGCATCACCGTGTCGCCGTCGCCGGCGCGTCTTGGCAAAACGCTTGCCGAAAAGTTGAAGT
CCTAA

Upstream 100 bases:

>100_bases
GCGCAGAAGATCGTCGCCGCCGTGAAGGGAGCCTGAGGCCGCTTCTCGGCCTCTCCGCTGCCTCCGACCATTCCGTTCGA
CCGCGAAAGCATCACCGACC

Downstream 100 bases:

>100_bases
TTCAAACCTTGTGTCGTTCCGAGCTTACATTTCCCTAGAATAGGATAAAAGGTGCACTATGTTGCTGATCCGGTAACCGG
ATCAGCTTATCGCGATTAAG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSILIDSNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGSTHLGLPVFDTVREARDKTGADASVIYVPPPGAAD
AICEAIDAEIPLIVCITEGIPVLDMVRVKRSLNGSKSRLIGPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYE
AVFQTSAEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEDAAQFLIDEAKRGRKKPMVGFIAG
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS

Sequences:

>Translated_294_residues
MSILIDSNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGSTHLGLPVFDTVREARDKTGADASVIYVPPPGAAD
AICEAIDAEIPLIVCITEGIPVLDMVRVKRSLNGSKSRLIGPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYE
AVFQTSAEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEDAAQFLIDEAKRGRKKPMVGFIAG
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS
>Mature_293_residues
SILIDSNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGSTHLGLPVFDTVREARDKTGADASVIYVPPPGAADA
ICEAIDAEIPLIVCITEGIPVLDMVRVKRSLNGSKSRLIGPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYEA
VFQTSAEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEDAAQFLIDEAKRGRKKPMVGFIAGV
TAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=67.4657534246575, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI38569423, Length=258, Percent_Identity=29.4573643410853, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI38569421, Length=258, Percent_Identity=29.4573643410853, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=67.9180887372014, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=64.0138408304498, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=63.3561643835616, Blast_Score=353, Evalue=5e-98,
Organism=Caenorhabditis elegans, GI17551266, Length=260, Percent_Identity=27.6923076923077, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17557344, Length=223, Percent_Identity=29.1479820627803, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324716, Length=297, Percent_Identity=54.2087542087542, Blast_Score=302, Evalue=5e-83,
Organism=Drosophila melanogaster, GI21356559, Length=292, Percent_Identity=60.6164383561644, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI28574296, Length=293, Percent_Identity=63.8225255972696, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI281363477, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363475, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363473, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30078; Mature: 29947

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILIDSNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGSTHLGLPVFDTVREA
CEEEEECCCEEEEEECCCCCCCCCCCCHHEECCEECCCCCCCCCCCCCCCCCHHHHHHHH
RDKTGADASVIYVPPPGAADAICEAIDAEIPLIVCITEGIPVLDMVRVKRSLNGSKSRLI
HHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEC
GPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYEAVFQTSAEGLGQTTAVGIGG
CCCCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCEEEEHHHHHHHCCCCCEEEEECCC
DPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEDAAQFLIDEAKRGRKKPMVGFIAG
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILIDSNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGSTHLGLPVFDTVREA
EEEEECCCEEEEEECCCCCCCCCCCCHHEECCEECCCCCCCCCCCCCCCCCHHHHHHHH
RDKTGADASVIYVPPPGAADAICEAIDAEIPLIVCITEGIPVLDMVRVKRSLNGSKSRLI
HHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEC
GPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYEAVFQTSAEGLGQTTAVGIGG
CCCCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCEEEEHHHHHHHCCCCCEEEEECCC
DPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEDAAQFLIDEAKRGRKKPMVGFIAG
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]