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The map label for this gene is pth [H]

Identifier: 190571326

GI number: 190571326

Start: 1000481

End: 1001044

Strand: Direct

Name: pth [H]

Synonym: WPa_0931

Alternate gene names: 190571326

Gene position: 1000481-1001044 (Clockwise)

Preceding gene: 190571325

Following gene: 190571328

Centisome position: 67.49

GC content: 31.91

Gene sequence:

>564_bases
GTGCATTTAATAGCTGGGCTTGGTAATCCTGGTAGTCAATATGAGTTAACTCATCATAATATTGGTTTTATCGTTATTGA
CGCAATCTACAAATATTGGAATTTTCAGTCATTTTCTAAGAAAGCCGATTACTTGATAACCTCTGGCATAATTAACAATA
ATAAAGTTATGCTAATAAAGCCTTATTCGTTTATGAATAATTCAGGTATTCCTGTTGCAAAAATAAAAAATTTTTACAAA
TTATCGCTAGACAATATTGTTGTCATACATGATGATGCTGACTTGAAATTTGGAAGAATAAAAGTAAAAAAAGGTGGTAG
TTCTGCTGGACATAATGGACTTAAGTCTATAGATAGCTTTATTGGTAATGATTATTGGCGTTTAAGATTTGGAGTAGGCA
GGCCTGAAGGTCAGAAAAGCTTAGCAGACTATGTGTTATCAAAATTTGAAAATTTTGATAACGTTATCCTCTTAGTGGAA
AAAATAGCAAAAAATATACACCTAATGCTGCAAGGAGATACCACAGCTTTTATCAACTCGGTTGAGAGTGAAACTTTAGT
ATAG

Upstream 100 bases:

>100_bases
GTGTTAAATTTGTAGCTCATGAGGAAGAAAATTTCACCATTGTAACAATCTCTGCTGCCGATAGTGATGTTGAAGAGACT
CAAACAAAAACAGAGGAGTA

Downstream 100 bases:

>100_bases
CAAACGAATACTGCCCAATACAAACTAATTTAGATTAGAATACTGATTCTTCTAGAAGTTGTTCGCGTTCCTCTTCTATT
GCAATGGAATTATCATGATT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MHLIAGLGNPGSQYELTHHNIGFIVIDAIYKYWNFQSFSKKADYLITSGIINNNKVMLIKPYSFMNNSGIPVAKIKNFYK
LSLDNIVVIHDDADLKFGRIKVKKGGSSAGHNGLKSIDSFIGNDYWRLRFGVGRPEGQKSLADYVLSKFENFDNVILLVE
KIAKNIHLMLQGDTTAFINSVESETLV

Sequences:

>Translated_187_residues
MHLIAGLGNPGSQYELTHHNIGFIVIDAIYKYWNFQSFSKKADYLITSGIINNNKVMLIKPYSFMNNSGIPVAKIKNFYK
LSLDNIVVIHDDADLKFGRIKVKKGGSSAGHNGLKSIDSFIGNDYWRLRFGVGRPEGQKSLADYVLSKFENFDNVILLVE
KIAKNIHLMLQGDTTAFINSVESETLV
>Mature_187_residues
MHLIAGLGNPGSQYELTHHNIGFIVIDAIYKYWNFQSFSKKADYLITSGIINNNKVMLIKPYSFMNNSGIPVAKIKNFYK
LSLDNIVVIHDDADLKFGRIKVKKGGSSAGHNGLKSIDSFIGNDYWRLRFGVGRPEGQKSLADYVLSKFENFDNVILLVE
KIAKNIHLMLQGDTTAFINSVESETLV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=161, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=7e-20,
Organism=Escherichia coli, GI1787455, Length=151, Percent_Identity=37.7483443708609, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20974; Mature: 20974

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2 ; PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLIAGLGNPGSQYELTHHNIGFIVIDAIYKYWNFQSFSKKADYLITSGIINNNKVMLIK
CEEEECCCCCCCCEEEEECCCCEEEHHHHHHHHCCCCCCCCCCEEEEECEECCCEEEEEE
PYSFMNNSGIPVAKIKNFYKLSLDNIVVIHDDADLKFGRIKVKKGGSSAGHNGLKSIDSF
CHHHCCCCCCCHHHHHHEEEEECCCEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHH
IGNDYWRLRFGVGRPEGQKSLADYVLSKFENFDNVILLVEKIAKNIHLMLQGDTTAFINS
HCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCHHHHHC
VESETLV
CCCCCCC
>Mature Secondary Structure
MHLIAGLGNPGSQYELTHHNIGFIVIDAIYKYWNFQSFSKKADYLITSGIINNNKVMLIK
CEEEECCCCCCCCEEEEECCCCEEEHHHHHHHHCCCCCCCCCCEEEEECEECCCEEEEEE
PYSFMNNSGIPVAKIKNFYKLSLDNIVVIHDDADLKFGRIKVKKGGSSAGHNGLKSIDSF
CHHHCCCCCCCHHHHHHEEEEECCCEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHH
IGNDYWRLRFGVGRPEGQKSLADYVLSKFENFDNVILLVEKIAKNIHLMLQGDTTAFINS
HCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCHHHHHC
VESETLV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA