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The map label for this gene is fghA [H]

Identifier: 190894918

GI number: 190894918

Start: 635898

End: 636734

Strand: Reverse

Name: fghA [H]

Synonym: RHECIAT_PC0000583

Alternate gene names: 190894918

Gene position: 636734-635898 (Counterclockwise)

Preceding gene: 190894919

Following gene: 190894917

Centisome position: 58.33

GC content: 61.65

Gene sequence:

>837_bases
ATGAAAACCATCTCGATCGACAAGTCTTACGGCGGCACTCAGGGCGTCTACGTCAGCCGCTCCGAAGCCTGCGACTGCGA
CATGACCTTTGCGGTCTTCGTGCCGCCGCAGGCGGCCGAAGGCAAGCGCCCGGTTCTGTGGTACCTGTCCGGCCTGACCT
GCACGCATGCCAATGTCATGGACAAGGGCGAATATCGGCGGCTTGCCGCCGAGCTCGGGCTGATCATCGTCTGCCCGGAT
ACCAGCCCCCGCGGCGATCACGTTCCTGACGAGCCCGACAATTGGCAATTCGGCAAGGGCGCCGGGTTTTACGTCGATGC
CACCGAGCCGCCGTTTTCGGCCAATTATCGCATGTACAGCTACGTCACCGACGAGCTGCCGCGTCTGCTTGCCGCCGAAT
TTCCCGCCGATATGGATCGCCAGGGAATTTTCGGCCATTCGATGGGCGGACATGGGGCGATCACCATTGCGCTCAAGAAT
CCCGACCGCTTCCGGAGCTGCTCGGCCTTCGCGCCGATCAGCCACCCCTCGGTTTCCGGCTGGTCGAAACCGGCCTTGCG
GAAATATCTCGGAGCTGACGAAAAGACCTGGCGGGCCTATGACGCCTGCTCGCTGATCGAAGATGGGCATCGCTTCGCCG
AGCTCTTCGTCGACCAGGGAACGGCGGACAGTTTTCTGGAGGACGGGTTGCGTCCCGACGAGCTTCGGCAGGCCTGCGAG
GCGGCGGGCATTCCCCTCAAGCTTCGCATGCAGGAAGGCTATGGCCACTCCTACTTTTTCATTTCGACATTCATGGAAGA
CCATCTGCGCTGGCACGCGCAGAGGCTTGGAAAATGA

Upstream 100 bases:

>100_bases
CCCGATGATCACCCACACGATGCCGCTCGACGACATCAACAAGGGCTTCGACATGATGCACAAGGGTGAGAGCATCCGTG
GCGTGGTGGTCTACTGAGCC

Downstream 100 bases:

>100_bases
TTGCAGAGCTCGGCCGGGCATAACGCAAACGGCCAGGGAGGGAAGGAGAGAAGCAATGAGCAGCATAGCCATTCATCCGG
CAGTGGATTCGGGCTTTCGA

Product: putative S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKTISIDKSYGGTQGVYVSRSEACDCDMTFAVFVPPQAAEGKRPVLWYLSGLTCTHANVMDKGEYRRLAAELGLIIVCPD
TSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYSYVTDELPRLLAAEFPADMDRQGIFGHSMGGHGAITIALKN
PDRFRSCSAFAPISHPSVSGWSKPALRKYLGADEKTWRAYDACSLIEDGHRFAELFVDQGTADSFLEDGLRPDELRQACE
AAGIPLKLRMQEGYGHSYFFISTFMEDHLRWHAQRLGK

Sequences:

>Translated_278_residues
MKTISIDKSYGGTQGVYVSRSEACDCDMTFAVFVPPQAAEGKRPVLWYLSGLTCTHANVMDKGEYRRLAAELGLIIVCPD
TSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYSYVTDELPRLLAAEFPADMDRQGIFGHSMGGHGAITIALKN
PDRFRSCSAFAPISHPSVSGWSKPALRKYLGADEKTWRAYDACSLIEDGHRFAELFVDQGTADSFLEDGLRPDELRQACE
AAGIPLKLRMQEGYGHSYFFISTFMEDHLRWHAQRLGK
>Mature_278_residues
MKTISIDKSYGGTQGVYVSRSEACDCDMTFAVFVPPQAAEGKRPVLWYLSGLTCTHANVMDKGEYRRLAAELGLIIVCPD
TSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYSYVTDELPRLLAAEFPADMDRQGIFGHSMGGHGAITIALKN
PDRFRSCSAFAPISHPSVSGWSKPALRKYLGADEKTWRAYDACSLIEDGHRFAELFVDQGTADSFLEDGLRPDELRQACE
AAGIPLKLRMQEGYGHSYFFISTFMEDHLRWHAQRLGK

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=52.1428571428571, Blast_Score=305, Evalue=3e-83,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=45.1263537906137, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1788477, Length=280, Percent_Identity=45.3571428571429, Blast_Score=250, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17510185, Length=279, Percent_Identity=46.2365591397849, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=38.047138047138, Blast_Score=203, Evalue=2e-53,
Organism=Drosophila melanogaster, GI45551932, Length=280, Percent_Identity=48.2142857142857, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24648347, Length=280, Percent_Identity=48.2142857142857, Blast_Score=260, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30981; Mature: 30981

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTISIDKSYGGTQGVYVSRSEACDCDMTFAVFVPPQAAEGKRPVLWYLSGLTCTHANVM
CCEEEECCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCEEECCCHH
DKGEYRRLAAELGLIIVCPDTSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYS
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEE
YVTDELPRLLAAEFPADMDRQGIFGHSMGGHGAITIALKNPDRFRSCSAFAPISHPSVSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCCCCCCCCC
WSKPALRKYLGADEKTWRAYDACSLIEDGHRFAELFVDQGTADSFLEDGLRPDELRQACE
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHH
AAGIPLKLRMQEGYGHSYFFISTFMEDHLRWHAQRLGK
HCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTISIDKSYGGTQGVYVSRSEACDCDMTFAVFVPPQAAEGKRPVLWYLSGLTCTHANVM
CCEEEECCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCEEECCCHH
DKGEYRRLAAELGLIIVCPDTSPRGDHVPDEPDNWQFGKGAGFYVDATEPPFSANYRMYS
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEE
YVTDELPRLLAAEFPADMDRQGIFGHSMGGHGAITIALKNPDRFRSCSAFAPISHPSVSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCCCCCCCCCC
WSKPALRKYLGADEKTWRAYDACSLIEDGHRFAELFVDQGTADSFLEDGLRPDELRQACE
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHH
AAGIPLKLRMQEGYGHSYFFISTFMEDHLRWHAQRLGK
HCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]