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The map label for this gene is tdh [H]

Identifier: 192288544

GI number: 192288544

Start: 122594

End: 123634

Strand: Reverse

Name: tdh [H]

Synonym: Rpal_0111

Alternate gene names: 192288544

Gene position: 123634-122594 (Counterclockwise)

Preceding gene: 192288545

Following gene: 192288543

Centisome position: 2.15

GC content: 68.97

Gene sequence:

>1041_bases
ATGAAGGCTGCAGTGTTCGAGAAAACCGGGGAGCGGCTCGTCGTCCGCGACGTCGCCGCGCCGGCGCTGGGCGATAACGA
ATTGCTGCTCAAGGTGGCGTTCACCGGCATCTGCGGCTCTGATCTGCACGCCGCCGAGACGCCGGGCATGTTGCAGTCCG
GCACTGTGATGGGGCACGAATTCACCGGCGAAATCGTGCAGTCGACCGCGCCCGACTGGCCGGTCGGCGCCCGCGTCGCG
GCCAACCCGTATTGGCTATGCGACGCCTGCGCGGCCGGCGGCTCTTGTAGCGGCGGCGGCGATGCGGCCTGTGCCAACGG
CAGCTTCATGGGCTTCCGTCCCGACCTGCCGGGGGCCTATGCGGACTACGTGCGGATTCGCGCCGGGCAGGCGATCCGCC
TGCCCGATAAAGTCAGCCTGCGCGACGGCGCGCTGATGGAGCCGCTGGCCGTTGCGCGTCATGCGGTGGATGTCTGCGGC
CCGATGCAGGGCGCCGACGTGCTGGTGATCGGTGGCGGGCCAATCGGGCTCGGCGTCGTGCTGATGGCGCGCGATGCCGG
CGCCGCGCGGGTGGTGGTCAGCGAGCCGGATCCGAACCGCCGTGCCTGCGCGCTGCAGGTCGGTGCCGTCGCGGCGATCG
ATCCGATCGCCGAAGATCTGCCGACCGCGCTCGGCGGGCTCGGCCTCGGTGCGCCGGGCATCGTGTTCGAATGCGTCGGC
GCGCCCGGCTTTTTGCAGCAGACCATCGACGTCATGGCGCTGCGCGGCCGGGCCGTGATCGTCGGCGTCTGCATGACGGA
GGACCGGGTGTTGCCGCGCGCCGCGATCCGCAAGGAAGCGACGCTCAAATTCGTGCTCGGCTACACGATGGCCGACTTCC
ATCACGTCAGTCGTTATCTCGAGGAGCATGCTGCGACCGCCGCCGCGATGATCTCGCGCGTTGTGTCGCTGAGTGAGCTT
CCCGAGATCTTCGACCGGCTGCGCGCCGAGAAGTCACTGATCAAGGTGCTGGTGCGGCCGGACCAGGGATCTGGCACATA
A

Upstream 100 bases:

>100_bases
CGATCAGCGACGAGAAGCGCGAGATCATGATCCCCTACTACGAGAACATCCCGATCCGTCCGCAGGCGTGAACGGCTCAC
ATCAGCGCGGAGGCGATCAG

Downstream 100 bases:

>100_bases
CAACAAGGGGGAAAGCCTAATGACCGCCATGGACCGCCGCTGCTTTCTGCTCGGCACCGCTACCACCATGCTGGTGGCGA
CATCGATGAAAGCGCAGGCC

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAAVFEKTGERLVVRDVAAPALGDNELLLKVAFTGICGSDLHAAETPGMLQSGTVMGHEFTGEIVQSTAPDWPVGARVA
ANPYWLCDACAAGGSCSGGGDAACANGSFMGFRPDLPGAYADYVRIRAGQAIRLPDKVSLRDGALMEPLAVARHAVDVCG
PMQGADVLVIGGGPIGLGVVLMARDAGAARVVVSEPDPNRRACALQVGAVAAIDPIAEDLPTALGGLGLGAPGIVFECVG
APGFLQQTIDVMALRGRAVIVGVCMTEDRVLPRAAIRKEATLKFVLGYTMADFHHVSRYLEEHAATAAAMISRVVSLSEL
PEIFDRLRAEKSLIKVLVRPDQGSGT

Sequences:

