Click here to switch to the map view.

The map label for this gene is yciC [H]

Identifier: 190894592

GI number: 190894592

Start: 259745

End: 260977

Strand: Reverse

Name: yciC [H]

Synonym: RHECIAT_PC0000255

Alternate gene names: 190894592

Gene position: 260977-259745 (Counterclockwise)

Preceding gene: 190894593

Following gene: 190894591

Centisome position: 23.91

GC content: 63.42

Gene sequence:

>1233_bases
ATGATGCGTACAGATATCAGATTGCCGGTTACGGTTCTCGCCGGGTTTCTCGGCGCCGGGAAGACGACTGTCCTCAATCA
TATCCTGAGCAATCGGGAGGGTCGTCGGGTCGCTGTCATCGTCAACGATATGAGCGAGGTCAATATCGATGCGGATCTCG
TGCGCGAGGGGAGCGCAGACCTCTCGCGCACGGACGAGACGCTTGTGGAGCTCACCAACGGATGCATCTGCTGCACGCTG
CGCGAGGATCTCCTGAGTGAGGTCAGGCGGCTGGCAGCCGCCGGCCGTTTCGACTATCTGCTGATCGAGGGCACCGGCAT
TGCCGAACCGCTGCCCGTTGCAGCCACCTTCTCCTTCCGCGACGAAAGCGGAGCGGCCCTTTGCGACGTGGCAAGGCTCG
ACACGATGGTTTGCGTCGTCGATGCGGTCAATCTGCTCGCCGATTACCAGAGCGCCGAGTTTCTTGCCGATCGCGGCGAA
AGGCGTGACGGGGACGATGAGCGCAAGCTCGTGGAATTGCTCGTCGAGCAGATCGAATTTTCCGATGTCGTCATCATCAA
CAAGGCAGGCGACGTGTCCTGCGCCGACCTTGCCGAGGTTCGCCGGGTCGTCGCGGCACTGAATCCGGATGCCCAAGTGA
TCGAAGCGGTCTTCGGCCAGGTGCCGCTCGGCGCGATTCTCGATACCGGCCTCTTCAGCGAGGCGAAGGCCGCCCGCCAT
CCGCTCTGGCACAAGGAACTCTTCGGTTGGGGCGACCATGTGCCGGAGACCGAGGAATACGGCATCAGAAGCTTCGTCTA
TCGCAGCCGCCGGCCGTTTGATCCCTCGAAGCTGCAGGGTTTCCTCGGCAGGAAATGGCCGGGCCTCATCCGGGCAAAGG
GGCATTTCTGGCTTGCGACGAGGCCGGACGAGATCGGTTTGCTGTCGATCGCCGGCACCCAGTGCCGCATCGATACCAGG
GGTTACTGGTGGGCCTCCGTGCCGAAGGGGCAGTGGCCACGCTTTCCGCAGTTTCGCCAACTCATCGACCGGCATTGGGA
CGAGGTCTGGGGCGACCGCCGCCAGGAGCTCGTCTTCATCGGCGCCGGCTTCGACGAAGGCGCAATCAGGGTCGCACTCG
ACGACTGCCTGACCGGTGAGGAGACAGGCTTCGATCCGCAGACGGCCGTCGGGCTCCGGGACCCGTTTCCAGCGTGGCCG
CACGGGGCTGTCCACGCACATTCGAGCGGTTAG

Upstream 100 bases:

>100_bases
AGCACGAACTACTACGTGGACGTGGCATTCAAACCGCAGCTCGCGGCGTAACGCCCACGCGGATGCAAGACCAAGCATGC
CGTAAAGTGTGAGAGTATCG

Downstream 100 bases:

>100_bases
TGCGTCCCGCTGGGCGTGCGACGCTTTGATCAACAAGAGGAGAGAACAATGAGCAATGAACTTTACGCAGACGGCATCGG
CGAAATCACCATTACCGGAA

Product: putative cobalamin biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MMRTDIRLPVTVLAGFLGAGKTTVLNHILSNREGRRVAVIVNDMSEVNIDADLVREGSADLSRTDETLVELTNGCICCTL
REDLLSEVRRLAAAGRFDYLLIEGTGIAEPLPVAATFSFRDESGAALCDVARLDTMVCVVDAVNLLADYQSAEFLADRGE
RRDGDDERKLVELLVEQIEFSDVVIINKAGDVSCADLAEVRRVVAALNPDAQVIEAVFGQVPLGAILDTGLFSEAKAARH
PLWHKELFGWGDHVPETEEYGIRSFVYRSRRPFDPSKLQGFLGRKWPGLIRAKGHFWLATRPDEIGLLSIAGTQCRIDTR
GYWWASVPKGQWPRFPQFRQLIDRHWDEVWGDRRQELVFIGAGFDEGAIRVALDDCLTGEETGFDPQTAVGLRDPFPAWP
HGAVHAHSSG

