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The map label for this gene is gltA [H]

Identifier: 190571375

GI number: 190571375

Start: 1050419

End: 1051660

Strand: Direct

Name: gltA [H]

Synonym: WPa_0983

Alternate gene names: 190571375

Gene position: 1050419-1051660 (Clockwise)

Preceding gene: 190571374

Following gene: 190571381

Centisome position: 70.86

GC content: 35.43

Gene sequence:

>1242_bases
ATGGATAAAAAAGCATTATTGGAACTAAGTAATGGGTCAAAAATTGATCTGCCCGTATTAAGTGGAACAGTAGGTCCTGA
CGTGTTAAATATTAAGGATTTATATAAGACGACAGGATTATTCACTTATGATCCGGGGTTTGTTTCCACAGCTTCATGCT
CTTCCACAATTACATTCATTGATGGAGATGAAGGAGTTCTTAAGTATAGGGGACATGATATAGCTGATTTGGCAGAGAAT
AATAGTTTTACTGCTGTGATTTATTTATTGCTCTATGGTGAACTACCCAGTTCAGAGCAACACAAAAAATTTCTTCTCAA
AATACAAGAATCATCCAAAGTATCAGAGCAAGTTACAAATGTAATCAAAGCATTTCCAAAAACTGCTCACCCTATGTCGA
TTTTAGTTGCATGTTTTGCAAATTTGTCAGCATCTTACCATGAAACACATGGCAACAATGTCAATGGTGAAGATTTAGAT
TTTGGAATTTCTGCAATAGCACAAGTTCCTGCAATTGTTGCAATGATTTATAGACATATCAACAATCAGGAATTCACAAA
TGCTAATAATAAATTAAGTTATAGTGAGAATTTCTTAAATATGATATTTGGCAGTGCTGTTAATAATACCCTTTTTGTAA
AAGCTCTGGATAAAATATTTACTCTCCATGCTGATCATGAACAGAATGCTTCTACAGCAGCTGTCAGATTGGTAGGGTCA
GCTGGTTCTAATCTATTTGCAAGCCTGTCTGCAGGAGTTGCTACACTTTGGGGTCCAGCACACGGTGGAGCTAATGAGGC
AGTTATAAATATGCTAAAAGAGATAGAGCAAAGTGGAGATGTAGATAGATTCATTGAGAAAGCTAAAGATGATAAAGATC
CATTTAAGCTAATGGGATTTGGACATCGTGTTTATAAAAACTATGATCCGCGCGCGCTTATATTAAAGGATGCTTGTCAT
GAGATTTTAAGCAAACTAGAGCAAAACAATGAATTACTTGAAATTGCAAAAAAACTTGAAGAAATAGCTTTAAAGGATGA
GTATTTTATTACACGTAAGTTGTATCCAAATGTTGATTTTTATTCAGGTATAATAATGAATGCTATCGGTATCCCTTCAA
GTATGTTTACACCCATTTTTGCACTTGCAAGAACCACTGGTTGGGTTGCCCAGTGGTATGAAATGGTAAACGATAAAGAA
ACCAAGATTTGTAGGCCAAGGCAGCTCTACCTTGGCAAATAA

Upstream 100 bases:

>100_bases
AAAGCATTGATGACCGCTTAATACGGTTAATGTAAAGTTAACTATATTAATATATACTTTTCAGTTTGTATATTCTGTAT
AAAATTAAGTAGCTCAAGTG

Downstream 100 bases:

>100_bases
ACTTTCATTCACAATTCATCTTTGAATAGCCTAATTTCCTTTAGCTATAAAATACAACAAATTGATTTTTTATTAGTTGA
TGTCTGCTTTTTTGCAGAAC

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDKKALLELSNGSKIDLPVLSGTVGPDVLNIKDLYKTTGLFTYDPGFVSTASCSSTITFIDGDEGVLKYRGHDIADLAEN
NSFTAVIYLLLYGELPSSEQHKKFLLKIQESSKVSEQVTNVIKAFPKTAHPMSILVACFANLSASYHETHGNNVNGEDLD
FGISAIAQVPAIVAMIYRHINNQEFTNANNKLSYSENFLNMIFGSAVNNTLFVKALDKIFTLHADHEQNASTAAVRLVGS
AGSNLFASLSAGVATLWGPAHGGANEAVINMLKEIEQSGDVDRFIEKAKDDKDPFKLMGFGHRVYKNYDPRALILKDACH
EILSKLEQNNELLEIAKKLEEIALKDEYFITRKLYPNVDFYSGIIMNAIGIPSSMFTPIFALARTTGWVAQWYEMVNDKE
TKICRPRQLYLGK

Sequences:

