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The map label for this gene is yciC [H]

Identifier: 190894594

GI number: 190894594

Start: 266493

End: 267674

Strand: Reverse

Name: yciC [H]

Synonym: RHECIAT_PC0000257

Alternate gene names: 190894594

Gene position: 267674-266493 (Counterclockwise)

Preceding gene: 190894595

Following gene: 190894593

Centisome position: 24.52

GC content: 62.35

Gene sequence:

>1182_bases
ATGAATAAGGAGCGGCTCCCGGTAACCGTGCTGGCCGGCTTCCTCGGCGCCGGCAAGACGACGCTGCTCAGCCATGTCCT
GAATAACCGCCAAGGCCTGCGGGCCGCGGTCATCGTCAACGATATGAGCGAAGTGAACATAGACGCCAGTCTCATTCGCG
ACGGCGGCTGCAACCTGTCGCACACGACGGAGACATTGATCGAGCTCAGCAATGGCTGCATCTGCTGTACCCTGCGCAAC
GACCTTCTGACGGAAGTGCGACGACTGGCCCAAGAGGGGCGATACGACTATCTGCTAATCGAAGGAACGGGCATTGCCGA
GCCGCGCCCTATCGCGGCAACCTTTTCCTTCCGCGACGAGACCGGCGTCTCGCTCTCCGATTTTGCTCGCCTCGACACGA
TGGTGACCGTTGTCGACGCTGCAAGCCTCCTGGCCGATTACAGCAGCGCCGATCTGCTTGCCGACCGCGGCCTGCAGAGG
GACGGCGAGGACCGGCGCACCCTTATCGACTTGCTGGTCGACCAGATCGAGTTTGCCGATGTCGTGGTGATCAACAAGAT
CTCGGACGCGAACGAAGAGACCCGCGCCGAAGTCCGCAAAACGGTGGCTGCCCTCAATCCGGATGCCCACCAGGTGGAGA
CGGATTTCGGCAGGATTTCTCTCGAATCCCTTCTCAATACGGGTCTCTTCGATGAAGCAAAAGCCGCCGCGCATCCTTTG
TGGCACAAGGAATTGTACAGCCCGGGGGAGCATGTTCCCGAGACGGAGGAATACGGGGTATCGAGTTTCGTCTATCGCAC
GAGGCGTCCTTTCGACCCGATGCGGTTTCGGGCATTTCTCGATGCGCCCTGGCCGGGCGTGTTGCGTGCCAAGGGCCATT
TCTGGCTCGCCACGCGCCCACGCCACGTGGGCCTGATGTCGGCTGCCGGGATCCAGCGGCGCTGCGAACCCATGGGGCTG
TGGTGGGCAGCCGTGCCCCGGCAGGACTGGCCGGACCATCAGCAATTTCATCGGCACCTTCAGAGCCGATGGGACAGTGC
TTGGGGCGATCGCCGGCAGGAGTTGGTTTTTATCGGCGTAGACATGGACGAGACCGGTGTGCGGACTGCACTGGACGGAT
GCCTCGCGAGCGCCGATCCGCGCGACTGGGCCACCCTCGAAGATCCGTTTCCGGCCTGGTAG

Upstream 100 bases:

>100_bases
GAAAGGATAAGGTCAGGGAGCGGTTTCGCATGAGGTTAATACGGTGCAAATGCGGGTCGCAGCGAGGGGAACTGCCTCCG
CTGTCGTTCAAGGGACTCCG

Downstream 100 bases:

>100_bases
CACGGGCGGCGCAGGATAGCGCGTGCGTGTTAACCGGCCCGACCAGCCGGGATGCGGTGAGGATCATCACATCGACGTAT
GGGTGTACCACCCACATACC

Product: putative cobalamin biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNKERLPVTVLAGFLGAGKTTLLSHVLNNRQGLRAAVIVNDMSEVNIDASLIRDGGCNLSHTTETLIELSNGCICCTLRN
DLLTEVRRLAQEGRYDYLLIEGTGIAEPRPIAATFSFRDETGVSLSDFARLDTMVTVVDAASLLADYSSADLLADRGLQR
DGEDRRTLIDLLVDQIEFADVVVINKISDANEETRAEVRKTVAALNPDAHQVETDFGRISLESLLNTGLFDEAKAAAHPL
WHKELYSPGEHVPETEEYGVSSFVYRTRRPFDPMRFRAFLDAPWPGVLRAKGHFWLATRPRHVGLMSAAGIQRRCEPMGL
WWAAVPRQDWPDHQQFHRHLQSRWDSAWGDRRQELVFIGVDMDETGVRTALDGCLASADPRDWATLEDPFPAW

Sequences:

>Translated_393_residues
MNKERLPVTVLAGFLGAGKTTLLSHVLNNRQGLRAAVIVNDMSEVNIDASLIRDGGCNLSHTTETLIELSNGCICCTLRN
DLLTEVRRLAQEGRYDYLLIEGTGIAEPRPIAATFSFRDETGVSLSDFARLDTMVTVVDAASLLADYSSADLLADRGLQR
DGEDRRTLIDLLVDQIEFADVVVINKISDANEETRAEVRKTVAALNPDAHQVETDFGRISLESLLNTGLFDEAKAAAHPL
WHKELYSPGEHVPETEEYGVSSFVYRTRRPFDPMRFRAFLDAPWPGVLRAKGHFWLATRPRHVGLMSAAGIQRRCEPMGL
WWAAVPRQDWPDHQQFHRHLQSRWDSAWGDRRQELVFIGVDMDETGVRTALDGCLASADPRDWATLEDPFPAW
>Mature_393_residues
MNKERLPVTVLAGFLGAGKTTLLSHVLNNRQGLRAAVIVNDMSEVNIDASLIRDGGCNLSHTTETLIELSNGCICCTLRN
DLLTEVRRLAQEGRYDYLLIEGTGIAEPRPIAATFSFRDETGVSLSDFARLDTMVTVVDAASLLADYSSADLLADRGLQR
DGEDRRTLIDLLVDQIEFADVVVINKISDANEETRAEVRKTVAALNPDAHQVETDFGRISLESLLNTGLFDEAKAAAHPL
WHKELYSPGEHVPETEEYGVSSFVYRTRRPFDPMRFRAFLDAPWPGVLRAKGHFWLATRPRHVGLMSAAGIQRRCEPMGL
WWAAVPRQDWPDHQQFHRHLQSRWDSAWGDRRQELVFIGVDMDETGVRTALDGCLASADPRDWATLEDPFPAW

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=266, Percent_Identity=32.3308270676692, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI126722884, Length=265, Percent_Identity=32.8301886792453, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI148727351, Length=265, Percent_Identity=32.4528301886792, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI146231952, Length=265, Percent_Identity=32.4528301886792, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI223941779, Length=224, Percent_Identity=34.8214285714286, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI223941776, Length=255, Percent_Identity=31.7647058823529, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI119120938, Length=138, Percent_Identity=38.4057971014493, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082430, Length=381, Percent_Identity=28.3464566929134, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788499, Length=238, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=241, Percent_Identity=28.2157676348548, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 44022; Mature: 44022

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKERLPVTVLAGFLGAGKTTLLSHVLNNRQGLRAAVIVNDMSEVNIDASLIRDGGCNLS
CCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCHHHHCCCCCCCC
HTTETLIELSNGCICCTLRNDLLTEVRRLAQEGRYDYLLIEGTGIAEPRPIAATFSFRDE
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCC
TGVSLSDFARLDTMVTVVDAASLLADYSSADLLADRGLQRDGEDRRTLIDLLVDQIEFAD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
VVVINKISDANEETRAEVRKTVAALNPDAHQVETDFGRISLESLLNTGLFDEAKAAAHPL
EEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEEHHHHHCCCCCHHHHHHHCCH
WHKELYSPGEHVPETEEYGVSSFVYRTRRPFDPMRFRAFLDAPWPGVLRAKGHFWLATRP
HHHHHCCCCCCCCCCHHHCHHHHHHHHCCCCCHHHHHHEECCCCCCCEEECCCEEEEECC
RHVGLMSAAGIQRRCEPMGLWWAAVPRQDWPDHQQFHRHLQSRWDSAWGDRRQELVFIGV
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEE
DMDETGVRTALDGCLASADPRDWATLEDPFPAW
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKERLPVTVLAGFLGAGKTTLLSHVLNNRQGLRAAVIVNDMSEVNIDASLIRDGGCNLS
CCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCHHHHCCCCCCCC
HTTETLIELSNGCICCTLRNDLLTEVRRLAQEGRYDYLLIEGTGIAEPRPIAATFSFRDE
HHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCC
TGVSLSDFARLDTMVTVVDAASLLADYSSADLLADRGLQRDGEDRRTLIDLLVDQIEFAD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
VVVINKISDANEETRAEVRKTVAALNPDAHQVETDFGRISLESLLNTGLFDEAKAAAHPL
EEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEEHHHHHCCCCCHHHHHHHCCH
WHKELYSPGEHVPETEEYGVSSFVYRTRRPFDPMRFRAFLDAPWPGVLRAKGHFWLATRP
HHHHHCCCCCCCCCCHHHCHHHHHHHHCCCCCHHHHHHEECCCCCCCEEECCCEEEEECC
RHVGLMSAAGIQRRCEPMGLWWAAVPRQDWPDHQQFHRHLQSRWDSAWGDRRQELVFIGV
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEE
DMDETGVRTALDGCLASADPRDWATLEDPFPAW
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]