Sequences:

>Translated_410_residues
MMRTDIRLPVTVLAGFLGAGKTTVLNHILSNREGRRVAVIVNDMSEVNIDADLVREGSADLSRTDETLVELTNGCICCTL
REDLLSEVRRLAAAGRFDYLLIEGTGIAEPLPVAATFSFRDESGAALCDVARLDTMVCVVDAVNLLADYQSAEFLADRGE
RRDGDDERKLVELLVEQIEFSDVVIINKAGDVSCADLAEVRRVVAALNPDAQVIEAVFGQVPLGAILDTGLFSEAKAARH
PLWHKELFGWGDHVPETEEYGIRSFVYRSRRPFDPSKLQGFLGRKWPGLIRAKGHFWLATRPDEIGLLSIAGTQCRIDTR
GYWWASVPKGQWPRFPQFRQLIDRHWDEVWGDRRQELVFIGAGFDEGAIRVALDDCLTGEETGFDPQTAVGLRDPFPAWP
HGAVHAHSSG
>Mature_410_residues
MMRTDIRLPVTVLAGFLGAGKTTVLNHILSNREGRRVAVIVNDMSEVNIDADLVREGSADLSRTDETLVELTNGCICCTL
REDLLSEVRRLAAAGRFDYLLIEGTGIAEPLPVAATFSFRDESGAALCDVARLDTMVCVVDAVNLLADYQSAEFLADRGE
RRDGDDERKLVELLVEQIEFSDVVIINKAGDVSCADLAEVRRVVAALNPDAQVIEAVFGQVPLGAILDTGLFSEAKAARH
PLWHKELFGWGDHVPETEEYGIRSFVYRSRRPFDPSKLQGFLGRKWPGLIRAKGHFWLATRPDEIGLLSIAGTQCRIDTR
GYWWASVPKGQWPRFPQFRQLIDRHWDEVWGDRRQELVFIGAGFDEGAIRVALDDCLTGEETGFDPQTAVGLRDPFPAWP
HGAVHAHSSG

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=262, Percent_Identity=31.6793893129771, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI126722884, Length=262, Percent_Identity=31.2977099236641, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI148727351, Length=262, Percent_Identity=30.9160305343511, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI146231952, Length=262, Percent_Identity=30.9160305343511, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI223941779, Length=212, Percent_Identity=32.5471698113208, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223941776, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI119120938, Length=138, Percent_Identity=36.9565217391304, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI87082430, Length=379, Percent_Identity=27.4406332453826, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788499, Length=229, Percent_Identity=26.6375545851528, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324356, Length=240, Percent_Identity=25.4166666666667, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45452; Mature: 45452

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRTDIRLPVTVLAGFLGAGKTTVLNHILSNREGRRVAVIVNDMSEVNIDADLVREGSAD
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCC
LSRTDETLVELTNGCICCTLREDLLSEVRRLAAAGRFDYLLIEGTGIAEPLPVAATFSFR
HHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEC
DESGAALCDVARLDTMVCVVDAVNLLADYQSAEFLADRGERRDGDDERKLVELLVEQIEF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
SDVVIINKAGDVSCADLAEVRRVVAALNPDAQVIEAVFGQVPLGAILDTGLFSEAKAARH
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHC
PLWHKELFGWGDHVPETEEYGIRSFVYRSRRPFDPSKLQGFLGRKWPGLIRAKGHFWLAT
CCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCEEEEE
RPDEIGLLSIAGTQCRIDTRGYWWASVPKGQWPRFPQFRQLIDRHWDEVWGDRRQELVFI
CCCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
GAGFDEGAIRVALDDCLTGEETGFDPQTAVGLRDPFPAWPHGAVHAHSSG
ECCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCC
>Mature Secondary Structure
MMRTDIRLPVTVLAGFLGAGKTTVLNHILSNREGRRVAVIVNDMSEVNIDADLVREGSAD
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCC
LSRTDETLVELTNGCICCTLREDLLSEVRRLAAAGRFDYLLIEGTGIAEPLPVAATFSFR
HHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEC
DESGAALCDVARLDTMVCVVDAVNLLADYQSAEFLADRGERRDGDDERKLVELLVEQIEF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
SDVVIINKAGDVSCADLAEVRRVVAALNPDAQVIEAVFGQVPLGAILDTGLFSEAKAARH
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHC
PLWHKELFGWGDHVPETEEYGIRSFVYRSRRPFDPSKLQGFLGRKWPGLIRAKGHFWLAT
CCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCEEEEE
RPDEIGLLSIAGTQCRIDTRGYWWASVPKGQWPRFPQFRQLIDRHWDEVWGDRRQELVFI
CCCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
GAGFDEGAIRVALDDCLTGEETGFDPQTAVGLRDPFPAWPHGAVHAHSSG
ECCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]