>Translated_346_residues
MKAAVFEKTGERLVVRDVAAPALGDNELLLKVAFTGICGSDLHAAETPGMLQSGTVMGHEFTGEIVQSTAPDWPVGARVA
ANPYWLCDACAAGGSCSGGGDAACANGSFMGFRPDLPGAYADYVRIRAGQAIRLPDKVSLRDGALMEPLAVARHAVDVCG
PMQGADVLVIGGGPIGLGVVLMARDAGAARVVVSEPDPNRRACALQVGAVAAIDPIAEDLPTALGGLGLGAPGIVFECVG
APGFLQQTIDVMALRGRAVIVGVCMTEDRVLPRAAIRKEATLKFVLGYTMADFHHVSRYLEEHAATAAAMISRVVSLSEL
PEIFDRLRAEKSLIKVLVRPDQGSGT
>Mature_346_residues
MKAAVFEKTGERLVVRDVAAPALGDNELLLKVAFTGICGSDLHAAETPGMLQSGTVMGHEFTGEIVQSTAPDWPVGARVA
ANPYWLCDACAAGGSCSGGGDAACANGSFMGFRPDLPGAYADYVRIRAGQAIRLPDKVSLRDGALMEPLAVARHAVDVCG
PMQGADVLVIGGGPIGLGVVLMARDAGAARVVVSEPDPNRRACALQVGAVAAIDPIAEDLPTALGGLGLGAPGIVFECVG
APGFLQQTIDVMALRGRAVIVGVCMTEDRVLPRAAIRKEATLKFVLGYTMADFHHVSRYLEEHAATAAAMISRVVSLSEL
PEIFDRLRAEKSLIKVLVRPDQGSGT

Specific function: Threonine catabolism; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=333, Percent_Identity=30.6306306306306, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1790045, Length=339, Percent_Identity=28.9085545722714, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI226510992, Length=331, Percent_Identity=31.4199395770393, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=26.865671641791, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1788075, Length=345, Percent_Identity=29.2753623188406, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=26.865671641791, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788407, Length=325, Percent_Identity=26.7692307692308, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=288, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=266, Percent_Identity=30.8270676691729, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=226, Percent_Identity=28.3185840707965, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=344, Percent_Identity=30.5232558139535, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562878, Length=227, Percent_Identity=32.5991189427313, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=145, Percent_Identity=33.1034482758621, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=29.0322580645161, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=386, Percent_Identity=27.979274611399, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=344, Percent_Identity=26.1627906976744, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=26.3929618768328, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=26.3313609467456, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=146, Percent_Identity=33.5616438356164, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=24.6376811594203, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=354, Percent_Identity=23.1638418079096, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=347, Percent_Identity=24.4956772334294, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17737897, Length=231, Percent_Identity=31.6017316017316, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137530, Length=231, Percent_Identity=30.3030303030303, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 35925; Mature: 35925

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVFEKTGERLVVRDVAAPALGDNELLLKVAFTGICGSDLHAAETPGMLQSGTVMGHE
CCCCCHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEECCH
FTGEIVQSTAPDWPVGARVAANPYWLCDACAAGGSCSGGGDAACANGSFMGFRPDLPGAY
HHHHHHHCCCCCCCCCCEEECCCCEEEHHHCCCCCCCCCCCCEECCCCEECCCCCCCCHH
ADYVRIRAGQAIRLPDKVSLRDGALMEPLAVARHAVDVCGPMQGADVLVIGGGPIGLGVV
HHHHEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEE
LMARDAGAARVVVSEPDPNRRACALQVGAVAAIDPIAEDLPTALGGLGLGAPGIVFECVG
EEEECCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
APGFLQQTIDVMALRGRAVIVGVCMTEDRVLPRAAIRKEATLKFVLGYTMADFHHVSRYL
CCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHEEEEHHHHHHHHHHHHHHH
EEHAATAAAMISRVVSLSELPEIFDRLRAEKSLIKVLVRPDQGSGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure
MKAAVFEKTGERLVVRDVAAPALGDNELLLKVAFTGICGSDLHAAETPGMLQSGTVMGHE
CCCCCHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEECCH
FTGEIVQSTAPDWPVGARVAANPYWLCDACAAGGSCSGGGDAACANGSFMGFRPDLPGAY
HHHHHHHCCCCCCCCCCEEECCCCEEEHHHCCCCCCCCCCCCEECCCCEECCCCCCCCHH
ADYVRIRAGQAIRLPDKVSLRDGALMEPLAVARHAVDVCGPMQGADVLVIGGGPIGLGVV
HHHHEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEE
LMARDAGAARVVVSEPDPNRRACALQVGAVAAIDPIAEDLPTALGGLGLGAPGIVFECVG
EEEECCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
APGFLQQTIDVMALRGRAVIVGVCMTEDRVLPRAAIRKEATLKFVLGYTMADFHHVSRYL
CCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHEEEEHHHHHHHHHHHHHHH
EEHAATAAAMISRVVSLSELPEIFDRLRAEKSLIKVLVRPDQGSGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA