Click here to switch to the map view.

The map label for this gene is adhCc [H]

Identifier: 190894919

GI number: 190894919

Start: 636738

End: 637865

Strand: Reverse

Name: adhCc [H]

Synonym: RHECIAT_PC0000584

Alternate gene names: 190894919

Gene position: 637865-636738 (Counterclockwise)

Preceding gene: 190894920

Following gene: 190894918

Centisome position: 58.44

GC content: 63.39

Gene sequence:

>1128_bases
ATGGACGTTCGCGCCGCCGTAGCCGTTCAGGCCGGAAAACCGCTCGAAGTGATGACCGTGCAGCTGGAGGGGCCAAAGGC
CGGCGAAGTGTTGGTCGAGGTCAAGGCGACCGGCATCTGCCATACCGACGATTTCACCCTGTCCGGCGCCGATCCGGAAG
GCCTGTTTCCTGCCATTCTCGGCCATGAGGGTGCCGGCATCGTCGTCGACGTCGGCCCGGGTGTGACCACGGTCAAGAAG
GGCGACCACGTCATTCCGCTCTACACGCCGGAATGCCGCGAATGCTATTCCTGCCTGTCCCGCAAGACCAATCTCTGCAC
CGCCATCCGTTCGACCCAGGGCCAGGGCGTGATGCCGGACGGGACCTCGCGCTTTTCGATCGGCAAGGACAAGATCCATC
ACTATATGGGCTGCTCGACCTTCGCCAATTACACCGTGCTGCCGGAGATTGCGCTCGCCAAGGTCAATCCCGACGCCCCC
TTCGACAAGATCTGCTACATCGGCTGCGGTGTGACGACCGGCATCGGCGCGGTGATCAACACCGCCAAGGTCGAGATCGG
TTCGACGGCGATCGTCTTCGGTCTCGGCGGCATCGGCCTCAACGTGCTGCAGGGCCTGCGGCTTGCCGGCGCCGACATGA
TCATCGGCGTCGACATCAATCCTGACCGCAAGGCCTGGGGCGAGAAATTCGGCATGACGCATTTCGTCAATCCGAAGGAG
GTCGGCGACGACATCGTGCCCTATCTCGTCAATATGACGAAGCGGGGTGGCGACCTGATCGGCGGCGCCGACTATACCTT
CGACTGCACCGGCAACACCAAGGTGATGCGCCAGGCGCTGGAGGCCTCCCACCGCGGTTGGGGCAAATCAGTCATCATCG
GCGTTGCCGGCGCCGGCCAGGAGATCTCCACCCGGCCGTTCCAGCTGGTCACCGGCCGCAACTGGATGGGCACCGCCTTC
GGCGGCGCGCGCGGCCGCACCGATGTGCCGAAGATCGTCGACTGGTACATGCAGGGCAAGATCCAGATCGACCCGATGAT
CACCCACACGATGCCGCTCGACGACATCAACAAGGGCTTCGACATGATGCACAAGGGTGAGAGCATCCGTGGCGTGGTGG
TCTACTGA

Upstream 100 bases:

>100_bases
GGGATGACACCAAGATGAGGCCGAAGCAGATGGTTTCGATCGCTCGGTCGCATCCCGCATAATTAACAACGGAAATTGAA
TTAACAGGAGGGATTATCAA

Downstream 100 bases:

>100_bases
GCCATGAAAACCATCTCGATCGACAAGTCTTACGGCGGCACTCAGGGCGTCTACGTCAGCCGCTCCGAAGCCTGCGACTG
CGACATGACCTTTGCGGTCT

Product: formaldehyde dehydrogenase (glutathione)/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MDVRAAVAVQAGKPLEVMTVQLEGPKAGEVLVEVKATGICHTDDFTLSGADPEGLFPAILGHEGAGIVVDVGPGVTTVKK
GDHVIPLYTPECRECYSCLSRKTNLCTAIRSTQGQGVMPDGTSRFSIGKDKIHHYMGCSTFANYTVLPEIALAKVNPDAP
FDKICYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINPDRKAWGEKFGMTHFVNPKE
VGDDIVPYLVNMTKRGGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQEISTRPFQLVTGRNWMGTAF
GGARGRTDVPKIVDWYMQGKIQIDPMITHTMPLDDINKGFDMMHKGESIRGVVVY

Sequences:

>Translated_375_residues
MDVRAAVAVQAGKPLEVMTVQLEGPKAGEVLVEVKATGICHTDDFTLSGADPEGLFPAILGHEGAGIVVDVGPGVTTVKK
GDHVIPLYTPECRECYSCLSRKTNLCTAIRSTQGQGVMPDGTSRFSIGKDKIHHYMGCSTFANYTVLPEIALAKVNPDAP
FDKICYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINPDRKAWGEKFGMTHFVNPKE
VGDDIVPYLVNMTKRGGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQEISTRPFQLVTGRNWMGTAF
GGARGRTDVPKIVDWYMQGKIQIDPMITHTMPLDDINKGFDMMHKGESIRGVVVY
>Mature_375_residues
MDVRAAVAVQAGKPLEVMTVQLEGPKAGEVLVEVKATGICHTDDFTLSGADPEGLFPAILGHEGAGIVVDVGPGVTTVKK
GDHVIPLYTPECRECYSCLSRKTNLCTAIRSTQGQGVMPDGTSRFSIGKDKIHHYMGCSTFANYTVLPEIALAKVNPDAP
FDKICYIGCGVTTGIGAVINTAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINPDRKAWGEKFGMTHFVNPKE
VGDDIVPYLVNMTKRGGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQEISTRPFQLVTGRNWMGTAF
GGARGRTDVPKIVDWYMQGKIQIDPMITHTMPLDDINKGFDMMHKGESIRGVVVY

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=57.1045576407507, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI71565152, Length=380, Percent_Identity=43.421052631579, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=44, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=43.7333333333333, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI262073058, Length=376, Percent_Identity=42.8191489361702, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI71743840, Length=376, Percent_Identity=42.8191489361702, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=42.9333333333333, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=42.0485175202156, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=42.3076923076923, Blast_Score=303, Evalue=1e-82,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=58.9333333333333, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1787863, Length=365, Percent_Identity=23.8356164383562, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082125, Length=388, Percent_Identity=24.7422680412371, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790045, Length=353, Percent_Identity=26.9121813031161, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=369, Percent_Identity=25.7452574525745, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786825, Length=382, Percent_Identity=25.130890052356, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081918, Length=372, Percent_Identity=26.8817204301075, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=54.089709762533, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=53.8057742782152, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=54.5189504373178, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562584, Length=378, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=374, Percent_Identity=24.8663101604278, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=382, Percent_Identity=24.869109947644, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=54.9597855227882, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322619, Length=363, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=27.2980501392758, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=377, Percent_Identity=27.8514588859416, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=358, Percent_Identity=26.2569832402235, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=280, Percent_Identity=28.2142857142857, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=373, Percent_Identity=26.0053619302949, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=368, Percent_Identity=25.8152173913043, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=354, Percent_Identity=24.8587570621469, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=58.8235294117647, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39947; Mature: 39947

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRAAVAVQAGKPLEVMTVQLEGPKAGEVLVEVKATGICHTDDFTLSGADPEGLFPAIL
CCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGIVVDVGPGVTTVKKGDHVIPLYTPECRECYSCLSRKTNLCTAIRSTQGQGVMPD
CCCCCEEEEECCCCEEEEECCCEEEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
GTSRFSIGKDKIHHYMGCSTFANYTVLPEIALAKVNPDAPFDKICYIGCGVTTGIGAVIN
CCCEECCCHHHHHHHHCHHHHCCEEECCCEEEEEECCCCCCCCEEEEECCHHHHHHHHEE
TAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINPDRKAWGEKFGMTHFVNPKE
EEEEEECCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCEECCCHHH
VGDDIVPYLVNMTKRGGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQ
HCCHHHHHHHHHHCCCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
EISTRPFQLVTGRNWMGTAFGGARGRTDVPKIVDWYMQGKIQIDPMITHTMPLDDINKGF
CCCCCCEEEEECCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCEEEECCCHHHHHCCH
DMMHKGESIRGVVVY
HHHHCCCCCEEEEEC
>Mature Secondary Structure
MDVRAAVAVQAGKPLEVMTVQLEGPKAGEVLVEVKATGICHTDDFTLSGADPEGLFPAIL
CCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGIVVDVGPGVTTVKKGDHVIPLYTPECRECYSCLSRKTNLCTAIRSTQGQGVMPD
CCCCCEEEEECCCCEEEEECCCEEEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
GTSRFSIGKDKIHHYMGCSTFANYTVLPEIALAKVNPDAPFDKICYIGCGVTTGIGAVIN
CCCEECCCHHHHHHHHCHHHHCCEEECCCEEEEEECCCCCCCCEEEEECCHHHHHHHHEE
TAKVEIGSTAIVFGLGGIGLNVLQGLRLAGADMIIGVDINPDRKAWGEKFGMTHFVNPKE
EEEEEECCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCEECCCHHH
VGDDIVPYLVNMTKRGGDLIGGADYTFDCTGNTKVMRQALEASHRGWGKSVIIGVAGAGQ
HCCHHHHHHHHHHCCCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
EISTRPFQLVTGRNWMGTAFGGARGRTDVPKIVDWYMQGKIQIDPMITHTMPLDDINKGF
CCCCCCEEEEECCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCEEEECCCHHHHHCCH
DMMHKGESIRGVVVY
HHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]