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The map label for this gene is hpd [H]

Identifier: 192288438

GI number: 192288438

Start: 7213

End: 8331

Strand: Reverse

Name: hpd [H]

Synonym: Rpal_0005

Alternate gene names: 192288438

Gene position: 8331-7213 (Counterclockwise)

Preceding gene: 192288440

Following gene: NA

Centisome position: 0.15

GC content: 62.73

Gene sequence:

>1119_bases
ATGGGACCATTTCCGCACGATGCGCAGCCGGCCACGATCAGCGCCGACAATCCGATGGGCACCGACGGATTCGAGTTTGT
CGAATTCGCTCATCCGGATCCGGCGCAACTTCATAGCCTGTTCAAGCTGATGGGCTTCAGCTTGGTCGCAAAGCATCGCA
CCAAGGCGATTTCGGTCTATCGCCAGGGCGACGTCAACTATCTGGTCAACGAGCAGCCCGGCACCCACGGCACCGACTTC
GTCACTGCACACGGCCCGTGCGCGCCGTCGATGGCGTTCCGCGTGGTCGATGCCAAGCAGGCCTACGAGCGCGCGATCTC
GCTCGGCGCCGAACCGGCCGGCGTGACGGCCGCGGAGGCGACACTGGACGTACCAGCCATCAAGGGCATCGGCGGCAGTC
TGCTGTATTTCGTCGACCGCTACGGTGCCAAGGGGTCGGCCTACGATGCTGAATTCGACTGGGTCGGTGCCCGCGACGTT
CGGCCCGCCGGCGCCGGGCTCTATTACATCGATCATCTGACTCACAACGTCCATCGCGGCCGTATGGATGTCTGGACCGG
GTTCTATGCCAAACTGTTCAACTTCCGGCAGATACGCTTCTTCGACATCGAAGGTCGCGCCTCCGGCCTGTTCTCGCGTG
CGCTGACCAGCCCGGACGGCAAGATTCGGATTCCGATCAACGAGGACGCCGGTGATTCAGGCCAGATCGAAGAGTATCTC
AGCCTGTATCGCGGCGAGGGCATCCAGCATATCGCCTGCGGCTGCCGCGACATCTACAGCACGGTCGAAGGACTTCGTGC
CGCCGGCCTGCCATTCATGCCGTCGCCGCCGGAGACGTATTTCGAACGCGTCGATGCACGTCTGCCGGAGCATGGTGAGG
ACGTCGCCCGGCTGCAGCGGAACGGCATCCTGATCGACGGTGAAGGCGTCGTCGACGGCGGTCAGACCAAGGTGCTACTG
CAGATCTTCTCGGCGAATGCGATCGGCCCGATCTTCTTCGAATTCATCCAGCGCAAGGGCGACGACGGCTTCGGCGAAGG
CAACTTCAAGGCGCTATTCGAGTCGATCGAAGAAGACCAGATCCGCCGAGGCGTGCTGAAAGCGGAGCGTGCGGCGTAG

Upstream 100 bases:

>100_bases
GATCGTGCACAATCTATCGCAACCGGCTTGCATTTGCACGCCCCTTGCGGGGCGGGCAGACGATACTACCGGCTCAAGAA
CAAAGCTGGAGGAGCACCCG

Downstream 100 bases:

>100_bases
CGCGGACAAAGTGCCGCGATCGACGGATTAAGAGACGTTTGCATTCTTCCTAGTCGTGCCCGGCCTTGTGCCGGACATCC
TTGAGCCGCGACGAAGACAT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MGPFPHDAQPATISADNPMGTDGFEFVEFAHPDPAQLHSLFKLMGFSLVAKHRTKAISVYRQGDVNYLVNEQPGTHGTDF
VTAHGPCAPSMAFRVVDAKQAYERAISLGAEPAGVTAAEATLDVPAIKGIGGSLLYFVDRYGAKGSAYDAEFDWVGARDV
RPAGAGLYYIDHLTHNVHRGRMDVWTGFYAKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
SLYRGEGIQHIACGCRDIYSTVEGLRAAGLPFMPSPPETYFERVDARLPEHGEDVARLQRNGILIDGEGVVDGGQTKVLL
QIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQIRRGVLKAERAA

Sequences:

>Translated_372_residues
MGPFPHDAQPATISADNPMGTDGFEFVEFAHPDPAQLHSLFKLMGFSLVAKHRTKAISVYRQGDVNYLVNEQPGTHGTDF
VTAHGPCAPSMAFRVVDAKQAYERAISLGAEPAGVTAAEATLDVPAIKGIGGSLLYFVDRYGAKGSAYDAEFDWVGARDV
RPAGAGLYYIDHLTHNVHRGRMDVWTGFYAKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
SLYRGEGIQHIACGCRDIYSTVEGLRAAGLPFMPSPPETYFERVDARLPEHGEDVARLQRNGILIDGEGVVDGGQTKVLL
QIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQIRRGVLKAERAA
>Mature_371_residues
GPFPHDAQPATISADNPMGTDGFEFVEFAHPDPAQLHSLFKLMGFSLVAKHRTKAISVYRQGDVNYLVNEQPGTHGTDFV
TAHGPCAPSMAFRVVDAKQAYERAISLGAEPAGVTAAEATLDVPAIKGIGGSLLYFVDRYGAKGSAYDAEFDWVGARDVR
PAGAGLYYIDHLTHNVHRGRMDVWTGFYAKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYLS
LYRGEGIQHIACGCRDIYSTVEGLRAAGLPFMPSPPETYFERVDARLPEHGEDVARLQRNGILIDGEGVVDGGQTKVLLQ
IFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQIRRGVLKAERAA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=333, Percent_Identity=27.6276276276276, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI285002264, Length=333, Percent_Identity=27.6276276276276, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI14249394, Length=360, Percent_Identity=27.5, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555220, Length=215, Percent_Identity=38.6046511627907, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17550752, Length=211, Percent_Identity=30.3317535545024, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667510, Length=320, Percent_Identity=31.25, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21356105, Length=306, Percent_Identity=31.6993464052288, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40713; Mature: 40582

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHDAQPATISADNPMGTDGFEFVEFAHPDPAQLHSLFKLMGFSLVAKHRTKAISVY
CCCCCCCCCCCEEECCCCCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHEEEEE
RQGDVNYLVNEQPGTHGTDFVTAHGPCAPSMAFRVVDAKQAYERAISLGAEPAGVTAAEA
ECCCCEEEECCCCCCCCCCEEEECCCCCCCHHEEEHHHHHHHHHHHHCCCCCCCCCHHHH
TLDVPAIKGIGGSLLYFVDRYGAKGSAYDAEFDWVGARDVRPAGAGLYYIDHLTHNVHRG
EECCCHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCC
RMDVWTGFYAKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHH
SLYRGEGIQHIACGCRDIYSTVEGLRAAGLPFMPSPPETYFERVDARLPEHGEDVARLQR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
NGILIDGEGVVDGGQTKVLLQIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQ
CCEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IRRGVLKAERAA
HHHHHHHHHCCC
>Mature Secondary Structure 
GPFPHDAQPATISADNPMGTDGFEFVEFAHPDPAQLHSLFKLMGFSLVAKHRTKAISVY
CCCCCCCCCCEEECCCCCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHEEEEE
RQGDVNYLVNEQPGTHGTDFVTAHGPCAPSMAFRVVDAKQAYERAISLGAEPAGVTAAEA
ECCCCEEEECCCCCCCCCCEEEECCCCCCCHHEEEHHHHHHHHHHHHCCCCCCCCCHHHH
TLDVPAIKGIGGSLLYFVDRYGAKGSAYDAEFDWVGARDVRPAGAGLYYIDHLTHNVHRG
EECCCHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCC
RMDVWTGFYAKLFNFRQIRFFDIEGRASGLFSRALTSPDGKIRIPINEDAGDSGQIEEYL
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHH
SLYRGEGIQHIACGCRDIYSTVEGLRAAGLPFMPSPPETYFERVDARLPEHGEDVARLQR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
NGILIDGEGVVDGGQTKVLLQIFSANAIGPIFFEFIQRKGDDGFGEGNFKALFESIEEDQ
CCEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IRRGVLKAERAA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]