>Translated_413_residues
MDKKALLELSNGSKIDLPVLSGTVGPDVLNIKDLYKTTGLFTYDPGFVSTASCSSTITFIDGDEGVLKYRGHDIADLAEN
NSFTAVIYLLLYGELPSSEQHKKFLLKIQESSKVSEQVTNVIKAFPKTAHPMSILVACFANLSASYHETHGNNVNGEDLD
FGISAIAQVPAIVAMIYRHINNQEFTNANNKLSYSENFLNMIFGSAVNNTLFVKALDKIFTLHADHEQNASTAAVRLVGS
AGSNLFASLSAGVATLWGPAHGGANEAVINMLKEIEQSGDVDRFIEKAKDDKDPFKLMGFGHRVYKNYDPRALILKDACH
EILSKLEQNNELLEIAKKLEEIALKDEYFITRKLYPNVDFYSGIIMNAIGIPSSMFTPIFALARTTGWVAQWYEMVNDKE
TKICRPRQLYLGK
>Mature_413_residues
MDKKALLELSNGSKIDLPVLSGTVGPDVLNIKDLYKTTGLFTYDPGFVSTASCSSTITFIDGDEGVLKYRGHDIADLAEN
NSFTAVIYLLLYGELPSSEQHKKFLLKIQESSKVSEQVTNVIKAFPKTAHPMSILVACFANLSASYHETHGNNVNGEDLD
FGISAIAQVPAIVAMIYRHINNQEFTNANNKLSYSENFLNMIFGSAVNNTLFVKALDKIFTLHADHEQNASTAAVRLVGS
AGSNLFASLSAGVATLWGPAHGGANEAVINMLKEIEQSGDVDRFIEKAKDDKDPFKLMGFGHRVYKNYDPRALILKDACH
EILSKLEQNNELLEIAKKLEEIALKDEYFITRKLYPNVDFYSGIIMNAIGIPSSMFTPIFALARTTGWVAQWYEMVNDKE
TKICRPRQLYLGK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=361, Percent_Identity=26.0387811634349, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1786939, Length=415, Percent_Identity=50.1204819277108, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1786527, Length=347, Percent_Identity=30.835734870317, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17555174, Length=373, Percent_Identity=25.4691689008043, Blast_Score=111, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=392, Percent_Identity=27.2959183673469, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324328, Length=361, Percent_Identity=28.2548476454294, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325257, Length=364, Percent_Identity=27.4725274725275, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24640126, Length=372, Percent_Identity=25, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24640124, Length=372, Percent_Identity=25, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21356863, Length=364, Percent_Identity=25.8241758241758, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 45711; Mature: 45711

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKALLELSNGSKIDLPVLSGTVGPDVLNIKDLYKTTGLFTYDPGFVSTASCSSTITFI
CCCCCEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHCCCEEECCCCCEECCCCCEEEEE
DGDEGVLKYRGHDIADLAENNSFTAVIYLLLYGELPSSEQHKKFLLKIQESSKVSEQVTN
ECCCCEEEECCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VIKAFPKTAHPMSILVACFANLSASYHETHGNNVNGEDLDFGISAIAQVPAIVAMIYRHI
HHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
NNQEFTNANNKLSYSENFLNMIFGSAVNNTLFVKALDKIFTLHADHEQNASTAAVRLVGS
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCHHHEEEECC
AGSNLFASLSAGVATLWGPAHGGANEAVINMLKEIEQSGDVDRFIEKAKDDKDPFKLMGF
CCCHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHCC
GHRVYKNYDPRALILKDACHEILSKLEQNNELLEIAKKLEEIALKDEYFITRKLYPNVDF
CHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHEEEEECCCCCCH
YSGIIMNAIGIPSSMFTPIFALARTTGWVAQWYEMVNDKETKICRPRQLYLGK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MDKKALLELSNGSKIDLPVLSGTVGPDVLNIKDLYKTTGLFTYDPGFVSTASCSSTITFI
CCCCCEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHCCCEEECCCCCEECCCCCEEEEE
DGDEGVLKYRGHDIADLAENNSFTAVIYLLLYGELPSSEQHKKFLLKIQESSKVSEQVTN
ECCCCEEEECCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VIKAFPKTAHPMSILVACFANLSASYHETHGNNVNGEDLDFGISAIAQVPAIVAMIYRHI
HHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
NNQEFTNANNKLSYSENFLNMIFGSAVNNTLFVKALDKIFTLHADHEQNASTAAVRLVGS
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCHHHEEEECC
AGSNLFASLSAGVATLWGPAHGGANEAVINMLKEIEQSGDVDRFIEKAKDDKDPFKLMGF
CCCHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHCC
GHRVYKNYDPRALILKDACHEILSKLEQNNELLEIAKKLEEIALKDEYFITRKLYPNVDF
CHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHEEEEECCCCCCH
YSGIIMNAIGIPSSMFTPIFALARTTGWVAQWYEMVNDKETKICRPRQLYLGK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112124; 9823893; 7557459 [H]